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1. 发明申请

WO2009082547A1 NEAR-INFRARED ELECTROMAGNETIC MODIFICATION OF CELLULAR STEADY-STATE MEMBRANE POTENTIALS 审中-公开
标题翻译：细胞状态膜电位的近红外电磁修正
公开(公告)号：WO2009082547A1
公开(公告)日：2009-07-02
申请号：PCT/US2008/082130
申请日：2008-10-31
申请人： NOMIR MEDICAL TECHNOLOGIES, INC. , BORNSTEIN, Eric
发明人： BORNSTEIN, Eric
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61K31/337 , A61K31/404 , A61K31/407 , A61K31/538 , A61K31/65 , A61K31/704 , A61K31/7048 , A61K38/12 , A61K38/14 , A61K41/0019 , A61K41/0057 , A61N5/06 , A61N5/0601 , A61N5/0624 , A61N2005/0658 , A61N2005/067 , C12N13/00
摘要： Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (ΔΨ-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ΔΨ of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug- resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ΔΨ, the affiliated weakening of the proton motive force Δp, and the associated lowered phosphorylation potential ΔGp. Within the area of irradiation exposure, the decrease in membrane potentials ΔΨ will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.
摘要翻译：本文公开了用于施加近红外光学能量和剂量测定法以通过光学去极化效应改变所有辐射细胞的生物能量稳态跨膜和线粒体电位（Δε-稳定）的系统和方法。这种去极化引起跨膜电位的绝对值的伴随减少？的被照射的线粒体和质膜。许多细胞合成代谢反应和药物抗性机制可以通过膜电位降低，质子运动力βp的相关弱化以及相关联的降低的磷酸化潜能ΔGp而降低功能和/或减轻。在照射暴露区域内，膜电位降低？将在细菌，真菌和哺乳动物细胞中一致发生。该膜去极化提供了针对仅靶向不期望的细胞增强抗微生物，抗真菌和/或抗肿瘤药物的能力。

2. 发明申请

WO2010019800A1 THERAPEUTIC LIGHT DELIVERY APPARATUS, METHOD, AND SYSTEM 审中-公开
标题翻译：治疗光递送装置，方法和系统
公开(公告)号：WO2010019800A1
公开(公告)日：2010-02-18
申请号：PCT/US2009/053752
申请日：2009-08-13
申请人： NOMIR MEDICAL TECHNOLOGIES, INC. , BORNSTEIN, Eric , SINOFSKY, Eric
发明人： BORNSTEIN, Eric , SINOFSKY, Eric
IPC分类号： G02B6/44
CPC分类号： G02B6/262 , A61B2018/2261 , A61N5/0601 , A61N5/0624 , A61N2005/063 , A61N2005/0659 , G02B6/32
摘要： An optical delivery apparatus is disclosed including: an optical fiber extending between a distal end having a distal end face and a proximal end having a proximal end face, an optical element positioned to receive the light emitted from the distal end face and direct the light to an illumination region; and a non-metallic housing containing the optical fiber and the optical element and maintaining the relative position of the optical fiber and the optical element.
摘要翻译：公开了一种光学传送装置，包括：在具有远端面的远端和具有近端面的近端之间延伸的光纤，定位成接收从远端面发射的光并将光引导到照明区域; 以及包含光纤和光学元件并保持光纤和光学元件的相对位置的非金属外壳。

3. 发明申请

WO2009117672A3 MODIFICATION OF CELLULAR STEADY-STATE MEMBRANE POTENTIALS IN DRUG RESISTANT BACTERIA 审中-公开
公开(公告)号：WO2009117672A3
公开(公告)日：2009-09-24
申请号：PCT/US2009/037830
申请日：2009-03-20
申请人： NOMIR MEDICAL TECHNOLOGIES,INC. , BORNSTEIN, Eric
发明人： BORNSTEIN, Eric
IPC分类号： A61N5/067
摘要： Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (ΔΨ-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ΔΨ of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ΔΨ, the affiliated weakening of the proton motive force Δp, and the associated lowered phosphorylation potential ΔGp. Within the area of irradiation exposure, the decrease in membrane potentials ΔΨ will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.

