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1. 发明公开

EP2045253A4 alpha-AMINO ACID DERIVATIVE AND PHARMACEUTICAL COMPRISING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译： α-氨基酸衍生物和药物，这作为活性成分的
公开(公告)号：EP2045253A4
公开(公告)日：2013-01-23
申请号：EP07767879
申请日：2007-06-29
申请人： NISSAN CHEMICAL IND LTD , CHUGAI PHARMACEUTICAL CO LTD
发明人： OHRAI KAZUHIKO , ADACHI MICHIAKI , TOYAMA KOJI , SHIMIZU TAKANORI , HAYASHI KEISHI , MINAMI MASATAKA , SUZUKI YOSHIYUKI , SUGIYAMA MASAKAZU , OHTA MASATERU , KADONO SHOJIRO , SHIRAISHI TAKUYA , SATO HARUHIKO , WATANABE YOSHIAKI , ISHII NOBUYA , SAKAITANI MASAHIRO , HASEGAWA MASAMI
IPC分类号： C07D513/04 , A61K31/429 , A61K31/4439 , A61P9/04 , A61P35/00 , A61P43/00
CPC分类号： C07D513/04

2. 发明公开

EP0811629A4 OPTICALLY ACTIVE BIDENTATE PHOSPHINE LIGAND/PALLADIUM COMPLEX 失效
标题翻译：的光学活性2齿膦配体的钯络合物
公开(公告)号：EP0811629A4
公开(公告)日：1998-05-13
申请号：EP96903223
申请日：1996-02-23
申请人： NISSAN CHEMICAL IND LTD
发明人： SHIBASAKI MASAKATSU , SODEOKA MIKIKO , OHRAI KAZUHIKO
IPC分类号： B01J31/24 , C07F15/00 , C07C45/45 , C07C49/747 , C07C49/83
CPC分类号： B01J31/2295 , B01J31/2409 , B01J31/2414 , B01J31/2452 , B01J2231/4272 , B01J2531/0205 , B01J2531/0266 , B01J2531/824 , B01J2531/842 , C07F15/0066
摘要： Novel optically active bidentate phosphine ligand/palladium complexes represented by general formula (I) or (II) and used as a catalyst in the production of optically active beta -hydroxy ketones serving as intermediates for producing medicines, wherein Y represents a counter anion capable of forming a slat, and X represents a group represented by any of general formulae (a), (b), (c), (d), (e), (f), (g), (h) or (i), wherein R represents hydrogen, C1-C6 alkyl, C1-C6 alkoxy, cyano, nitro, halo, phenyl, etc.; m represents 1 or 2, provided when m is 2, 2R groups may be the same or different from each other; and A and B represent each independently phenyl or cyclohexyl, each of which may be substituted by R which has the same meaning as R .

3. 发明公开

EP0693283A4 HEART FAILURE REMEDY 失效
标题翻译： MEANS心力衰竭
公开(公告)号：EP0693283A4
公开(公告)日：1997-07-23
申请号：EP94910589
申请日：1994-04-01
申请人： NISSAN CHEMICAL IND LTD
发明人： SETO KIYOTOMO , MATSUMOTO HIROO , KAMIKAWAJI YOSHIMASA , OHRAI KAZUHIKO , YAMASHITA TORU , MASUDA YUKINORI
IPC分类号： A61K31/41 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5355 , A61K31/5377 , A61P9/04 , C07D491/04 , C07D491/052 , C07D498/04 , C07D513/04 , A61K31/415
CPC分类号： C07D491/04 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/4245 , A61K31/433 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5355 , A61K31/5377 , C07D513/04
摘要： A cardiotonic containing a compound represented by general formula (I) or, if any, a pharmaceutically acceptable salt thereof as the active ingredient, wherein X?1 and X2¿ are absent or each represents oxygen; A represents OH or C¿1?-C4 acyloxy; B represents hydrogen or is combined with A to form a bond; X represents oxygen, nitrogen, sulfur, etc.; R?1 and R2¿ represent each hydrogen, C¿1? - C4 alkyl, etc.; and R?3 and R4¿ represent each hydrogen, C¿1? - C4 alkyl, etc., or they may be combined together to represent 1,4-butylene, 1,5-pentylene, etc. The compound has potent activities of increasing cardiac contractility and reducing cardiac rate and is lowly toxic, thus being useful as a cardiotonic.

