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1. 发明申请

WO2007147491A1 PROCESS FOR THE PRODUCTION OF 2- [4 - ( 3- AND 2-FLU0R0BENZYL0XY) BENZYLAMIN0] PROPAN AMIDES 审中-公开
标题翻译： 2- [4-（3-和2-氟代苄基）苯甲酰胺0]丙酰胺的制备方法
公开(公告)号：WO2007147491A1
公开(公告)日：2007-12-27
申请号：PCT/EP2007/005105
申请日：2007-06-08
申请人： NEWRON PHARMACEUTICALS S.P.A. , BARBANTI, Elena , CACCIA, Carla , SALVATI, Patricia , VELARDI, Francesco , RUFILLI, Tiziano , BOGOGNA, Luigi
发明人： BARBANTI, Elena , CACCIA, Carla , SALVATI, Patricia , VELARDI, Francesco , RUFILLI, Tiziano , BOGOGNA, Luigi
IPC分类号： C07C231/10 , C07C233/13 , A61K31/165
CPC分类号： C07C231/12 , C07C231/18 , C07C237/06
摘要： A process for obtaining therapeutically active 2-[4-(3- and 2- (fluorobenzyloxy)benzylamino]propanamides and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. The process is carried out by submitting the Schiff bases intermediates 2- [4-(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to catalytic hydrogenation in the presence of a heterogeneous catalyst in a protic organic solvent.
摘要翻译：一种获得治疗活性的2- [4-（3-和2-（氟苄氧基）苄氨基]丙酰胺及其与药学上可接受的酸的高纯度程度的盐，特别是二苄基衍生物杂质含量低于0.03％的方法，优选低于0.01重量％，该方法通过将席夫碱中间体2- [4-（3-和2-氟苄氧基）亚苄基氨基]丙酰胺在质子有机溶剂中的非均相催化剂存在下进行催化氢化来进行。

2. 发明申请

WO2006027052A2 USE OF (HALOBENZYLOXY)BENZYLAMINO-PROPANAMIDES FOR THE MANUFACTURE OF MEDICAMENTS ACTIVE AS SODIUM AND/OR CALCIUM CHANNEL SELECTIVE MODULATORS 审中-公开
标题翻译：（HALOBENZYLOXY）苯甲酰胺丙酰胺用于制备作为钠和/或钙通道选择性调节剂活性的药物的用途
公开(公告)号：WO2006027052A2
公开(公告)日：2006-03-16
申请号：PCT/EP2005/008200
申请日：2005-07-28
申请人： NEWRON PHARMACEUTICALS S.P.A. , BARBANTI, Elena , THALER, Florian , CACCIA, Carla , FARIELLO, Ruggero , SALVATI, Patricia
发明人： BARBANTI, Elena , THALER, Florian , CACCIA, Carla , FARIELLO, Ruggero , SALVATI, Patricia
IPC分类号： A61K31/165 , A61K31/00 , A61K45/06 , A61P29/00 , A61P25/06 , A61P25/02 , A61P9/00 , A61P13/00 , A61P3/00 , A61P1/00
CPC分类号： C07C237/06 , A61K31/00 , A61K31/165 , A61K45/06 , A61K2300/00
摘要： The invention relates to the use of selected (R) -2-[(halobenzyloxy)benzylamino]-propanamides and the pharmaceutically acceptable salts thereof for the manufacture of medicament, that are selectively active assodium and/or calcium channel modulators and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, pain, migraine, periferal diseases, cardiovascular diseases, inflammatory processes affecting all body systems, disorders affecting skin and related tissues, disorders of the respiratory system, disorders of the immune and endocrinological systems, gastrointestinal, urogenital, metabolic and seizure disorders, where the above mechanisms have been described as playing a pathological role.
摘要翻译：本发明涉及选择的（R）-2 - [（卤代苄氧基）苄氨基] - 丙酰胺及其药学上可接受的盐在制备药物中的用途，所述药物是选择性活性的脯氨酸和/或钙通道调节剂，因此可用于预防减轻并治愈各种病症，包括疼痛，偏头痛，周围疾病，心血管疾病，影响所有身体系统的炎症过程，影响皮肤和相关组织的疾病，呼吸系统疾病，免疫和内分泌系统疾病，胃肠道，泌尿生殖，代谢和发作障碍，其中上述机制被描述为发挥病理作用。

