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1. 发明申请

WO2011072082A3 MODULATION OF HSP47 EXPRESSION 审中-公开
标题翻译： HSP47表达调控
公开(公告)号：WO2011072082A3
公开(公告)日：2011-08-18
申请号：PCT/US2010059578
申请日：2010-12-08
申请人： NITTO DENKO CORP , QUARK PHARMACEUTICALS INC , JIN XIAOMEI , YU LEI , TAKAHASHI HIROKAZU , TANAKA YASUNOBU , NIITSU YOSHIRO , FEINSTEIN ELENA , AVKIN-NACHUM SHARON , KALINSKI HAGAR , METT IGOR , ERLICH SHAI , SQUIERS ELIZABETH C
发明人： JIN XIAOMEI , YU LEI , TAKAHASHI HIROKAZU , TANAKA YASUNOBU , NIITSU YOSHIRO , FEINSTEIN ELENA , AVKIN-NACHUM SHARON , KALINSKI HAGAR , METT IGOR , ERLICH SHAI , SQUIERS ELIZABETH C
IPC分类号： A61K31/7088 , C07H21/00
CPC分类号： C12N15/113 , A61K31/713 , C12N2310/11 , C12N2310/14 , C12N2310/31 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/531 , C12N2320/30 , C12N2310/3521
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly heat shock protein 47 (hsp47). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding hsp47, for example, the gene encoding human hsp47. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with hsp47 such as liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译：本文提供用于调节靶基因，特别是热休克蛋白47（hsp47）的表达的组合物，方法和试剂盒。组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA））），其调节编码hsp47的基因，例如编码人hsp47的基因。本文公开的组合物和方法也可用于治疗与hsp47相关的病症和病症，例如肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。

2. 发明申请

WO2012044620A2 MODULATION OF TIMP1 AND TIMP2 EXPRESSION 审中-公开
标题翻译： TIMP1和TIMP2表达的调控
公开(公告)号：WO2012044620A2
公开(公告)日：2012-04-05
申请号：PCT/US2011053496
申请日：2011-09-27
申请人： NITTO DENKO CORP , QUARK PHARMACEUTICALS INC , NIITSU YOSHIRO , TAKAHASHI HIROKAZU , TANAKA YASUNOBU , FEINSTEIN ELENA , AVKIN-NACHUM SHARON , KALINSKI HAGAR , METT IGOR
发明人： NIITSU YOSHIRO , TAKAHASHI HIROKAZU , TANAKA YASUNOBU , FEINSTEIN ELENA , AVKIN-NACHUM SHARON , KALINSKI HAGAR , METT IGOR
IPC分类号： A61K48/00
CPC分类号： C12N15/113 , A61K9/0019 , A61K31/713 , C07K14/8146 , C12N2310/14 , C12N2310/3519 , C12N2320/30 , C12N2320/32
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly of tissue inhibitor of metalloproteinase 1 and of tissue inhibitor of metalloproteinase 2 (TIMP1 and TIMP2, respectively). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding TIMP1 and TIMP2, for example, the gene encoding human TIMP1 and TIMP2. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with TIMP1 and TIMP2 including fibrotic diseases and disorders including liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.
摘要翻译：本文提供用于调节靶基因，特别是金属蛋白酶1的组织抑制剂和金属蛋白酶2的组织抑制剂（分别为TIMP1和TIMP2）的表达的组合物，方法和试剂盒。组合物，方法和试剂盒可以包括核酸分子（例如，短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）或短发夹RNA（shRNA））），其调节编码TIMP1和TIMP2的基因，例如编码人TIMP1和TIMP2的基因。本文公开的组合物和方法也可用于治疗与TIMP1和TIMP2相关的病症和病症，包括纤维化疾病和病症，包括肝纤维化，肺纤维化，腹膜纤维化和肾纤维化。

