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1. 发明申请

WO2012051173A2 A METHOD FOR PROMOTING THE SYNTHESIS OF COLLAGEN AND PROTEOGLYCAN IN CHONDROCYTES 审中-公开
标题翻译：促进胶原和胶原蛋白合成的方法
公开(公告)号：WO2012051173A2
公开(公告)日：2012-04-19
申请号：PCT/US2011/055757
申请日：2011-10-11
申请人： NIPPON ZOKI PHARMACEUTICAL CO., LTD. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MASUDA, Koichi , NAIKI, Mitsuru
发明人： MASUDA, Koichi , NAIKI, Mitsuru
IPC分类号： A61K35/36
CPC分类号： C12Q1/025 , A61K35/32 , A61K35/36 , A61K35/76 , G01N33/5082 , G01N2333/07
摘要： The synthesis of collagen and proteoglycan in chondrocytes, such as intervertebral disc cells, articular chondrocytes and meniscal cells is promoted by administration of an extract from inflamed tissue inoculated with vaccinia virus.
摘要翻译：软骨细胞如椎间盘细胞，关节软骨细胞和半月板细胞中的胶原和蛋白聚糖的合成通过施用痘苗病毒接种的发炎组织的提取物来促进。

2. 发明申请

WO2016022917A3 A METHOD FOR PROTECTING LIVER AND A LIVER PROTECTING AGENT 审中-公开
公开(公告)号：WO2016022917A3
公开(公告)日：2016-02-11
申请号：PCT/US2015/044204
申请日：2015-08-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , NIPPON ZOKI PHARMACEUTICAL CO., LTD.
发明人： SEKI, Ekihiro , MASUDA, Koichi , NAIKI, Mitsuru
IPC分类号： A61K35/12 , A61K39/285 , C12N5/071
摘要： An object of the present invention is to provide a protective method for liver comprising the administration of an extract from inflamed tissues inoculated with vaccinia virus to a patient who needs the treatment and to provide a liver protective agent, etc. where such an extract is an active ingredient. In the present invention, it has been recognized that, in hepatocytes, activation of NF- B, expression of NF- B target genes, activation of JNK, apoptosis and fat accumulation can be inhibited or suppressed. The agent containing the extract as an active ingredient is a drug exhibiting less adverse action and high safety. Accordingly, the present invention provides very useful protective method for liver and liver protecting agent.

3. 发明授权

EP2627343B1 AGENTS FOR USE FOR PROMOTING THE SYNTHESIS OF COLLAGEN AND PROTEOGLYCAN IN INTERVERTEBRAL DISC CELLS 有权
标题翻译：用于促进椎间盘细胞中胶原蛋白和蛋白多糖合成的药物
公开(公告)号：EP2627343B1
公开(公告)日：2018-01-10
申请号：EP11833245.1
申请日：2011-10-11
申请人： Nippon Zoki Pharmaceutical Co., Ltd. , The Regents of the University of California
发明人： MASUDA, Koichi , NAIKI, Mitsuru
IPC分类号： A61K35/32 , A61K35/36 , A61K35/76 , G01N33/50 , A61P9/00
CPC分类号： C12Q1/025 , A61K35/32 , A61K35/36 , A61K35/76 , G01N33/5082 , G01N2333/07
摘要： The synthesis of collagen and proteoglycan in chondrocytes, such as intervertebral disc cells, articular chondrocytes and meniscal cells is promoted by administration of an extract from inflamed tissue inoculated with vaccinia virus.

