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1. 发明申请

WO2009052998A3 COMPOSITE BIOMATERIAL FOR CONTROLLED RELEASE OF ACTIVE INGREDIENTS 审中-公开
标题翻译：生物材料代理商的控制递送
公开(公告)号：WO2009052998A3
公开(公告)日：2010-04-22
申请号：PCT/EP2008008801
申请日：2008-10-17
申请人： NMI UNIV TUEBINGEN , STOLL DIETER , STOOP REINOUT , VAZ NUERNBERGER JULIANA , GAISSMAIER CHRISTOPH , AHLERS MICHAEL , BOHNSACK CLAUDIA
发明人： STOLL DIETER , STOOP REINOUT , VAZ NUERNBERGER JULIANA , GAISSMAIER CHRISTOPH , AHLERS MICHAEL , BOHNSACK CLAUDIA
IPC分类号： A61L27/24 , A61L27/50 , A61L27/54
CPC分类号： A61L27/24 , A61L27/50 , A61L27/54 , A61L2300/25 , A61L2300/414 , A61L2300/416 , A61L2300/602
摘要： The present invention relates to a composite biomaterial and a process for producing a composite biomaterial with controlled release of active ingredients, comprising a three-dimensional polymer-based support structure, and a polymer-based matrix structure. The active ingredients are in this case incorporated into the composite biomaterial via the matrix structure, and the composite biomaterial is obtainable by introducing the matrix structure into the support structure. The active ingredients may in this case be incorporated for example adhesively, via specific binder molecules or via enzyme-labile linker molecules via the matrix structure into the composite biomaterial.
摘要翻译：本发明涉及生物材料和用于制造Bioverbundmaterials，与活性物质的控制释放，包括在聚合物基体，以及基于聚合物基质结构的三维支撑结构的方法。将活性成分掺入整个基体结构为生物材料和生物材料是通过在支持结构中引入基体结构获得。所述活性化合物可以是例如，胶粘方式经由特异性结合分子或基质结构到生物材料酶不稳定连接分子被整合。

2. 发明申请

WO2007057175A2 COMPOSITE MATERIAL, ESPECIALLY FOR MEDICAL USE, AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：复合材料，尤其是用于医疗用途，与方法研究
公开(公告)号：WO2007057175A2
公开(公告)日：2007-05-24
申请号：PCT/EP2006010972
申请日：2006-11-16
申请人： GELITA AG , TETEC AG , TETEC TISSUE ENGINEERING TECHN , AHLERS MICHAEL , BADZIONG WERNER , GAISSMAIER CHRISTOPH , FRITZ JUERGEN
发明人： AHLERS MICHAEL , BADZIONG WERNER , GAISSMAIER CHRISTOPH , FRITZ JUERGEN
IPC分类号： A61L27/36 , A61L27/38 , A61L27/48 , A61L27/56
CPC分类号： A61L27/56 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3804 , A61L27/3843 , A61L27/48 , C08L89/06
摘要： The invention relates to a composite material that has improved properties as compared with known materials. The problems associated with known materials are that cell-free biomaterials have to be first populated with cells, lack of biocompatibility due to a composition that cannot be exactly reproduced and purity or a only minimal influenceability of resorption times. The composite according to the invention comprises a first unsupported layer having a first material that is insoluble, resorbable and non-gelling under physiological conditions; and a second layer, produced based on a cross-linked, gelatinous second material, said second layer having a mainly open-pore structure.
摘要翻译：为了提供可用的复合材料具有其中栖息已知缺点，如先前与细胞的需要无细胞的生物材料，由于不能精确地再现的组成和纯度或只影响再吸收最小能力问题生物相容性可以在很大程度上避免，并且其中，相对于已知的材料改进的性质，所以建议该复合材料包含含有在生理条件下是不溶性的，可再吸收的和非胶凝第一材料的第一自支撑层; 和第二层，交联的，凝胶状的第二材料的基础上产生的，所述主要具有电开孔结构的第二层。

3. 发明申请

WO2010046477A2 FIXING ELEMENT FOR FIXING TISSUE AND/OR IMPLANTS 审中-公开
标题翻译：用于固定组织和/或植入物的固定元件
公开(公告)号：WO2010046477A2
公开(公告)日：2010-04-29
申请号：PCT/EP2009063997
申请日：2009-10-23
申请人： GELITA AG , AHLERS MICHAEL , BOHNSACK CLAUDIA
发明人： AHLERS MICHAEL , BOHNSACK CLAUDIA
IPC分类号： A61L27/22 , A61L27/58 , A61L31/04 , A61L31/14
CPC分类号： A61L31/045 , A61L31/148
摘要： In order to improve the properties of a fixing element for fixing tissue and/or implants in a damaged region of the human or animal body, the fixing element is made of a material containing crosslinked gelatin.
摘要翻译：为了提供用于将组织和/或植入物固定在人或动物体的具有改善特性的缺陷区域中的固定元件，建议固定元件由含有交联明胶的材料形成。

