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1. 发明专利

DE68910947T2 未知
公开(公告)号：DE68910947T2
公开(公告)日：1994-03-17
申请号：DE68910947
申请日：1989-12-27
申请人： NITTO DENKO CORP , HOKURIKU PHARMACEUTICAL
发明人： NAKANO YOSHIHISA , HORIUCHI TETSUO , FUJIWARA SANAE , UNOZAWA SENJI
IPC分类号： A61K9/70 , A61K31/135 , A61P11/00 , A61P25/02 , A61L15/16
摘要： A percutaneous preparation of tulobuterol is disclosed, comprising a support having thereon a base layer comprising a pressure-sensitive adhesive containing tulobuterol, the pressure-sensitive adhesive comprising polyisobutylene. The preparation achieves persistent and effective administration of tulobuterol through the skin into the body.

2. 发明专利

ES2045377T3 未知
公开(公告)号：ES2045377T3
公开(公告)日：1994-01-16
申请号：ES89124028
申请日：1989-12-27
申请人： NITTO DENKO CORP , HOKURIKU PHARMACEUTICAL
发明人： NAKANO YOSHIHISA , HORIUCHI TETSUO , FUJIWARA SANAE , UNOZAWA SENJI
IPC分类号： A61K9/70 , A61K31/135 , A61P11/00 , A61P25/02 , A61L15/16
摘要： A percutaneous preparation of tulobuterol is disclosed, comprising a support having thereon a base layer comprising a pressure-sensitive adhesive containing tulobuterol, the pressure-sensitive adhesive comprising polyisobutylene. The preparation achieves persistent and effective administration of tulobuterol through the skin into the body.

3. 发明专利

CA2006511C PERCUTANEOUS PREPARATION OF TULOBUTEROL 未知
公开(公告)号：CA2006511C
公开(公告)日：1999-01-26
申请号：CA2006511
申请日：1989-12-22
申请人： NITTO DENKO CORP , HOKURIKU PHARMACEUTICAL
发明人： FUJIWARA SANAE , UNOZAWA SENJI , NAKANO YOSHIHISA , HORIUCHI TETSUO
IPC分类号： A61K9/70 , A61K31/135 , A61P11/00 , A61P25/02 , A61K47/32 , A61K9/00
摘要： A percutaneous preparation of tulobuterol is disclosed, comprising a support having thereon a base layer comprising a pressure-sensitive adhesive containing tulobuterol, the pressure-sensitive adhesive comprising polyisobutylene. The preparation achieves persistent and effective administration of tulobuterol through the skin into the body.

4. 发明专利

DE68910947D1 未知
公开(公告)号：DE68910947D1
公开(公告)日：1994-01-05
申请号：DE68910947
申请日：1989-12-27
申请人： NITTO DENKO CORP , HOKURIKU PHARMACEUTICAL
发明人： NAKANO YOSHIHISA , HORIUCHI TETSUO , FUJIWARA SANAE , UNOZAWA SENJI
IPC分类号： A61K9/70 , A61K31/135 , A61P11/00 , A61P25/02 , A61L15/16
摘要： A percutaneous preparation of tulobuterol is disclosed, comprising a support having thereon a base layer comprising a pressure-sensitive adhesive containing tulobuterol, the pressure-sensitive adhesive comprising polyisobutylene. The preparation achieves persistent and effective administration of tulobuterol through the skin into the body.