4. 发明专利

CY1111250T1 ΤΡΙΚΥΚΛΙΚΗ ΕΝΩΣΗ ΒΕΝΖΟΠΥΡΑΝΙΟΥ ΜΕ ΙΔΙΟΤΗΤΑ ΑΝΤΙΑΡΡΥΘΜΙΚΩΝ ΠΑΡΑΓΟΝΤΩΝ 未知
公开(公告)号：CY1111250T1
公开(公告)日：2015-06-11
申请号：CY111100060
申请日：2011-01-19
申请人： NISSAN CHEMICAL IND LTD
发明人： OHRAI KAZUHIKO , SHIGETA YUKIHIRO , UESUGI OSAMU , OKADA TAKUMI , MATSUDA TOMOYUKI
IPC分类号： C07D491/04 , A61K31/436 , A61P9/06 , C07D498/04 , C07D513/04 , C07D515/04
摘要： Ηπαρούσαεφεύρεσηαφοράταπαράγωγατουβενζοπυρανίουτουτύπου (I) ή (II), ήφαρμακευτικάαποδεχτάάλατασχετικάμεαυτάόπουτα R1 και R2 είναι, ανεξάρτητατοένααπότοάλλο, άτομουδρογόνου, C1-6 αλκυλομάδαή C6-14 αρυλομάδα, το R3 είναιάτομουδρογόνουή C1-6 αλκυλοκαρβονυλοξυομάδαή σχηματίζειέναδεσμόμαζίμετο R4, το R4 είναιάτομουδρογόνουή σχηματίζειέναδεσμόμαζίμετο R3, το «m» είναιέναςακέραιοςαριθμόςαπότο 0-4, το «n» είναιέναςακέραιοςαριθμόςαπότο 0-4, το «V» είναιέναςμονόςδεσμός, CR7R8, NR9, Ο, S, SO ή SO2, το R5 είναιάτομουδρογόνουή C1-6 αλκυλομάδα, το R6 είναιάτομουδρογόνου, C1-6 αλκυλομάδα, C3-8 κυκλοαλκυλομάδα, C3-8 κυκλοαλκενυλομάδα, αμινομάδα, C1-6 αλκυλαμινομάδα, δι- C1-6, αλκυλαμινομάδα, C6-14 αρυλαμινομάδα, C2-9 ετεροαρυλαμινομάδα, C6-14 αρυλομάδα, C2-9 ετεροαρυλομάδαή C2-9 ετεροκυκλυλομάδα, τοΑ είναι 5-μελής, 6-μελήςή 7-μελήςδακτύλιοςσυζευγμένοςμεδακτύλιοβενζολίου, ωςσυστατικόάτομοτουδακτυλίου, τοάτομοοξυγόνου, τοάτομοαζώτου, ήτοάτομοθείουμπορείναπεριλαμβάνονταιστοναριθμό 1 έως 3 μόνατουςή σεσυνδυασμόσχετικάμεαυτά, οαριθμόςτουακόρεστουδεσμούστοδακτύλιοείναι 1, 2 ή 3 συμπεριλαμβανομένουενόςακόρεστουδεσμούτουδακτυλίουτουβενζολίουγιασύζευξη, ταάτομαάνθρακαπουαποτελούντοδακτύλιομπορείναείναικαρβονυλικάή θειοκαρβονυλικά. Οιπαρούσεςενώσειςείναιχρήσιμεςωςέναςαντιαρρυθμικόςπαράγοντας.

