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    • 10. 发明申请
    • PSEUDACYCLIN AND METHOD OF INDICATION OF A FUNGUS PSEUDALLESCHERIA BOYDII
    • PSEUDACYCLIN和指示真菌菌株BOYDII的方法
    • WO2009149675A3
    • 2010-04-08
    • PCT/CZ2009000081
    • 2009-06-10
    • INST OF MICROBIOLOGY AS CR V VHAVLICEK VLADIMIRKUZMA MAREKSKLENAR JANZABKA MARTINNEVDED JANNOVAK PETRLEMR KAREL
    • HAVLICEK VLADIMIRKUZMA MAREKSKLENAR JANZABKA MARTINNEVDED JANNOVAK PETRLEMR KAREL
    • C07K7/56A61K38/12G01N33/68
    • C07K7/56
    • Pseudacyclin and method of indication of a fungus Pseudallescheria boydii Pseudacyclins are secondary metabolites isolated from a filamentous fungus Pseudallescheria boydii. They reveal a cyclic-like structure which is represented by a cyclopeptide backbone consisting of an amino acid sequence: ornithine - phenylalanine - proline - isoleucine - the fifth amino acid. This cycle is completed by a peptide bond condensed from an amino group on a Cd of ornithine and a carboxyl group of the fifth amino acid, which is variable. The peptides further contain a side chain represented by a second variable residue, which is the sixth amino acid bound to the cyclopeptide skeleton. The attachment is made through a peptide bond originated from the condensation of the amino group at Ca of ornithine and carboxyl group of this sixth amino acid residue. Pseudacyclins as specific products of secondary metabolism of a pathogenic filamentous fungus Pseudallescheria boydii are useful as disease markers. Pseudacyclins are used as standards indicating the fungal presence in an organism.
    • 伪环霉素和真菌的指示方法假丝酵母假环孢素是从丝状真菌Pseudallescheria boydii分离的次级代谢物。 它们显示由由氨基酸序列组成的环肽主链表示的环状结构:鸟氨酸 - 苯丙氨酸 - 脯氨酸 - 异亮氨酸 - 第五氨基酸。 该循环通过从鸟氨酸的Cd上的氨基和第五个氨基酸的羧基缩合的肽键来完成,该羧基是可变的。 肽还含有由第二个可变残基表示的侧链,第二个可变残基是与环肽骨架结合的第六个氨基酸。 附着物是通过源鸟氨酸Ca和氨基酸氨基的缩合形成的第六个氨基酸残基的羧基。 作为病原性丝状真菌的二次代谢的特异性产物,假环孢素Pseudallescheria boydii可用作疾病标记物。 使用假环素作为表明生物体中真菌存在的标准。