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1. 发明申请

WO2007076516A3 BRAIN-BASED DEVICE HAVING A CEREBELLAR MODEL FOR PREDICTIVE MOTOR CONTROL 审中-公开
标题翻译：具有用于预测电动机控制的CEREBELLAR模型的基于BRAIN的装置
公开(公告)号：WO2007076516A3
公开(公告)日：2008-04-10
申请号：PCT/US2006062634
申请日：2006-12-27
申请人： NEUROSCIENCES RES FOUND , MCKINSKY JEFFREY L , EDELMAN GERALD M , KRICHMAR JEFFREY L
发明人： MCKINSKY JEFFREY L , EDELMAN GERALD M , KRICHMAR JEFFREY L
IPC分类号： G06F19/00
CPC分类号： G06N3/04 , G05B13/026 , G05B13/04 , G06N3/004 , G06N3/02
摘要： A mobile brain-based device (BBD) includes a mobile platform with sensors and effects, which is guided by a simulated nervous system that is an analogue of the cerebellar areas of the brain used for predictive motor control to determine interaction with a real-world environment. The simulated nervous system has neural areas including precerebellum nuclei (PN), Purkinje cells (PC), deep cerebellar nuclei (DCN) and an inferior olive (IO) for predicting turn and velocity control of the BBD during movement in a real-world environment. The BBD undergoes training and testing, and the simulated nervous system learns and performs control functions, based on a delayed eligibility trace learning rule.
摘要翻译：基于移动脑的设备（BBD）包括具有传感器和效果的移动平台，其由模拟神经系统引导，模拟神经系统是用于预测运动控制的大脑小脑区域的类似物，以确定与真实世界的交互环境。模拟神经系统具有包括脑前核（PN），浦肯野细胞（PC），深小脑核（DCN）和下橄榄（IO）的神经区域，用于预测在现实环境中运动期间BBD的转向和速度控制。 BBD经过培训和测试，模拟神经系统根据延迟资格追踪学习规则学习和执行控制功能。

2. 发明申请

WO2007076516A9 BRAIN-BASED DEVICE HAVING A CEREBELLAR MODEL FOR PREDICTIVE MOTOR CONTROL 审中-公开
标题翻译：具有预测马达控制的小脑模型的基于脑的装置
公开(公告)号：WO2007076516A9
公开(公告)日：2007-08-16
申请号：PCT/US2006062634
申请日：2006-12-27
申请人： NEUROSCIENCES RES FOUND , MCKINSKY JEFFREY L , EDELMAN GERALD M , KRICHMAR JEFFREY L
发明人： MCKINSKY JEFFREY L , EDELMAN GERALD M , KRICHMAR JEFFREY L
IPC分类号： G06F19/00
CPC分类号： G06N3/04 , G05B13/026 , G05B13/04 , G06N3/004 , G06N3/02
摘要： A mobile brain-based device (BBD) includes a mobile platform with sensors and effects, which is guided by a simulated nervous system that is an analogue of the cerebellar areas of the brain used for predictive motor control to determine interaction with a real-world environment. The simulated nervous system has neural areas including precerebellum nuclei (PN), Purkinje cells (PC), deep cerebellar nuclei (DCN) and an inferior olive (IO) for predicting turn and velocity control of the BBD during movement in a real-world environment. The BBD undergoes training and testing, and the simulated nervous system learns and performs control functions, based on a delayed eligibility trace learning rule.
摘要翻译：基于移动式大脑的设备（BBD）包括一个带有传感器和效应的移动平台，该模拟神经系统是模拟大脑小脑区域的模拟神经系统，用于预测运动控制，以确定与真实世界的相互作用环境。模拟神经系统具有神经区域，包括在现实世界环境中运动期间预测BBD的转向和速度控制的包括前核（PN），浦肯野细胞（PC），深小脑核（DCN）和劣质橄榄（IO）。 BBD进行训练和测试，模拟神经系统根据延迟资格追踪学习规则学习和执行控制功能。