3. 发明申请

WO2005040138A1 SUBSTITUTED BENZYLAMINOALKYLENE HETEROCYCLES 审中-公开
标题翻译：取代的苯甲酰氨基烯烃杂环化合物
公开(公告)号：WO2005040138A1
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011104
申请日：2004-10-05
申请人： NEWRON PHARMACEUTICALS S.P.A. , SALVATI, Patricia , CACCIA, Carla , MELLONI, Piero , RESTIVO, Alessandra , SABIDO DAVID, Cibele , VALLESE, Stefania
发明人： SALVATI, Patricia , CACCIA, Carla , MELLONI, Piero , RESTIVO, Alessandra , SABIDO DAVID, Cibele , VALLESE, Stefania
IPC分类号： C07D261/02
CPC分类号： C07D261/02 , A61K31/341 , A61K31/422 , A61K31/426 , C07D213/38 , C07D233/64 , C07D235/14 , C07D249/08 , C07D261/08 , C07D263/32 , C07D277/28 , C07D307/14 , C07D307/38 , C07D307/52 , C07D307/81 , C07D309/04 , C07D319/12 , C07D333/20
摘要： This invention is related to compounds of general formula (I) wherein X is oxygen or sulphur or a NR 7 group; R 1 is C 3 -C 8 alkyl, or C 1 -C 8 alkyl substituted by phenoxy or phenyl, both phenoxy or phenyl being optionally substituted by one or more fluoro, chloro, trifluoromethyl, C 1 -C 6 alkyl, hydroxyl, C 1 -C 6 alkoxy; R 2 , R 3 are independently hydrogen, C 1 -C 6 alkyl, halogen, trifluoromethyl, hydroxy or C 1 -C 6 alkoxy; R 4 is hydrogen, C 1 -C 8 alkyl; R 5 , R 6 are independently hydrogen, C 1 -C 3 alkyl, optionally substituted by hydroxy or phenyl; R 7 is hydrogen or straight or branched C 1 -C 3 alkyl; Het is a five to seven membered, saturated or unsaturated heteromonocyclic or an eight to ten membered, saturated or unsaturated heterobicyclic group, containing one or more heteroatoms chosen independently from nitrogen, oxygen and sulphur, said mono- or bicyclic groups being optionally substituted by C 1 -C 6 alkyl, halogen, hydroxyl or C 1 -C 6 alkoxy; and the pharmaceutically acceptable salts or prodrug thereof, that are active as sodium and/or calcium channel modulators and/or as selective MAO-B inhibitors and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.
摘要翻译：本发明涉及通式（I）的化合物，其中X是氧或硫或NR 7基团; R 1是C 3 -C 8烷基或被苯氧基或苯基取代的C 1 -C 8烷基，苯氧基或苯基任选被一个或多个氟，氯，三氟甲基，C 1 -C 6烷基，羟基，C 1 -C 6烷氧基取代; R 2，R 3独立地是氢，C 1 -C 6烷基，卤素，三氟甲基，羟基或C 1 -C 6烷氧基; R 4是氢，C 1 -C 8烷基; R 5，R 6独立地是氢，任选被羟基或苯基取代的C 1 -C 3烷基; R 7是氢或直链或支链C 1 -C 3烷基; Het是五至七元饱和或不饱和杂单环或八至十元饱和或不饱和杂双环基团，其含有一个或多个独立地选自氮，氧和硫的杂原子，所述单 - 或双环基团任选被C 1 -C 1-6烷基，卤素，羟基或C 1 -C 6烷氧基; 其作为钠和/或钙通道调节剂和/或作为选择性MAO-B抑制剂具有活性，因此可用于预防，缓解和治愈广泛范围的病症，包括但不限于神经，精神，心血管，炎症，眼科，泌尿，代谢和胃肠疾病，其中上述机制已被描述为发挥病理作用。