3. 发明申请

WO2012170957A2 RETINOID-LIPOSOMES FOR ENHANCING MODULATION OF HSP47 EXPRESSION 审中-公开
标题翻译：用于增强HSP47表达调控的反义脂质体
公开(公告)号：WO2012170957A2
公开(公告)日：2012-12-13
申请号：PCT/US2012041761
申请日：2012-06-08
申请人： NITTO DENKO CORP , QUARK PHARMACEUTICALS INC , NNTSU YOSHIRO , PAYNE JOSEPH E , KNOPOV VICTOR , AKOPIAN VIO ETTA , W TTE RICHARD P , AHMADIAN MOHAMMAD , PERELMAN LOREN A , TANAKA YASUNOBU , FEINSTEIN ELENA , AVK N-NAHUM SHARON , KAL NSKI HAGAR , METT IGOR , MINOMI KENJIRO , Y NG WENBIN , LUI YUN
发明人： NNTSU YOSHIRO , PAYNE JOSEPH E , KNOPOV VICTOR , AKOPIAN VIO ETTA , W TTE RICHARD P , AHMADIAN MOHAMMAD , PERELMAN LOREN A , TANAKA YASUNOBU , FEINSTEIN ELENA , AVK N-NAHUM SHARON , KAL NSKI HAGAR , METT IGOR , MINOMI KENJIRO , Y NG WENBIN , LUI YUN
IPC分类号： A61K48/00 , A61K38/17
CPC分类号： A61K9/1271 , A61K9/127 , A61K31/713 , C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2320/52
摘要： What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNHl_45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis.
摘要翻译：所描述的是包含包含有义链和反义链的双链核酸分子的药物组合物，其中有义链和反义链选自描述为SERPINH1_2的寡核苷酸（SEQ ID NO：60和127），SERPTNH1_45a（SEQ ID NO： NOS：98和165）和SERPTNH1_51（SEQ ID NO：101和168）和包含类视黄醇和脂质囊泡的混合物的药物载体，以及使用这些药物组合物治疗与hsp47浓缩有关的疾病的方法，包括纤维化。

4. 发明申请

WO2012170957A3 RETINOID-LIPOSOMES FOR ENHANCING MODULATION OF HSP47 EXPRESSION 审中-公开
标题翻译：维甲酸 - 脂质体用于增强HSP47表达的调节
公开(公告)号：WO2012170957A3
公开(公告)日：2013-04-11
申请号：PCT/US2012041761
申请日：2012-06-08
申请人： NITTO DENKO CORP , QUARK PHARMACEUTICALS INC , NNTSU YOSHIRO , PAYNE JOSEPH E , KNOPOV VICTOR , AKOPIAN VIO ETTA , W TTE RICHARD P , AHMADIAN MOHAMMAD , PERELMAN LOREN A , TANAKA YASUNOBU , FEINSTEIN ELENA , AVK N-NAHUM SHARON , KAL NSKI HAGAR , METT IGOR , MINOMI KENJIRO , Y NG WENBIN , LUI YUN
发明人： NNTSU YOSHIRO , PAYNE JOSEPH E , KNOPOV VICTOR , AKOPIAN VIO ETTA , W TTE RICHARD P , AHMADIAN MOHAMMAD , PERELMAN LOREN A , TANAKA YASUNOBU , FEINSTEIN ELENA , AVK N-NAHUM SHARON , KAL NSKI HAGAR , METT IGOR , MINOMI KENJIRO , Y NG WENBIN , LUI YUN
IPC分类号： C12N15/113 , A61K31/713 , C12N15/11
CPC分类号： A61K9/1271 , A61K9/127 , A61K31/713 , C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2320/52
摘要： What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNHl_45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis.
摘要翻译：所描述的是包含双链核酸分子的药物组合物，所述双链核酸分子包含有义链和反义链，其中有义链和反义链选自描述为SERPINH1_2（SEQ ID NOS：60和127），SERPTNH1_45a（SEQ ID NO： NOS：98和165）和SERPTNH1_51（SEQ ID NOS：101和168），以及包含类视色素和脂质囊泡混合物的药物载体，以及使用这些药物组合物治疗与hsp47表达相关的疾病的方法，包括纤维化。

5. 发明专利

RS57824B1 RETINOID-LIPOZOMI ZA POBOLJŠANJE MODULACIJE HSP47 EKSPRESIJE 未知
公开(公告)号：RS57824B1
公开(公告)日：2018-12-31
申请号：RSP20181081
申请日：2012-06-08
申请人： NITTO DENKO CORP
发明人： AKOPIAN VIOLETTA , MINOMI KENJIRO , NIITSU YOSHIRO , PAYNE JOSEPH E , KNOPOV VICTOR , WITTE RICHARD P , AHMADIAN MOHAMMAD , PERELMAN LOREN A , TANAKA YASUNOBU , FEINSTEIN ELENA , AVKIN-NACHUM SHARON , KALINSKI HAGAR , METT IGOR , YING WENBIN , LUI YUN
IPC分类号： C12N15/113 , A61K31/713 , C12N15/11

