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1. 发明申请

WO2011056679A2 HEAD HARNESS & WIRELESS EEG MONITORING SYSTEM 审中-公开
标题翻译：头带和无线脑电监测系统
公开(公告)号：WO2011056679A2
公开(公告)日：2011-05-12
申请号：PCT/US2010/054346
申请日：2010-10-27
申请人： NEUROVIGIL, INC. , LOW, Philip , CHI, Yu, M. , JOSHI, Siddaharth , UEBELHER, Christopher , DUBOIS, Yvon, A. , LIU, Kevin
发明人： LOW, Philip , CHI, Yu, M. , JOSHI, Siddaharth , UEBELHER, Christopher , DUBOIS, Yvon, A. , LIU, Kevin
IPC分类号： A61B5/0476 , A61B5/0478
CPC分类号： A61B5/0006 , A61B5/0416 , A61B5/0476 , A61B5/0478 , A61B5/6803 , A61B5/6831 , G06F19/00
摘要： An assembly and system for collection and assessment of physiological data is provided. The assembly includes a physiological data acquisition module that may be used in combination with a head harness for the collection, recordation, storage and transmission of quality physiological data. The assembly integrates easy to use, self-applied electrodes in a user- friendly system resulting in less data artifacts than commonly seen in conventional methods and techniques for collecting physiological data. The assembly and system captures high-quality physiological data for display, storage, processing and analysis.
摘要翻译：提供用于收集和评估生理数据的组件和系统。该组件包括生理数据采集模块，该模块可以与用于质量生理数据的收集，记录，存储和传输的头带组合使用。该组件将便于使用的自行应用电极集成在用户友好的系统中，与传统的采集生理数据的方法和技术中常见的相比，产生更少的数据假象。该组件和系统捕捉高品质的生理数据以进行显示，存储，处理和分析。

2. 发明公开

EP2493377A2 HEAD HARNESS & WIRELESS EEG MONITORING SYSTEM 审中-公开
标题翻译：头带和无线EEG监控系统
公开(公告)号：EP2493377A2
公开(公告)日：2012-09-05
申请号：EP10828911.7
申请日：2010-10-27
申请人： Neurovigil, Inc.
发明人： LOW, Philip , CHI, Yu, M. , JOSHI, Siddaharth , UEBELHER, Christopher , DUBOIS, Yvon, A. , LIU, Kevin
IPC分类号： A61B5/0476 , A61B5/0478
CPC分类号： A61B5/0006 , A61B5/0416 , A61B5/0476 , A61B5/0478 , A61B5/6803 , A61B5/6831 , G06F19/00
摘要： An assembly and system for collection and assessment of physiological data is provided. The assembly includes a physiological data acquisition module that may be used in combination with a head harness for the collection, recordation, storage and transmission of quality physiological data. The assembly integrates easy to use, self-applied electrodes in a user-friendly system resulting in less data artifacts than commonly seen in conventional methods and techniques for collecting physiological data. The assembly and system captures high-quality physiological data for display, storage, processing and analysis.

3. 发明申请

WO2007142905A3 1-SULFONYLINDAZOLYLAMINE AND -AMIDE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
公开(公告)号：WO2007142905A3
公开(公告)日：2007-12-13
申请号：PCT/US2007/012570
申请日：2007-05-25
申请人： WYETH , LIU, Kevin , LO, Jennifer Rebecca , ROBICHAUD, Albert Jean , ELOKDAH, Hassan Mahmoud
发明人： LIU, Kevin , LO, Jennifer Rebecca , ROBICHAUD, Albert Jean , ELOKDAH, Hassan Mahmoud
IPC分类号： C07D231/56 , C07D403/12 , A61K31/416 , A61K31/454 , A61P25/28
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.

