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1. 发明专利

CA2933509A1 PATCH PREPARATION 未知
公开(公告)号：CA2933509A1
公开(公告)日：2016-12-17
申请号：CA2933509
申请日：2016-06-17
申请人： NITTO DENKO CORP
发明人： TACHIKAWA YU , AMEYAMA SATOSHI , ABE ERIKO , NAKAMURA TETSUYA , URUSHIHARA NAOKO , ISHIKURA JUN , AOYAGI KAZUHIRO , INOUE YOSHITAKA , YOKOUCHI AKIRA , TANAKA TOMOYA
IPC分类号： A61K9/70 , A61K47/32
摘要： A patch preparation capable of inhibiting a deviation in pressure-sensitive adhesive properties of a pressure-sensitive adhesive layer even elapsing a long period of time until it is used after production and capable of keeping favorable pressure-sensitive adhesive properties is provided. The patch preparation includes a support and a pressure-sensitive adhesive layer formed on one surface of the support, and the pressure-sensitive adhesive layer includes: (A) a polymer prepared by copolymerizing monomer components including a hydroxyl group-containing monomer and an alkyl (meth)acrylate monomer; (B) a polymer prepared by copolymerizing monomer components including a methyl methacrylate monomer and a butyl methacrylate monomer; and (C) a basic drug, provided that bisoprolol and a salt thereof are excluded.

2. 发明专利

JP2014058466A Gelatin particle and use thereof, and device for administration of bioactive substance 审中-公开
标题翻译：凝胶颗粒及其用途及用于生物活性物质管理的设备
公开(公告)号：JP2014058466A
公开(公告)日：2014-04-03
申请号：JP2012203807
申请日：2012-09-18
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： MIURA CHIEKO , SUGAWARA SHINJIN , ABE ERIKO , MAKABE MIKI , YOSHIKAWA TOSHIYUKI
IPC分类号： A61K9/16 , A61B17/12 , A61K47/42 , A61L31/00
摘要： PROBLEM TO BE SOLVED: To provide: a nonporous-solid spherical gelatin particle having a specific volume swelling ratio; a gelatin particle having this gelatin particle in which bioactive substance is dissolved and retained; and a device for a use in which the bioactive substance dissolved, absorbed and retained in the gelatin particle is distributed in an injector together with saline solution.SOLUTION: The heat-crosslinked solid spherical gelatin particle has a circularity of 0.8 or more and a dry-particle diameter of 25 to 600 μm. In a case where the gelatin particle has been immersed in saline solution, the average volume swelling ratio is 200 to 2000% relative to the average volume of the dry-particle. The gelatin particle may be used for blood vessel embolization and sustained-release of the bioactive substance.
摘要翻译：要解决的问题：提供：具有比体积溶胀比的无孔固体球形明胶颗粒; 具有这种明胶颗粒的明胶颗粒，其中生物活性物质被溶解和保留; 以及其中溶解，吸收并保留在明胶颗粒中的生物活性物质与盐溶液一起分布在注射器中的用途的装置。溶解：热交联的固体球形明胶颗粒的圆形度为0.8以上，干燥 - 粒径为25〜600μm。在将明胶粒子浸渍在盐水溶液中的情况下，相对于干燥颗粒的平均体积，平均体积溶胀比为200〜2000％。明胶颗粒可用于生物活性物质的血管栓塞和持续释放。

