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3. 发明专利

JP2008248232A Multi-branched polyoxyalkylene derivative 有权
标题翻译：多分支聚氧乙烯衍生物
公开(公告)号：JP2008248232A
公开(公告)日：2008-10-16
申请号：JP2008046852
申请日：2008-02-27
申请人： Nof Corp , 日油株式会社
发明人： SAKAGAMI KENJI , YOSHIOKA HIROKI , SHIROSAKI TOMOHIRO
IPC分类号： C08G65/331 , A61K47/48 , C08G65/28
CPC分类号： C08G65/2609 , A61K47/60 , C08G65/327 , C08G65/3317 , C08G65/3318 , C08G65/33337 , C08G65/33372 , C08G65/33396 , C08L2203/02
摘要： PROBLEM TO BE SOLVED: To provide a novel multibranched polyoxyalkylene derivative and its production intermediate, in particular, provide a multibranched polyoxyalkylene derivative which can modify a biological substance so that the biological substance can keep its activity at high level and which can modify the biological substance in a simple manner; an intermediate of the derivative; and a conjugate of the multibranched polyoxyalkylene derivative with a biological substance bound thereto. SOLUTION: Provided are a polyoxyalkylene derivative (1) which has a functional group reactive with a biological substance; a biological substance modified by the reaction with the compound; and a polyoxyalkylene derivative (A) which is an intermediate for the production of the compound (wherein m is 20 to 500, n is 15 to 700, X is a functional group reactive with biological substance). COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供新颖的多分支聚氧化烯衍生物及其制备中间体，特别是提供一种多分支聚氧化烯衍生物，其可以改变生物物质，使得生物物质可以保持其活性在高水平并且可以修饰生物物质以简单的方式; 衍生物的中间体; 和多分支聚氧化烯衍生物与结合有生物物质的缀合物。解决方案：提供具有与生物物质反应的官能团的聚氧化烯衍生物（1）; 通过与化合物的反应改性的生物物质; 和作为制造化合物的中间体（其中m为20〜500，n为15〜700，X为与生物物质反应的官能团）的聚氧化烯衍生物（A）。版权所有（C）2009，JPO＆INPIT

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