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1. 发明申请

WO2021248028A1 HOLLOW FIBERS FOR OUTSIDE-IN DIALYSIS APPLICATIONS 审中-公开
公开(公告)号：WO2021248028A1
公开(公告)日：2021-12-09
申请号：PCT/US2021/035945
申请日：2021-06-04
申请人： NOVAFLUX, INC. , GEREMIA, Ilaria , STAMATIALIS, Dimitrios , LABIB, Mohamed , MATERNA, Peter
发明人： GEREMIA, Ilaria , STAMATIALIS, Dimitrios , LABIB, Mohamed , MATERNA, Peter
IPC分类号： B01D69/08 , B01D67/00 , B01D69/14 , B01D71/68 , A61M1/1625 , A61M2202/0421 , A61M2205/7527 , B01D2323/08 , B01D2323/22 , B01D2325/025 , B01D2325/20 , B01D67/0016 , B01D69/085 , B01D69/087 , B01D69/141 , D01D5/06 , D01D5/24 , D01F8/16 , D10B2331/06 , D10B2401/022 , D10B2401/10 , D10B2509/00
摘要： Disclosed are hollow fibers suitable for use in dialysis in an outside-in configuration. For such fibers, it is desirable that the fiber have a low albumin sieving coefficient and have a permeability high enough to be considered a High Flux dialyzer, and it is desirable that the outer (blood-facing) surface have a sufficiently small roughness and be hydrophilic. It is desirable that there be a selective layer on the outer surface and, interiorly of that, a porous structurally supportive region, which may contain elongated macrovoids. Such a fiber may be spun through a triple-concentric spinneret that produces a bore liquid surrounded by dope surrounded by a shower. The shower and the coagulation bath may be pure water, which is a non-solvent. The process may be performed at room temperature. Spinning parameters are discussed.

2. 发明申请

WO2017048224A1 CARTRIDGES AND SYSTEMS FOR OUTSIDE-IN FLOW IN MEMBRANE-BASED THERAPIES 审中-公开
标题翻译：基于膜的治疗外部流入的药物和系统
公开(公告)号：WO2017048224A1
公开(公告)日：2017-03-23
申请号：PCT/US2015/050004
申请日：2015-09-14
申请人： LABIB, Mohamed, E. , DUKHIN, Stanislav, S. , KELLY, Thomas , MATERNA, Peter
发明人： LABIB, Mohamed, E. , DUKHIN, Stanislav, S. , KELLY, Thomas , MATERNA, Peter
IPC分类号： B01D61/28 , B01D63/02 , A61M1/16
CPC分类号： A61M1/1625 , B01D61/28 , B01D63/02 , B01D2313/08
摘要： Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration. These various features may enable long-term application to all dialysis and ultrafiltration related therapies, and also to other therapies and to applications including implantables, portables and wearables.
摘要翻译：本发明的实施例涉及用于进行血液透析和相关的体外血液处理模式和疗法的药筒，系统和方法，其中血液在纤维间隙中流动并且透析液在中空纤维内腔中流动。可以提供适当的连接器和配合方向。可以提供轨道分配器，纤维的扇形和特征，以促进纤维束中的纤维间隔的均匀性。轨道分配器可以包含轮廓表面，流动重定向器，非均匀电导流动元件，通孔分配器和其他特征。可以将纤维束分成两组纤维，每组具有单独的控制流体。可以为各种疗法提供适当的系统。通过纤维的流动可以是平行的，横向的或其它构型。这些各种特征可以使得能够长期应用于所有透析和超滤相关疗法，以及其它疗法以及包括植入物，便携式和可穿戴物在内的应用。

3. 发明申请

WO2018064284A1 COMPOSITIONS FOR CLEANING AND DECONTAMINATION 审中-公开
标题翻译：清洁和去污组合物
公开(公告)号：WO2018064284A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/053925
申请日：2017-09-28
申请人： NOVAFLUX, INC.
发明人： LABIB, Mohamed Emam , DUKHIN, Stanislav S. , TABANI, Yacoob , LAI, Ching-Yue , MANGANARO, James L. , MATERNA, Peter , ROBERTSON, Jeffrey C.
IPC分类号： C11D3/43 , C11D11/00 , A61K8/02 , A61Q17/00 , B08B3/04
摘要： Provided among other things is a cleaning composition comprising: a carrier fluid; and Minute Fibrils suspended in the carrier fluid, wherein the composition is protein cleaning effective.
摘要翻译：除其他之外，提供一种清洁组合物，其包含：载液; 和悬浮在载体液中的Minute Fibrils，其中组合物是有效的蛋白质清洁剂。

