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1. 发明专利

DE60235786D1 未知
公开(公告)号：DE60235786D1
公开(公告)日：2010-05-12
申请号：DE60235786
申请日：2002-08-07
申请人： NOF CORP , NAGAMUNE TERUYUKI
发明人： NAGAMUNE TERUYUKI , ITOH CHIKA , YASUKOHCHI TOHRU , OHHASHI SYUNSUKE , KUBO KAZUHIRO
IPC分类号： C12N5/00 , C12N11/00 , G01N33/50
摘要： A cell in which a reaction product of a substance to be modified and an amphipathic compound is non-covalently bound to a cell membrane, wherein said compound has the following features: (1) having one or more aliphatic hydrocarbon groups at one end; (2) having one or more portions containing a hydrophilic group in a molecule; and (3) having one or more reactive functional groups which are capable of covalently binding with the substance to be modified at an end different from the end in the above (1).

2. 发明公开

EP0985697A4 OXIRANE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME 无效
标题翻译： OXIMANDERIVATE及其制备方法
公开(公告)号：EP0985697A4
公开(公告)日：2001-10-17
申请号：EP99909309
申请日：1999-03-23
申请人： NOF CORP
发明人： YASUKOHCHI TOHRU , SANCHIKA KOUZOH , ITOH CHIKA , MARUYAMA KEI-ICHI
IPC分类号： C08G65/26 , C08G65/28 , C08G65/30 , G01N30/90 , C08G65/32
CPC分类号： C08G65/2609 , C08G65/30 , G01N30/90
摘要： The present invention provides an high purity and high molecular oxirane derivative useful as a starting material for medical purposes, mainly drug delivery system, and a process for the preparation thereof. The present invention concerns an oxirane derivative represented by the following general formula:RO(C2H4O)nH (in which R represents a C2-7 hydrocarbon group; and n represents an integer of from 20 to 900), characterized in that the following requirements are satisfied: (A) Supposing that the straight line between the elution starting point and the elution end point on chromatogram obtained by gel permeation chromatography is PbaseL, the total peak area above PbaseL is Parea, the height of the top of the maximum peak of refractive index: Ptop, with respect to PbaseL is PtopH, and the peak area between the point at which the height of the elution curve from the elution starting point toward Ptop, with respect to PbaseL is 1/5 of PtopH and the point at which the height of the elution curve from Ptop toward the elution end point, with respect to PhaseL is 1/5 of PtopH is PareaM, Parea and PareaM satisfy the following relationship: ; and (B) Main spots having Rf value falling within the range of from 0.2 to 0.8 have a purity of not less than 98%, and a process for the preparation of such an oxirane derivative which comprises reacting ROH with oxirane in the condition that the water content in the reaction system is kept to not more than 5 ppm.

3. 发明公开

EP1550675A4 PHOSPHOLIPID DERIVATIVE 有权
标题翻译：磷脂
公开(公告)号：EP1550675A4
公开(公告)日：2006-01-11
申请号：EP03798560
申请日：2003-09-30
申请人： NOF CORP , DAIICHI SEIYAKU CO
发明人： OHHASHI SYUNSUKE , KUBO KAZUHIRO , ITOH CHIKA , YASUKOHCHI TOHRU , KIKUCHI H , SUZUKI N , TAKAHASHI M , YAMAUCHI H
IPC分类号： G01R5/16 , A61K8/14 , A61K8/81 , A61K9/127 , A61K31/795 , A61P35/00 , A61Q19/00 , C08F8/40 , C08L53/00 , A61K7/00 , A61K45/00 , A61K47/32
CPC分类号： C08F8/40 , A61K8/14 , A61K8/8164 , A61K9/127 , A61K9/1271 , A61K9/1278 , A61K31/795 , A61Q19/00 , C08F220/28 , C08F222/06 , C08L53/00 , C08F222/04 , C08L2666/02
摘要： A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) ÄR and R represent hydrogen atom or methyl group, provided that R and R do not simultaneously represent methyl group; R represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R CO and R CO represent an acyl group having 8 to 24 carbon atoms; R represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammoniumÜ wherein a molar ratio of the component unit A relative to a total of the component unit B and the component unit C is from 7/3 to 3/7, and the component unit C is contained at a ratio of from 1 to 4 moles per 1 mole of the copolymer.

