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1. 发明申请

WO2006062258A3 METHOD FOR PRODUCTION OF MODIFIED WATER ABSORBENT RESIN 审中-公开
公开(公告)号：WO2006062258A3
公开(公告)日：2006-06-15
申请号：PCT/JP2005/023103
申请日：2005-12-09
申请人： NIPPON SHOKUBAI CO., LTD. , MATSUMOTO, Makoto , MITSUKAMI, Yoshiro , IKEUCHI, Hiroyuki , TORII, Kazushi , IWAMURA, Taku , FLOHR, Andreas , LINDNER, Torsten
发明人： MATSUMOTO, Makoto , MITSUKAMI, Yoshiro , IKEUCHI, Hiroyuki , TORII, Kazushi , IWAMURA, Taku , FLOHR, Andreas , LINDNER, Torsten
IPC分类号： C08J3/28 , C08L101/14 , C08J3/24 , C08K3/30 , C08L33/02 , C08K5/14 , C08K5/23 , C08F8/44 , A61L15/60 , C08F6/00 , C08F220/06
摘要： This invention is to provide a method for producing a modified water absorbent resin excelling in water absorbing properties. This invention relates to a method for producing a modified water absorbent resin, which comprises a) mixing a water absorbent resin and a water-soluble radical polymerization initiator or a heat-degradable radical polymerization initiator without addition of an ethylenically unsaturated monomer and b) irradiating the resultant mixture with active energy rays. The method is particularly capable of exalting the absorbency against pressure and the saline flow conductivity.

2. 发明申请

WO2006062253A1 METHOD FOR SURFACE-TREATMENT OF WATER ABSORBENT RESIN 审中-公开
标题翻译：表面处理吸水树脂的方法
公开(公告)号：WO2006062253A1
公开(公告)日：2006-06-15
申请号：PCT/JP2005/023089
申请日：2005-12-09
申请人： NIPPON SHOKUBAI CO., LTD. , MATSUMOTO, Makoto , MITSUKAMI, Yoshiro , IKEUCHI, Hiroyuki , TORII, Kazushi , IWAMURA, Taku
发明人： MATSUMOTO, Makoto , MITSUKAMI, Yoshiro , IKEUCHI, Hiroyuki , TORII, Kazushi , IWAMURA, Taku
IPC分类号： C08J3/28 , C08J7/18 , C08J7/16 , C08F265/02 , A61L15/60
CPC分类号： C08F265/00 , C08F265/02 , C08J3/28 , C08J7/18 , C08J2300/14 , C08J2333/02 , C08L51/003 , C08L2666/02
摘要： This invention is to provide a method for surface-treatment of a water absorbent resin excelling in water absorption properties. This invention relates to a method for the surface-treatment of a water absorbent resin, which comprises: a) mixing 100 parts by weight of a water absorbent resin, 0.01 - 20 parts by weight of at least one radical polymerization initiator selected from the group consisting of persulfates, hydrogen peroxide, and azo compounds, and a radically polymerizing compound and b) irradiating the resultant mixture with active energy rays. The treatment particularly exalts the absorption ratio against pressure and the saline flow conductivity.
摘要翻译：本发明提供一种吸水性树脂表面处理方法，其吸水性优异。本发明涉及一种用于表面处理吸水性树脂的方法，其包括：a）将100重量份的吸水性树脂，0.01-20重量份的至少一种选自下组的自由基聚合引发剂由过硫酸盐，过氧化氢和偶氮化合物组成，和自由基聚合化合物，和b）用活性能量射线照射所得混合物。该处理特别提高了对压力和盐水流动传导率的吸收比。

