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1. 发明申请

WO2010122064A1 SUBSTITUTED NAPHTHYRIDINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：取代的萘啶衍生物及其医学用途
公开(公告)号：WO2010122064A1
公开(公告)日：2010-10-28
申请号：PCT/EP2010/055284
申请日：2010-04-21
申请人： NEUROSEARCH A/S , BROWN, William, Dalby , JESSEN, Carsten , MATTSSON, Cecilia , SOTT, Richard , STRØBÆK, Dorte
发明人： BROWN, William, Dalby , JESSEN, Carsten , MATTSSON, Cecilia , SOTT, Richard , STRØBÆK, Dorte
IPC分类号： C07D471/04 , A61K31/4375 , A61P25/00
CPC分类号： C07D471/04
摘要： The present application discloses novel substituted naphthyridine derivatives of Formula (I) and their use as modulators of the voltage gated K v 7 (KCNQ) potassium ion channels.In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.
摘要翻译：本申请公开了式（I）的新型取代的萘啶衍生物及其作为电压门控Kv7（KCNQ）钾离子通道的调节剂的用途。在其它方面，本申请公开了这些化合物在治疗和制药方法中的用途包含这些化合物的组合物。

2. 发明申请

WO2011026890A1 2, 3, 6 -TRIAMINO SUBSTITUTED PYRIDINES AS KV7 (KCNQ) CHANNEL MODULATORS 审中-公开
标题翻译： 2，3，6 - 作为KV7（KCNQ）通道调制器的三亚胺取代的吡啶
公开(公告)号：WO2011026890A1
公开(公告)日：2011-03-10
申请号：PCT/EP2010/062859
申请日：2010-09-02
申请人： NEUROSEARCH A/S , BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
发明人： BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
IPC分类号： C07D405/14 , C07D413/14
CPC分类号： C07D413/14 , C07D405/14
摘要： The present application relates to novel substituted aminopyridine derivatives, to their use in therapy, to pharmaceutical compositions comprising the derivatives, to the use of said derivatives in the manufacture of a medicament, and to therapeutic methods comprising the administration of the derivatives. The present derivatives are useful for treating a disorder responsive to activation of K V 7 channels. Due to the distribution of K V 7 channels within the organism, K V 7 channel modulators are considered potentially useful for the treatment or alleviation of conditions as diverse as CNS disorders, psychiatric disorders, CNS damage caused by trauma, stroke or neurodegenerative illness or diseases, a variety of neuronal hyperexcitability disorders and conditions, epilepsy, pain, neuropathic pain, migraine, tension type headache, learning and cognitive disorders, motion and motor disorders, multiple sclerosis, cardiac disorders, heart failure, cardio-myopathia, inflammatory diseases, ophthalmic conditions, deafness, progressive hearing loss, tinnitus, obstructive or inflammatory airway diseases, for inducing or maintaining bladder control including the treatment or prevention of urinary incontinence.
摘要翻译：本申请涉及用于治疗的新型取代的氨基吡啶衍生物，包含所述衍生物的药物组合物，所述衍生物在制备药物中的用途以及包括施用所述衍生物的治疗方法。本发明衍生物可用于治疗对KV7通道活化反应的病症。由于KV7通道在生物体内的分布，KV7通道调节剂被认为可用于治疗或减轻诸如CNS疾病，精神病学障碍，由创伤，中风或神经变性疾病或疾病引起的CNS损伤，各种各样的神经元过度兴奋性疾病和病症，癫痫，疼痛，神经性疼痛，偏头痛，紧张型头痛，学习和认知障碍，运动和运动障碍，多发性硬化，心脏病，心力衰竭，心肌病，炎性疾病，眼科疾病，耳聋，进行性听力损失，耳鸣，阻塞性或炎性气道疾病，用于诱导或维持膀胱控制，包括治疗或预防尿失禁。

3. 发明申请

WO2010051819A1 NOVEL 2,3-DIAMINO-QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：新型2,3-二氨基喹喔啉酮衍生物及其医学用途
公开(公告)号：WO2010051819A1
公开(公告)日：2010-05-14
申请号：PCT/DK2009/050293
申请日：2009-11-06
申请人： NEUROSEARCH A/S , JESSEN, Carsten , BROWN, William, Dalby , STRØBÆK, Dorte
发明人： JESSEN, Carsten , BROWN, William, Dalby , STRØBÆK, Dorte
IPC分类号： C07D239/95 , A61K31/517 , A61P25/00
CPC分类号： C07D239/95
摘要： The present invention relates to novel 2,3-diamino-quinazolinone derivatives having medical utility, to use of the derivatives for the manufacture of a medicament, to pharmaceutical compositions comprising the derivatives, and to methods of treating a disorder, disease or a condition responsive to activation of K V 7 channels.
摘要翻译：本发明涉及具有医疗效用的新型2,3-二氨基 - 喹唑啉酮衍生物，其用于制备药物的衍生物，包含该衍生物的药物组合物，以及治疗病症，疾病或病症的方法激活KV7通道。

