专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008066911A2 SPECTROSCOPICALLY ENHANCED IMAGING 审中-公开
标题翻译：光谱增强成像
公开(公告)号：WO2008066911A2
公开(公告)日：2008-06-05
申请号：PCT/US2007024653
申请日：2007-11-30
申请人： NEWTON LAB INC , FULGHUM STEPHEN F JR , VON ROSENBERG CHARLES W , FELD MICHAEL
发明人： FULGHUM STEPHEN F JR , VON ROSENBERG CHARLES W , FELD MICHAEL
IPC分类号： A61B5/00 , A61B1/00 , A61B1/04 , A61B1/05 , A61B1/07 , G01N21/47
CPC分类号： G01N21/645 , A61B1/00096 , A61B1/00167 , A61B1/00188 , A61B1/018 , A61B1/043 , A61B1/05 , A61B1/0638 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01N21/474 , G01N21/6486
摘要： The present invention provides systems and methods for the spectroscopic determination of the physical characteristics of the tissue under observation by an autofluorescence or other endoscope without the requirement of contacting the tissue directly. The optical probe contained in the endoscope itself is passive and may be either built into the endoscope or positioned in a biopsy channel of same. The spectroscopic information, combined with other information provided by the endoscope such as total fluorescence, improves the sensitivity and specificity of the identification of precancerous or cancerous lesions.
摘要翻译：本发明提供了用于通过自发荧光或其他内窥镜光谱测定待观察组织的物理特性而不需要直接接触组织的系统和方法。包含在内窥镜本身中的光学探头是被动的，并且可以被内置在内窥镜中或被定位在相同的活检通道中。光谱信息与内窥镜提供的其他信息（例如总荧光）相结合提高了癌前病变或癌变病变识别的灵敏度和特异性。

2. 发明申请

WO03062799A3 SPECTROSCOPIC DIAGNOSTIC METHODS AND SYSTEM 审中-公开
标题翻译：光谱诊断方法和系统
公开(公告)号：WO03062799A3
公开(公告)日：2003-10-16
申请号：PCT/US0301612
申请日：2003-01-17
申请人： NEWTON LAB INC , FULGHUM STEPHEN F JR
发明人： FULGHUM STEPHEN F JR
IPC分类号： G01B11/02 , A61B1/00 , A61B1/273 , A61B5/00 , A61B10/00 , G01N15/02 , G01N21/21 , G01N21/25 , G01N21/27 , G01N21/47 , G01N21/49 , G01N21/64
CPC分类号： G01N21/6486 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/7257 , G01N21/255 , G01N21/47 , G01N21/474 , G01N21/49 , G01N21/645 , G01N2021/6419 , G01N2021/6421
摘要： The present invention provides systems and methods for the determination of the physical characteristics of a structured superficial layer of material using light scattering spectroscopy. The light scattering spectroscopy system comprises optical probes that can be used with existing endoscopes without modification to the endoscope itself. The system uses a combination of optical and computational methods to detect physical characteristics such as the size distribution of cell nuclei in epithelial layers of organs. The light scattering spectroscopy system can be used alone, or in conjunction with other techniques, such as fluorescence spectroscopy and reflected light spectroscopy.
摘要翻译：本发明提供了使用光散射光谱学确定结构化表面材料层的物理特性的系统和方法。光散射光谱系统包括光学探针，其可以与现有的内窥镜一起使用而不修改内窥镜本身。该系统使用光学和计算方法的组合来检测物理特征，例如器官上皮层中细胞核的大小分布。光散射光谱系统可以单独使用，或与其他技术结合使用，例如荧光光谱和反射光谱。

