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1. 发明申请

WO0037422A3 ION CHANNEL MODULATING AGENTS 审中-公开
标题翻译：离子通道调节剂
公开(公告)号：WO0037422A3
公开(公告)日：2000-09-14
申请号：PCT/DK9900731
申请日：1999-12-22
申请人： NEUROSEARCH AS , BEYER JUERGEN , JENSEN BO SKAANING , STROEBAEK DORTE , CHRISTOPHERSEN PALLE , TEUBER LENE
发明人： BEYER JUERGEN , JENSEN BO SKAANING , STROEBAEK DORTE , CHRISTOPHERSEN PALLE , TEUBER LENE
IPC分类号： C07D249/18 , A61K31/216 , A61K31/381 , A61K31/4192 , A61K31/42 , A61K31/422 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4436 , A61P1/00 , A61P1/02 , A61P1/12 , A61P3/10 , A61P5/48 , A61P9/06 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/02 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/14 , A61P21/00 , A61P21/02 , A61P25/00 , A61P25/06 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P37/06 , A61P43/00 , C07C69/65 , C07C69/73 , C07C69/732 , C07C69/734 , C07C69/753 , C07C205/56 , C07C233/22 , C07C233/47 , C07C233/58 , C07C255/35 , C07C255/37 , C07D213/55 , C07D213/57 , C07D261/08 , C07D333/24 , C07D409/06 , C07D413/06 , C07C69/612 , C07D261/10 , C07D409/12 , C07D413/12
CPC分类号： C07C69/732 , C07C69/65 , C07C69/734 , C07C69/753 , C07C205/56 , C07C233/22 , C07C233/58 , C07C255/35 , C07C255/37
摘要： The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SKCa, IKCa and BKCa channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, for methods of therapy, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.
摘要翻译：本发明涉及离子通道调节剂。更具体地说，本发明涉及已被证明可用作SKCa，IKCa和BKCa通道调节剂的特定类别的化合物。在进一步的方面中，本发明涉及这些SK / IK / BK通道调节剂用于制造药物，治疗方法以及包含SK / IK / BK通道调节剂的药物组合物的用途。本发明的SK / IK / BK通道调节剂可用于治疗或缓解与SK / IK / BK通道相关的疾病和病症。

2. 发明申请

WO0069794A3 USE OF CALCIUM-ACTIVATED POTASSIUM CHANNEL-MODULATING AGENTS 审中-公开
标题翻译：钙激活钾通道调节剂的使用
公开(公告)号：WO0069794A3
公开(公告)日：2002-01-10
申请号：PCT/DK0000256
申请日：2000-05-12
申请人： NEUROSEARCH AS , JENSEN BO SKAANING , TEUBER LENE , STROEBAEK DORTE , CHRISTOPHERSEN PALLE , OLESEN SOEREN PETER
发明人： JENSEN BO SKAANING , TEUBER LENE , STROEBAEK DORTE , CHRISTOPHERSEN PALLE , OLESEN SOEREN PETER
IPC分类号： A61K31/122 , A61K31/15 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/55 , A61K45/06
CPC分类号： A61K45/06 , A61K31/122 , A61K31/15 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/55
摘要： The present invention relates to the use of a particular class of chemical compounds as modulators of SKCa, IKCa and BKCa channels, and to pharmaceutical compositions comprising the SK/IK/BK channel modulating agents.
摘要翻译：本发明涉及特定类别的化合物作为SKCa，IKCa和BKCa通道的调节剂的用途，以及包含SK / IK / BK通道调节剂的药物组合物。

3. 发明申请

WO2007042571A8 NOVEL PYRIMIDINE-2,4-DIAMINE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS 审中-公开
标题翻译：新型吡咯烷-2,4-二胺衍生物及其作为小肠钙激活钾通道的调节剂
公开(公告)号：WO2007042571A8
公开(公告)日：2008-04-17
申请号：PCT/EP2006067387
申请日：2006-10-13
申请人： NEUROSEARCH AS , SOERENSEN ULRIK SVANE , ERIKSEN BIRGITTE L , TEUBER LENE , PETERS DAN , STROEBAEK DORTE , JOHANSEN TINA HOLM , CHRISTOPHERSEN PALLE
发明人： SOERENSEN ULRIK SVANE , ERIKSEN BIRGITTE L , TEUBER LENE , PETERS DAN , STROEBAEK DORTE , JOHANSEN TINA HOLM , CHRISTOPHERSEN PALLE
IPC分类号： C07D239/48 , A61K31/505 , A61P25/28
CPC分类号： C07D239/48
摘要： This invention relates to novel pyrimidine-2,4-diamine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型嘧啶-2,4-二胺衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