4. 发明申请

WO2007071311A1 2 -PHENYLETHYLAMINO DERIVATIVES AS CALCIUM AND/OR SODIUM CHANNEL MODULATORS 审中-公开
标题翻译：作为钙和/或钠通道调节剂的2-苯乙烯胺衍生物
公开(公告)号：WO2007071311A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/011443
申请日：2006-11-29
申请人： NEWRON PHARMACEUTICALS S.P.A. , THALER, Florian , NAPOLETANO, Mauro , SABIDO-DAVID, Cibele , MORIGGI, Ermanno , CACCIA, Carla , FARAVELLI, Laura , RESTIVO, Alessandra , SALVATI, Patricia
发明人： THALER, Florian , NAPOLETANO, Mauro , SABIDO-DAVID, Cibele , MORIGGI, Ermanno , CACCIA, Carla , FARAVELLI, Laura , RESTIVO, Alessandra , SALVATI, Patricia
IPC分类号： C07D237/06 , C07D295/18 , C07D307/52 , C07D295/08 , C07D309/06 , C07D307/14 , C07D261/08 , C07D213/30 , C07D213/38 , A61K31/33 , A61K31/165 , A61P25/00 , A61P9/00 , A61P13/00 , A61P27/00
CPC分类号： C07D285/06 , C07C237/06 , C07C237/20 , C07C2601/02 , C07D211/58 , C07D213/30 , C07D213/38 , C07D213/64 , C07D231/12 , C07D233/64 , C07D261/12 , C07D295/185 , C07D307/14 , C07D307/52 , C07D333/20 , C07D405/12 , C07D409/12 , C07D413/12
摘要： 2-Phenylethylamino substituted carboxamide derivatives of formula (I); wherein J, W, R, R 0 R 1 , R 2 , R 3 , and R 4 have the meanings as defined in the specification and pharmaceutically acceptable salts thereof, pharmaceutical compositions containing them as active ingredient and their use as sodium and/or calcium channel modulators useful in preventing alleviating and curing a wide range of pathologies, including neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urology, and gastrointestinal diseases where the above mechanisms have been described as playing a pathological role, are described.
摘要翻译：式（I）的2-苯基乙基氨基取代的甲酰胺衍生物; 其中J，W，R，R 0，R 1，R 2，R 3和R 2 > 4 具有本说明书及其药学上可接受的盐中所定义的含义，含有它们作为活性成分的药物组合物及其作为钠和/或钙通道调节剂的用途，其可用于预防缓解和治愈多种病变，描述了上述机制已被描述为发挥病理作用的神经，精神，心血管，炎症，眼科，泌尿科和胃肠道疾病。

5. 发明申请

WO2005058800A1 HYDROXYLAMINE DERIVATIVES 审中-公开
标题翻译：羟基胺衍生物
公开(公告)号：WO2005058800A1
公开(公告)日：2005-06-30
申请号：PCT/EP2004/014077
申请日：2004-12-10
申请人： NEWRON PHARMACEUTICALS S.P.A. , VICURON PHARMACEUTICALS INC. , CACCIA, Carla , GIROLA, Laura , KALTOFEN, Petra, Karin , LOSI, Daniele , SALVATI, Patricia , SELVA, Enrico , THALER, Florian
发明人： CACCIA, Carla , GIROLA, Laura , KALTOFEN, Petra, Karin , LOSI, Daniele , SALVATI, Patricia , SELVA, Enrico , THALER, Florian
IPC分类号： C07C239/12
CPC分类号： C07C239/20 , A61K31/13 , C07C239/12 , C07C2602/10
摘要： This invention is related to hydroxylamino derivatives of the general formula (I) wherein n is 0, l or 2; R 1 and R 2 , independently of each other, are H, OH or OCH 3 ; R 3 is H or CH 3 ; R 4 is H, C 1 -C 3 straight or branched alkyl or, together with R 3 , forms a five to seven-membered carbocyclic ring; and R 5 and R 6 , independently of each other, are H or C 1 -C 5 straight or branched alkyl and the pharmaceutically acceptable salts or prodrug thereof, for the preparation of medicaments useful for the prevention, treatment and diagnosis of CNS degenerative disorders related to protein misfolding and/or misaggregation. The invention also relates to novel compounds included in formula (I), to a method for preparing said compounds and to pharmaceutical compositions containing them.
摘要翻译：本发明涉及通式（I）的羟基氨基衍生物，其中n为0,1或2; R 1和R 2彼此独立地是H，OH或OCH 3; R 3是H或CH 3; R 4是H，C 1 -C 3直链或支链烷基，或与R 3一起形成5至7元碳环; 和R 5和R 6彼此独立地是H或C 1 -C 5直链或支链烷基及其药学上可接受的盐或前药，用于制备用于预防，治疗和诊断CNS的药物与蛋白质错折叠和/或解聚相关的退行性疾病。本发明还涉及式（I）中包括的新化合物，涉及制备所述化合物的方法和含有它们的药物组合物。