4. 发明申请

WO2008006545A8 USE OF GELATIN AND A CROSS-LINKING AGENT FOR PRODUCING CROSS-LINKING MEDICAL GLUES 审中-公开
标题翻译：明胶和交联剂用于生产交联的医用接合剂使用
公开(公告)号：WO2008006545A8
公开(公告)日：2009-01-29
申请号：PCT/EP2007006105
申请日：2007-07-10
申请人： GELITA AG , TETEC TISSUE ENGINEERING TECHN , GAISSMAIER CHRISTOPH , AHLERS MICHAEL
发明人： GAISSMAIER CHRISTOPH , AHLERS MICHAEL
IPC分类号： A61L24/10
CPC分类号： A61L24/104
摘要： The invention relates to the novel use of gelatin and a cross-linking agent. More particularly, the invention relates to a medical glue which forms a cross-linked gelatin gel in an area of application of the human or animal body. According to the invention, (i) the gelatin and the cross-linking agent are mixed with each other to form the cross-linking medical glue which is then administered to the area of application; or (ii) the gelatin and the cross- linking agent are made available in separate form and are administered, simultaneously or one after the other, to the area of application while forming the cross-linking medical glue.
摘要翻译：在一个新颖的使用明胶和交联剂的上下文中，医用粘合剂提供具有改进的性能，其形成交联的明胶凝胶在人体或动物体，其中（i）明胶和交联剂的应用区域，以形成交联的医用粘合剂然后将其施用到的应用程序区域混合; 是，或（ii）的明胶和在分开的形式交联剂和同时或相继施用，以形成交联的医用粘合剂到应用区域。

5. 发明申请

WO2008006544A2 USE OF GELATIN AND A CROSS-LINKING AGENT FOR PRODUCING A CROSS-LINKING THERAPEUTIC COMPOSITION 审中-公开
标题翻译：明胶和交联剂用于生产含有交联的治疗组合物
公开(公告)号：WO2008006544A2
公开(公告)日：2008-01-17
申请号：PCT/EP2007006104
申请日：2007-07-10
申请人： GELITA AG , TETEC TISSUE ENGINEERING TECHN , GAISSMAIER CHRISTOPH , AHLERS MICHAEL
发明人： GAISSMAIER CHRISTOPH , AHLERS MICHAEL
IPC分类号： A61K47/42 , A61K38/43 , A61L27/22
CPC分类号： A61K38/45 , A61K35/12 , A61K35/28 , A61K35/32 , A61K47/42 , A61L27/222
摘要： The aim of the invention is to provide a therapeutic composition for use in biological regenerative methods, which composition can be administered to a target area of the body while ensuring that the suspended cells and/or the growth factors remain in the target area of the body and at the same time eliminating the need for the patient to maintain the treated body area immobilized for unreasonable periods. For this purpose, the invention relates to a novel of use gelatin and a cross-linking agent for producing a cross-linking therapeutic composition which forms a cross-linked gelatin gel as the cell matrix in a target area of the human or animal body. In particular, the invention relates to the use of said therapeutic composition for treating damages to the intervertebral disks, the cartilage, the menisci, the tendons or the bones in humans or animals. According to said method, (i) the gelatin and the cross-linking agent are mixed with each other to form the cross-linking therapeutic composition which is then administered to the target area; or (ii) the gelatin and the cross-linking agent are made available in separate form and are administered, simultaneously or one after the other, to the target area while forming the cross-linking therapeutic composition.
摘要翻译：以提供用于生物再生方法，其可被施用于身体的目标区域中的治疗组合物，它确保了悬浮的细胞和/或生长因子在体内的目标区域保持，没有患者需要的过长的处理的主体部分的固定化必须是，是一种新型的使用明胶和用于制备交联的治疗组合物，其形成交联的明胶凝胶在人体或动物体的目标区域中的单元矩阵，且特别是使用这样的治疗性组合物用于椎间盘损伤的治疗中的交联剂，软骨，半月板，和弦提出了人或动物骨，其中（i）明胶和交联剂的或以形成交联的治疗组合物然后将其施用到目标区域克混合在一起; 是，或（ii）的明胶和在分开的形式交联剂和同时或相继施用，以形成交联的治疗组合物进入目标区域。

6. 发明申请

WO2008006545A2 USE OF GELATIN AND A CROSS-LINKING AGENT FOR PRODUCING CROSS-LINKING MEDICAL GLUES 审中-公开
标题翻译：明胶和联网剂在生产网络医用胶粘剂中的应用
公开(公告)号：WO2008006545A2
公开(公告)日：2008-01-17
申请号：PCT/EP2007006105
申请日：2007-07-10
申请人： GELITA AG , TETEC TISSUE ENGINEERING TECHN , GAISSMAIER CHRISTOPH , AHLERS MICHAEL
发明人： GAISSMAIER CHRISTOPH , AHLERS MICHAEL
IPC分类号： A61L24/10
CPC分类号： A61L24/104
摘要： The invention relates to the novel use of gelatin and a cross-linking agent. More particularly, the invention relates to a medical glue which forms a cross-linked gelatin gel in an area of application of the human or animal body. According to the invention, (i) the gelatin and the cross-linking agent are mixed with each other to form the cross-linking medical glue which is then administered to the area of application; or (ii) the gelatin and the cross- linking agent are made available in separate form and are administered, simultaneously or one after the other, to the area of application while forming the cross-linking medical glue.
摘要翻译：在一个新颖的使用明胶和交联剂的上下文中，医用粘合剂提供具有改进的性能，其形成交联的明胶凝胶在人体或动物体，其中（i）明胶和交联剂的应用区域，以形成交联的医用粘合剂混合在一起，然后在应用领域施用; 或（ii）以分开的形式提供明胶和交联剂，并且同时或顺序施用至施用区域以形成交联医用粘合剂。

