专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006091716A3 NITRIC OXIDE ENHANCING DIURETIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：硝酸氧化物增强化学复合物，组合物和使用方法
公开(公告)号：WO2006091716A3
公开(公告)日：2007-07-12
申请号：PCT/US2006006375
申请日：2006-02-24
申请人： NITROMED INC , GARVEY DAVID S , LETTS GORDON L , EARL RICHARD A , EZAWA MAIKO , FANG XINQIN , GASTON RICKY D , KHANAPURE SUBHASH P , LIN CHIA-EN , RANATUNGE RAMANI R , STEVENSON CHERI A , WEY SHIOW-JYI
发明人： GARVEY DAVID S , LETTS GORDON L , EARL RICHARD A , EZAWA MAIKO , FANG XINQIN , GASTON RICKY D , KHANAPURE SUBHASH P , LIN CHIA-EN , RANATUNGE RAMANI R , STEVENSON CHERI A , WEY SHIOW-JYI
IPC分类号： A61K31/549 , C07D417/02
CPC分类号： C07D285/30 , C07D285/28 , C07D285/32 , C07D417/04 , C07D417/06 , C07D513/10
摘要： The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating conditions resulting from excessive water and/or electrolyte retention; (b) treating cardiovascular diseases; (c) treating renovascular diseases; (d) treating diabetes; (e) treating diseases resulting from oxidative stress; (f) treating endothelial dysfunctions; (g) treating diseases caused by endothelial dysfunctions; (h) treating cirrhosis; (j) treating pre-eclampsia; (k) treating osteoporosis; (1) treating nephropathy; (m) treating peripheral vascular diseases; (n) treating portal hypertension; (o) treating central nervous system disorders; (p) treating metabolic syndrome; (q) treating sexual dysfunctions; and (r) hyperlipidemia. The nitric oxide enhancing diuretic compounds comprise at least one nitric oxide enhancing group linked to the diuretic compound through one or more sites such as carbon, oxygen and/or nitrogen via a bond or moiety that cannot be hydrolyzed.
摘要翻译：本发明描述了包含至少一种一氧化氮增强利尿剂或其药学上可接受的盐，和任选的至少一种一氧化氮增强化合物和/或至少一种治疗剂的新型组合物和试剂盒。本发明还提供了（a）处理由过量水和/或电解质滞留导致的条件的方法; （二）治疗心血管疾病; （c）治疗血管性疾病; （d）治疗糖尿病; （e）治疗由氧化应激引起的疾病; （f）治疗内皮功能障碍; （g）治疗由内皮功能障碍引起的疾病; （h）治疗肝硬化; （j）治疗先兆子痫; （k）治疗骨质疏松症; （1）治疗肾病; （m）治疗外周血管疾病; （n）治疗门静脉高压; （o）治疗中枢神经系统疾病; （p）治疗代谢综合征; （q）治疗性功能障碍; 和（r）高脂血症。一氧化氮增强利尿化合物包含通过一个或多个位点如碳，氧和/或氮通过不能水解的键或部分与利尿剂化合物连接的至少一个一氧化氮增强基团。