3. 发明申请

WO2006063229A2 ABSORBENT MEMBERS COMPRISING MODIFIED WATER ABSORBENT RESIN FOR USE IN DIAPERS 审中-公开
标题翻译：包含改性水吸收树脂在吸收剂中的吸收剂
公开(公告)号：WO2006063229A2
公开(公告)日：2006-06-15
申请号：PCT/US2005/044607
申请日：2005-12-09
申请人： THE PROCTER & GAMBLE COMPANY , MATSUMOTO, Makoto , MITSUKAMI, Yoshiro , IKEUCHI, Hiroyuki , TORII, Kazushi , IWAMURA, Taku , FLOHR, Andreas , LINDNER, Torsten
发明人： MATSUMOTO, Makoto , MITSUKAMI, Yoshiro , IKEUCHI, Hiroyuki , TORII, Kazushi , IWAMURA, Taku , FLOHR, Andreas , LINDNER, Torsten
IPC分类号： A61L15/60
CPC分类号： C08J3/28 , A61L15/60 , C08J2333/02
摘要： An absorbent member for use in disposable diapers, wherein the absorbent member comprises a modified water absorbent resin. The modified water absorbent resin is made according to the method which comprises a) mixing a water absorbent resin and a water-soluble radical polymerization initiator or a heat-degradable radical polymerization initiator without addition of an ethylenically unsaturated monomer and b) irradiating the resultant mixture with active energy rays. The method is particularly capable of exalting the absorbency against pressure and the saline flow conductivity.
摘要翻译：一种用于一次性尿布的吸收件，其中吸收件包括改性吸水树脂。改性吸水性树脂根据以下方法制备：a）将混合吸水性树脂和水溶性自由基聚合引发剂或热降解自由基聚合引发剂混合，不加入烯属不饱和单体，b）照射所得混合物具有活跃的能量射线。该方法特别能够提高抗压力和盐水流动导电性的吸收性。

4. 发明申请

WO2009048160A1 SURFACE TREATMENT METHOD FOR WATER-ABSORBENT RESIN 审中-公开
标题翻译：吸水树脂的表面处理方法
公开(公告)号：WO2009048160A1
公开(公告)日：2009-04-16
申请号：PCT/JP2008/068694
申请日：2008-10-08
申请人： NIPPON SHOKUBAI CO., LTD. , MITSUKAMI, Yoshiro , IWAMURA, Taku , MATSUMOTO, Makoto
发明人： MITSUKAMI, Yoshiro , IWAMURA, Taku , MATSUMOTO, Makoto
IPC分类号： C08J3/24 , C08J3/12
CPC分类号： C08J3/245 , C08J2300/14
摘要： Provided is a surface treatment method for a water-absorbent resin having excellent production efficiency, absorption capacity against pressure, fluid permeability or the like. Provided is a method for the surface treatment of a water-absorbent resin which comprises a) a step for mixing 0.1 to 20 parts by weight of an acid group-containing radically polymerizable compound and 5 to 20 parts by weight of water, relative to 100 parts by weight of a water-absorbent resin; and b) a step for polymerizing the acid group-containing radically polymerizable compound, wherein neutralization ratio of the acid group-containing radically polymerizable compound is 0 to 60% by mol, and is lower than neutralization ratio of the water-absorbent resin.
摘要翻译：提供了具有优异的生产效率，对压力的吸收能力，流体渗透性等的吸水性树脂的表面处理方法。本发明提供一种吸水性树脂的表面处理方法，该方法包括：a）将0.1〜20重量份含酸基的自由基聚合性化合物和5〜20重量份的水相对于100 吸水树脂重量份; 和b）使含酸基的自由基聚合性化合物的中和率为0〜60摩尔％，并且低于吸水性树脂的中和率的含有酸基的自由基聚合性化合物的工序。

5. 发明申请

WO2007119730A1 METHOD FOR PRODUCTION OF MODIFIED WATER ABSORBENT RESIN 审中-公开
标题翻译：生产改性吸水树脂的方法
公开(公告)号：WO2007119730A1
公开(公告)日：2007-10-25
申请号：PCT/JP2007/057936
申请日：2007-04-04
申请人： NIPPON SHOKUBAI CO., LTD. , MITSUKAMI, Yoshiro , MATSUMOTO, Makoto , IWAMURA, Taku
发明人： MITSUKAMI, Yoshiro , MATSUMOTO, Makoto , IWAMURA, Taku
IPC分类号： C08J3/24 , C08J3/12 , C08J3/28
CPC分类号： C08J3/28 , C08J2333/08
摘要： This invention is to provide a method for producing a modified water absorbent resin having excellent production efficiency, and manifesting excellent absorbency against pressure, absorption speed, gel strength, a liquid permeability, and the like. This invention relates to a method for the production of a modified water absorbent resin, which comprises a) a mixing step comprising mixing a water absorbent resin, water, and a water-soluble radical polymerization initiator without addition of an ethylenically unsaturated monomer, to obtain a water absorbent resin composition, and b) an irradiating step comprising irradiating said water absorbent resin composition obtained in the mixing step with active energy rays, wherein a surface water content of said water absorbent resin in said water absorbent resin composition at least at any point of time in the irradiating step is controlled to a level of not lower than 3.0% by weight based on 100% by weight of the water absorbent resin.
摘要翻译：本发明提供一种制造生产效率优异，表现出优异的耐压吸收性，吸收速度，凝胶强度，透液性等的改性吸水性树脂的制造方法。本发明涉及一种生产改性吸水性树脂的方法，该方法包括：a）混合步骤，包括在不加入烯属不饱和单体的情况下混合吸水树脂，水和水溶性自由基聚合引发剂，以获得吸水性树脂组合物，以及b）照射步骤，包括用活性能量射线照射在所述混合步骤中获得的所述吸水性树脂组合物，其中所述吸水性树脂组合物中的吸水性树脂的表面含水量至少在任何点基于100重量％的吸水性树脂，将照射步骤的时间控制在不低于3.0重量％的水平。

