专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007137258A3 C-GLYCOLIPIDS WITH ENHANCED TH-1 PROFILE 审中-公开
公开(公告)号：WO2007137258A3
公开(公告)日：2007-11-29
申请号：PCT/US2007/069461
申请日：2007-05-22
申请人： NEW YORK UNIVERSITY , RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK , THE AARON DIAMOND AIDS RESEARCH CENTER FOR THE CITY OF NEW YORK, INC. , TSUJI, Moriya , CHEN, Guangwu , FRANCK, Richard , YANG, Guangli
发明人： TSUJI, Moriya , CHEN, Guangwu , FRANCK, Richard , YANG, Guangli
IPC分类号： A61K31/70 , C07H7/02
摘要： The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI -type immune response characterized by enhanced IL- 12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants.

2. 发明申请

WO2005102049A1 NOVEL SYNTHETIC C-GLYCOLIPIDS, THEIR SYNTHESIS AND USE TO TREAT INFECTIONS, CANCER AND AUTOIMMUNE DISEASES 审中-公开
标题翻译：新型合成C-GLYCOLIPIDS，它们的合成和用途治疗感染，癌症和自发性疾病
公开(公告)号：WO2005102049A1
公开(公告)日：2005-11-03
申请号：PCT/US2005/010889
申请日：2005-03-31
申请人： NEW YORK UNIVERSITY , THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK , TSUJI, Moriya , FRANCK, Richard , CHEN, Guangwu
发明人： TSUJI, Moriya , FRANCK, Richard , CHEN, Guangwu
IPC分类号： A01N43/04
CPC分类号： C07H7/02 , C07D309/10 , C07H13/00
摘要： The invention is directed to novel compounds of formulae (I), (II) and (III): wherein X is O or NH; R 3 is OH or a monosaccharide and R 4 is hydrogen, or R 3 is hydrogen and R 4 is OH or a monosaccharide; R 5 is hydrogen or a monosaccharide; and pharmaceutically acceptable salts or esters thereof. The invention is also directed to the use of the compounds both directly and as immune adjuvants for treating cancer, infectious diseases and autoimmune diseases. The invention is also directed to syntheses of the intermediates which can be used to make these novel compounds.
摘要翻译：本发明涉及式（I），（II）和（III）的新化合物：其中X是O或NH; R 3是OH或单糖，R 4是氢，或R 3是氢，R 4是OH或单糖; R 5是氢或单糖; 及其药学上可接受的盐或酯。本发明还涉及直接用作免疫佐剂的化合物用于治疗癌症，感染性疾病和自身免疫性疾病的用途。本发明还涉及可用于制备这些新化合物的中间体的合成。

3. 发明申请

WO2003105769A2 SYNTHETIC C-GLYCOLIPID AND ITS USE FOR TREATING CANCER INFECTIOUS DISEASES AND AUTOIMMUNE DISEASES 审中-公开
标题翻译：合成C-GLYCOLIPID及其用于治疗癌症感染性疾病和自身免疫性疾病
公开(公告)号：WO2003105769A2
公开(公告)日：2003-12-24
申请号：PCT/US2003/018789
申请日：2003-06-13
申请人： NEW YORK UNIVERSITY , TSUJI, Moriya , FRANCK, Richard, W. , YANG, Guangli , CHEN, Guangwu
发明人： TSUJI, Moriya , FRANCK, Richard, W. , YANG, Guangli , CHEN, Guangwu
IPC分类号： A61K
CPC分类号： C07H5/06 , C07H7/00 , C07H15/10
摘要： The invention is directed to compounds of formula (I) wherein X is O, OR NH; R’ is a hydrocarbon chain; R 3 and R4 are hydrogen, OH or a monosaccharide; R 5 is hydrogen or a monosaccharide; Q’ is optionally present and may be a C 1-10 hydrocarbon; X’ is optionally present and may be O, S or NR 8 ; and Q3 may be a hydrocarbon or hydrogen. The invention is also directed to the use of the compounds for treating cancer, infectious diseases and autoimmune diseases. The invention is also directed to syntheses of the compounds of formula (I).
摘要翻译：本发明涉及式（I）的化合物，其中X是O，OR NH; R'是烃链; R 3和R 4是氢，OH或单糖; R 5是氢或单糖; Q'任选存在，可以是C 1-10烃; X'任选存在并且可以是O，S或NR 8; 和Q3可以是烃或氢。本发明还涉及该化合物用于治疗癌症，感染性疾病和自身免疫性疾病的用途。本发明还涉及式（I）化合物的合成。