4. 发明公开

EP1498420A4 PHOSPHOLIPID DERIVATIVE 有权
标题翻译：磷脂
公开(公告)号：EP1498420A4
公开(公告)日：2010-12-08
申请号：EP03715589
申请日：2003-03-28
申请人： NOF CORP , DAIICHI SEIYAKU CO
发明人： ITO CHIKA , KURO KAZUHIRO , OHHASHI SYUNSUKE , YASUKOHCHI TOHRU , KIKUCHI HIROSHI , SUZUKI NORIO , TAKAHASHI MIHO , YAMAUCHI HITOSHI
IPC分类号： A61K8/14 , A61K8/55 , A61K8/86 , A61K9/127 , A61P35/00 , A61Q19/00 , C07F9/10 , C08G65/26 , C08G65/335 , C07F9/09 , A61K7/00 , A61K7/48 , A61K47/24
CPC分类号： A61K47/24 , A61K8/14 , A61K8/553 , A61K8/556 , A61K8/86 , A61K9/1271 , A61Q19/00 , C07F9/10 , C08G65/2609 , C08G65/3353

5. 发明公开

EP1591447A4 PHOSPHOLIPID DERIVATIVES AND PROCESS FOR THE PRODUCTION THERE 有权转让
标题翻译：磷脂和生产过程
公开(公告)号：EP1591447A4
公开(公告)日：2009-11-11
申请号：EP03778894
申请日：2003-12-12
申请人： NOF CORP , DAIICHI SEIYAKU CO
发明人： KUBO KAZUHIRO , ITOH CHIKA , OHHASHI SYUNSUKE , YASUKOHCHI TOHRU , OHKAWA YUSUKE , KIKUCHI HIROSHI , SUZUKI NORIO , TAKAHASHI MIHO , YAMAUCHI HITOSHI
IPC分类号： A61K8/14 , A61K8/55 , A61K9/127 , A61K47/24 , A61P35/00 , A61Q19/00 , C07F9/10 , C08G65/26 , C08G65/335 , A61K7/00 , A61K45/00 , B01F17/14
CPC分类号： A61K9/127 , A61K8/14 , A61K8/553 , A61K9/0014 , A61K9/1273 , A61K47/24 , A61Q19/00 , C07F9/10 , C08G65/2609 , C08G65/3353 , C08G2650/34

6. 发明公开

EP1564236A4 MODIFIED BIOLOGICAL SUBSTANCE, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATE 有权转让
标题翻译：改良生物科学基金会，哈佛大学生物科学与技术研究所
公开(公告)号：EP1564236A4
公开(公告)日：2006-01-25
申请号：EP03811545
申请日：2003-11-20
申请人： NOF CORP
发明人： NAKAMOTO KEN-ICHIRO , OHHASHI SHUNSUKE , YAMAMOTO YUJI , SAKANOUE KENJI , ITOH CHIKA , YASUKOHCHI TOHRU
IPC分类号： A61K47/48 , A61P43/00 , C07C43/13 , C07C43/164 , C07K14/47 , C08G65/26 , C08G65/28 , C08G65/329 , C08G85/00 , C08G65/32 , A61K38/17 , A61K38/43
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified biological substance having, per molecule, at least one polyalkylene glycoloxy group represented by the following formula (1): (1) wherein R is a C1-24 hydrocarbon group and OA1 and OA2 each is C2-4 oxyalkylene, provided that R and OA2 in the same molecule are the same or different; and n and m, which indicate the average number of moles of the oxyalkylene added, are 0 to 1,000 and 10 to 1,000, respectively.
摘要翻译：一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：其中R是具有1至24个碳原子的烃基， 1和OA 2各自为具有2〜4个碳原子的氧化烯基，R 1和OA 2在一个分子中彼此相同或不同，n和m各自是氧化烯基的平均摩尔数 n表示0〜1000，m表示10〜1000。