6. 发明申请

WO2007120561A2 AN ABSORBENT MEMBER COMPRISING A MODIFIED WATER ABSORBENT RESIN 审中-公开
标题翻译：包含改性吸水树脂的吸收构件
公开(公告)号：WO2007120561A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/008475
申请日：2007-04-04
申请人： THE PROCTER & GAMBLE COMPANY , MATSUMOTO, Makoto , MITSUKAMI, Yoshiro , IWAMURA, Taku
发明人： MATSUMOTO, Makoto , MITSUKAMI, Yoshiro , IWAMURA, Taku
IPC分类号： C08J3/28
CPC分类号： C08J3/28 , A61L15/60 , C08J2300/14 , C08J2333/02 , Y10T428/31855 , C08L33/02
摘要： This invention is to provide an absorbent member and a method for making such an absorbent member. The absorbent member comprises modified water absorbent having good production efficiency, good absorbency against pressure, good absorption speed, gel strength, good liquid permeability, and the like. The modified water absorbent resin is made by a method, which comprises (i) a mixing step comprising mixing a water absorbent resin, water, and a water-soluble radical polymerization initiator without addition of an ethylenically unsaturated monomer, to obtain a water absorbent resin composition, and (ii) an irradiating step comprising irradiating said water absorbent resin composition obtained in the mixing step with active energy rays, wherein the surface water content of said water absorbent resin in said water absorbent resin composition at least at any point of time in the irradiating step (ii) is controlled to a level of not lower than 3.0% by weight based on 100% by weight of the water absorbent resin. Preferably, the amount of water mixed in said step (i) exceeds 20 parts by weight and is not more than 100 parts by weight based on 100 parts by weight of the water absorbent resin.
摘要翻译：本发明提供一种吸收体及其制造方法。吸收体包括具有良好生产效率，对压力良好的吸收性，良好的吸收速度，凝胶强度，良好的液体渗透性等的改性吸水剂。改性吸水性树脂通过以下方法制备：（i）混合步骤，包括混合吸水性树脂，水和水溶性自由基聚合引发剂，而不加入烯属不饱和单体，得到吸水性树脂组合物，和（ii）照射步骤，包括用活性能量射线照射在混合步骤中获得的吸水性树脂组合物，其中吸水性树脂组合物中的吸水性树脂的表面水含量至少在任何时间点基于100重量％的吸水性树脂，将照射步骤（ii）控制在不低于3.0重量％的水平。优选地，基于100重量份的吸水性树脂，所述步骤（i）中混合的水的量超过20重量份且不超过100重量份。