6. 发明专利

ES2689696T3 Liposomas de retinoide para potenciar la modulación de la expresión de hsp47 未知
公开(公告)号：ES2689696T3
公开(公告)日：2018-11-15
申请号：ES16169874
申请日：2012-06-08
申请人： NITTO DENKO CORP
发明人： AKOPIAN VIOLETTA , MINOMI KENJIRO , NIITSU YOSHIRO , PAYNE JOSEPH E , KNOPOV VICTOR , WITTE RICHARD P , AHMADIAN MOHAMMAD , PERELMAN LOREN A , TANAKA YASUNOBU , FEINSTEIN ELENA , AVKIN-NACHUM SHARON , KALINSKI HAGAR , METT IGOR , YING WENBIN , LUI YUN
IPC分类号： C12N15/113 , A61K31/713 , C12N15/11
摘要： Composición farmacéutica que comprende (i) una molécula de ácido nucleico bicatenario y un portador de fármaco que comprende una mezcla de un retinoide y un lípido, en la que la molécula de ácido nucleico bicatenario comprende la estructura (A1): (A1) 5' (N)x - Z 3' (cadena antisentido) 3' Z'-(N')y -z" 5' (cadena sentido) en la que cada uno de N y N' es un nucleótido que puede no estar modificado o estar modificado, o un resto no convencional; en la que cada uno de (N)x y (N')y es un oligonucleótido en el que cada N o N' consecutivo está unido al siguiente N o N' mediante un enlace covalente; en la que cada uno de Z y Z' está independientemente presente o ausente, pero si está presente incluye independientemente 1-5 nucleótidos o restos distintos de nucleótidos consecutivos o una combinación de los mismos unidos covalentemente al extremo 3'-terminal de la cadena en la que está presente; en la que z" puede estar presente o ausente, pero si está presente es un resto de ocupación de centros reactivos unido covalentemente al extremo 5'-terminal de (N')y; en la que cada uno de x e y es independientemente un número entero de entre 18 y 40; en la que la secuencia de (N')y tiene complementariedad con respecto a la secuencia de (N)x; en la que (N)x incluye una secuencia antisentido con respecto a la secuencia codificante de ARNm para hsp47 humana mostrada a modo de ejemplo mediante SEQ ID NO: 1; y en la que el lípido comprende un lípido seleccionado del grupo que consiste en **Fórmula** o (ii) una molécula de ácido nucleico bicatenario que comprende una cadena sentido y una cadena antisentido en la que las cadenas sentido y antisentido se seleccionan de los oligonucleótidos descritos como SERPINH1_2 (SEQ ID NO: 60 y 127), SERPINH1_45a (SEQ ID NO: 98 y 165) y SERPINH1_51 (SEQ ID NO: 101 y 168), y un portador de fármaco que comprende una mezcla de una vesícula lipídica y un retinoide o un conjugado de retinoide, en la que la vesícula lipídica comprende un lípido seleccionado del grupo que consiste en **Fórmula**