2. 发明申请

WO2004004648A2 NITROSATED NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：硝酸化的非甾体抗炎药化合物，组合物和使用方法
公开(公告)号：WO2004004648A2
公开(公告)日：2004-01-15
申请号：PCT/US0321026
申请日：2003-07-03
申请人： NITROMED INC , EARL RICHARD A , EZAWA MAIKO , FANG XINQIN , GARVEY DAVID S , GASTON RICKY D , KHANAPURE SUBHASH P , LETTS GORDON L , LIN CHIA-EN , RANATUNGE RAMANI R , RICHARDSON STEWART K , SCHROEDER JOSEPH D , STEVENSON CHERI A , WEY SHIOW-JYI
发明人： EARL RICHARD A , EZAWA MAIKO , FANG XINQIN , GARVEY DAVID S , GASTON RICKY D , KHANAPURE SUBHASH P , LETTS GORDON L , LIN CHIA-EN , RANATUNGE RAMANI R , RICHARDSON STEWART K , SCHROEDER JOSEPH D , STEVENSON CHERI A , WEY SHIOW-JYI
IPC分类号： C07D295/08 , A61K31/21 , A61K31/405 , A61K31/445 , A61K45/00 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/14 , A61P3/04 , A61P17/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07C203/04 , C07C205/40 , C07C205/56 , C07C219/10 , C07C229/42 , C07C235/08 , C07C235/12 , C07C235/34 , C07C235/42 , C07C237/08 , C07C243/28 , C07C271/16 , C07C271/64 , C07C291/02 , C07C311/17 , C07C317/18 , C07C317/32 , C07C317/46 , C07C323/12 , C07C327/28 , C07D209/18 , C07D209/28 , C07D211/22 , C07D211/56 , C07D493/04 , C07F9/40 , A61K
CPC分类号： C07D493/04 , C07C291/02 , C07C311/17 , C07C317/18 , C07C323/12 , C07C327/28 , C07D209/18 , C07D211/22 , C07D211/56
摘要： The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated NSAID, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated NSAID, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating gastrointestinal disorders; for facilitating wound healing; for treating and/or preventing gastrointestinal, renal and/or respiratory toxicities resulting from the use of nonsteroidal antiinflammatory compounds; for treating inflammatory disease states and/or disorders; and for treating and/or preventing ophthalmic diseases and/or disorders.
摘要翻译：本发明描述了新的亚硝化非甾族抗炎药（NSAID）及其药学上可接受的盐，以及包含至少一种亚硝化NSAID和任选地至少一种捐赠，转移或释放一氧化氮的化合物的新组合物，刺激一氧化氮，提高内源性内皮细胞衍生的松弛因子的水平或者是一氧化氮合酶的底物，和/或至少一种治疗剂。本发明还提供了新组合物，其包含至少一种亚硝基化的NSAID和至少一种提供，转移或释放一氧化氮，提高内源性内皮水平的内皮衍生的松弛因子，刺激内源性合成一氧化氮或者是一氧化氮的底物合酶和/或至少一种治疗剂。本发明还提供了新颖的试剂盒，其包含至少一种亚硝化的NSAID和任选的至少一种一氧化氮供体和/或至少一种治疗剂。本发明还提供治疗炎症，疼痛和发热的方法; 用于治疗胃肠疾病; 用于促进伤口愈合; 用于治疗和/或预防由使用非甾体抗炎化合物引起的胃肠，肾和/或呼吸毒性; 用于治疗炎性疾病状态和/或病症; 并用于治疗和/或预防眼科疾病和/或病症。

3. 发明申请

WO2005018561A2 NITROSATED AND NITROSYLATED CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：硝酸和硝基化血管化合物，组合物和使用方法
公开(公告)号：WO2005018561A2
公开(公告)日：2005-03-03
申请号：PCT/US2004026909
申请日：2004-08-20
申请人： NITROMED INC , GARVEY DAVID S , LETTS GORDON L , WORCEL MANUEL , GASTON RICKY D
发明人： GARVEY DAVID S , LETTS GORDON L , WORCEL MANUEL , GASTON RICKY D
IPC分类号： A61K20060101 , A61K31/405 , A61K31/44 , A61K31/535 , C07D209/04 , C07D221/02 , C07D415/00 , A61K
CPC分类号： C07D493/04 , C07D407/04 , C07K5/06026
摘要： The invention describes novel nitrosated and/or nitrosylated cardiovascular compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated cardiovascular compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at,least one cardiovascular compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; and (k) treating nephropathy. The nitrosated and/or nitrosylated cardiovascular compounds are preferably nitrosated and/or nitrosylated P-adrenergic antagonists, nitrosated and/or nitrosylated angiotensinconverting enzyme (ACE) inhibitors, nitrosated and/or nitrosylated anti-hyperlipidemic compounds, and nitrosated and/or nitrosylated antithrombotic and vasodilator compounds.
摘要翻译：本发明描述了新的亚硝化和/或亚硝基化的心血管化合物或其药学上可接受的盐，以及包含至少一种亚硝化和/或亚硝基化的心血管化合物和任选的至少一种一氧化氮供体和/或至少一种治疗剂的新组合物。本发明还提供了包含至少一种本发明的心血管化合物，其任选被亚硝化和/或亚硝基化的新组合物和试剂盒，以及任选的至少一种一氧化氮供体化合物和/或至少一种治疗剂。本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; 和（k）治疗肾病。亚硝化和/或亚硝基化的心血管化合物优选为亚硝化和/或亚硝化的P-肾上腺素能拮抗剂，亚硝化和/或亚硝化的血管紧张素转换酶（ACE）抑制剂，亚硝化和/或亚硝化的抗高脂血症化合物，以及亚硝化和/或亚硝化的抗血栓形成和/ 血管扩张剂化合物。