4. 发明申请

WO2009059233A2 NEAR-INFRARED ELECTROMAGNETIC MODIFICATION OF CELLULAR STEADY-STATE MEMBRANE POTENTIALS 审中-公开
标题翻译：近红外电磁改性细胞稳态膜电位
公开(公告)号：WO2009059233A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/082124
申请日：2008-10-31
申请人： NOMIR MEDICAL TECHNOLOGIES, INC. , BORNSTEIN, Eric
发明人： BORNSTEIN, Eric
IPC分类号： C12N5/04
CPC分类号： A61K41/0019 , A61K41/0057 , A61N5/06 , A61N5/0601 , A61N5/0624 , A61N2005/067 , C12N13/00
摘要： Systems and methods are disclosed herein for applying near-infrared optical enegies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (ΔΨ-steady) of all irradiated cells through an optical depolarization effect, This depolarization causes a concomitant decrease in the absolute valie of the trans-membrane potentials ΔΨ of the irradiated mitochondrial and palsma membranes. Many cellular anabolic reactions and drug-reistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ΔΨ, the affiliated weakening of the proton motive force Δp, and the associated lowered phosphorylation potential ΔGp. Within the area of irridation exposure, the derease in membrane potentials ΔΨ will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the abitlity to petentiate antimicrobial, antifungal and/or antineoplastic drugs agains only targeted undesirable cells.
摘要翻译：本文公开了用于应用近红外光学能量和剂量测定以通过光学去极化效应改变所有照射细胞的生物能稳态跨膜和线粒体电位（ΔΨ-稳定）的系统和方法这种去极化导致辐射的线粒体和麻膜膜的跨膜电位ΔΨ的绝对值相伴降低。许多细胞合成代谢反应和药物耐受机制可能由于膜电位ΔΨ下降，质子动力Δp的附加弱化和相关的降低的磷酸化电位ΔGp降低而变得功能减弱和/或减轻。在虹膜暴露区域内，膜电位ΔΨ的减少将在细菌，真菌和哺乳动物细胞中一致发生。这种膜去极化提供了有利于抗微生物，抗真菌和/或抗肿瘤药物再次靶向不良细胞的有利条件。

5. 发明申请

WO2009059230A2 NEAR-INFRARED MICROBIAL ELIMINATION LASER SYSTEMS (NIMELS) 审中-公开
标题翻译：近红外微波消除激光系统（NIMELS）
公开(公告)号：WO2009059230A2
公开(公告)日：2009-05-07
申请号：PCT/US2008/082121
申请日：2008-10-31
申请人： NOMIR MEDICAL TECHNOLOGIES, INC. , BORNSTEIN, Eric
发明人： BORNSTEIN, Eric
IPC分类号： A61N5/06 , A61N5/067 , A61B18/18
CPC分类号： A61L2/08 , A61L2/084 , A61L2/085 , A61L2202/24 , A61N5/0613 , A61N5/0624 , A61N2005/0642 , A61N2005/0659 , C02F1/30 , C02F2103/026 , C02F2303/20 , C02F2305/023
摘要： Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo . Suitable medical devices includ cahteters, stents, artificial joints, and the like. NIMELS methods, systems, and apparatus can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant associated with traditional approaches described in the art (e.g., loss of viability, or thermolysis). Lasers including diode lasers may be used for one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) to an application region that can include patient tissue. Exemplary embodiments utilize light in a range of 850nm-900nm and/or 905nm-945nm at suitable NIMELS dosimetries.
摘要翻译：公开了包括与医疗设备一起使用的近红外微生物消除激光系统（NIMELS）的方法，系统和装置。医疗器械可以位于体内。合适的医疗装置包括手套，支架，人造关节等。 NIMELS方法，系统和装置可以应用能够损害生物污染物的某些波长的近红外辐射能和剂量测定，而不是与本领域中描述的传统方法相关的靶向生物污染物以外的生物部分不具有不可容忍的风险和/或不利影响（例如，活力丧失或热解）。包括二极管激光器的激光器可以用于一个或多个光源。输送组件可用于将由源产生的光辐射递送到可包括患者组织的应用区域。示例性实施例在合适的NIMELS剂量测定中使用在850nm-900nm和/或905nm-945nm范围内的光。