7. 发明专利

DE102007051059A1 未知
公开(公告)号：DE102007051059A1
公开(公告)日：2009-04-30
申请号：DE102007051059
申请日：2007-10-18
申请人： NMI UNIV TUEBINGEN
发明人： STOLL DIETER , STOOP REINOUT , VAZ NUERNBERGER JULIANA , GAISSMAIER CHRISTOPH , AHLERS MICHAEL , BOHNSACK CLAUDIA
IPC分类号： A61K9/00 , A61K47/30 , A61K47/48 , C08J5/12
摘要： The present invention relates to a composite biomaterial and a process for producing a composite biomaterial with controlled release of active ingredients, comprising a three-dimensional polymer-based support structure, and a polymer-based matrix structure. The active ingredients are in this case incorporated into the composite biomaterial via the matrix structure, and the composite biomaterial is obtainable by introducing the matrix structure into the support structure. The active ingredients may in this case be incorporated for example adhesively, via specific binder molecules or via enzyme-labile linker molecules via the matrix structure into the composite biomaterial.

8. 发明专利

DE102007051059B4 Bioverbundmaterial für die kontrollierte Freisetzung von Wirkstoffen 未知
公开(公告)号：DE102007051059B4
公开(公告)日：2014-04-03
申请号：DE102007051059
申请日：2007-10-18
申请人： NMI UNIV TUEBINGEN
发明人： STOLL DIETER , STOOP REINOUT , VAZ NUERNBERGER JULIANA , GAISSMAIER CHRISTOPH , AHLERS MICHAEL , BOHNSACK CLAUDIA
IPC分类号： A61K9/00 , A61K47/30 , A61K47/48 , C08J5/12
摘要： Bioverbundmaterial mit lokaler, kontrollierter Freisetzung von Wirkstoffen, umfassend eine dreidimensionale Trägerstruktur auf Polymerbasis, sowie eine Matrixstruktur auf Polymerbasis, dadurch gekennzeichnet, dass die Wirkstoffe über die Matrixstruktur in das Bioverbundmaterial eingelagert sind.

9. 发明申请

WO2007057178A3 ANGIOGENESIS-PROMOTING SUBSTRATE 审中-公开
标题翻译：血管促进基质
公开(公告)号：WO2007057178A3
公开(公告)日：2007-08-02
申请号：PCT/EP2006010977
申请日：2006-11-16
申请人： GELITA AG , AHLERS MICHAEL , SCHLOSSHAUER BURKHARD , DRESSMANN LARS
发明人： AHLERS MICHAEL , SCHLOSSHAUER BURKHARD , DRESSMANN LARS
IPC分类号： A61K9/70 , A61K9/00 , A61K47/42 , A61L27/22 , A61L31/04
CPC分类号： A61L27/222 , A61K9/0024 , A61K9/7007 , A61K47/42 , A61L27/56 , A61L27/58
摘要： The aim of the invention is to provide an angiogenesis-promoting substrate which can be produced in a simple manner and with reproducible quality and which remains stable especially under physiological conditions for a predetermined period of time and is yet biocompatible and resorbable. For this purpose, the angiogenesis-promoting substrate comprises a porous shaped body which consists of a gelatinous material that is insoluble and resorbable under physiological conditions.
摘要翻译：为了提供血管生成促进衬底，其是简单的，并且可以以可再现的质量产生并稳定地保持在特定的生理条件下的预定时间段，并且仍然是生物相容的和可再吸收的，建议的是，促进血管生成的基底包括多孔模制体，其由生理上不溶性的，可吸收的含明胶材料形成。

10. 发明专利

CA2031246A1 TWO-DIMENSIONALLY CRYSTALLIZED MACROMOLECULAR FILMS 未知
公开(公告)号：CA2031246A1
公开(公告)日：1991-06-03
申请号：CA2031246
申请日：1990-11-30
申请人： FUCHS HARALD , LICHT ULRIKE , RINGSDORF HELMUT , BLANKENBURG RAINER , AHLERS MICHAEL
发明人： FUCHS HARALD , LICHT ULRIKE , RINGSDORF HELMUT , BLANKENBURG RAINER , AHLERS MICHAEL
IPC分类号： C07K14/00 , C07K17/02 , C12N11/00 , C12N11/06 , C12Q1/00 , G01N33/543 , G01N1/28
摘要： Two-dimensionally crystallized macromolecular films are built up with the aid of a lipid monofilm carrying biotin units.

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