5. 发明专利

SK287023B6 Benzopyran derivates and drug comprising thereof 未知
公开(公告)号：SK287023B6
公开(公告)日：2009-09-07
申请号：SK10002003
申请日：2002-02-14
申请人： NISSAN CHEMICAL IND LTD
发明人： OHARA YOSHIO , OHRAI KAZUHIKO , YANAGIHARA KAZUFUMI , SHIGETA YUKIHIRO , TSUKAGOSHI TORU , YAMASHITA TORU
IPC分类号： C07D311/00 , C07D311/68 , A61K31/353 , A61P9/00 , A61P9/06 , C07D311/70 , C07D311/72
摘要： It is described benzopyran derivatives of the formula (I) wherein, R1 and R2 represent each independently a C1-6alkyl group, etc, R3 represents a hydroxyl group, etc, R4 represents a hydrogen atom, etc, R6 represents a hydrogen atom, R7 represents a hydrogen atom, etc, X is absent, or represents C=O, etc, R8 represents a hydrogen atom, a C1-6alkyl group, etc, R9 represents a hydrogen atom or a nitro group, when R9 represents a nitro group, Y represents a C4-8alkylene group, -(CH2)m-CR11R12-(CH2)n- or -(CH2)o-O-(CH2)p-, R5 represents a hydrogen atom, an amino group, a C1-6alkoxy group, a C1-6alkylthio group, a C1-6alkylamino group, a C1-6 alkoxycarbonylamino group, etc, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarythmic agent.

6. 发明专利

SK50792006A3 Tricyclic benzopyran compound as anti-arrhythmic agents 未知
公开(公告)号：SK50792006A3
公开(公告)日：2007-09-06
申请号：SK50792006
申请日：2005-03-23
申请人： NISSAN CHEMICAL IND LTD
发明人： OHRAI KAZUHIKO , UESUGI OSAMU , OKADA TAKUMI , MATSUDA TOMOYUKI , SHIGETA YUKIHIRO
IPC分类号： C07D491/00 , A61K31/00 , A61P9/00 , C07D491/04 , C07D498/00 , C07D498/04 , C07D513/00 , C07D513/04 , C07D515/00 , C07D515/04
摘要： This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.

7. 发明专利

DE60206505T2 未知
公开(公告)号：DE60206505T2
公开(公告)日：2006-07-06
申请号：DE60206505
申请日：2002-06-17
申请人： NISSAN CHEMICAL IND LTD
发明人： OHARA YOSHIO , OHRAI KAZUHIKO , YANAGIHARA KAZUFUMI , SHIGETA YUKIHIRO , TSUKAGOSHI TORU , YAMASHITA TORU
IPC分类号： C07D311/68 , A61K31/353 , A61P9/06
摘要： This invention relates to benzopyran derivatives of the formula (1) or the formula (2) wherein R 1 and R 2 represent independently of each other hydrogen atom or C 1-6 alkyl group, R 3 represents hydroxyl group or C 1-6 alkylcarbonyloxy group, R 4 represents hydrogen atom or C 1-6 alkyl group, R 5 represents C 1-6 alkyl group substituted with C 6-14 aryl group or heteroaryl group, R 6 represents C 1-6 alkyl group, C 1-6 alkoxy group, halogen atom, nitro group, C(O)NH 2 , C(O)NHR 8 or C(O)NR 8 R 9 , or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent

8. 发明专利

AT311378T 未知
公开(公告)号：AT311378T
公开(公告)日：2005-12-15
申请号：AT00961032
申请日：2000-09-14
申请人： NISSAN CHEMICAL IND LTD
发明人： TANIKAWA KEIZO , OHRAI KAZUHIKO , YANAGIHARA KAZUFUMI , SHIGETA YUKIHIRO , TSUKAGOSHI TORU , YAMASHITA TORU
IPC分类号： A61K31/352 , A61K31/353 , A61P9/06 , C07D311/68 , C07D311/70 , C07D405/12 , C07D411/12 , A61K31/453
摘要： This invention relates a benzopyran denvative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a (substituted)C1-6 alkyl group or a (substituted)phenyl group,R3 represents a hydroxyl group or C1-6 alkylcarbonyloxy group, R4 represents a hydrogen atom, or R3 and R4 together form a bond, m represents an integer of 0-4, n represents an integer of 0-4, Y is absent, or represents CR11R12 in which R11 and R12 represent each independently a hydrogen atom or a C1-6 alkyl group, R5 represents an aryl group or a (substituted)heteroaryl group,R6 represents a hydrogen atom or a C1-6 alkyl group,R7 represents a hydrogen atom or a C1-6 alkyl group,X is absent, or represents C=O or SO2, R8 represents a hydrogen atom, a (substituted)C1-6 alkyl group or C3-6 cycloalkyl group, and R9 represents a nitro group, etc., or a pharmaceutically acceptable salt thereof. And this invention also relates an antiarrhythmic agent having the prolongation effect on the functional refractory period comprising said compound or a pharmaceutically acceptable salt thereof as an active ingredient.

9. 发明专利

DE60200937D1 未知
公开(公告)号：DE60200937D1
公开(公告)日：2004-09-16
申请号：DE60200937
申请日：2002-02-14
申请人： NISSAN CHEMICAL IND LTD
发明人： OHARA YOSHIO , OHRAI KAZUHIKO , YANAGIHARA KAZUFUMI , SHIGETA YUKIHIRO , TSUKAGOSHI TORU , YAMASHITA TORU NISSAN CHEM IND
IPC分类号： C07D311/68 , A61K31/353 , A61P9/00 , A61P9/06 , C07D311/70 , C07D311/72
摘要： This invention relates to benzopyran derivatives of the formula (I) wherein, R and R represent each independently a C1-6alkyl group, etc, R represents a hydroxyl group, etc, R represents a hydrogen atom, etc, R represents a hydrogen atom, R represents a hydrogen atom, etc, X is absent, or represents C=O, etc, R represents a hydrogen atom, a C1-6alkyl group, etc, R represents a hydrogen atom or a nitro group, when R represents a nitro group, Y represents a C4-8alkylene group, -(CH2)m-CR R -(CH2)n- or -(CH2)o-O-(CH2)p-, R represents a hydrogen atom, an amino group, a C1-6alkoxy group, a C1-6alkylthio group, a C1-6alkylamino group, a C1-6 alkoxycarbonylamino group, etc, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent.

10. 发明专利

AT273294T 未知
公开(公告)号：AT273294T
公开(公告)日：2004-08-15
申请号：AT02712344
申请日：2002-02-14
申请人： NISSAN CHEMICAL IND LTD
发明人： OHARA YOSHIO , OHRAI KAZUHIKO , YANAGIHARA KAZUFUMI , SHIGETA YUKIHIRO , TSUKAGOSHI TORU , YAMASHITA TORU , OAZA SHIRAOKA
IPC分类号： C07D311/68 , A61K31/353 , A61P9/00 , A61P9/06 , C07D311/70 , C07D311/72
摘要： This invention relates to benzopyran derivatives of the formula (I) wherein, R and R represent each independently a C1-6alkyl group, etc, R represents a hydroxyl group, etc, R represents a hydrogen atom, etc, R represents a hydrogen atom, R represents a hydrogen atom, etc, X is absent, or represents C=O, etc, R represents a hydrogen atom, a C1-6alkyl group, etc, R represents a hydrogen atom or a nitro group, when R represents a nitro group, Y represents a C4-8alkylene group, -(CH2)m-CR R -(CH2)n- or -(CH2)o-O-(CH2)p-, R represents a hydrogen atom, an amino group, a C1-6alkoxy group, a C1-6alkylthio group, a C1-6alkylamino group, a C1-6 alkoxycarbonylamino group, etc, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent.

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