4. 发明公开

EP2627343A2 A METHOD FOR PROMOTING THE SYNTHESIS OF COLLAGEN AND PROTEOGLYCAN IN CHONDROCYTES 有权
标题翻译：程序对促进胶原蛋白的合成蛋白多糖AT软骨细胞
公开(公告)号：EP2627343A2
公开(公告)日：2013-08-21
申请号：EP11833245.1
申请日：2011-10-11
申请人： Nippon Zoki Pharmaceutical Co., Ltd. , The Regents of the University of California
发明人： MASUDA, Koichi , NAIKI, Mitsuru
IPC分类号： A61K35/36
CPC分类号： C12Q1/025 , A61K35/32 , A61K35/36 , A61K35/76 , G01N33/5082 , G01N2333/07
摘要： The synthesis of collagen and proteoglycan in chondrocytes, such as intervertebral disc cells, articular chondrocytes and meniscal cells is promoted by administration of an extract from inflamed tissue inoculated with vaccinia virus.

5. 发明申请

WO2021146252A1 METHODS OF PRESERVING TISSUES FOR TRANSPLANTATION 审中-公开
公开(公告)号：WO2021146252A1
公开(公告)日：2021-07-22
申请号：PCT/US2021/013195
申请日：2021-01-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： MASUDA, Koichi
IPC分类号： A01N1/02 , C01B25/30 , C01D7/00
摘要： Provided herein are systems and methods for preserving and transporting tissues for transplantation. In particular, tissue to be implanted is encapsulated in an alginate gel, which is exposed to culture medium to improve cell viability and suppress inflammatory factors during long-term storage and transport.

6. 发明申请

WO2013056174A1 XENOGRAFT MODEL OF HUMAN BONE METASTATIC PROSTATE CANCER 审中-公开
标题翻译：人骨髓前列腺癌XENOGRAFT模型
公开(公告)号：WO2013056174A1
公开(公告)日：2013-04-18
申请号：PCT/US2012/060128
申请日：2012-10-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： JAMIESON, Christina , KULIDJIAN, Anna, A. , JAMIESON, Catriona, H. , KANE, Christopher, J. , MASUDA, Koichi , WU, Christina, CN , RAHEEM, Omer, A.
IPC分类号： A01K67/027 , C12N5/10 , G01N33/15
CPC分类号： A01K67/0271 , A01K2207/12 , A01K2227/10 , A01K2227/105 , A01K2267/0331 , G01N33/5088
摘要： The disclosure herein provides a bone metastasis -derived prostate cancer xenograft model. The disclosure also provides methods for making a bone metastasis- derived prostate cancer xenograft model. In alternative embodiments, the disclosure provides compositions and methods for testing whether a drug, compound, diet, therapy or treatment is effective or efficacious for preventing, ameliorating, slowing the progress of, stopping or slowing the metastasis of, or for causing a full or partial remission of, a cancer, or a prostate cancer, or a human prostate cancer. The disclosure provides compositions and methods whether a drug, compound, diet, therapy or treatment is effective or efficacious for modifying or effecting the structure or organization or vascularization of a tumor microenvironment; or effects the growth, survival, phenotype or histology (tissue or organ structure or microenvironments) of connective tissue, bone cells, osteoblasts, osteocytes, osteoclasts, bone marrow cells, fibroblasts or angiogenic cells.
摘要翻译：本文的公开内容提供了骨转移来源的前列腺癌异种移植模型。本公开还提供了制备骨转移来源的前列腺癌异种移植模型的方法。在替代实施方案中，本公开提供了用于测试药物，化合物，饮食，治疗或治疗是否有效或有效用于预防，改善，减缓转移的进展，停止或减缓转移或导致完全或癌症或前列腺癌或人类前列腺癌的部分缓解。本公开提供组合物和方法，药物，化合物，饮食，治疗或治疗是否对修饰或实现肿瘤微环境的结构或组织或血管形成有效或有效; 或影响结缔组织，骨细胞，成骨细胞，骨细胞，破骨细胞，骨髓细胞，成纤维细胞或血管生成细胞的生长，存活，表型或组织学（组织或器官结构或微环境）。