3. 发明专利

JP2013202554A Droplet generator 审中-公开
标题翻译： DROPLET发电机
公开(公告)号：JP2013202554A
公开(公告)日：2013-10-07
申请号：JP2012076082
申请日：2012-03-29
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： SAOMOTO KENJIRO , SUGIURA SHINSUKE , SUGAWARA SHINJIN , ABE ERIKO , NAKAGAWA MASAO
IPC分类号： B01J13/00 , B01J19/00
CPC分类号： B01J2/06 , B01F3/0807 , B01F5/0471 , B01F13/0059 , B01F15/0264
摘要： PROBLEM TO BE SOLVED: To provide a droplet generator that can be disassembled and assembled easily.SOLUTION: A droplet generator 1 includes: a base member 2 formed by laminating a plurality of substrates including an intermediate substrate 21 and a lower substrate 23; a flow passage structure 211 formed in the intermediate substrate 21 and having a plurality of droplet generation flow passages that cause a dispersed-phase material in the liquid state and a continuous-phase material in the liquid state to flow and generates droplets of the dispersed-phase material by a shearing force of the continuous-phase material; a liquid reservoir part 231 formed in the lower substrate 23 and configured to store a dispersed-phase material 200 in the liquid state and a continuous-phase material 100 in the liquid state; a dispersed-phase introduction part configured to introduce the dispersed-phase material 200 in the liquid state from the liquid reservoir part 231 into each of the droplet generation flow passages of the flow passage structure 211; and a continuous-phase introduction part configured to introduce the continuous-phase material 100 from the liquid reservoir part 231 to each of the droplet generation flow passages of the flow passage structure 211.
摘要翻译：要解决的问题：提供可以容易地拆卸和组装的液滴发生器。解决方案：液滴发生器1包括：通过层叠包括中间基板21和下基板23的多个基板形成的基底构件2; 形成在中间基板21中并具有多个液滴产生流路的流路结构211，其使液相状态的分散相物质和液态的连续相材料流动并产生分散相的液滴，通过连续相材料的剪切力的相材料; 形成在下部基板23内并被配置为存储处于液态的分散相材料200的液体储存部231和处于液态的连续相材料100; 分散相导入部，将从液体储存部231向液态生成流路的液体生成流路流入液态的分散相原料200，以及连续相导入部，其将连续相材料100从储液部231引导到流路结构体211的各液滴产生流路。

4. 发明专利

JP2013023485A Production method of gelatin particle 审中-公开
标题翻译：凝胶颗粒的生产方法
公开(公告)号：JP2013023485A
公开(公告)日：2013-02-04
申请号：JP2011161162
申请日：2011-07-22
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： NAKAGAWA MASAO , ABE ERIKO
IPC分类号： A61K38/17 , A61K9/14 , A61P7/04 , A61P15/00 , A61P35/00
摘要： PROBLEM TO BE SOLVED: To provide a production method of gelatin particles, with a smaller amount of residual fat and oil and no aggregation among the particles, and to preferably provide a method for producing embolus particles of gelatin suitable for embolization therapy or the like.SOLUTION: The production method of gelatin particles includes: a liquid droplet formation step of forming liquid droplets of a gelatin aqueous solution by dispersing the gelatin aqueous solution into a fat and oil; a gelation step of gelating the liquid droplets of the gelatin aqueous solution by cooling; and a dehydration step, a cleaning step, a drying step and a crosslinking step. The cooling temperature in the gelation step is 0 to 3°C. A dehydration solvent and a cleaning solvent used in the dehydration step and the cleaning step are hydrophilic solvents having at least 10 wt.% of the solubility in water. The obtained gelatin particles do not have porous shapes, and have solid sphere shapes.
摘要翻译：要解决的问题：为了提供明胶颗粒的制造方法，具有较少量的残余脂肪和油，并且在颗粒之间没有聚集，并且优选地提供用于制备适于栓塞治疗的明胶栓塞颗粒的方法或类似。解决方案：明胶颗粒的制备方法包括：液滴形成步骤，通过将明胶水溶液分散在油脂中形成明胶水溶液的液滴; 通过冷却凝胶化明胶水溶液的液滴的凝胶化步骤; 脱水工序，清洗工序，干燥工序，交联工序等。凝胶化步骤中的冷却温度为0至3℃。在脱水步骤和清洁步骤中使用的脱水溶剂和清洗溶剂是具有至少10重量％在水中的溶解度的亲水溶剂。所得明胶颗粒不具有多孔形状，并且具有固体球形。版权所有（C）2013，JPO＆INPIT

