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1. 发明授权

EP0312794B1 Thiazetidine derivatives 失效
标题翻译：噻嗪衍生物
公开(公告)号：EP0312794B1
公开(公告)日：1993-05-19
申请号：EP88115623.6
申请日：1988-09-22
申请人： NIPPON SHINYAKU COMPANY, LIMITED
发明人： Kise, Masahiro , Ozaki, Masakuni , Kazuno, Kenji , Tomii, Yoshifumi , Segawa, Jun , Yasufuki, Shoji
IPC分类号： C07D513/14
CPC分类号： C07D513/14

2. 发明授权

EP0315827B1 Derivatives of quinolinecarboxylic acid 有权
标题翻译：喹啉羧酸的衍生物
公开(公告)号：EP0315827B1
公开(公告)日：1992-04-08
申请号：EP88117809.9
申请日：1988-10-26
申请人： NIPPON SHINYAKU COMPANY, LIMITED
发明人： Kise, Masahiro , Kitano, Masahiko , Ozaki, Masakuni , Kazuno, Kenji , Matsuda, Masahito , Shirahase, Ichiro Nippon Shinyaku , Tomii, Yoshifumi
IPC分类号： C07D513/04 , A61K31/47
CPC分类号： C07D513/04

3. 发明公开

EP0312794A1 Thiazetidine derivatives 失效
标题翻译：硫氮杂环丁烷衍生物
公开(公告)号：EP0312794A1
公开(公告)日：1989-04-26
申请号：EP88115623.6
申请日：1988-09-22
申请人： NIPPON SHINYAKU COMPANY, LIMITED
发明人： Kise, Masahiro , Ozaki, Masakuni , Kazuno, Kenji , Tomii, Yoshifumi , Segawa, Jun , Yasufuki, Shoji
IPC分类号： C07D513/14
CPC分类号： C07D513/14
摘要： Thiezetidine derivatives as represented by the following general formula (I) :
in which R¹ represents hydrogen, alkyl or aryl,
R² represents hydrogen or alkyl,
A represents N or CX where X represents a halogen atom; and
B represents O or NR³ where R represents a hydrogen atom, an alkyl group, an acyl group, an alcoxycarbonyl group or (5-methyl-2-oxo-1,3-dioxolen 4-yl)methyl. These derivatives and their salts are novel compounds having a bactericidal activity and they are useful as a remedial medicine for various infectious diseases.
摘要翻译：由下列通式（Ⅰ）表示的噻吖啶衍生物：其中R 1代表氢，烷基或芳基，R 2代表氢或烷基，A代表N或CX，其中X代表卤素原子; 和B代表O或NR 3，其中R代表氢原子，烷基，酰基，烷氧基羰基或（5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基）甲基。这些衍生物及其盐是具有杀菌活性的新型化合物，可用作各种传染病的治疗药。

4. 发明公开

EP0315827A1 Derivatives of quinolinecarboxylic acid 有权
标题翻译：喹啉羧酸衍生物
公开(公告)号：EP0315827A1
公开(公告)日：1989-05-17
申请号：EP88117809.9
申请日：1988-10-26
申请人： NIPPON SHINYAKU COMPANY, LIMITED
发明人： Kise, Masahiro , Kitano, Masahiko , Ozaki, Masakuni , Kazuno, Kenji , Matsuda, Masahito , Shirahase, Ichiro Nippon Shinyaku , Tomii, Yoshifumi
IPC分类号： C07D513/04 , A61K31/47
CPC分类号： C07D513/04
摘要： Derivative of quinolinecarboxylic acid represented by the following general formula (I) and physiologically-acceptable salt thereof:
wherein R¹ is hydrogen, alkyl or substituted or unsubstituted pheny; R² is hydrogen or alkyl; and
is substituted or unsubstituted cyclic amino which may further contain nitrogen, oxygen or sulfur atom(s) as other member(s). These compounds exhibit antibacterial activity and are useful as therapeutic agents for various infectious diseases.
摘要翻译：由下列通式（I）表示的喹啉羧酸及其生理上可接受的盐的衍生物：其中R 1为氢，烷基或取代或未取代的苯基; R 2是氢或烷基; 并且是取代或未取代的环状氨基，其可以进一步包含作为其它成员的氮，氧或硫原子。这些化合物具有抗菌活性，可用作各种传染病的治疗剂。