7. 发明申请

WO2007043542A1 ANTITUBERCULOUS COMPOSITION COMPRISING OXAZOLE COMPOUNDS 审中-公开
标题翻译：包含奥沙唑化合物的抗菌组合物
公开(公告)号：WO2007043542A1
公开(公告)日：2007-04-19
申请号：PCT/JP2006/320239
申请日：2006-10-04
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , MATSUMOTO, Makoto , HASHIZUME, Hiroyuki , TOMISHIGE, Tatsuo , KAWASAKI, Masanori , SHIMOKAWA, Yoshihiko
发明人： MATSUMOTO, Makoto , HASHIZUME, Hiroyuki , TOMISHIGE, Tatsuo , KAWASAKI, Masanori , SHIMOKAWA, Yoshihiko
IPC分类号： A61P31/06 , A61K31/424 , A61K31/454 , A61K31/496 , A61K45/06
CPC分类号： A61K31/4965 , A61K31/133 , A61K31/424 , A61K31/427 , A61K31/451 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/52 , A61K31/536 , A61K45/06 , A61K2300/00
摘要： The present invention provides antituberculous therapeutic drugs with a higher potency. The present invention provides also antituberculous therapeutic drugs containing oxazole compounds represented by (I) general formula (1): [wherein R 1 represents a hydrogen atom or C1-6 alkyl group, n represents an integer of 0-6, and R 2 represents general formula (A) or the like, wherein R 3 represents a phenoxy group (at least one group selected from the group consisting of a halogen atom, an optionally halogen-substituted C1-6 alkyl group and an optionally halogen-substituted C1-6 alkoxy group may be substituted on the phenyl ring) or the like], optically active forms thereof or salts thereof, and drugs (II) such as primary antituberculous drugs.
摘要翻译：本发明提供了具有较高效力的抗结核药物。本发明还提供含有（I）通式（1）表示的恶唑化合物的抗结核治疗药物：其中R 1表示氢原子或C 1-6烷基，n表示0的整数 -6和R 2表示通式（A）等，其中R 3表示苯氧基（至少一个选自卤素原子，任选卤素取代的C 1-6烷基和任选卤素取代的C 1-6烷氧基可以在苯环上取代）等，其光学活性形式或其盐，和药物（II）等作为主要的抗结核药物。

8. 发明申请

WO2012141338A1 6,7 - DIHYDROIMIDAZO [2, 1 - B] [1, 3] OXAZINE BACTERICIDES 审中-公开
标题翻译： 6,7-二氢咪唑并[2,1-B] [1,3]氧化杀菌剂
公开(公告)号：WO2012141338A1
公开(公告)日：2012-10-18
申请号：PCT/JP2012/060645
申请日：2012-04-13
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , KAWANO, Yoshikazu , HARAGUCHI, Yoshikazu , SASAKI, Hirofumi , UEMATSU, Yukitaka , TSUBOUCHI, Hidetsugu , YATA, Hiromi , SHIMIZU, Hiroshi , KOHASHI, Kazuho , ITOTANI, Motohiro , TAI, Kuninori , TAKEMURA, Isao , HAYASHI, Mikayo , HASHIZUME, Hiroyuki , MATSUBA, Miki , NAKAMURA, Izuru , CHEN, Xiuhao , MATSUMOTO, Makoto
发明人： KAWANO, Yoshikazu , HARAGUCHI, Yoshikazu , SASAKI, Hirofumi , UEMATSU, Yukitaka , TSUBOUCHI, Hidetsugu , YATA, Hiromi , SHIMIZU, Hiroshi , KOHASHI, Kazuho , ITOTANI, Motohiro , TAI, Kuninori , TAKEMURA, Isao , HAYASHI, Mikayo , HASHIZUME, Hiroyuki , MATSUBA, Miki , NAKAMURA, Izuru , CHEN, Xiuhao , MATSUMOTO, Makoto
IPC分类号： C07D498/04 , A61K31/5365 , A61P31/04 , A61P31/06
CPC分类号： C07D498/04
摘要： The present invention provides a novel 6,7-dihydroimidazo[2,1-b][1,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R 1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R 1 each being substituted directly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicycloheptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazinyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R 2 represents hydrogen or lower alkyl. The present invention further provides a pharmaceutical composition containing the above.
摘要翻译：本发明提供了对结核杆菌，多重耐药性结核杆菌和非典型抗酸杆菌具有优异杀菌作用的新型6,7-二氢咪唑并[2,1-b] [1,3]恶嗪化合物。具体地说，本发明提供由式（1）表示的化合物或其盐，其中R1表示四氢异喹啉基，四氢喹啉基，四氢苯并氮杂基，苯并恶唑基，苯并噻唑基，吲哚基，异吲哚啉基，萘基，喹啉基，苯基，联苯基或吡啶基。任选被取代的苯基，联苯基和吡啶基，其各自被直接取代或经由具有至少一个选自四氢吡啶基，二氮杂环庚烷基，二氮杂双环庚烷基，四氢三唑并吡嗪基，四氢咪唑并吡嗪基，氮杂双环辛基，恶唑基，哌嗪基，哌啶基，噻唑基等，这些基团各自任选被取代; 并且R 2表示氢或低级烷基。本发明还提供含有上述物质的药物组合物。