6. 发明申请

WO2009080470A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC DISORDERS 审中-公开
标题翻译：用于治疗心理疾病的ALPHA-氨基腺苷衍生物
公开(公告)号：WO2009080470A1
公开(公告)日：2009-07-02
申请号：PCT/EP2008/066884
申请日：2008-12-05
申请人： NEWRON PHARMACEUTICALS S.P.A. , IZZO, Emanuela , FARAVELLI, Laura , BARBANTI, Elena , SALVATI, Patricia
发明人： IZZO, Emanuela , FARAVELLI, Laura , BARBANTI, Elena , SALVATI, Patricia
IPC分类号： A61K31/165 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/00
CPC分类号： A61K31/165
摘要： The present invention relates to pharmacotherapy of a psychiatric disorder which is schizophrenia and/or anxiety wherein schizophrenia includes schizophrenia related disorder such as brief psychotic disorders, delusional disorders, schizoaffective disorders, and schizophreniform disorders, and anxiety includes panic disorders, obsessive-compulsive disorders (OCD), post-traumatic stress disorders (PTSD), social phobia or social anxiety disorders, specific phobia, and generalized anxiety disorders (GAD). The compounds of the invention are useful for the treatment of the above psychiatric disorders alone or in combination with other therapeutical agents effective in the treatment of schizophrenia and/or anxiety disorders.
摘要翻译：本发明涉及精神障碍的精神病药物治疗，其中精神分裂症和/或焦虑症，其中精神分裂症包括精神分裂症相关疾病如短暂精神病，妄想症，分裂情感障碍和精神分裂症样症状，焦虑包括恐慌症，强迫症（强迫症） OCD），创伤后应激障碍（PTSD），社交恐惧症或社会焦虑症，特定恐惧症和广泛性焦虑症（GAD）。本发明的化合物可用于单独或与治疗精神分裂症和/或焦虑症有效的其它治疗剂组合治疗上述精神疾病。

7. 发明申请

WO2006102958A1 SUBSTITUTED AMINOALKYL- AND AMIDOALKYL-BENZOPYRAN DERIVATIVES 审中-公开
标题翻译：取代的氨基甲酰基和氨基二苯甲酮衍生物
公开(公告)号：WO2006102958A1
公开(公告)日：2006-10-05
申请号：PCT/EP2006/001572
申请日：2006-02-22
申请人： NEWRON PHARMACEUTICALS S.P.A. , CAROTTI, Angelo , MELLONI, Piero , THALER, Florian , CACCIA, Carla , MAESTRONI, Sara , SALVATI, Patricia
发明人： CAROTTI, Angelo , MELLONI, Piero , THALER, Florian , CACCIA, Carla , MAESTRONI, Sara , SALVATI, Patricia
IPC分类号： C07D311/08 , C07D311/58 , C07D311/74 , C07D405/12 , A61K31/37 , A61K31/353 , A61P25/00
CPC分类号： C07D311/16 , C07D311/58
摘要： This invention is related to novel aminoalkyl- and amidoalkyl- b enzopyran derivatives of the following general formula (I) wherein: the group (a) is a substituent in position 6 or 7 wherein: R is amono- or bi-cyclic (C 6 -C 10 ) aryl or a mono- or bi-cyclic (5-10) membered heteroaryl radical, said radicals rings being optionally substituted by one or two substituents selected from (C 1 -C 5 ) straight or branched alkyl, (C 1 -C 5 ) straight or branched alkoxy, hydroxy, halo and trifluoromethyl; m is zero or an integer from 1 to 3; n, p, R 1 and R 2 are as herein indicated and R 3 and R 4 are both hydrogen or taken together represent an oxygen atom, and the pharmaceutically acceptable salts thereof. The compounds that are active as selective and reversible MAO-B inhibitors in vitro and in vivo , are useful as medicaments for the prevention and the treatment of CNS degenerative disorders.
摘要翻译：本发明涉及以下通式（I）的新型氨基烷基 - 和酰氨基烷基 - 苯并吡喃衍生物，其中：（a）是位置6或7的取代基，其中：R是亚氨基或双环（C < 所述基团环任选地被一个或两个选自以下的取代基取代：（C 1 -C 10）芳基或单环或双环（5-10） C 1 -C 5 -C 5直链或支链烷基，（C 1 -C 5 -C 5）直链或支链烷氧基，羟基，卤素和三氟甲基; m为0或1〜3的整数; n，p，R 1和R 2 2如本文所示，R 3和R 4均为氢或一起代表氧原子及其药学上可接受的盐。在体外作为选择性和可逆的MAO-B抑制剂具有活性的化合物