7. 发明申请

WO2021146400A1 METHODS AND COMPOSITIONS RELATING TO PROLONGED INFLAMMATORY INHIBITION AND/OR PROLONGED TREATMENT OF SPINAL PAIN BY CHIMERA DECOY 审中-公开
公开(公告)号：WO2021146400A1
公开(公告)日：2021-07-22
申请号：PCT/US2021/013404
申请日：2021-01-14
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ANGES, INC.
发明人： MASUDA, Koichi , NAKAZAWA, Takahiro
IPC分类号： A61K31/713 , A61K47/59 , A61P19/04 , C12N15/115
摘要： Provided herein are methods and compositions for long term treatment of spinal pain. In particular, use of double-stranded oligonucleotide decoys capable of binding to the DNA binding sites of two transcription factors are provided for treatment of spinal pain for over seven days, where the decoys are administered without a drug delivery system.

8. 发明公开

EP4096684A1 METHODS AND COMPOSITIONS RELATING TO PROLONGED INFLAMMATORY INHIBITION AND/OR PROLONGED TREATMENT OF SPINAL PAIN BY CHIMERA DECOY 审中-实审
公开(公告)号：EP4096684A1
公开(公告)日：2022-12-07
申请号：EP21741929.0
申请日：2021-01-14
申请人： The Regents of the University of California , AnGes, Inc.
发明人： MASUDA, Koichi , NAKAZAWA, Takahiro
IPC分类号： A61K31/713 , A61K47/59 , A61P19/04 , C12N15/115

9. 发明申请

WO2003062457A1 TISSUE ENGINEERED CARTILAGE FOR DRUG DISCOVERY 审中-公开
标题翻译：组织工程化疗药物发现
公开(公告)号：WO2003062457A1
公开(公告)日：2003-07-31
申请号：PCT/US2003/001395
申请日：2003-01-17
申请人： RUSH-PRESBYTERIAN-ST. LUKE'S MEDICAL CENTER , MASUDA, Koichi , THONAR, Eugene , PFISTER, Brian , HEJNA, Michael
发明人： MASUDA, Koichi , THONAR, Eugene , PFISTER, Brian , HEJNA, Michael
IPC分类号： C12Q1/00
CPC分类号： G01N33/5082
摘要： A culture system and method for determining the effect of a test agent on the development, homeostasis or degradation of engineered cartilage tissue. The engineered cartilage tissue is obtained by isolating chondrogenic cells and culturing them to obtain chondrocytes in a cell-associated matrix. The chondrocytes and cell associated matrix are then cultured on a semipermeable membrane to provide the engineered cartilage tissue. The engineered tissue, or one of its precursors, can be contacted with the test agent to determine what effect, if any, the test agent has on engineered cartilage.
摘要翻译：用于确定测试试剂对工程软骨组织的发育，稳态或降解的影响的培养系统和方法。通过分离软骨形成细胞并培养它们以获得细胞相关基质中的软骨细胞来获得工程软骨组织。然后将软骨细胞和细胞相关基质在半透膜上培养以提供工程化的软骨组织。工程组织或其前体之一可与测试试剂接触，以确定测试试剂对工程软骨的影响（如果有的话）。

10. 发明申请

WO2005091960A2 METHOD FOR INHIBITING FIBROCARTILAGE DEGRADATION 审中-公开
标题翻译：阻止纤维素降解的方法
公开(公告)号：WO2005091960A2
公开(公告)日：2005-10-06
申请号：PCT/US2005/006946
申请日：2005-03-04
申请人： RUSH UNIVERSITY MEDICAL CENTER , MASUDA, Koichi
发明人： MASUDA, Koichi
CPC分类号： A61K31/35
摘要： Described herein is a method for inhibiting cartilage, typically fibrocartilage, degradation using esculetin and chemically related compounds. In some embodiments, the esculetin compound is used to prevent degradation of intervertebral disc tissues.
摘要翻译：本文描述了一种通过使用七叶亭和化学相关化合物抑制软骨，通常纤维软骨退化的方法。在一些实施方案中，七叶亭化合物用于防止椎间盘组织的降解。

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