5. 发明专利

JP2014058465A Absorbing gelatin particle and gelatin particle for sustained-release of bioactive substance, and device for administration of bioactive substance 审中-公开
标题翻译：用于持续释放生物物质的吸收性凝胶颗粒和凝胶颗粒，以及用于生物活性物质管理的装置
公开(公告)号：JP2014058465A
公开(公告)日：2014-04-03
申请号：JP2012203806
申请日：2012-09-18
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： MAKABE MIKI , ABE ERIKO , MIURA CHIEKO , SUGAWARA SHINJI , YOSHIKAWA TOSHIYUKI
IPC分类号： A61K38/17 , A61K9/10 , A61K45/00 , A61K47/42 , A61P7/04
摘要： PROBLEM TO BE SOLVED: To provide: an absorbing gelatin particle which is comprised of nonporous-solid spherical gelatin having a specific jelly strength; a gelatin particle having this gelatin particle in which bioactive substance is dissolved and retained; and a device for a use in which the bioactive substance dissolved, absorbed and retained in the gelatin particle is distributed in an injector together with saline solution.SOLUTION: The absorbing gelatin particle comprises gelatin having of the jelly strength of 80 to 120 g, in which solid spherical gelatin is crosslinked with heat and the absorbing gelatin particle has the particle diameter of 50 to 2000 μm. In particular, the invention is available as a device for: blood vessel embolization; sustained-release of bioactive substance in which bioactive substance is dissolved and retained; administration into a living body by the way where the gelatin particle for sustained-release of a bioactive substance is distributed together with saline solution in an injector and the injector is filled up with it.
摘要翻译：要解决的问题：提供：由具有特定果冻强度的无孔固体球形明胶组成的吸收性明胶颗粒; 具有这种明胶颗粒的明胶颗粒，其中生物活性物质被溶解和保留; 以及用于将生物活性物质溶解，吸收并保留在明胶颗粒中的用途的装置与盐溶液一起分布在注射器中。溶液：吸收性明胶颗粒包含凝胶强度为80至120g的明胶，该固体球形明胶加热交联，吸收性明胶粒子的粒径为50〜2000μm。特别地，本发明可用作以下装置：血管栓塞; 缓释生物活性物质溶解和保留的生物活性物质; 通过将生物活性物质的持续释放的明胶颗粒与盐溶液一起分布在注射器中并且注射器被填充的方式施用到活体中。

6. 发明专利

JP2013202555A Liquid droplet generation module 审中-公开
标题翻译：液滴产生模块
公开(公告)号：JP2013202555A
公开(公告)日：2013-10-07
申请号：JP2012076095
申请日：2012-03-29
申请人： Nitto Denko Corp , 日東電工株式会社
发明人： SAOMOTO KENJIRO , SUGIURA SHINSUKE , SUGAWARA SHINJIN , ABE ERIKO , NAKAGAWA MASAO
IPC分类号： B01F15/02 , A61B17/12 , B01F3/08 , B01F5/00
CPC分类号： A61B17/1204 , A61B17/12181 , A61B2017/00004 , A61B2017/00526 , A61B2017/1205 , B01F3/0807 , B01F5/0471 , B01F13/0059 , B01F15/0264
摘要： PROBLEM TO BE SOLVED: To provide a liquid droplet generation module having a flow passage structure capable of forming more liquid droplet generation flow passages and of saving a space.SOLUTION: A liquid droplet generation module 1 includes a base member 2 and a flow passage structure 300. The flow passage structure 300 includes a plurality of liquid droplet generation flow passages 3. In each liquid droplet generation flow passage 3, a liquid dispersing phase material and a liquid continuous phase material are distributed, liquid droplets of the dispersing phase material are generated by shearing force of the continuous phase material, and discharge ports 112, 122 for discharging the generated liquid droplets are installed. Each liquid droplet generation flow passage 3 is formed in the base member 2 so that the direction of each of the discharge ports 112, 122 faces one point P. Since the direction of each discharge port of the plurality of liquid droplet generation flow passages 3 is concentrated on one point, spaces required for the discharge ports 112, 122 can be reduced compared to a case where the direction of each discharge port is dispersed.
摘要翻译：要解决的问题：提供一种具有能够形成更多液滴产生流路并具有节省空间的流路结构的液滴产生组件。液滴生成模块1包括基底构件2和流路结构流路结构300包括多个液滴产生流路3.在每个液滴产生流路3中，分散有液相分散相材料和液体连续相材料，生成分散相材料的液滴通过连续相材料的剪切力，并且安装用于排出所产生的液滴的排出口112,122。每个液滴产生流路3形成在基部构件2中，使得排出口112,122的方向面对一个点P.由于多个液滴产生流路3的排出口的方向为集中在一点上，与每个排放口的方向分散的情况相比，可以减少排出口112,122所需的空间。

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