8. 发明申请

WO2004048361A1 HALOTHENOYL-CYCLOPROPANE-1-CARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译：乙烯基环丙烷-1-羧酸衍生物
公开(公告)号：WO2004048361A1
公开(公告)日：2004-06-10
申请号：PCT/EP2003/013244
申请日：2003-11-25
申请人： NEWRON PHARMACEUTICALS S.P.A. , BENATTI, Luca , FARIELLO, Ruggero , SALVATI, Patricia , PELLICCIARI, Roberto , CACCIA, Carla
发明人： BENATTI, Luca , FARIELLO, Ruggero , SALVATI, Patricia , PELLICCIARI, Roberto , CACCIA, Carla
IPC分类号： C07D333/28
CPC分类号： C07D333/28
摘要： Compounds of formula (I) wherein R is hydroxy, linear or branched C 1 -C 6 alkoxy, phenoxy, benzyloxy, a group -N(R 1 R 2 ) wherein R 1 is hydrogen, linear or branched C 1 -C 4 alkyl, benzyl, phenyl and R 2 is hydrogen or linear or branched C 1 -C 4 alkyl, or R is a glycoside residue or a primary alkoxy residue from ascorbic acid, optionally having one or more hydroxy groups alkylated or acylated by linear or branched C 1 -C 4 alkyl or acyl groups; X is a halogen atom and n 1 or 2 are long lasting inhibitors of kynurenine 3-monooxygenase (KMO) and potent glutamate (GLU) release inhibitors.
摘要翻译：其中R是羟基，直链或支链C 1 -C 6烷氧基，苯氧基，苄氧基，基团-N（R 1 R 2）的式（I）化合物，其中R 1是氢，直链或支链C1- C4烷基，苄基，苯基和R 2是氢或直链或支链C 1 -C 4烷基，或R是来自抗坏血酸的糖苷残基或伯烷氧基残基，任选具有一个或多个羟基被烷基化或酰化直链或支链C 1 -C 4烷基或酰基; X是卤素原子，n 1或2是犬尿苷3-单加氧酶（KMO）和强力谷氨酸（GLU）释放抑制剂的长效抑制剂。

9. 发明申请

WO2005070405A1 ALPHA-AMINOAMIDE DERIVATIVES USEFUL IN THE TREATMENT OF LOWER URINARY TRACT DISORDERS 审中-公开
标题翻译：用于治疗下尿路感染疾病的ALPHA-氨基酰胺衍生物
公开(公告)号：WO2005070405A1
公开(公告)日：2005-08-04
申请号：PCT/EP2005/000514
申请日：2005-01-20
申请人： NEWRON PHARMACEUTICALS S.P.A. , BARBANTI, Elena , VENERONI, Orietta , THALER, Florian , PELLICCIARI, Roberto , BENATTI, Luca , SALVATI, Patricia
发明人： BARBANTI, Elena , VENERONI, Orietta , THALER, Florian , PELLICCIARI, Roberto , BENATTI, Luca , SALVATI, Patricia
IPC分类号： A61K31/165
CPC分类号： A61K31/4015 , A61K31/165 , A61K31/277 , A61K31/34 , A61K31/353 , A61K31/381 , C07D307/28 , C07D311/58 , C07D313/08 , C07D333/32 , C07D333/58
摘要： Methods of using certain α-aminoamide derivatives to treat lower urinary tract disorders. The therapeutic agents of the invention are able to reduce or even stop the lower urinary tract disorders substantially without side effects.
摘要翻译：使用某些α-氨基酰胺衍生物治疗下尿路疾病的方法。本发明的治疗剂能够基本上没有副作用减少甚至阻止下尿路疾病。