9. 发明申请

WO2009020236A2 NOVEL VIRAL VECTOR 审中-公开
标题翻译：新的VIRAL VECTOR
公开(公告)号：WO2009020236A2
公开(公告)日：2009-02-12
申请号：PCT/JP2008/064503
申请日：2008-08-06
申请人： EDUCATIONAL FOUNDATION JICHI MEDICAL UNIVERSITY , OTSUKA PHARMACEUTICAL CO., LTD. , YOSHIDA, Shigeto , KAWASAKI, Masanori , MATSUMOTO, Makoto , OHBA, Yoshio , SAITO, Masahiro , GOTO, Yoshihiro , INAGAKI, Katsuya , MIZUKOSHI, Masami , HARIGUCHI, Norimitsu , HIROTA, Kuniko
发明人： YOSHIDA, Shigeto , KAWASAKI, Masanori , MATSUMOTO, Makoto , OHBA, Yoshio , SAITO, Masahiro , GOTO, Yoshihiro , INAGAKI, Katsuya , MIZUKOSHI, Masami , HARIGUCHI, Norimitsu , HIROTA, Kuniko
IPC分类号： C12N15/866 , A61K39/145 , A61K39/015
CPC分类号： C07K16/1018 , A61K39/015 , A61K39/12 , A61K39/145 , A61K2039/5256 , C07K14/005 , C07K14/445 , C07K16/205 , C07K2319/735 , C12N7/00 , C12N15/86 , C12N2710/14122 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134 , C12N2830/15 , C12N2830/60 , C12N2830/85 , Y02A50/412
摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; and pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; and pharmaceuticals containing the recombinant baculovirus as an active ingredient.
摘要翻译：本发明提供新型转移载体和重组杆状病毒; 生产方法; 以及含有重组杆状病毒作为活性成分的药物，其可用作疟疾和流感等感染性疾病的预防或治疗药物。更具体地，本发明提供能够表达在双重启动子控制下与病毒基因融合的外源基因的重组转移载体; 重组杆状病毒; 生产方法; 以及含有重组杆状病毒作为有效成分的药物。

10. 发明申请

WO2005042542A1 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS 审中-公开
标题翻译：用于治疗结肠镜的2,3-二氢-6-硝基咪唑（2,1-B）氧唑化合物
公开(公告)号：WO2005042542A1
公开(公告)日：2005-05-12
申请号：PCT/JP2004/016492
申请日：2004-10-29
申请人： OTSUKA PHARMACEUTICAL CO., LTD. , TSUBOUCHI, Hidetsugu , SASAKI, Hirofumi , ITOTANI, Motohiro , HARAGUCHI, Yoshikazu , MIYAMURA, Shin , MATSUMOTO, Makoto , HASHIZUME, Hiroyuki , TOMISHIGE, Tatsuo , KAWASAKI, Masanori , OHGURO, Kinue , SUMIDA, Takumi , HASEGAWA, Takeshi , TANAKA, Kazuho , TAKEMURA, Isao
发明人： TSUBOUCHI, Hidetsugu , SASAKI, Hirofumi , ITOTANI, Motohiro , HARAGUCHI, Yoshikazu , MIYAMURA, Shin , MATSUMOTO, Makoto , HASHIZUME, Hiroyuki , TOMISHIGE, Tatsuo , KAWASAKI, Masanori , OHGURO, Kinue , SUMIDA, Takumi , HASEGAWA, Takeshi , TANAKA, Kazuho , TAKEMURA, Isao
IPC分类号： C07D498/04
CPC分类号： C07D498/04
摘要： The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: (1)in the above formula (1), R1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R1 and -(CH2)nR2 may form a spiro ring represented by the formula (30) below, together with the adjacent carbon atom (in the formula below, RRR represents a piperidyl group which may have substituents on the piperidine ring), (30)and R2 represents a benzothiazolyloxy group, quinolyloxy group, pyridyloxy group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and atypical acid-fast bacteria.
摘要翻译：本发明提供由上述通式（1）中的通式（1）表示的2,3-二氢-6-硝基咪唑并[2,1-b]恶唑化合物，R1表示氢原子或C1-C6 烷基，n表示0〜6的整数，R1和 - （CH2）nR2可以与相邻的碳原子一起形成由下式（30）表示的螺环（在下式中，RRR表示哌啶基其可以在哌啶环上具有取代基），（30），R 2表示苯并噻唑氧基，喹啉氧基，吡啶氧基等。本发明化合物对结核分枝杆菌，多药耐药结核分枝杆菌和非典型酸性抗菌细菌具有优异的杀菌作用。

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