7. 发明专利

CY1117039T1 ΤΡΟΠΟΠΟΙΗΣΗ ΤΗΣ ΕΚΦΡΑΣΗΣ TOY HSP47 未知
公开(公告)号：CY1117039T1
公开(公告)日：2017-04-05
申请号：CY151101137
申请日：2015-12-11
申请人： NITTO DENKO CORP
发明人： JIN XIAOMEI , YU LEI , TAKAHASHI HIROKAZU , TANAKA YASUNOBU , NIITSU YOSHIRO , FEINSTEIN ELENA , AVKIN-NACHUM SHARON , KALINSKI HAGAR , METT IGOR , ERLICH SHAI , SQUIERS ELIZABETH C , CHEN NING
IPC分类号： C12N15/113 , A61K31/713 , C07H21/00
摘要： Παρέχονταιειςτοπαρόνσυνθέσεις, μέθοδοικαικιτγιατροποποίησητηςέκφρασηςγονιδίων-στόχοι, ειδικότεραδετηςπρωτεΐνηςθερμικούσοκ 47 (hsp47). Οισυνθέσεις, οιμέθοδοικαιτακιτμπορείνασυμπεριλάβουνμόριαπυρηνικώνοξέων (γιαπαράδειγμα, βραχύπαρεισφρέονπυρηνικόοξύ (siNA), βραχύπαρεισφρέον RNA (siRNA), διπλά-κλωνισμένο RNA (dsRNA), μικρο-RNA (miRNA) ήβραχύ RNA φουρκέτας (shRNA)) πουτροποποιούνέναγονίδιοεγκωδικεύονταςτο hsp47, γιαπαράδειγμα, τογονίδιοεγκωδικεύονταςτο hsp47 ανθρώπου. Ησύνθεσηκαιοιμέθοδοιπουαποκαλύπτονταιειςτοπαρόνμπορείεπίσηςναχρησιμοποιηθούνκαιστηναγωγήκαταστάσεωνκαιδιαταραχώνπουσυσχετίζονταιμετο hsp47 όπωςείναιη ίνωσητουήπατος, ηπνευμονικήίνωση, ηπεριτοναϊκήίνωσηκαιη ίνωσητωννεφρών.

8. 发明专利

AU2011307259A1 Modulation of TIMP1 and TIMP2 expression 未知
公开(公告)号：AU2011307259A1
公开(公告)日：2013-05-02
申请号：AU2011307259
申请日：2011-09-27
申请人： NITTO DENKO CORP
发明人： NIITSU YOSHIRO , TAKAHASHI HIROKAZU , TANAKA YASUNOBU , FEINSTEIN ELENA , AVKIN-NACHUM SHARON , KALINSKI HAGAR , METT IGOR
IPC分类号： A61K31/713 , A61K48/00 , C07H21/02
摘要： Provided herein are compositions, methods and kits for modulating expression of target genes, particularly of tissue inhibitor of metalloproteinase 1 and of tissue inhibitor of metalloproteinase 2 (TIMP1 and TIMP2, respectively). The compositions, methods and kits may include nucleic acid molecules (for example, short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA) or short hairpin RNA (shRNA)) that modulate a gene encoding TIMP1 and TIMP2, for example, the gene encoding human TIMP1 and TIMP2. The composition and methods disclosed herein may also be used in treating conditions and disorders associated with TIMP1 and TIMP2 including fibrotic diseases and disorders including liver fibrosis, pulmonary fibrosis, peritoneal fibrosis and kidney fibrosis.

9. 发明专利

CA2836925A1 RETINOID-LIPOSOMES FOR ENHANCING MODULATION OF HSP47 EXPRESSION 未知
公开(公告)号：CA2836925A1
公开(公告)日：2012-12-13
申请号：CA2836925
申请日：2012-06-08
申请人： NITTO DENKO CORP
发明人： AKOPIAN VIOLETTA , MINOMI KENJIRO , NNTSU YOSHIRO , PAYNE JOSEPH E , KNOPOV VICTOR , WITTE RICHARD P , AHMADIAN MOHAMMAD , PERELMAN LOREN A , TANAKA YASUNOBU , FEINSTEIN ELENA , AVKIN-NAHUM SHARON , KALINSKI HAGAR , METT IGOR , YING WENBIN , LIU YUN
IPC分类号： C12N15/113 , A61K31/713 , A61K38/17 , C12N15/11
摘要： What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNHl_45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis.

10. 发明专利

CA2836925C RETINOID-LIPOSOMES FOR ENHANCING MODULATION OF HSP47 EXPRESSION 未知
公开(公告)号：CA2836925C
公开(公告)日：2021-11-16
申请号：CA2836925
申请日：2012-06-08
申请人： NITTO DENKO CORP
发明人： AKOPIAN VIOLETTA , MINOMI KENJIRO , NIITSU YOSHIRO , PAYNE JOSEPH E , KNOPOV VICTOR , WITTE RICHARD P , AHMADIAN MOHAMMAD , PERELMAN LOREN A , TANAKA YASUNOBU , FEINSTEIN ELENA , AVKIN-NAHUM SHARON , KALINSKI HAGAR , METT IGOR , YING WENBIN , LIU YUN
IPC分类号： C12N15/113 , A61K31/713 , A61K38/17 , C12N15/11
摘要： What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNHl_45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis.

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