4. 发明申请

WO2007117413A1 SULFONYL-3-HETEROCYCLYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
标题翻译：作为5-羟基木聚糖-6配位体的三氟甲磺酰基-3-喹唑啉衍生物
公开(公告)号：WO2007117413A1
公开(公告)日：2007-10-18
申请号：PCT/US2007/008234
申请日：2007-03-30
申请人： WYETH , LIU, Kevin , ROBICHAUD, Albert Jean , LO, Jennifer, Rebecca , ELOKDAH, Hassan, Mahmoud
发明人： LIU, Kevin , ROBICHAUD, Albert Jean , LO, Jennifer, Rebecca , ELOKDAH, Hassan, Mahmoud
IPC分类号： C07D401/04 , A61K31/416 , A61P25/28
CPC分类号： C07D401/04
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式（I）化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统疾病的用途。

5. 发明申请

WO2007032833A1 AZINYL-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
标题翻译：作为5-羟基木聚糖-6配位体的亚氨基-3-磺酰基吖啶衍生物
公开(公告)号：WO2007032833A1
公开(公告)日：2007-03-22
申请号：PCT/US2006/030837
申请日：2006-08-08
申请人： WYETH , GROSANU, Cristina , ELOKDAH, Hassan, Mahmoud , GREENFIELD, Alexander, Alexei , LIU, Kevin , MCFARLANE, Geraldine, Ruth , LO, Jennifer, Rebecca , ROBICHAUD, Albert, Jean
发明人： GROSANU, Cristina , ELOKDAH, Hassan, Mahmoud , GREENFIELD, Alexander, Alexei , LIU, Kevin , MCFARLANE, Geraldine, Ruth , LO, Jennifer, Rebecca , ROBICHAUD, Albert, Jean
IPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , A61P25/00
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
摘要翻译：本发明提供式（I）化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统病症的用途。

6. 发明申请

WO2004092117A1 PARA-SULFONYL SUBSTITUTED PHENYL COMPOUNDS AS MODULATORS OF PPARS 审中-公开
标题翻译：作为PPARS调节剂的PARA-SULFONYL取代的苯基化合物
公开(公告)号：WO2004092117A1
公开(公告)日：2004-10-28
申请号：PCT/US2004/010889
申请日：2004-04-07
申请人： KALYPSYS, INC. , LIU, Kevin , MALECHA, James, William , NOBLE, Stewart, Alwyn , WASH, Paul, L.
发明人： LIU, Kevin , MALECHA, James, William , NOBLE, Stewart, Alwyn , WASH, Paul, L.
IPC分类号： C07C317/12
CPC分类号： C07D213/74 , C07D239/42 , C07D295/26 , C07D307/68
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译：公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。

7. 发明申请

WO2007021711A3 SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS 审中-公开
公开(公告)号：WO2007021711A3
公开(公告)日：2007-02-22
申请号：PCT/US2006/030965
申请日：2006-08-08
申请人： WYETH , ELOKDAH, Hassan, Mahmoud , GREENFIELD, Alexander, Alexei , LIU, Kevin , MCDEVITT, Robert, Emmett , MCFARLANE, Geraldine, Ruth , GROSANU, Cristina , LO, Jennifer, Rebecca , LI, Yanfang , ROBICHAUD, Albert, Jean , BERNOTAS, Ronald, Charles
发明人： ELOKDAH, Hassan, Mahmoud , GREENFIELD, Alexander, Alexei , LIU, Kevin , MCDEVITT, Robert, Emmett , MCFARLANE, Geraldine, Ruth , GROSANU, Cristina , LO, Jennifer, Rebecca , LI, Yanfang , ROBICHAUD, Albert, Jean , BERNOTAS, Ronald, Charles
IPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D413/12 , C07D403/06 , A61K31/40 , A61P25/00
摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.

8. 发明申请

WO2004092130A2 N-CONTAINING HETEROAROMATIC COMPOUNDS AS MODULATORS OF PPARS AND METHODS OF TREATING METABOLIC DISORDERS 审中-公开
标题翻译：作为PPARS调节剂的N-含有异构体化合物和治疗代谢紊乱的方法
公开(公告)号：WO2004092130A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/010737
申请日：2004-04-07
申请人： KALYPSYS, INC. , LIU, Kevin , ZHAO, Cunxiang
发明人： LIU, Kevin , ZHAO, Cunxiang
IPC分类号： C07D209/00
CPC分类号： C07D213/74 , C07D213/79 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译：公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法，（I）其中（i）是单环或双酯芳族部分，其中至少一个环原子是并且选自（ii），（iii），（iv），（v）和（vi）组成的组; L选自由键和CH2组成的组。