6. 发明申请

WO2010056537A1 NEAR-INFRARED ELECTROMAGNETIC MODIFICATION OF CELLULAR STEADY-STATE MEMBRANE POTENTIALS 审中-公开
标题翻译：细胞状态膜电位的近红外电磁修正
公开(公告)号：WO2010056537A1
公开(公告)日：2010-05-20
申请号：PCT/US2009/062533
申请日：2009-10-29
申请人： NOMIR MEDICAL TECHNOLOGIES, INC. , BORNSTEIN, Eric , WLASSICH, John
发明人： BORNSTEIN, Eric , WLASSICH, John
IPC分类号： A61N5/06
CPC分类号： A61N5/0624 , A61B2018/00988 , A61B2018/2035 , A61B2018/207 , A61N5/0616 , A61N2005/0628 , A61N2005/063 , A61N2005/0643 , A61N2005/0644 , A61N2005/0645 , A61N2005/0659
摘要： Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (ΔΨ-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ΔΨ of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ΔΨ, the affiliated weakening of the proton motive force Δp, and the associated lowered phosphorylation potential ΔGp. Within the area of irradiation exposure, the decrease in membrane potentials ΔΨ will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.
摘要翻译：本文公开了用于施加近红外光学能量和剂量测定法以通过光学去极化效应改变所有辐射细胞的生物能量稳态跨膜和线粒体电位（Δε-稳定）的系统和方法。这种去极化引起跨膜电位的绝对值的伴随减少？的被照射的线粒体和质膜。许多细胞合成代谢反应和药物抗性机制可以通过膜电位降低降低功能和/或减轻，质子动力的相关弱化Δp以及相关的降低的磷酸化潜能ΔGp。在照射暴露区域内，膜电位降低？将在细菌，真菌和哺乳动物细胞中一致发生。该膜去极化提供了针对仅靶向不期望的细胞增强抗微生物，抗真菌和/或抗肿瘤药物的能力。

7. 发明申请

WO2009059223A3 NEAR-INFRARED ELECTROMAGNETIC MODIFICATION OF CELLULAR STEADY-STATE MEMBRANE POTENTIALS 审中-公开
公开(公告)号：WO2009059223A3
公开(公告)日：2009-05-07
申请号：PCT/US2008/082113
申请日：2008-10-31
申请人： NOMIR MEDICAL TECHNOLOGIES, INC. , BORNSTEIN, Eric
发明人： BORNSTEIN, Eric
IPC分类号： A61N5/067
摘要： Systems and methods are disclosed herein for applying n ear-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (ΔΨ-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ΔΨ of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ΔΨ, the affiliated weakening of the proton motive force Δp, and the associated lowered phosphorylation potential ΔGp. Within the area of irradiation exposure, the decrease in membrane potentials ΔΨ will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.

8. 发明申请

WO2008073979A2 NEAR-INFRARED ELECTROMAGNETIC MODIFICATION OF CELLULAR STEADY- STATE MEMBRANE POTENTIALS 审中-公开
标题翻译：细胞状态膜电位的近红外电磁修正
公开(公告)号：WO2008073979A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/087264
申请日：2007-12-12
申请人： NOMIR MEDICAL TECHNOLOGIES, INC. , BORNSTEIN, Eric
发明人： BORNSTEIN, Eric
IPC分类号： C12N5/04
CPC分类号： C12N13/00 , A61K41/0019 , A61K41/0057 , A61N5/06 , A61N5/0601 , A61N5/0624 , A61N2005/067
摘要： Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (ΔΨ-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ΔΨ of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ΔΨ, the affiliated weakening of the proton motive force Δp, and the associated lowered phosphorylation potential ΔGp. Within the area of irradiation exposure, the decrease in membrane potentials ΔΨ will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.
摘要翻译：本文公开了用于施加近红外光学能量和剂量测定法以通过光学去极化效应改变所有辐射细胞的生物能量稳态跨膜和线粒体电位（Δε-稳定）的系统和方法。这种去极化引起跨膜电位的绝对值的伴随减少？的被照射的线粒体和质膜。许多细胞合成代谢反应和药物抗性机制可以通过膜电位降低降低功能和/或减轻，质子动力的相关弱化Δp以及相关的降低的磷酸化潜能ΔGp。在照射暴露区域内，膜电位降低？将在细菌，真菌和哺乳动物细胞中一致发生。该膜去极化提供了针对仅靶向不期望的细胞增强抗微生物，抗真菌和/或抗肿瘤药物的能力。