4. 发明申请

WO2004012659A3 NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：氮化质子泵抑制剂，组合物和使用方法
公开(公告)号：WO2004012659A3
公开(公告)日：2004-10-07
申请号：PCT/US0323963
申请日：2003-08-01
申请人： NITROMED INC , FANG XINQIN , GARVEY DAVID S , LETTS GORDON L
发明人： FANG XINQIN , GARVEY DAVID S , LETTS GORDON L
IPC分类号： A61K31/44 , A61K31/4439 , A61K45/00 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/14 , A61P3/04 , A61P17/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/22 , A61P35/02 , A61P43/00 , C07D233/54 , C07D401/12 , A61K31/415 , C07D235/04 , C07D401/00 , C07D471/02
CPC分类号： C07D401/12
摘要： The invention describes novel nitrosated proton pump inhibitor compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated proton pump inhibitor compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated proton pump inhibitor compound, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated proton pump inhibitor compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating gastrointestinal disorders; facilitating ulcer healing; decreasing the recurrence of ulcers; improving gastroprotective properties, anti-Helicobacter pylori properties or antacid properties of proton pump inhibitors; decreasing or reducing the gastrointestinal toxicity associated with the use of nonsteroidal antiinflammatory compounds; treating bacterial infections and/or viral infections.
摘要翻译：本发明描述了新的亚硝化质子泵抑制剂化合物及其药学上可接受的盐，并且包含至少一种亚硝化质子泵抑制剂化合物和任选地至少一种捐赠，转移或释放一氧化氮的化合物的新组合物刺激硝酸盐氧化物，提高内源性内皮细胞衍生的松弛因子的水平或者是一氧化氮合酶的底物，和/或至少一种治疗剂。本发明还提供了新组合物，其包含至少一种亚硝基化质子泵抑制剂化合物和至少一种捐赠，转移或释放一氧化氮的化合物，提高内源性内皮水平的内皮衍生的松弛因子，刺激一氧化氮的内源合成或是底物用于一氧化氮合酶和/或至少一种治疗剂。本发明还提供了新型试剂盒，其包含至少一种亚硝化质子泵抑制剂化合物和任选的至少一种一氧化氮供体和/或至少一种治疗剂。本发明还提供了治疗胃肠疾病的方法; 促进溃疡愈合; 减少溃疡的复发; 改善质子泵抑制剂的胃保护特性，抗幽门螺杆菌特性或抗酸特性; 减少或减少与使用非甾体抗炎化合物相关的胃肠毒性; 治疗细菌感染和/或病毒感染。