3. 发明申请

WO0042910A9 AUTOFLUORESCENCE IMAGING SYSTEM FOR ENDOSCOPY 审中-公开
标题翻译：内窥镜自动成像系统
公开(公告)号：WO0042910A9
公开(公告)日：2001-10-25
申请号：PCT/US0001673
申请日：2000-01-26
申请人： NEWTON LAB INC , FULGHUM STEPHEN F JR
发明人： FULGHUM STEPHEN F JR
IPC分类号： G01N21/64 , A61B1/00 , A61B5/00
CPC分类号： A61B1/0638 , A61B1/00009 , A61B1/00126 , A61B1/043 , A61B1/0646 , A61B1/0669 , A61B1/07 , A61B5/0071 , A61B5/0084
摘要： A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.
摘要翻译：描述了一种用于通过视频内窥镜成像组织自体荧光的系统和方法，包括能够提供能够诱导组织自发荧光的紫外光和诱发很少或没有自发荧光的可见光的光源，将两个波长带传送到具有相同表观空间和角度强度分布的组织，使用在内窥镜的远侧末端处的单个成像检测器数字获取所得到的可见荧光和可见反射图像的装置，以及用于数字处理所述图像以产生最终，用于显示的伪彩色图像，其指示组织发育不良的区域。该系统可以添加到现有的视频内窥镜上或集成到其结构中。组合系统可以在正常白光成像和荧光成像之间进行电子切换。

4. 发明专利

AU3349200A Autofluorescence imaging system for endoscopy 未知
公开(公告)号：AU3349200A
公开(公告)日：2000-08-07
申请号：AU3349200
申请日：2000-01-26
申请人： NEWTON LAB INC
发明人： FULGHUM STEPHEN F JR
IPC分类号： G01N21/64 , A61B1/00 , A61B5/00
摘要： A fluorescence imaging endoscope system comprising a diode laser light source for producing excitation light having a wavelength in the range of 300 to 420 nm that induces visible fluorescence in tissue and a second light source for producing a reference light including red, green and blue wavelength bands, an optical combiner that optically couples said excitation light and said reference light onto a common optical path, said combined light being coupled into an optical guide that delivers the combined light to the tissue through an endoscope, a single image detector at a distal end of the endoscope that detects an autofluorescence image and a reference image of the tissue; and a data processor that processes the autofluorescence image and said reference image to produce a processed output image of the tissue.

5. 发明专利

AU2628200A Imaging of tissue using polarized light 未知
公开(公告)号：AU2628200A
公开(公告)日：2000-08-07
申请号：AU2628200
申请日：2000-01-25
申请人： NEWTON LAB INC
发明人： FULGHUM STEPHEN F JR
IPC分类号： G01N21/21 , A61B5/00 , A61B10/00 , G01N21/00 , G01N21/27 , G01N21/47 , G01N21/49 , G02B23/26
摘要： The present invention relates to the differential detection of directly backscattered light from epithelial tissues in order to determine the cell nuclear size distribution for the purpose of detecting tissue dysplasia. Light directly backscattered from surface tissue is differentiated from the light backscattered from underlying tissue by means of polarization, angular distribution or both. Both point measurement embodiments and imaging embodiments are presented. Optical systems for delivery and collection of light include endoscopic and fiber optic systems.

6. 发明专利

AT309739T 未知
公开(公告)号：AT309739T
公开(公告)日：2005-12-15
申请号：AT00911623
申请日：2000-01-26
申请人： NEWTON LAB INC
发明人： FULGHUM STEPHEN F JR
IPC分类号： G01N21/64 , A61B1/00 , A61B5/00
摘要： A fluorescence imaging endoscope system comprising a diode laser light source for producing excitation light having a wavelength in the range of 300 to 420 nm that induces visible fluorescence in tissue and a second light source for producing a reference light including red, green and blue wavelength bands, an optical combiner that optically couples said excitation light and said reference light onto a common optical path, said combined light being coupled into an optical guide that delivers the combined light to the tissue through an endoscope, a single image detector at a distal end of the endoscope that detects an autofluorescence image and a reference image of the tissue; and a data processor that processes the autofluorescence image and said reference image to produce a processed output image of the tissue.

7. 发明专利

CA2359637A1 AUTOFLUORESCENCE IMAGING SYSTEM FOR ENDOSCOPY 未知
公开(公告)号：CA2359637A1
公开(公告)日：2000-07-27
申请号：CA2359637
申请日：2000-01-26
申请人： NEWTON LAB INC
发明人： FULGHUM STEPHEN F JR
IPC分类号： G01N21/64 , A61B1/00 , A61B5/00
摘要： A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial a nd angular intensity distribution, a means for digitally acquiring the resultin g, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式