10. 发明申请

WO2005040108A1 PROLINAMIDE DERIVATIVES AS SODIUM AND/OR CALCIUM CHANNEL BLOCKERS OR SELECTIVE MAO-B INHIBITORS 审中-公开
标题翻译：丙氨酰胺衍生物作为钠和/或钙通道阻断剂或选择性MAO-B抑制剂
公开(公告)号：WO2005040108A1
公开(公告)日：2005-05-06
申请号：PCT/EP2004/011105
申请日：2004-10-05
申请人： NEWRON PHARMACEUTICALS S.P.A. , CACCIA, Carla , LA PORTA, Elena , MAESTRONI, Sara , MELLONI, Piero , SABIDO DAVID, Cibele , SALVATI, Patricia
发明人： CACCIA, Carla , LA PORTA, Elena , MAESTRONI, Sara , MELLONI, Piero , SABIDO DAVID, Cibele , SALVATI, Patricia
IPC分类号： C07D207/16
CPC分类号： C07D401/12 , C07D207/16 , C07D211/60 , C07D223/06
摘要： This invention is related to novel prolinamide derivatives and analogues of general formula (I) wherein Q is C 3 -C 8 alkyl, or C 1 -C 8 alkyl substituted by phenoxy or saturated or unsaturated 5 to 7 membered ring optionally containing one or more heteroatoms chosen independently from nitrogen, oxygen or sulphur, the rings being optionally substituted by one or more halogen atoms, trifluoromethyl, C 1 -C 6 alkyl, hydroxyl, C 1 -C 6 alkoxy; X is an oxygen, sulphur or a NR 5 group; R, R 1 are independently hydrogen, C 1 -C 6 alkyl, halogen, trifluoromethyl, hydroxy or C 1 -C 6 alkoxy; R 2 is hydrogen or hydroxyl; R 3 R 4 R 5 are independently hydrogen or straight or branched C 1 -C 3 alkyl; n is an integer from 1 to 3 and a pharmaceutically acceptable salt or prodrug thereof, that areactive as sodium and/or calcium channel modulators and/or as selective MAOB inhibitors and therefore useful in preventing, alleviating and curing a wide range of pathologies, including, but not limited to, neurological, psychiatric, cardiovascular, inflammatory, ophthalmic, urologic, metabolic and gastrointestinal diseases, where the above mechanisms have been described as playing a pathological role.
摘要翻译：本发明涉及新的脯氨酰胺衍生物和通式（I）的类似物，其中Q为C 3 -C 8烷基或被苯氧基或饱和或不饱和5至7元环任选地含有一个或多个独立地选自以下的杂原子取代的C 1 -C 8烷基：氮，氧或硫，所述环任选被一个或多个卤素原子，三氟甲基，C 1 -C 6烷基，羟基，C 1 -C 6烷氧基取代; X是氧，硫或NR 5基团; R 1，R 2独立地是氢，C 1 -C 6烷基，卤素，三氟甲基，羟基或C 1 -C 6烷氧基; R 2是氢或羟基; R 3 R 4独立地是氢或直链或支链C 1 -C 3烷基; n是1至3的整数及其药学上可接受的盐或前药，其作为钠和/或钙通道调节剂和/或作为选择性MAOB抑制剂起作用，因此可用于预防，减轻和治愈广泛范围的病症，包括但不限于神经，精神，心血管，炎症，眼科，泌尿系，代谢和胃肠道疾病，其中上述机制已被描述为发挥病理作用。

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