9. 发明申请

WO2007142904A3 BENZOXAZOLE AND BENZOTHIAZOLE DERIVATIVES AS 5-HYDROXYTRYTAMINE-6 LIGANDS 审中-公开
公开(公告)号：WO2007142904A3
公开(公告)日：2007-12-13
申请号：PCT/US2007/012569
申请日：2007-05-25
申请人： WYETH , LIU, Kevin , ROBICHAUD, Albert Jean , ELOKDAH, Hassan, Mahmoud
发明人： LIU, Kevin , ROBICHAUD, Albert Jean , ELOKDAH, Hassan, Mahmoud
IPC分类号： C07D263/58 , C07D277/82 , A61K31/423 , A61K31/428
摘要： The present invention provides a compound of Formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.

10. 发明申请

WO2004093879A1 (3-{3-‘(2,4-BIS-TRIFLUORMETHYL-BENZYL)-(5-ETHYL-PYRIMIDIN-2-YL)-AMINO!-PROPOXY}-PHENYL)-ACETIC ACID AND RELATED COMPOUNDS AS MODULATORS OF PPARS AND METHODS OF TREATING METABOLIC DISORDERS 审中-公开
标题翻译：（3- {3 - （（2,4-BIS-三氟甲基）苄基） - （5-乙基 - 嘧啶-2-基） - 氨基} - 苯基） - 甲酸和相关化合物作为PPARS的调节剂治疗代谢障碍的方法
公开(公告)号：WO2004093879A1
公开(公告)日：2004-11-04
申请号：PCT/US2004/010970
申请日：2004-04-07
申请人： KALYPSYS, INC. , LIU, Kevin , ZHAO, Cunxiang
发明人： LIU, Kevin , ZHAO, Cunxiang
IPC分类号： A61K31/505
CPC分类号： C07D239/42 , C07D213/38 , C07D213/74 , C07D263/58 , C07D277/82
摘要： Disclosed are compounds of formula I as modulators of peroxisome proliferator activated receptors (PPARs) for the treatment of metabolic diseases such as obesity: wherein Ar 1 is selected from the group consisting of a monocyclic heteroarornatic ring structure and a bicyclic heteroaromatic ring structure; Ar 2 is selected from the group consisting of a monocyclic, a bicyclic, and a tricyclic carbocyclic aryl ring structure R 1 is selected from the group consisting of alkyl, optionally substituted a five-membered or six-membered heteroarylring or a six-membered aryl ring, optionally substituted R 2 is selected from the group consisting of hydrogen; alkyl, optionally substituted a five-membered or six-membered heteroaryl ring or a six-membered aryl ring, optionally substituied cyano; nitro; an amino; an amido; perhaloalkyl; and halogen; R 3 is selected from the group consisting of hydrogen; alkyl, optionally substituted and B is a five-membered or six-membered heteroaryl ring, or -(CH 2 )j-C(O)OR 4 , wherein j is 0 or I 1 when Ar 2 is a bicyclic or tricyclic carbocyclic ring structure and j is 1 when Ar 2 is a monocyclic carbocyclic ring structure; and R 4 is selected from the group consisting of hydrogen; alkyl, optionally substituted a five-membered or six-membered heteroaryl ring or a six-membered aryl ring, optionally substituted. The obtional substituents are as defined in claim 1.
摘要翻译：公开了作为用于治疗代谢疾病如肥胖症的过氧化物酶体增殖物激活受体（PPAR）的调节剂的式I化合物：其中Ar1选自单环杂芳环结构和双环杂芳环结构; Ar 2选自单环，双环和三环碳环芳基环结构，R 1选自烷基，任选被五元或六元杂芳基环或六元芳环取代，任选取代的R 2选自氢; 烷基，任选取代五元或六元杂芳环或六元芳环，任选取代的氰基; 硝基; 氨基; 一个amido; 全卤; 和卤素; R3选自氢; 烷基，任选取代，B是五元或六元杂芳环，或 - （CH 2）j C（O）OR 4，其中当Ar 2是双环或三环碳环结构时，j是0或I 1，并且j是1 当Ar 2是单环碳环结构时; 并且R 4选自氢; 烷基，任选被取代的任选被取代的五元或六元杂芳基环或六元芳环。所述取代基如权利要求1所定义。

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