7. 发明专利

CA2502948C MODIFIED BIO-RELATED SUBSTANCE, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATE 未知
公开(公告)号：CA2502948C
公开(公告)日：2013-04-02
申请号：CA2502948
申请日：2003-11-20
申请人： NOF CORP
发明人： NAKAMOTO KEN-ICHIRO , OHHASHI SYUNSUKE , YAMAMOTO YUJI , SAKANOUE KENJI , ITOH CHIKA , YASUKOHCHI TOHRU
IPC分类号： A61K47/48 , C08G65/32 , A61K38/17 , A61K38/43 , A61P43/00 , C07C43/13 , C07C43/164 , C07K14/47 , C08G65/26 , C08G65/28 , C08G65/329 , C08G85/00
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule: (see formula 1) wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA1 and OA2 are each an oxyalkylene group having 2 to 4 carbon atoms, the groups represented by R are the same or different from each other in one molecule, and the groups represented by OA2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.

8. 发明专利

CA2513144C PHOSPHOLIPID DERIVATIVE AND METHOD FOR PRODUCING THE SAME 未知
公开(公告)号：CA2513144C
公开(公告)日：2012-03-13
申请号：CA2513144
申请日：2003-12-12
申请人： NOF CORP , DAIICHI SEIYAKU CO
发明人： KUBO KAZUHIRO , ITOH CHIKA , OHHASHI SYUNSUKE , YASUKOHCHI TOHRU , OHKAWA YUSUKE , KIKUCHI HIROSHI , SUZUKI NORIO , TAKAHASHI MIHO , YAMAUCHI HITOSHI
IPC分类号： C07F9/10 , A61K8/14 , A61K8/55 , A61K9/127 , A61K45/00 , A61K47/24 , A61P35/00 , A61Q19/00 , C08G65/26 , C08G65/335 , C09K23/14
摘要： A phospholipid derivative represented by the following formula (1): (see formula 1) wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol "a" independently represents an integer of 0 to 5, symbol "b" independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1~ k1 ~ (k+2)/2, 0~ k2, and k1 + k2 + k3 = k + 2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.

9. 发明专利

DE69929311T2 未知
公开(公告)号：DE69929311T2
公开(公告)日：2006-09-07
申请号：DE69929311
申请日：1999-03-23
申请人： NOF CORP
发明人： YASUKOHCHI TOHRU , SANCHIKA KOUZOH , ITOH CHIKA , MARUYAMA KEI-ICHI
IPC分类号： C08G65/28 , C08G65/26 , C08G65/30 , C08G65/32 , G01N30/90
摘要： The present invention provides an high purity and high molecular oxirane derivative useful as a starting material for medical purposes, mainly drug delivery system, and a process for the preparation thereof. The present invention concerns an oxirane derivative represented by the following general formula:RO(C2H4O)nH (in which R represents a C2-7 hydrocarbon group; and n represents an integer of from 20 to 900), characterized in that the following requirements are satisfied: (A) Supposing that the straight line between the elution starting point and the elution end point on chromatogram obtained by gel permeation chromatography is PbaseL, the total peak area above PbaseL is Parea, the height of the top of the maximum peak of refractive index: Ptop, with respect to PbaseL is PtopH, and the peak area between the point at which the height of the elution curve from the elution starting point toward Ptop, with respect to PbaseL is 1/5 of PtopH and the point at which the height of the elution curve from Ptop toward the elution end point, with respect to PhaseL is 1/5 of PtopH is PareaM, Parea and PareaM satisfy the following relationship: ; and (B) Main spots having Rf value falling within the range of from 0.2 to 0.8 have a purity of not less than 98%, and a process for the preparation of such an oxirane derivative which comprises reacting ROH with oxirane in the condition that the water content in the reaction system is kept to not more than 5 ppm.

10. 发明专利

DE60208454T2 未知
公开(公告)号：DE60208454T2
公开(公告)日：2006-09-07
申请号：DE60208454
申请日：2002-03-04
申请人： NOF CORP
发明人： KUBO KAZUHIRO , ITOH CHIKA , OHHASHI SYUNSUKE , YASUKOHCHI TOHRU
IPC分类号： C07F9/10 , A61K8/14 , A61K8/86 , A61Q19/00 , C08G65/335 , C09K23/14
摘要： A polyalkylene oxide-modified phospholipid represented by formula (1) defined in the specification, has a monoacyl phospholipid content of not more than 3% by weight and a content of a base having a nitrogen atom of not more than 0.02% by weight.

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