5. 发明公开

EP0249043A2 Quinolinecarboxylic acid derivatives 失效
标题翻译： Chinolincarbonsäurederivate。
公开(公告)号：EP0249043A2
公开(公告)日：1987-12-16
申请号：EP87106953.0
申请日：1987-05-13
申请人： NIPPON SHINYAKU COMPANY, LIMITED
发明人： Kise, Masahiro , Kitano, Masahiko , Ozaki, Masakuni , Kazuno, Kenji , Shirahase, Ichiro , Tomii, Yoshifumi , Segawa, Jun Room 405
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： Quinolinecarboxylic acid derivatives represented by the following general formula (I) and physiologically-acceptable salts thereof.
wherein R' is hydrogen, alkyl, or substituted or unsubstituted phenyl; R 2 is hydrogen, alkyl, alkoxy, hydroxy, halogen, nitro or substituted or unsubstituted amino; R 3 is hydrogen or optionally-substituted alkyl; R 4 and R 5 are same or different and are alkyl or hydroxyalkyl or R 4 and R 5 may be combined and may form a cyclic amino together with the adjacent nitrogen atom and said cyclic amino may also be substituted and may further contain nitrogen, oxygen or sulfur as heteroatoms therein; and X is halogen, have been found to be very effective antibacterial therapeutic agents for systemic and local infectious diseases caused by P. aeruginosa and Gram-positive and negative bacteria.
摘要翻译：由以下通式（I）表示的喹啉羧酸衍生物及其生理学上可接受的盐。其中R 1为氢，烷基或取代或未取代的苯基; R 2是氢，烷基，烷氧基，羟基，卤素，硝基或取代或未取代的氨基; R 3是氢或任选取代的烷基; R 4和R 5相同或不同，并且是烷基或羟基烷基，或者R 4和R 5可以相互结合形成环状氨基并且所述环状氨基也可以是并且可以进一步含有氮，氧或硫作为其中的杂原子; X为卤素。已经被发现是非常有效的抗菌治疗剂，用于由铜绿假单胞菌和脾阳性和阴性细菌引起的全身和局部感染性疾病。

6. 发明授权

EP0249043B1 Quinolinecarboxylic acid derivatives 失效
标题翻译：喹喔啉羧酸衍生物
公开(公告)号：EP0249043B1
公开(公告)日：1993-08-04
申请号：EP87106953.0
申请日：1987-05-13
申请人： NIPPON SHINYAKU COMPANY, LIMITED
发明人： Kise, Masahiro , Kitano, Masahiko , Ozaki, Masakuni , Kazuno, Kenji , Shirahase, Ichiro , Tomii, Yoshifumi , Segawa, Jun Room 405
IPC分类号： C07D513/04
CPC分类号： C07D513/04

7. 发明授权

EP0315828B1 Quinolinecarboxylic acid derivatives 有权
标题翻译：喹喔啉羧酸衍生物
公开(公告)号：EP0315828B1
公开(公告)日：1992-04-08
申请号：EP88117810.7
申请日：1988-10-26
申请人： NIPPON SHINYAKU COMPANY, LIMITED
发明人： Kise, Masahiro , Kitano, Masahiko , Ozaki, Masakuni , Kazuno, Kenji , Matsuda, Masahito , Shirahase, Ichiro , Segawa, Jun
IPC分类号： C07D513/04 , A61K31/47
CPC分类号： C07D513/04