4. 发明申请

WO2016040731A1 ENERGY STORAGE BY PUMPED STORAGE BASED ON LIQUIDS HAVING DIFFERENT DENSITIES 审中-公开
标题翻译：基于具有不同浓度液体的储存储存的能源储存
公开(公告)号：WO2016040731A1
公开(公告)日：2016-03-17
申请号：PCT/US2015/049568
申请日：2015-09-11
申请人： MATERNA, Peter , HENSLER, Ralph
发明人： MATERNA, Peter , HENSLER, Ralph
IPC分类号： F03B13/06 , F03G7/04
CPC分类号： F03B13/06 , F05B2260/42 , Y02E10/22 , Y02E60/17 , Y02P90/50
摘要： In embodiments of the invention, energy is stored as a result of work performed against the pressure difference resulting from two liquids having unequal densities. There may be an upper storage region and a lower storage region and a connecting conduit connecting the two storage regions. The less-dense liquid can be the ocean, which may surround the apparatus. The more-dense liquid can be concentrated from seawater or can be an aqueous solution of other solutes. In some embodiments, the storage regions and the connecting conduit may all rest on the seafloor, wherein the seafloor topography provides an appropriate elevation difference between the two storage regions. In other embodiments, the upper storage region may float at or near the surface of the ocean. The storage regions may be flexible bags, or impoundments on the ocean floor, or, for the upper storage region, a ship or barge.
摘要翻译：在本发明的实施例中，作为针对由具有不等密度的两种液体产生的压力差执行的工作的结果来存储能量。可以存在上部存储区域和下部存储区域以及连接两个存储区域的连接导管。较不密集的液体可以是围绕设备的海洋。更致密的液体可以从海水中浓缩，或者可以是其它溶质的水溶液。在一些实施例中，存储区域和连接管道都可以搁置在海底上，其中海底地形在两个存储区域之间提供适当的高度差。在其他实施例中，上部存储区域可以在海洋表面处或附近浮动。存储区域可以是柔性袋，或在海底上的蓄水池，或者对于上部存储区域，船舶或驳船。

5. 发明申请

WO2003030787A1 SYSTEM AND METHOD FOR RAPIDLY CUSTOMIZING DESIGN, MANUFACTURE AND/OR SELECTION OF BIOMEDICAL DEVICES 审中-公开
标题翻译：用于快速自定义生物医学设备的设计，制造和/或选择的系统和方法
公开(公告)号：WO2003030787A1
公开(公告)日：2003-04-17
申请号：PCT/US2001/042496
申请日：2001-10-05
申请人： THERICS, INC. , BRADBURY, Thomas, J. , GAYLO, Christopher, M. , FAIRWEATHER, James , CHESMEL, Kathleen, D. , MATERNA, Peter , YOUSSEF, Adolphe
发明人： BRADBURY, Thomas, J. , GAYLO, Christopher, M. , FAIRWEATHER, James , CHESMEL, Kathleen, D. , MATERNA, Peter , YOUSSEF, Adolphe
IPC分类号： A61F2/30
CPC分类号： A61F2/30942 , A61F2/186 , A61F2/2803 , A61F2/2875 , A61F2002/2878 , A61F2002/30062 , A61F2002/30677 , A61F2002/30678 , A61F2002/30948 , A61F2002/30952 , A61F2002/30953 , A61F2002/30962 , A61F2002/30968 , A61F2210/0004 , A61F2240/002 , A61F2310/00293 , B33Y50/00 , B33Y80/00 , G05B2219/45172 , G06F19/00 , G16H50/50
摘要： The rapid design and manufacture of biomedical devices such as implants, oral dosage pills and implantable pharmaceuticals employs electronic data and modeling transmissions via a computer network. Patient information and patient-specific radiological data is captured and transmitted via a computer network to a design and/or manufacturing site. A multi-dimensional digital model is created based on the radiological data and patient information. Communications interchanges between a clinical/diagnostic site and a design/manufacturing site permit modification of the digital model until approved. The approved digital model is converted into machine instructions to construct the biomedical device. Alternatively, the digital model is employed in a best fit selection of a biomedical device from a pre-existing set of biomedical devices or machine-instructions. Transmittal of data over computer networks is further directed to the use of a Website to perform various client-interaction and follow-up tasks.
摘要翻译：生物医学装置如植入物，口服药丸和可植入药物的快速设计和制造采用电子数据和通过计算机网络建模传输。患者信息和患者特定放射学数据被捕获并通过计算机网络传输到设计和/或制造现场。基于放射学数据和患者信息创建多维数字模型。临床/诊断现场与设计/生产现场之间的通信交换允许修改数字模型，直到获得批准。将批准的数字模型转换为机器指令以构建生物医学装置。或者，数字模型被用于从预先存在的一组生物医学装置或机器指令的生物医学装置的最佳拟合选择。通过计算机网络传输数据进一步涉及使用网站执行各种客户端交互和后续任务。