4. 发明申请

WO2011026891A1 SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：取代的吡啶衍生物及其医学用途
公开(公告)号：WO2011026891A1
公开(公告)日：2011-03-10
申请号：PCT/EP2010/062860
申请日：2010-09-02
申请人： NEUROSEARCH A/S , BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
发明人： BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
IPC分类号： C07D405/12 , A61K31/443 , A61P13/10 , A61P25/04 , A61P25/08 , A61P25/18
CPC分类号： C07D405/12
摘要： The present application relates to novel substituted pyridine derivatives, to their use in therapy, to pharmaceutical compositions comprising the derivatives, to the use of said derivatives in the manufacture of a medicament, and to therapeutic methods comprising the administration of the derivatives. The present derivatives are useful for treating a disorder responsive to activation of K v 7 channels. Formula (I).
摘要翻译：本申请涉及新型取代的吡啶衍生物，其在治疗中的用途，包含该衍生物的药物组合物，所述衍生物在制备药物中的用途，以及包括施用衍生物的治疗方法。本发明的衍生物可用于治疗对Kv7通道的激活作出反应的病症。式（I）。

5. 发明申请

WO2010097379A1 SUBSTITUTED PYRIMIDIN DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：取代的吡咯嗪衍生物及其医学用途
公开(公告)号：WO2010097379A1
公开(公告)日：2010-09-02
申请号：PCT/EP2010/052257
申请日：2010-02-23
申请人： NEUROSEARCH A/S , JESSEN, Carsten , BROWN, William, Dalby , STRØBÆK, Dorte
发明人： JESSEN, Carsten , BROWN, William, Dalby , STRØBÆK, Dorte
IPC分类号： C07D405/12 , A61P25/00 , A61K31/506
CPC分类号： C07D405/12
摘要： The present application discloses novel substituted tetrahydro-pyran-4-ylmethyl-pyrimidin derivatives and their use as modulators of the voltage gated K V 7 (KCNQ) potassium ion channels. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.
摘要翻译：本申请公开了新型取代的四氢 - 吡喃-4-基甲基嘧啶衍生物及其作为电压门控KV7（KCNQ）钾离子通道的调节剂的用途。在其它方面，本申请公开了这些化合物在治疗方法中的用途以及包含这些化合物的药物组合物。

6. 发明申请

WO2010026104A1 4-TETRAHYDROPYRAN-AMINOPYRIDINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译： 4-四氢吡喃氨基吡啶衍生物及其医学用途
公开(公告)号：WO2010026104A1
公开(公告)日：2010-03-11
申请号：PCT/EP2009/061125
申请日：2009-08-28
申请人： NEUROSEARCH A/S , JESSEN, Carsten , BROWN, William, Dalby , STRØBÆK, Dorte
发明人： JESSEN, Carsten , BROWN, William, Dalby , STRØBÆK, Dorte
IPC分类号： C07D213/40 , A61K31/444 , A61P25/00
CPC分类号： C07D405/12 , C07D405/14
摘要： The present invention relates to novel 4-tetrahydropyran-aminopyridine derivatives, to their use in therapy, to pharmaceutical compositions comprising the derivatives, to the use of said derivatives in the manufacture of a medicament, and to therapeutic methods comprising the administration of the derivatives. The present derivatives are useful for treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of K v 7 channels.
摘要翻译：本发明涉及新的4-四氢吡喃 - 氨基吡啶衍生物，其在治疗中的用途，包含该衍生物的药物组合物，所述衍生物在制备药物中的用途，以及包括施用衍生物的治疗方法。本发明的衍生物可用于治疗疾病，疾病或受试者的病症，该疾病，疾病或病症对Kv7通道的激活有反应。