8. 发明公开

EP0058392A1 Substituted carboxylic acid derivatives 有权
标题翻译：替代品Carbonsäure-Derivate。
公开(公告)号：EP0058392A1
公开(公告)日：1982-08-25
申请号：EP82101006.3
申请日：1982-02-11
申请人： NIPPON SHINYAKU COMPANY, LIMITED
发明人： Matsumura, Shingo , Kise, Masahiro , Ozaki, Masakuni , Tada, Shinichi , Kazuno, Kenji , Watanabe, Hisao , Kunimoto, Katsutoshi , Tsuda, Masami Nippon Shinyaku , Enomoto, Hiroshi , Kitano, Masahiko , Morita, Iwao
IPC分类号： C07D513/04 , C07D513/14 , A61K31/47
CPC分类号： C07D215/56 , C07D277/10 , C07D513/04 , C07D513/14
摘要： Novel substituted carboxylic acid derivatives, especially quinolinecarboxylic acid derivatives, represented by the general formulas
or
as well as pharmaceutically acceptable acid addition salts thereof, all having antibacterial activity.
摘要翻译：新型取代羧酸衍生物，特别是由通式或表示的喹啉羧酸衍生物及其药学上可接受的酸加成盐，均具有抗菌活性。

9. 发明公开

EP0315828A1 Quinolinecarboxylic acid derivatives 有权
标题翻译： Chinolincarbonsäure衍。
公开(公告)号：EP0315828A1
公开(公告)日：1989-05-17
申请号：EP88117810.7
申请日：1988-10-26
申请人： NIPPON SHINYAKU COMPANY, LIMITED
发明人： Kise, Masahiro , Kitano, Masahiko , Ozaki, Masakuni , Kazuno, Kenji , Matsuda, Masahito , Shirahase, Ichiro , Segawa, Jun
IPC分类号： C07D513/04 , A61K31/47
CPC分类号： C07D513/04
摘要： Quinolinecarboxylic acid derivative represented by the following general formula (I) and physiologicallyac- ceptable salt thereof:
in which R 1 is hydrogen, alkyl or substituted or unsubstituted phenyl; R 2 is hydrogen or alkyl; and R 3 is hydrogen, halogen or alkoxy. These compounds exhibit antibacterial activity and are useful as remedies for various infectious diseases.
摘要翻译：由以下通式（I）表示的喹啉羧酸衍生物及其生理学上可接受的盐：其中R 1为氢，烷基或取代或未取代的苯基的 R 2是氢或烷基; R 3为氢，卤素或烷氧基。这些化合物表现出抗菌活性，可用作各种感染性疾病的补救措施。

10. 发明公开

EP0249043A3 Quinolinecarboxylic acid derivatives 失效
标题翻译：喹喔啉羧酸衍生物
公开(公告)号：EP0249043A3
公开(公告)日：1988-03-02
申请号：EP87106953
申请日：1987-05-13
申请人： NIPPON SHINYAKU COMPANY, LIMITED
发明人： Kise, Masahiro , Kitano, Masahiko , Ozaki, Masakuni , Kazuno, Kenji , Shirahase, Ichiro , Tomii, Yoshifumi , Segawa, Jun Room 405
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： Quinolinecarboxylic acid derivatives represented by the following general formula (I) and physiologically-acceptable salts thereof.
wherein R' is hydrogen, alkyl, or substituted or unsubstituted phenyl; R 2 is hydrogen, alkyl, alkoxy, hydroxy, halogen, nitro or substituted or unsubstituted amino; R 3 is hydrogen or optionally-substituted alkyl; R 4 and R 5 are same or different and are alkyl or hydroxyalkyl or R 4 and R 5 may be combined and may form a cyclic amino together with the adjacent nitrogen atom and said cyclic amino may also be substituted and may further contain nitrogen, oxygen or sulfur as heteroatoms therein; and X is halogen, have been found to be very effective antibacterial therapeutic agents for systemic and local infectious diseases caused by P. aeruginosa and Gram-positive and negative bacteria.

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