6. 发明申请

WO2018039443A1 APPARATUS AND METHODS FOR HYGIENE TESTING A MEDICAL DEVICE 审中-公开
标题翻译：用于卫生测试医疗设备的设备和方法
公开(公告)号：WO2018039443A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/048401
申请日：2017-08-24
申请人： NOVAFLUX, INC.
发明人： LABIB, Mohamed E. , DUKHIN, Stanislav S. , ROBERTSON, Jeffrey C. , MATERNA, Peter , LAI, Ching-Yue , TABANI, Yacoob
IPC分类号： G01N1/10 , G01N1/22 , A61B1/12 , C12Q1/06
摘要： Provided among other things is a sampling system for determining an amount or type of contamination a narrow, elongated passageway in a medical device, said sampling system comprising: (a) a fluid supply system that supplies to said passageway a sampling liquid for flowing through said passageway and a gas for flowing through said passageway; and (b) a receiving container that receives liquid from said passageway, wherein said sampling liquid is sterile, wherein said sampling liquid is configured to allow recovery of viable pathogens from the passageway, and wherein said sampling liquid comprises an amount and selection of surfactant effective to enhance the dislodgement of Enterococcus faecalis and Pseudomonas aeruginosa bacteria from the narrow passageways.
摘要翻译：除其他外，提供了一种取样系统，用于确定医疗设备中狭窄细长通道的污染量或类型，所述取样系统包括：（a）流体供应系统，其向所述用于流过所述通道的采样液体和用于流过所述通道的气体; （b）接收来自所述通道的液体的接收容器，其中所述取样液体是无菌的，其中所述取样液体被配置为允许从通道回收活的病原体，并且其中所述取样液体包括表面活性剂的量和选择以增强从狭窄通道中去除粪肠球菌和铜绿假单胞菌的能力。

7. 发明申请

WO2017015571A1 IMPLANTS AND CONSTRUCTS INCLUDING HOLLOW FIBERS 审中-公开
标题翻译：包括中空纤维的植入物和构造
公开(公告)号：WO2017015571A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/043585
申请日：2016-07-22
申请人： NOVAFLUX, INC.
发明人： LABIB, Mohamed E. , DUKHIN, Stanislav S. , MATERNA, Peter , ROBERTSON, Jeffrey C. , LAI, Ching-Yue , TABANI, Yacoob
IPC分类号： A61M31/00 , A61L27/54 , A61L27/58 , A61L27/14
CPC分类号： A61K9/0092 , A61B17/06166 , A61B2017/00893 , A61C15/041 , A61F2/0063 , A61F13/00063 , A61F2250/0068 , A61L17/005 , A61L31/04 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/406 , A61M27/002 , A61M37/00
摘要： Hollow fiber drug delivery devices are described. Device can contain structural or solid fibers. Fabric can be formed by fibers being interwoven or joined to each other. All or some of the fibers can be resorbable. Fibers can be subdivided, by deformations or closure points, into numerous compartments that separately deliver drug. Deformations can be located at points of fiber intersection or joining. Different drug or drug formulation can be provided in different places. Fibers can be given appropriate surface treatments or coatings to achieve desired properties such as wetting of pores and surfaces. Different release characteristics in different directions can be achieved. The hollow fibers can contain solid particles of drug, and can contain gel. Possible applications include hernia meshes, pouches, sutures, catheters, wound dressings, stents, nerve regrowth guides, refillable/drainable devices, and devices that deliver drug to lymphatic flow.
摘要翻译：描述了中空纤维药物递送装置。设备可以包含结构或固体纤维。织物可以由彼此交织或接合的纤维形成。全部或部分纤维可以再吸收。纤维可以通过变形或闭合点细分成多个单独递送药物的隔室。变形可以位于光纤交叉点或接合处。可以在不同的地方提供不同的药物或药物制剂。纤维可以被给予适当的表面处理或涂层，以达到所需的性能，如孔和表面的润湿。可以实现不同方向的不同释放特性。中空纤维可以含有药物的固体颗粒，并且可以含有凝胶。可能的应用包括疝网，袋，缝合线，导管，伤口敷料，支架，神经再生长导管，可再灌注/可排出装置以及将药物递送至淋巴流的装置。