9. 发明申请

WO2007019305A2 NEAR INFRARED MICROBIAL ELIMINATION LASER SYSTEMS (NIMELS) FOR USE WITH MEDICAL DEVICES 审中-公开
标题翻译：用于医疗设备的近红外微波消除激光系统（NIMELS）
公开(公告)号：WO2007019305A2
公开(公告)日：2007-02-15
申请号：PCT/US2006/030434
申请日：2006-08-03
申请人： NOMIR MEDICAL TECHNOLOGIES, INC. , BORNSTEIN, Eric
发明人： BORNSTEIN, Eric
IPC分类号： A61N5/06
CPC分类号： A61N5/06 , A61B90/37 , A61B2018/2211 , A61N5/0601 , A61N2005/063 , A61N2005/067
摘要： Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) including use with medical devices are disclosed. The medical devices can be situated in vivo. Suitable medical devices include catheters, stents, artificial joints, and the like. NIMELS methods, systems, and apparatus can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant associated with traditional approaches described in the art (e.g., loss of viability, or thermolysis). Lasers including diode lasers may be used for one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. Exemplary embodiments utilize light in a range of 850nm-900 run and/or 905nm-945nm at suitable NIMELS dosimetries.
摘要翻译：公开了包括与医疗设备一起使用的近红外微生物消除激光系统（NIMELS）的方法，系统和装置。医疗器械可以位于体内。合适的医疗装置包括导管，支架，人造关节等。 NIMELS方法，系统和装置可以应用能够损害生物污染物的某些波长的近红外辐射能量和剂量测定，而不是与本领域中描述的传统方法相关的靶向生物污染物以外的生物部分不具有不可容忍的风险和/或不利影响（例如，活力丧失或热解）。包括二极管激光器的激光器可以用于一个或多个光源。输送组件可以用于将产生的源产生的光辐射递送到可包括患者组织的应用区域。示例性实施例在合适的NIMELS剂量测定中使用在850nm-900nm和/或905nm-945nm范围内的光。

10. 发明申请

WO2007014130A2 NEAR INFRARED MICROBIAL ELIMINATION LASER SYSTEM (NIMELS) 审中-公开
标题翻译：近红外微生物消除激光系统（NIMELS）
公开(公告)号：WO2007014130A2
公开(公告)日：2007-02-01
申请号：PCT/US2006/028616
申请日：2006-07-21
申请人： NOMIR MEDICAL TECHNOLOGIES, INC. , BORNSTEIN, Eric
发明人： BORNSTEIN, Eric
IPC分类号： A61N5/067
CPC分类号： A61N5/06 , A61L2/085 , A61L2202/24 , A61N5/0624 , A61N2005/0659 , A61N2005/067
摘要： Methods, systems, and apparatus for Near Infrared Microbial Elimination Laser Systems (NIMELS) are disclosed that can apply near infrared radiant energy of certain wavelengths and dosimetries capable of impairing biological contaminants, for example fungus, without intolerable risks and/or adverse effects to biological moieties other than a targeted biological contaminant. Lasers including diode lasers may be used as one or more light sources. A delivery assembly can be used to deliver the optical radiation produced by the source(s) produced to an application region that can include patient tissue. A flat top lens can be included to produce a flat top beam distribution. Exemplary embodiments utilize laser light in a near infrared range of 850nm-900nm and/or 905nm-945nm at suitable NIMELS dosimetries. For certain applications, laser light in two spectral ranges including 870 nm and 930 nm, respectively, can be utilized.
摘要翻译：公开了近红外微生物消除激光系统（NIMELS）的方法，系统和设备，其可以应用特定波长的近红外辐射能量和能够损害生物污染物例如真菌的剂量测定法，而不会令人难以忍受对靶生物污染物以外的生物部分的风险和/或不利影响。包括二极管激光器的激光器可以用作一个或多个光源。递送组件可以用于将由生产的源产生的光辐射递送至可以包括患者组织的应用区域。可以包括平顶透镜以产生平顶光束分布。示例性实施例利用在适合的NIMELS剂量测量下在850nm-900nm和/或905nm-945nm的近红外范围内的激光。对于某些应用，可以分别使用两种光谱范围的激光，包括870nm和930nm。

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