7. 发明申请

WO2009074591A1 NOVEL 2-DIMETHYLAMINO-3-AMIDO-6-AMINO-PYRIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS 审中-公开
标题翻译：新型2-二甲基氨基-3-氨基-6-氨基吡啶衍生物作为钾通道激活剂有用
公开(公告)号：WO2009074591A1
公开(公告)日：2009-06-18
申请号：PCT/EP2008/067161
申请日：2008-12-10
申请人： NEUROSEARCH A/S , BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
发明人： BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
IPC分类号： C07D213/75 , A61K31/44 , A61P29/00
CPC分类号： C07D213/75
摘要： This invention relates to novel 2-dimethylamino-3-amido-6-amino-pyhdine derivatives having medical utility, to use of the 2-dimethylamino-3-amido-6-amino- pyridine derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the 2-dimethylamino-3-amido-6-amino- pyridine derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of K v 7 channels.
摘要翻译：本发明涉及具有医疗效用的新的2-二甲基氨基-3-氨基-6-氨基 - 吡啶衍生物，其用于制备本发明的2-二甲基氨基-3-氨基-6-氨基吡啶衍生物涉及包含本发明的2-二甲基氨基-3-氨基-6-氨基 - 吡啶衍生物的药物组合物，以及治疗受试者的病症，疾病或病症的方法，该病症，疾病或病症对活化有反应的Kv7通道。

8. 发明申请

WO2007057447A1 NOVEL QUINAZOLINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：新型喹唑啉衍生物及其医学用途
公开(公告)号：WO2007057447A1
公开(公告)日：2007-05-24
申请号：PCT/EP2006/068627
申请日：2006-11-17
申请人： NEUROSEARCH A/S , BROWN, William, Dalby , TEUBER, Lene , DYHRING, Tino , STRØBÆK, Dorte , JESSEN, Carsten
发明人： BROWN, William, Dalby , TEUBER, Lene , DYHRING, Tino , STRØBÆK, Dorte , JESSEN, Carsten
IPC分类号： C07D239/88 , C07D239/90 , A61K31/517
CPC分类号： C07D239/88 , C07D239/90
摘要： This invention relates to novel quinazoline derivatives having medical utility, to use of the quinazoline derivatives of the invention for the manufacture of a medicament, to pharmaceutical compositions comprising the quinazoline derivatives of the invention, and to methods of treating a disorder, disease or a condition of a subject, which disorder, disease or condition is responsive to activation of K v 7 channels.
摘要翻译：本发明涉及具有医疗效用的新型喹唑啉衍生物，本发明喹唑啉衍生物用于制备药物，包含本发明喹唑啉衍生物的药物组合物，以及治疗病症，疾病或病症的方法受试者，哪种疾病，疾病或病症对K7通道的激活有反应。

9. 发明申请

WO2010094645A1 SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：取代的吡啶衍生物及其医学用途
公开(公告)号：WO2010094645A1
公开(公告)日：2010-08-26
申请号：PCT/EP2010/051840
申请日：2010-02-15
申请人： NEUROSEARCH A/S , BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
发明人： BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
IPC分类号： C07D413/04 , A61K31/5377 , A61P25/00
CPC分类号： C07D413/04
摘要： The present application discloses novel substituted 1,4-oxazepanyl-pyridine derivatives and their use as modulators of the voltage gated K V 7 (KCNQ) potassium ion channels. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds.
摘要翻译：本申请公开了新的取代的1,4-氧氮杂环己基 - 吡啶衍生物及其作为电压门控KV7（KCNQ）钾离子通道的调节剂的用途。在其它方面，本申请公开了这些化合物在治疗方法中的用途以及包含这些化合物的药物组合物。

10. 发明申请

WO2010094644A1 SUBSTITUTED PYRIDINE DERIVATIVES AND THEIR MEDICAL USE 审中-公开
标题翻译：取代的吡啶衍生物及其医学用途
公开(公告)号：WO2010094644A1
公开(公告)日：2010-08-26
申请号：PCT/EP2010/051839
申请日：2010-02-15
申请人： NEUROSEARCH A/S , BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
发明人： BROWN, William, Dalby , JESSEN, Carsten , STRØBÆK, Dorte
IPC分类号： A61P13/02 , A61P25/00 , A61K31/4439 , C07D213/75
CPC分类号： C07D213/75 , C07D401/04
摘要： The present application discloses novel substituted morpholinyl-pyridine derivatives (I) and their use as modulators of the voltage gated K v 7 (KCNQ) potassium ion channels. In other aspects the application discloses the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising these compounds. a stereoisomer or a mixture of its stereoisomers, or a pharmaceutically-acceptable addition salt thereof, or an N-oxide thereof.
摘要翻译：本申请公开了新型取代的吗啉基 - 吡啶衍生物（I）及其作为电压门控Kv7（KCNQ）钾离子通道的调节剂的用途。在其它方面，本申请公开了这些化合物在治疗方法中的用途以及包含这些化合物的药物组合物。立体异构体或其立体异构体的混合物或其药学上可接受的加成盐或其N-氧化物。

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