5. 发明专利

AT97581T 未知
公开(公告)号：AT97581T
公开(公告)日：1993-12-15
申请号：AT89124028
申请日：1989-12-27
申请人： NITTO DENKO CORP , HOKURIKU PHARMACEUTICAL
发明人： NAKANO YOSHIHISA , HORIUCHI TETSUO , FUJIWARA SANAE , UNOZAWA SENJI
IPC分类号： A61K9/70 , A61K31/135 , A61L15/16

6. 发明专利

CA2006511A1 PERCUTANEOUS PREPARATION OF TULOBUTEROL 未知
公开(公告)号：CA2006511A1
公开(公告)日：1990-06-23
申请号：CA2006511
申请日：1989-12-22
申请人： NITTO DENKO CORP , HOKURIKU PHARMACEUTICAL
发明人： NAKANO YOSHIHISA , HORIUCHI TETSUO , FUJIWARA SANAE , UNOZAWA SENJI
IPC分类号： A61K9/70 , A61K31/135 , A61P11/00 , A61P25/02
摘要： A percutaneous preparation of tulobuterol is disclosed, comprising a support having thereon a base layer comprising a pressure-sensitive adhesive containing tulobuterol, the pressure-sensitive adhesive comprising polyisobutylene. The preparation achieves persistent and effective administration of tulobuterol through the skin into the body.

7. 发明专利

JPH0499720A MEDICINAL PHARMACEUTICAL FOR PERCUTANEOUS ADMINISTRATION 失效
公开(公告)号：JPH0499720A
公开(公告)日：1992-03-31
申请号：JP24762989
申请日：1989-09-22
申请人： NITTO DENKO CORP , HOKURIKU PHARMACEUTICAL
发明人： NAKANO YOSHIHISA , HORIUCHI TETSUO , FUJIWARA SANAE , UNOSAWA YOSHIJI
IPC分类号： A61K9/70 , A61K31/135 , A61P11/00 , A61P25/02
摘要： PURPOSE:To obtain a medicinal pharmaceutical capable of substainedly, effectively and percutaneously absorbing tulobuterol and exhibiting excellent drug effects by forming a substrate layer containing the tulobuterol in a pressure-sensitive adhesive consisting essentially of polyisobutylene on a carrier. CONSTITUTION:A medicinal pharmaceutical is obtained by forming a substrate layer containing tulobuterol which is a beta-blocker in a pressure-sensitive adhesive consisting essentially of polyisobutylene, preferably a pressure-sensitive adhesive composed of a mixture of two or more selected from (A) polyisobutylene having 500-4000 viscosity-average molecular weight, (B) polyisobutylene having 10000-200000 viscosity average molecular weight and (C) polyisobutylene having 900000-2100000 viscosity-average molecular weight on a carrier. The aforementioned adhesive functions as a drug holder and simultaneously also as a drug release controlling layer. Thereby, the adhesive acts as a barrier to diffusion and migration of the tulobuterol by blending and containing a thermoplastic resin in the aforementioned adhesive and sustained releasability is further improved.

8. 发明专利

JPH0474119A PLASTER AND PLASTER PREPARATION 失效
公开(公告)号：JPH0474119A
公开(公告)日：1992-03-09
申请号：JP18866090
申请日：1990-07-16
申请人： NITTO DENKO CORP
发明人： FUJIWARA SANAE , TSUDA TOSHINOBU , NINOMIYA KAZUHISA
IPC分类号： A61K9/70
摘要： PURPOSE:To obtain a plaster having balanced transcutaneous absorbability of drug and skin irritation and suitable for repeated application to the same part of the skin by using a plaster layer composed of a specific composition and a tacky adhesive material consisting of a polymeric substance having carboxyl group. CONSTITUTION:The objective plaster can be prepared by compounding (A) a fatty acid glycerol ester (e.g. glycerol monooleate) and (B) an alkali metal hydroxide to (C) a tacky adhesive agent consisting of a polymeric substance having carboxyl group, preferably and acrylic polymer containing >= 50 wt.% of (meth)acrylic acid ester having alkyl groups having an average C number of >= 4 and copolymerized with a copolymerizable functional monomer and laminating the obtained plaster layer to a flexible substrate. Preferably, the thickness of the plaster layer is 10-100mum and that of the substrate is 5-150mum. When a drug is compounded to the plaster, the drug can be stably held in the plaster to prevent the decrease of the drug content. Excellent effect can be attained especially in the case of using a drug having carboxyl group.

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