4. 发明申请

WO2006013210A3 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS 审中-公开
标题翻译： 2-氨基苯并咪唑衍生物及其作为小肠钙激活钾通道的调节剂
公开(公告)号：WO2006013210A3
公开(公告)日：2006-05-04
申请号：PCT/EP2005053792
申请日：2005-08-03
申请人： NEUROSEARCH AS , SOERENSEN ULRIK SVANE , TEUBER LENE , PETERS DAN , STROEBAEK DORTE , JOHANSEN TINA HOLM , NIELSEN KARIN SANDAGER , CHRISTOPHERSEN PALLE
发明人： SOERENSEN ULRIK SVANE , TEUBER LENE , PETERS DAN , STROEBAEK DORTE , JOHANSEN TINA HOLM , NIELSEN KARIN SANDAGER , CHRISTOPHERSEN PALLE
IPC分类号： C07D235/30 , A61K31/4184
CPC分类号： C07D235/30
摘要： This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型2-氨基苯并咪唑衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

5. 发明申请

WO2008003667A3 COMBINATIONS OF MONOAMINE REUPTAKE INHIBITORS AND POTASSIUM CHANNEL ACTIVATORS 审中-公开
标题翻译：单胺类抑制剂和钾通道激活剂的组合
公开(公告)号：WO2008003667A3
公开(公告)日：2008-03-20
申请号：PCT/EP2007056624
申请日：2007-07-02
申请人： NEUROSEARCH AS , SOERENSEN ULRIK SVANE , ERIKSEN BIRGITTE L , TEUBER LENE , PETERS DAN , STROEBAEK DORTE , JOHANSEN TINA HOLM , CHRISTOPHERSEN PALLE , REDROBE JOHN PAUL
发明人： SOERENSEN ULRIK SVANE , ERIKSEN BIRGITTE L , TEUBER LENE , PETERS DAN , STROEBAEK DORTE , JOHANSEN TINA HOLM , CHRISTOPHERSEN PALLE , REDROBE JOHN PAUL
IPC分类号： A61K31/445 , A61K31/495 , A61K45/06 , A61P1/00 , A61P25/00 , A61P25/16 , A61P25/30 , A61P43/00
CPC分类号： A61K45/06 , A61K31/445 , A61K31/495 , A61K2300/00
摘要： This invention provides pharmaceutical compositions comprising therapeutically effective amounts of a monoamine reuptake inhibitor and an SK inhibitor. In another aspect the invention provides novel benzoimidazole derivatives for use according to the invention.
摘要翻译：本发明提供包含治疗有效量的单胺再摄取抑制剂和SK抑制剂的药物组合物。另一方面，本发明提供了用于本发明的新的苯并咪唑衍生物。

6. 发明申请

WO2006136580A2 NOVEL 2-(PHENYLAMINO)BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS 审中-公开
标题翻译：新型2-（苯基）苯并咪唑衍生物及其作为小肠钙激活钾通道的调节剂
公开(公告)号：WO2006136580A2
公开(公告)日：2006-12-28
申请号：PCT/EP2006063405
申请日：2006-06-21
申请人： NEUROSEARCH AS , SOERENSEN ULRIK SVANE , TEUBER LENE , PETERS DAN , STROEBAEK DORTE , JOHANSEN TINA HOLM , NIELSEN KARIN SANDAGER , CHRISTOPHERSEN PALLE
发明人： SOERENSEN ULRIK SVANE , TEUBER LENE , PETERS DAN , STROEBAEK DORTE , JOHANSEN TINA HOLM , NIELSEN KARIN SANDAGER , CHRISTOPHERSEN PALLE
IPC分类号： C07D235/30
CPC分类号： C07D235/30
摘要： This invention relates to novel 2-(phenylamino)benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型2-（苯基氨基）苯并咪唑衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