4. 发明申请

WO2003105769A3 SYNTHETIC C-GLYCOLIPID AND ITS USE FOR TREATING CANCER INFECTIOUS DISEASES AND AUTOIMMUNE DISEASES 审中-公开
公开(公告)号：WO2003105769A3
公开(公告)日：2003-12-24
申请号：PCT/US2003/018789
申请日：2003-06-13
申请人： NEW YORK UNIVERSITY , TSUJI, Moriya , FRANCK, Richard, W. , YANG, Guangli , CHEN, Guangwu
发明人： TSUJI, Moriya , FRANCK, Richard, W. , YANG, Guangli , CHEN, Guangwu
IPC分类号： A01N43/04
摘要： The invention is directed to compounds of formula (I) wherein X is O, OR NH; R’ is a hydrocarbon chain; R 3 and R4 are hydrogen, OH or a monosaccharide; R 5 is hydrogen or a monosaccharide; Q’ is optionally present and may be a C 1-10 hydrocarbon; X’ is optionally present and may be O, S or NR 8 ; and Q3 may be a hydrocarbon or hydrogen. The invention is also directed to the use of the compounds for treating cancer, infectious diseases and autoimmune diseases. The invention is also directed to syntheses of the compounds of formula (I).

5. 发明公开

EP1732384A1 NOVEL SYNTHETIC C-GLYCOLIPIDS, THEIR SYNTHESIS AND USE TO TREAT INFECTIONS, CANCER AND AUTOIMMUNE DISEASES 审中-公开
标题翻译：新型合成C-糖脂，其对感染，癌症和自身免疫性疾病的治疗合成和用途
公开(公告)号：EP1732384A1
公开(公告)日：2006-12-20
申请号：EP05767488.9
申请日：2005-03-31
申请人： NEW YORK UNIVERSITY , The Research Foundation of the City University of New York
发明人： TSUJI, Moriya , FRANCK, Richard , CHEN, Guangwu
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H7/02 , C07D309/10 , C07H13/00
摘要： The invention is directed to novel compounds of formulae (I), (II) and (III): wherein X is O or NH; R3 is OH or a monosaccharide and R4 is hydrogen, or R3 is hydrogen and R4 is OH or a monosaccharide; R5 is hydrogen or a monosaccharide; and pharmaceutically acceptable salts or esters thereof. The invention is also directed to the use of the compounds both directly and as immune adjuvants for treating cancer, infectious diseases and autoimmune diseases. The invention is also directed to syntheses of the intermediates which can be used to make these novel compounds.

6. 发明授权

EP1551228B1 SYNTHETIC C-GLYCOLIPID AND ITS USE FOR TREATING CANCER INFECTIOUS DISEASES AND AUTOIMMUNE DISEASES 有权
标题翻译：合成C-糖脂及其用于癌症的治疗，感染性疾病和自身免疫性疾病
公开(公告)号：EP1551228B1
公开(公告)日：2012-10-03
申请号：EP03760354.5
申请日：2003-06-13
申请人： New York University , The Research Foundation of the City University of New York
发明人： TSUJI, Moriya , FRANCK, Richard, W. , YANG, Guangli , CHEN, Guangwu
IPC分类号： A01N43/04 , A61K31/70 , C07H5/04 , C07H5/06 , C07H7/06 , C07H7/00 , C07H15/10
CPC分类号： C07H5/06 , C07H7/00 , C07H15/10

7. 发明公开

EP2035011A2 C-GLYCOLIPIDS WITH ENHANCED TH-1 PROFILE 审中-公开
标题翻译：具有改进的TH-1-PROFILE C-糖脂
公开(公告)号：EP2035011A2
公开(公告)日：2009-03-18
申请号：EP07762288.4
申请日：2007-05-22
申请人： NEW YORK UNIVERSITY , The Research Foundation of the City University of New York , Aaron Diamond Aids Research Center
发明人： TSUJI, Moriya , CHEN, Guangwu , FRANCK, Richard , YANG, Guangli
IPC分类号： A61K31/70 , C07H7/02
CPC分类号： C07H13/06 , A61K31/7004 , A61K31/7028 , A61K31/7042 , C07H7/00 , C07H15/06
摘要： The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI -type immune response characterized by enhanced IL- 12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants.

