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1. 发明公开

KR20200131230A 해수 의 치료를 위한 의약 审中-公开
公开(公告)号：KR20200131230A
公开(公告)日：2020-11-23
申请号：KR20207025402
申请日：2019-03-14
申请人： NIPPON CHEMIPHAR CO , HOSHI UNIV
发明人： IMAI TOSHIYASU , KAMEI JUNZO
IPC分类号： A61K31/551 , A61K31/498 , A61K31/517 , A61K31/5513 , A61P11/14 , A61P43/00
摘要： 본발명은, P2X4 수용체길항작용을갖는화합물, 상기화합물의호변이성체, 입체이성체혹은그 약학적으로허용되는염, 또는그 수화물혹은용매화물을유효성분으로서포함하는, 해수의예방또는치료를위한의약에관한것이다.

2. 发明专利

CA2861024C P2X4 RECEPTOR ANTAGONIST 未知
公开(公告)号：CA2861024C
公开(公告)日：2020-09-22
申请号：CA2861024
申请日：2013-01-10
申请人： NIPPON CHEMIPHAR CO
发明人： USHIODA MASATOSHI , KOBAYASHI KUNIO , SAITO DAISUKE , SAKUMA SHOGO , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D243/12 , A61K31/551 , A61P25/04 , A61P43/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to a compound of formula (I) (see formula I) or a pharmacologically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, A, B, D, E, G and m are as defined herein, for use as a P2X4 receptor antagonist, which may therefore be used in the treatment or prophylaxis of neurogenic pain.

3. 发明专利

CA2810150C P2X4 RECEPTOR ANTAGONIST 未知
公开(公告)号：CA2810150C
公开(公告)日：2018-06-05
申请号：CA2810150
申请日：2011-07-27
申请人： NIPPON CHEMIPHAR CO
发明人： USHIODA MASATOSHI , SAKUMA SHOGO , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D239/70 , A61K31/517 , A61P25/04 , A61P43/00 , C07D403/10
摘要： A compound having the following formula (II) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: (see formula II) wherein each of R11 and R12 is hydrogen, C1-8 alkyl or the like; R13 is hydrogen, C1-8 alkyl or the like; R14 is C1-8 alkoxy, hydroxyl, cyano, a heterocyclic group optionally having a substituent or the like; and the condensed ring consisting of W1 and the neighboring benzene ring is naphthalene ring or the like.

4. 发明专利

DK2803662T3 P2X4-receptorantagonist 未知
公开(公告)号：DK2803662T3
公开(公告)日：2017-05-01
申请号：DK13736295
申请日：2013-01-10
申请人： NIPPON CHEMIPHAR CO
发明人： USHIODA MASATOSHI , KOBAYASHI KUNIO , SAITO DAISUKE , SAKUMA SHOGO , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D243/12 , A61K31/551 , A61K31/5513 , A61P25/04 , A61P43/00 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12

5. 发明专利

CA2921203A1 P2X4 RECEPTOR ANTAGONIST 未知
公开(公告)号：CA2921203A1
公开(公告)日：2015-01-15
申请号：CA2921203
申请日：2014-07-11
申请人： NIPPON CHEMIPHAR CO , UNIV KYUSHU
发明人： SAKUMA SHOGO , KOBAYASHI KUNIO , USHIODA MASATOSHI , SAITO DAISUKE , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D403/10 , A61K31/551 , A61P25/04 , A61P43/00 , C07D401/04 , C07D403/08
摘要： The present invention relates to a compound represented by general formula (II) having a P2X4 receptor antagonist action. (II) (In the formula, R1a to R6a are a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, etc., Xa is C or N, and Ya is N or C (=O), provided that when Xa is C, Ya is N, and when Xa is N, Ya is C (=O), a dual line consisting of solid and broken lines is a single bond or a double bond, Aa is a benzene ring, a pyridine ring, etc., Da is a tetrazole ring, an imidazole ring, etc., Ea is -(CR9aR10a)p-Ta-, and Ga is a benzene ring, a pyridine ring, etc.)

6. 发明专利

CA2921203C DIAZEPINEDIONE DERIVATIVES AND COMPOSITIONS THEREOF USEFUL AS P2X4 RECEPTOR ANTAGONIST 未知
公开(公告)号：CA2921203C
公开(公告)日：2021-07-27
申请号：CA2921203
申请日：2014-07-11
申请人： NIPPON CHEMIPHAR CO , UNIV KYUSHU
发明人： SAITO DAISUKE , IMAI TOSHIYASU , INOUE KAZUHIDE , SAKUMA SHOGO , KOBAYASHI KUNIO , USHIODA MASATOSHI
IPC分类号： C07D403/10 , A61K31/551 , A61P25/04 , A61P43/00 , C07D401/04 , C07D403/08
摘要： The present invention relates to a compound represented by general formula (II) having a P2X4 receptor antagonist action. (II) (In the formula, R1a to R6a are a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, etc., Xa is C or N, and Ya is N or C (=O), provided that when Xa is C, Ya is N, and when Xa is N, Ya is C (=O), a dual line consisting of solid and broken lines is a single bond or a double bond, Aa is a benzene ring, a pyridine ring, etc., Da is a tetrazole ring, an imidazole ring, etc., Ea is -(CR9aR10a)p-Ta-, and Ga is a benzene ring, a pyridine ring, etc.)