8. 发明申请

WO2019195403A1 CLEANING COMPOSITION WITH SUPERABSORBENT POLYMER 审中-公开
公开(公告)号：WO2019195403A1
公开(公告)日：2019-10-10
申请号：PCT/US2019/025558
申请日：2019-04-03
申请人： NOVAFLUX, INC.
发明人： LABIB, Mohamed Emam , DUKHIN, Stanislav S. , TABANI, Yacoob , LAI, Ching-Yue , MANGANARO, James L. , MATERNA, Peter , ROBERTSON, Jeffrey C. , SOHN, Seo Yean
IPC分类号： C11D3/14 , B08B3/08
摘要： Provided among other things are a cleaning composition comprising a carrier fluid comprising in the carrier fluid polymer comprising particulate super absorbent polymer (PSAP), wherein the PSAP as in the cleaning composition is substantially at the percolation volume fraction or higher; wherein the cleaning composition can be passed over a surface driven by a pressure drop effective to render the composition traditional biofilm (TBF) cleaning effective and protein cleaning effective.

9. 发明公开

EP4161688A1 HOLLOW FIBERS FOR OUTSIDE-IN DIALYSIS APPLICATIONS 审中-公开
公开(公告)号：EP4161688A1
公开(公告)日：2023-04-12
申请号：EP21736118.7
申请日：2021-06-04
申请人： Novaflux Inc.
发明人： MATERNA, Peter , STAMATIALIS, Dimitrios , GEREMIA, Ilaria , LABIB, Mohamed
IPC分类号： B01D69/08 , B01D67/00 , B01D69/14 , B01D71/68

10. 发明公开

EP3325079A1 IMPLANTS AND CONSTRUCTS INCLUDING HOLLOW FIBERS 审中-实审
公开(公告)号：EP3325079A1
公开(公告)日：2018-05-30
申请号：EP16828615.1
申请日：2016-07-22
申请人： Novaflux, Inc.
发明人： LABIB, Mohamed E. , DUKHIN, Stanislav S. , MATERNA, Peter , ROBERTSON, Jeffrey C. , LAI, Ching-Yue , TABANI, Yacoob
IPC分类号： A61M31/00 , A61L27/54 , A61L27/58 , A61L27/14
CPC分类号： A61K9/0092 , A61B17/06166 , A61B2017/00893 , A61C15/041 , A61F2/0063 , A61F13/00063 , A61F2250/0068 , A61L17/005 , A61L31/04 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/406 , A61M27/002 , A61M37/00
摘要： Hollow fiber drug delivery devices are described. Device can contain structural or solid fibers. Fabric can be formed by fibers being interwoven or joined to each other. All or some of the fibers can be resorbable. Fibers can be subdivided, by deformations or closure points, into numerous compartments that separately deliver drug. Deformations can be located at points of fiber intersection or joining. Different drug or drug formulation can be provided in different places. Fibers can be given appropriate surface treatments or coatings to achieve desired properties such as wetting of pores and surfaces. Different release characteristics in different directions can be achieved. The hollow fibers can contain solid particles of drug, and can contain gel. Possible applications include hernia meshes, pouches, sutures, catheters, wound dressings, stents, nerve regrowth guides, refillable/drainable devices, and devices that deliver drug to lymphatic flow.

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