7. 发明申请

WO2008003752A8 2 -AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL - CONDUCTANCE CALCIUM -ACT IVATED POTASSIUM CHANNELS 审中-公开
标题翻译： 2-氨基苯并咪唑衍生物及其作为小导管钙离子磷酸盐通道的调节剂
公开(公告)号：WO2008003752A8
公开(公告)日：2008-03-13
申请号：PCT/EP2007056826
申请日：2007-07-05
申请人： NEUROSEARCH AS , SOERENSEN ULRIK SVANE , ERIKSEN BIRGITTE L , TEUBER LENE , PETERS DAN , STROEBAEK DORTE , JOHANSEN TINA HOLM , CHRISTOPHERSEN PALLE
发明人： SOERENSEN ULRIK SVANE , ERIKSEN BIRGITTE L , TEUBER LENE , PETERS DAN , STROEBAEK DORTE , JOHANSEN TINA HOLM , CHRISTOPHERSEN PALLE
IPC分类号： C07D235/30 , A61K31/416
CPC分类号： C07D235/30
摘要： This invention relates to 2-amino benzimidazole derivatives of Formula (1a) or (1b): which are useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及式（1a）或（1b）的2-氨基苯并咪唑衍生物：其可用作小电导钙激活钾通道（SK通道）的调节剂。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

8. 发明申请

WO2008092942A3 PYRIDINYL-PYRAZOLE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：吡啶基 - 吡唑衍生物及其作为钾通道调节剂的用途
公开(公告)号：WO2008092942A3
公开(公告)日：2008-10-09
申请号：PCT/EP2008051233
申请日：2008-02-01
申请人： NEUROSEARCH AS , ERIKSEN BIRGITTE L , SOERENSEN ULRIK SVANE , HOUGAARD CHARLOTTE , TEUBER LENE , PETERS DAN , JOHANSEN TINA HOLM , CHRISTOPHERSEN PALLE
发明人： ERIKSEN BIRGITTE L , SOERENSEN ULRIK SVANE , HOUGAARD CHARLOTTE , TEUBER LENE , PETERS DAN , JOHANSEN TINA HOLM , CHRISTOPHERSEN PALLE
IPC分类号： C07D401/04 , A61K31/4439 , A61P11/00 , C07D405/14
CPC分类号： C07D401/04 , C07D405/14
摘要： This invention relates to novel pyridinyl-pyrazole derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新的吡啶基吡唑衍生物及其作为钾通道调节剂的用途。此外，本发明涉及用于治疗或缓解与钾通道活性有关的疾病或病症的药物组合物。

9. 发明申请

WO2008028935A3 PYRIDINYL-PYRIMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS 审中-公开
标题翻译：适用于钾通道调节剂的吡啶基吡啶衍生物
公开(公告)号：WO2008028935A3
公开(公告)日：2008-05-08
申请号：PCT/EP2007059313
申请日：2007-09-06
申请人： NEUROSEARCH AS , ERIKSEN BIRGITTE L , SOERENSEN ULRIK SVANE , HOUGAARD CHARLOTTE , TEUBER LENE , PETERS DAN , CHRISTOPHERSEN PALLE , JOHANSEN TINA HOLM
发明人： ERIKSEN BIRGITTE L , SOERENSEN ULRIK SVANE , HOUGAARD CHARLOTTE , TEUBER LENE , PETERS DAN , CHRISTOPHERSEN PALLE , JOHANSEN TINA HOLM
IPC分类号： C07D401/04 , A61K31/506 , A61P11/00
CPC分类号： C07D401/04
摘要： This invention relates to novel pyridinyl-pyrimidine derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels. Formula (I).
摘要翻译：本发明涉及新的吡啶基 - 嘧啶衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。式（I）。