7. 发明专利

CA2921200C DIAZEPINYL DERIVATIVES AND COMPOSITIONS THEROF USEFUL AS P2X4 RECEPTOR ANTAGONIST 未知
公开(公告)号：CA2921200C
公开(公告)日：2021-07-13
申请号：CA2921200
申请日：2014-07-11
申请人： NIPPON CHEMIPHAR CO , UNIV KYUSHU
发明人： SAKUMA SHOGO , KOBAYASHI KUNIO , USHIODA MASATOSHI , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D243/10 , A61K31/551 , A61P25/04 , A61P29/00 , A61P43/00 , C07D401/12
摘要： The present invention relates to a compound represented by general formula (I) having a P2X4 receptor antagonist action. (I) (In the formula, R1, R2 and R3 are a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, etc., X is C or N, and Y is N or C (=O), provided that when X is C, Y is N, and when X is N, Y is C (=O), a dual line consisting of solid and broken lines is a single bond or a double bond, n is an integer of 0 to 6, Z is O, S or a bond, and A is a benzene ring, a pyridine ring, etc.)

8. 发明专利

ES2753422T3 Antagonista de receptor P2X4 未知
公开(公告)号：ES2753422T3
公开(公告)日：2020-04-08
申请号：ES14822945
申请日：2014-07-11
申请人： NIPPON CHEMIPHAR CO , UNIV KYUSHU
发明人： SAKUMA SHOGO , KOBAYASHI KUNIO , USHIODA MASATOSHI , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D243/10 , A61K31/551 , A61P25/04 , A61P29/00 , A61P43/00 , C07D401/12 , C07D401/14
摘要： Compuesto representado por la siguiente fórmula general (I), un tautómero o un estereoisómero del compuesto, o una sal farmacológicamente aceptable del mismo, o un solvato de cualquiera de los anteriores:**Fórmula** en la que, en la fórmula, R1, R2 y R3 pueden ser iguales o diferentes, y representan átomo de hidrógeno, un grupo alquilo que tiene de 1 a 8 átomos de carbono, un grupo cicloalquilo que tiene de 3 a 8 átomos de carbono, un grupo alquenilo que tiene de 2 a 8 átomos de carbono, un grupo alcoxilo que tiene de 1 a 8 átomos de carbono, un grupo alquilo que tiene de 1 a 8 átomos de carbono y sustituido con de 1 a 3 átomos de halógeno, un grupo alcoxilo que tiene de 1 a 8 átomos de carbono y sustituido con de 1 a 3 átomos de halógeno, un átomo de halógeno, grupo hidroxilo, grupo nitro, grupo ciano, grupo amino, un grupo alquilamino que tiene de 1 a 8 átomos de carbono o un grupo dialquilamino que tiene de 2 a 8 átomos de carbono, X representa C o N, Y representa N o C(=O), siempre que cuando X es C, Y representa N, y cuando X es N, Y representa C(=O), la línea doble que consiste en la línea continua y la línea discontinua representa un enlace sencillo o doble enlace, n representa un número entero de 0 a 6, Z representa O, S o un enlace atómico, y A representa un anillo de piridina que tiene los mismos o diferentes de 1 a 5 sustituyentes seleccionados de N(R4)(R5) como sustituyente, en el que R4 y R5 se unen para representar, junto con el átomo de nitrógeno al que R4 y R5 se unen, un anillo de 5 a 7 miembros, que puede contener además átomo de oxígeno o átomo de azufre como heteroátomo constituyente de anillo.

9. 发明专利

CA3110619A1 MEDICINE FOR DIABETIC PERIPHERAL NEUROPATHY 未知
公开(公告)号：CA3110619A1
公开(公告)日：2020-03-12
申请号：CA3110619
申请日：2019-09-03
申请人： NIPPON CHEMIPHAR CO
发明人： IMAI TOSHIYASU
IPC分类号： A61K45/00 , A61K31/551 , A61P3/10 , A61P25/02 , A61P25/04 , A61P43/00
摘要： A medicine for preventing or treating pain such as nociceptive pain, inflammatory pain or neuropathic pain, said medicine comprising as an active ingredient a compound having P2X4 receptor antagonism, a tautomer or stereoisomer of the compound, a pharmaceutically acceptable salt thereof or a hydrate or solvate of the same. This medicine neither affects the ability to drive or operate machines, nor affects the ability to drive motor vehicles, nor requires any restriction to administration thereof to patients operating dangerous machines including driving motor vehicles, but can be administered to patients operating dangerous machines including driving motor vehicles.

10. 发明专利

CA2807354C P2X4 RECEPTOR ANTAGONIST 未知
公开(公告)号：CA2807354C
公开(公告)日：2018-06-05
申请号：CA2807354
申请日：2011-07-13
申请人： NIPPON CHEMIPHAR CO
发明人： SAKUMA SHOGO , ARAI MASAHIKO , KOBAYASHI KUNIO , WATANABE YOSHIKAZU , IMAI TOSHIYASU , INOUE KAZUHIDE
IPC分类号： C07D243/12 , A61K31/551 , A61P25/04 , A61P43/00 , C07D403/10
摘要： A diazepine derivative having the following formula (III) or a pharmacologically acceptable salt thereof is used as A P2X4 receptor antagonist: wherein each of R21 and R22 is hydrogen, a C1-8 alkyl group or the like; R23 is hydrogen, a C1-8 alkyl group or the like; each of R24 and R25 is hydrogen, a C1-8 alkyl group or the like; R26 is hydrogen, a C1-8 alkyl group, a halogen atom, hydroxyl, nitro, cyano, phenyl optionally having one or more substituents, or a heterocyclic group optionally having one or more substituents or the like; and p is 0 or 1.

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