8. 发明申请

WO2002100874A1 VERBINDUNGEN ZUM ANLAGERN VON NUCLEINSÄUREN 审中-公开
标题翻译：连接对于处置核酸
公开(公告)号：WO2002100874A1
公开(公告)日：2002-12-19
申请号：PCT/EP2002/006404
申请日：2002-06-11
申请人： UNIVERSITÄT HANNOVER , TECHNISCHE UNIVERSITÄT CLAUSTHAL , KIRSCHNING, Andreas , KALESSE, Markus , CHEN, Guangwu
发明人： KIRSCHNING, Andreas , KALESSE, Markus , CHEN, Guangwu
IPC分类号： C07H5/06
CPC分类号： C07H5/06
摘要： Beschreiben werden Verbindungen der Formel (I), wobei A jeweils unabhängig von der oder weiteren A-Gruppen eine Gruppe ist mit - einem Ring aus 5-6 Ringatomen, der - einen oder mehrere Aminosubstituenten trägt, die ausgewählt sind aus -NH 2 , -NHR, -NR 2 wobei jeder Rest R unabhängig ausgewählt ist aus -CH 3 oder C 2 H 5 , -NX 2 , wobei jeder substituenten X unabhängig von dem anderen eine Gruppe ist, in der die Gesamtsumme aus Kohlenstoff-, Stickstoff-, Sauerstoff- und Schwefelatomen zwischen 1 und 60 liegt, (II) und (III), B jeweils unabhängig von der oder den anderen B-Gruppen eine Linker-Gruppe ist, die Ringatome zweier A-Gruppen durch eine Kette aus 1-8 Atomen verbindet, wobei die Kettenatome ausgewählt sind aus Kohlenstoff, Stickstoff und Sauerstoff, und n 2-6 ist. Diese Verbindungen können sich an Nucleinsäuren anlagern und gegebenenfalls deren Tertiärstruktur verändern. Sie sind daher von hoher medizinischer Bedeutung.
摘要翻译：将描述式（I），其中每个A是独立于其它，或A基团的是具有一组化合物 - 选自-NH 2，-NHR，选择带有一个或多个氨基取代基 - 5-6个环原子的环，其，-NR 2，其中每个R独立地选自-CH 3或C 2 H 5中选择，-NX2其中每个X独立地取代基的其他的基团，是在其中总和碳，氮，氧和硫原子的1至60之间是，（II）和（III）中，B是各自独立地为一个或多个其它B-基团通过1-8个原子的链连接两个基团的环的原子的连接基团，所述链原子选自碳的是氮和氧，和n是2-6。这些化合物可以附着于核酸和可能改变它们的三级结构。因此具有重大的医学重视他们。

9. 发明公开

EP1551228A2 SYNTHETIC C-GLYCOLIPID AND ITS USE FOR TREATING CANCER INFECTIOUS DISEASES AND AUTOIMMUNE DISEASES 有权
标题翻译：合成C-糖脂及其用于癌症的治疗，感染性疾病和自身免疫性疾病
公开(公告)号：EP1551228A2
公开(公告)日：2005-07-13
申请号：EP03760354.5
申请日：2003-06-13
申请人： New York University
发明人： TSUJI, Moriya , FRANCK, Richard, W. , YANG, Guangli , CHEN, Guangwu
IPC分类号： A01N43/04 , A61K31/70 , C07H5/04 , C07H5/06 , C07H7/06
CPC分类号： C07H5/06 , C07H7/00 , C07H15/10
摘要： The invention is directed to compounds of formula (I) wherein X is O, OR NH; R' is a hydrocarbon chain; R and are hydrogen, OH or a monosaccharide; R is hydrogen or a monosaccharide; Q' is optionally present and may be a C1-10 hydrocarbon; X' is optionally present and may be O, S or NR ; and Q3 may be a hydrocarbon or hydrogen. The invention is also directed to the use of the compounds for treating cancer, infectious diseases and autoimmune diseases. The invention is also directed to syntheses of the compounds of formula (I).

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式