10. 发明申请

WO2007071632A3 2-PYRIDIN-2-YL-QUINAZOLINE DERIVATIVES AS POTASSIUM CHANNEL MODULATING AGENTS FOR THE TREATMENT OF RESPIRATORY DISEASES 审中-公开
标题翻译：作为用于治疗呼吸道疾病的钾通道调节剂的2-吡啶-2-基 - 喹喔啉衍生物
公开(公告)号：WO2007071632A3
公开(公告)日：2007-08-30
申请号：PCT/EP2006069795
申请日：2006-12-18
申请人： NEUROSEARCH AS , ERIKSEN BIRGITTE L , SOERENSEN ULRIK SVANE , TEUBER LENE , PETERS DAN , HOUGAARD CHARLOTTE , JOHANSEN TINA HOLM , CHRISTOPHERSEN PALLE
发明人： ERIKSEN BIRGITTE L , SOERENSEN ULRIK SVANE , TEUBER LENE , PETERS DAN , HOUGAARD CHARLOTTE , JOHANSEN TINA HOLM , CHRISTOPHERSEN PALLE
IPC分类号： C07D401/04 , A61K31/517 , A61P11/06
CPC分类号： C07D401/04
摘要： This invention relates to novel pyridinyl-quinazoline derivatives of formula (I) and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels. n is 0, 1, 2 or 3; X represents O, S or NR'; wherein R' represents hydrogen, alky I, cycloalkyl or cycloalkyl-alkyl; or, when n is 0 and X is NR', R' together with Y and together with the nitrogen to which they are attached form a heterocyclic ring, which heterocyclic ring may optionally be substituted with alkyl of phenyl; Y represents alkyl, cycloalkyl, alkyl-cycloalkyl, alkenyl or phenyl, which phenyl is optionally substituted one or more times with substituents selected from the group consisting of alkyl, amino-alkyl, alkyl-amino, alkyl-amino-alkyl, hydroxy-alkyl, alkoxy-alkyl, cycloalkyl, cycloalkyl-alkyl, alkenyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy, cyano, nitro and amino; or, when n is O, Y together with R' and together with the nitrogen to which they are attached form a heterocyclic ring, which heterocyclic ring may optionally be substituted with alkyl of phenyl; and R 1 , R 2 , R 3 and R 4 , independently of each other, represent hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, alkenyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkoxy-carbonyl, cyano, nitro, amino, phenyl or benzoyl; or R 1 and R 2 , or R 2 and R 3 , or R 3 and R 4 , respectively, together form a benzo-fused carbocyclic ring, optionally substituted with alkyl, cycloalkyl, cycloalkyl-alkyl, alkenyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy, alkoxy-carbonyl, cyano, nitro, amino, phenyl or benzoyl; and the remaining of R 1 , R 2 , R 3 and R 4 represent hydrogen, alkyl, cycloalkyl, cycloalkyl-alkyl, alkenyl, halo, haloalkyl, hydroxy, alkoxy, haloalkoxy. alkoxy-carbonyl, cyano, nitro, amino, phenyl or benzoyl.
摘要翻译：本发明涉及式（I）的新型吡啶基 - 喹唑啉衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。 n为0,1,2或3; X表示O，S或NR'; 其中R'表示氢，烷基I，环烷基或环烷基 - 烷基; 或者当n为0且X为NR'时，R'与Y一起并与它们所连接的氮一起形成杂环，该杂环可任选被苯基的烷基取代; Y表示烷基，环烷基，烷基 - 环烷基，烯基或苯基，该苯基任选被取代基取代一次或多次，所述取代基选自烷基，氨基 - 烷基，烷基 - 氨基，烷基 - 氨基 - 烷基，羟基 - 烷基烷氧基，烷基，环烷基，环烷基 - 烷基，烯基，卤素，卤代烷基，羟基，烷氧基，卤代烷氧基，氰基，硝基和氨基; 或当n为O时，Y与R'一起并与它们所连接的氮一起形成杂环，该杂环可任选被苯基的烷基取代; 和R 1，R 2，R 3和R 4彼此独立地表示氢，烷基氰基，硝基，氨基，苯基或苯甲酰基; 或R 1和R 2，或R 2和R 3或R 3， SUP和R 4分别一起形成苯并稠合的碳环，任选地被烷基，环烷基，环烷基 - 烷基，烯基，卤素，卤代烷基，羟基，烷氧基，卤代烷氧基，烷氧羰基，氰基，硝基，氨基，苯基或苯甲酰基; 而R 1，R 2，R 3和R 4的剩余部分代表氢，烷基，环烷基，环烷基 - 烷基，烯基，卤素，卤代烷基，羟基，烷氧基，卤代烷氧基。烷氧羰基，氰基，硝基，氨基，苯基或苯甲酰基。

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