5. 发明申请

WO2005023182A3 NITROSATED AND NITROSYLATED CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：硝酸和硝基化血管化合物，组合物和使用方法
公开(公告)号：WO2005023182A3
公开(公告)日：2006-10-19
申请号：PCT/US2004026910
申请日：2004-08-20
申请人： NITROMED INC , GARVEY DAVID S , LETTS GORDON L , WORCEL MANUEL
发明人： GARVEY DAVID S , LETTS GORDON L , WORCEL MANUEL
IPC分类号： A61K31/4523 , A61K20060101 , A61K31/517 , A61K31/5415 , A61K31/549 , C07D211/00 , C07D285/22 , C07D295/00 , C07D307/00 , C07D417/12 , C07D417/14
CPC分类号： C07D403/10 , C07C205/40 , C07D233/68 , C07D235/18 , C07D257/04 , C07D307/52 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/10 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： The invention describes novel nitrosated and/or nitrosylated cardiovascular compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated cardiovascular compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at least one cardiovascular compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; and (k) treating nephropathy. The nitrosated and/or nitrosylated cardiovascular compounds are preferably nitrosated and/or nitrosylated aldosterone antagonists, nitrosated and/or nitrosylated angiotensin II antagonists, nitrosated and/or nitrosylated calcium channel blockers, nitrosated and/or nitrosylated endothelin antagonists, nitrosated and/or nitrosylated hydralazine compounds, nitrosated and/or nitrosylated neutral endopeptidase inhibitors and nitrosated and/or nitrosylated renin inhibitors.
摘要翻译：本发明描述了新的亚硝化和/或亚硝基化的心血管化合物或其药学上可接受的盐，以及包含至少一种亚硝化和/或亚硝基化的心血管化合物和任选的至少一种一氧化氮供体和/或至少一种治疗剂的新组合物。本发明还提供了包含至少一种本发明的心血管化合物，其任选被亚硝化和/或亚硝基化的新组合物和试剂盒，以及任选的至少一种一氧化氮供体化合物和/或至少一种治疗剂。本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; 和（k）治疗肾病。亚硝化和/或亚硝基化的心血管化合物优选为亚硝化和/或亚硝基化的醛固酮拮抗剂，亚硝化和/或亚硝酰化的血管紧张素II拮抗剂，亚硝化和/或亚硝酰化的钙通道阻断剂，亚硝化和/或亚硝基化的内皮素拮抗剂，亚硝化和/ 化合物，亚硝化和/或亚硝基化的中性内肽酶抑制剂和亚硝化和/或亚硝基化的肾素抑制剂。

6. 发明申请

WO2007041681A2 METHODS FOR TREATING RESPIRATORY DISORDERS 审中-公开
标题翻译：治疗呼吸系统疾病的方法
公开(公告)号：WO2007041681A2
公开(公告)日：2007-04-12
申请号：PCT/US2006038965
申请日：2006-10-04
申请人： NITROMED INC , LETTS GORDON L
发明人： LETTS GORDON L
IPC分类号： A61K31/345
CPC分类号： A61K45/06 , A61K31/34 , A61K31/345 , A61K31/502 , A61K2300/00
摘要： The invention provides methods for treating respiratory disorders in a patient in need thereof comprising administering an effective amount of (i) at least one hydralazine compound or a pharmaceutically acceptable salt thereof, (ii) isosorbide dinitrate and/or isosorbide mononitrate, and (iii) optionally at least one therapeutic agent. The hydralazine compound may be hydralazine hydrochloride. The respiratory disorders may be chronic obstructive pulmonary disease, pulmonary hypertension, emphysema, asthma, cystic fibrosis and bronchitis.
摘要翻译：（i）至少一种肼屈嗪化合物或其药学上可接受的盐，（ii）二硝酸异山梨酯和/或单硝酸异山梨酯，和（iii）任选地至少一种治疗剂。肼苯哒嗪化合物可以是盐酸肼苯哒嗪。呼吸障碍可以是慢性阻塞性肺病，肺高血压，肺气肿，哮喘，囊性纤维化和支气管炎。

