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    • 8. 发明专利
    • BR9610943A
    • 1999-12-21
    • BR9610943
    • 1996-08-28
    • NITTO DENKO CORPHOKURIKU PHARMACEUTICAL
    • NAKANO YOSHIHISAOTSUKA SABURO
    • A61K9/70A61K31/137A61K31/135
    • A percutaneous tulobuterol preparation obtained by laminating a pressure-sensitive adhesive layer comprising as the main component a synthetic rubber containing micro-crystalline tulobuterol of 2 to 20 mu m in average particle size onto a support; in particular, a percutaneous tulobuterol preparation wherein the micro-crystalline tulobuterol is one obtained by dissolving tulobuterol and a pressure-sensitive adhesive comprising as the main component a synthetic resin in a good solvent followed by recrystallization; and a process for producing the preparation which comprises homogeneously dissolving the adhesive and tulobuterol in a good solvent, applying the resulting adhesive solution onto one face of a peelable film and drying to thereby form an adhesive layer; then laminating the adhesive layer onto a support; and recrystallizing tulobuterol at 10 to 30 DEG C to thereby give an adhesive layer wherein microcrystals of 2 to 20 mu m in average particle size have been homogeneously dispersed. The preparation is excellent in the long-lasting drug effect. The above process makes it possible to efficiently produce the preparation.