7. 发明专利

CA2536173A1 NITROSATED AND NITROSYLATED CARDIOVASCULAR COMPOUNDS, COMPOSITIONS AND METHODS OF USE 未知
公开(公告)号：CA2536173A1
公开(公告)日：2005-03-03
申请号：CA2536173
申请日：2004-08-20
申请人： NITROMED INC
发明人： GASTON RICKY D , WORCEL MANUEL , GARVEY DAVID S , LETTS GORDON L
IPC分类号： C07D417/04 , A61K20060101 , A61K31/138 , A61K31/165 , A61K31/403 , A61K31/405 , A61K31/44 , A61K31/535 , A61K31/5355 , C07C237/40 , C07D209/04 , C07D221/02 , C07D415/00
摘要： The invention describes novel nitrosated and/or nitrosylated cardiovascular compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated cardiovascular compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at,least one cardiovascular compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; and (k) treating nephropathy. The nitrosated and/or nitrosylated cardiovascular compounds are preferably nitrosated and/or nitrosylated P-adrenergic antagonists, nitrosated and/or nitrosylated angiotensinconverting enzyme (ACE) inhibitors, nitrosated and/or nitrosylated anti-hyperlipidemic compounds, and nitrosated and/or nitrosylated antithrombotic and vasodilator compounds.

8. 发明专利

CA2493618A1 NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE 未知
公开(公告)号：CA2493618A1
公开(公告)日：2004-02-12
申请号：CA2493618
申请日：2003-08-01
申请人： NITROMED INC
发明人： GARVEY DAVID S , FANG XINQIN , LETTS GORDON L
IPC分类号： A61K31/44 , A61K31/4439 , A61K45/00 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/14 , A61P3/04 , A61P17/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/22 , A61P35/02 , A61P43/00 , C07D233/54 , C07D401/12 , C07D495/04 , A61P31/00 , C07D401/02 , C07D471/04
摘要： The invention describes novel nitrosated proton pump inhibitor compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated proton pump inhibitor compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated proton pump inhibitor compound, and at least one compound that donates, transfers or releases nitr ic oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated proton pump inhibitor compound, and, optionally, at least one nitric oxide donor and/or at least o ne therapeutic agent. The invention also provides methods for treating gastrointestinal disorders; facilitating ulcer healing; decreasing the recurrence of ulcers; improving gastroprotective properties, anti-Helicobact er pylori properties or antacid properties of proton pump inhibitors; decreasin g or reducing the gastrointestinal toxicity associated with the use of nonsteroidal antiinflammatory compounds; treating bacterial infections and/or viral infections.

9. 发明专利

AU2003254282A1 NITROSATED PROTON PUMP INHIBITORS, COMPOSITIONS AND METHODS OF USE 未知
公开(公告)号：AU2003254282A1
公开(公告)日：2004-02-23
申请号：AU2003254282
申请日：2003-08-01
申请人： NITROMED INC
发明人： FANG XINQIN , GARVEY DAVID S , LETTS GORDON L
IPC分类号： A61K31/44 , A61K31/4439 , A61K45/00 , A61P1/00 , A61P1/04 , A61P1/10 , A61P1/14 , A61P3/04 , A61P17/02 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/22 , A61P35/02 , A61P43/00 , C07D233/54 , C07D401/12
摘要： The invention describes novel nitrosated proton pump inhibitor compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated proton pump inhibitor compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one nitrosated proton pump inhibitor compound, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated proton pump inhibitor compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating gastrointestinal disorders; facilitating ulcer healing; decreasing the recurrence of ulcers; improving gastroprotective properties, anti-Helicobacter pylori properties or antacid properties of proton pump inhibitors; decreasing or reducing the gastrointestinal toxicity associated with the use of nonsteroidal antiinflammatory compounds; treating bacterial infections and/or viral infections.

10. 发明专利

DE69637830D1 未知
公开(公告)号：DE69637830D1
公开(公告)日：2009-03-19
申请号：DE69637830
申请日：1996-04-11
申请人： NITROMED INC
发明人： GARVEY DAVID S , LETTS GORDON L , RENFROE BURT H , TAM SANG W
IPC分类号： A61K31/54 , A61K38/00 , A61P29/00 , C07C203/00 , C07C327/28 , C07C381/00 , C07D209/28 , C07D417/12 , C07D513/00 , C07D513/02 , C07D513/04 , C07J41/00 , C07K5/02
摘要： A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a pharmaceutical composition including the compounds and methods of treatment of pain and/or inflammation using the compounds and compositions are disclosed. Also disclosed is a composition comprising a non-steroidal antiinflammatory agent and a compound that donates, transfers or releases nitric oxide.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式