3. 发明申请

WO2006019791A3 MOBILE BRAIN-BASED DEVICE HAVING A SIMULATED NERVOUS SYSTEM BASED ON THE HIPPOCAMPUS 审中-公开
标题翻译：具有基于海马的模拟神经系统的基于移动通信的设备
公开(公告)号：WO2006019791A3
公开(公告)日：2009-04-16
申请号：PCT/US2005024814
申请日：2005-07-13
申请人： NEUROSCIENCES RES FOUND , EDELMAN GERALD M , KRICHMAR JEFFREY L , NITZ DOUGLAS A
发明人： EDELMAN GERALD M , KRICHMAR JEFFREY L , NITZ DOUGLAS A
IPC分类号： G06N5/00
CPC分类号： G06N3/08 , G05D1/0088 , G05D1/0242 , G05D1/0246 , G05D1/0272 , G06N3/004 , Y02T10/82
摘要： A method for automatically constructing a taxonomy (130) for a collection of documents. For a given collection of documents, a method in accordance with an embodiment of the present invention creates document clusters (330), assigns taxons (titles) to the clusters, and organizes the clusters in a hierarchy. The clusters in the hierarchy are ordered from general to specific in the depth of the hierarchy, and from most similar (120) to least similar in the breadth of the hierarchy. This method is capable of producing meaningful classifications in a short time.
摘要翻译：一种用于自动构建文档集合的分类法（130）的方法。对于给定的文档集合，根据本发明的实施例的方法创建文档集群（330），分配分类集（标题）到集群，并且在层次结构中组织集群。层次结构中的集群在层次结构的深度从一般到特定排序，从层次结构的宽度的最相似（120）到最不相似。这种方法能够在短时间内产生有意义的分类。

4. 发明申请

WO2005106762A3 MOBILE BRAIN-BASED DEVICE FOR USE IN A REAL WORLD ENVIRONMENT 审中-公开
标题翻译：用于实际世界环境的基于移动电脑的设备
公开(公告)号：WO2005106762A3
公开(公告)日：2007-02-22
申请号：PCT/US2005012541
申请日：2005-04-14
申请人： NEUROSCIENCES RES FOUND , SETH ANIL K , MCKINSTRY JEFFREY L , EDELMAN GERALD M , KRICHMAR JEFFREY L
发明人： SETH ANIL K , MCKINSTRY JEFFREY L , EDELMAN GERALD M , KRICHMAR JEFFREY L
IPC分类号： G06N3/00 , G05B17/00 , G06F3/01 , G06F19/00 , G06K9/62 , G06N3/02 , G06N3/06 , G06N3/067 , G06N3/08
CPC分类号： G06F15/18 , G06F3/015 , G06K9/629 , G06N3/004 , G06N3/049 , G16H50/50
摘要： A mobile brain-based device BBD includes a mobile base equipped with sensors and effectors (Neurally Organized Mobile Adaptive Device or NOMAD), which is guided by a simulated nervous system that is an analogue of cortical and sub-cortical areas of the brain required for visual processing, decision-making, reward, and motor responses. These simulated cortical and sub-cortical areas are reentrantly connected and each area contains neuronal units representing both the mean activity level and the relative timing of the activity of groups of neurons. The brain-based device BBD learns to discriminate among multiple objects with shared visual features, and associated "target" objects with innately preferred auditory cues. Globally distributed neuronal circuits that correspond to distinct objects in the visual field of NOMAD 10 are activated. These circuits, which are constrained by a reentrant neuroanatomy and modulated by behavior and synaptic plasticity, result in successful discrimination of objects. The brain-based device BBD is moveable, in a rich real-world environment involving continual changes in the size and location of visual stimuli due to self-generated or autonomous, movement, and shows that reentrant connectivity and dynamic synchronization provide an effective mechanism for binding the features of visual objects so as to reorganize object features such as color, shape and motion while distinguishing distinct objects in the environment.
摘要翻译：基于移动脑的设备BBD包括配备有传感器和效应器（神经有机移动自适应装置或NOMAD）的移动基座，其由模拟神经系统引导，该模拟神经系统是大脑所需的皮层和皮质下皮质区域的类似物视觉处理，决策，奖励和运动反应。这些模拟的皮质和皮质区域是可重复连接的，每个区域包含表示神经元组的平均活动水平和相对时间的神经元单位。基于脑的设备BBD学习使用共享的视觉特征和相关联的“目标”对象与具有本来优选的听觉线索的多个对象之间进行区分。对应于NOMAD 10的视野中的不同物体的全球分布的神经元电路被激活。这些由折返性神经解剖学限制并由行为和突触可塑性调节的电路导致对象的成功辨别。基于大脑的设备BBD可以在丰富的现实环境中移动，包括由于自我生成或自主运动引起的视觉刺激的大小和位置的不断变化，并且表明可重入连接性和动态同步为绑定视觉对象的特征，以便重新组织对象特征，如颜色，形状和运动，同时区分环境中的不同对象。

5. 发明申请

WO2007033101A2 HYBRID CONTROL DEVICE 审中-公开
标题翻译：混合控制装置
公开(公告)号：WO2007033101A2
公开(公告)日：2007-03-22
申请号：PCT/US2006035357
申请日：2006-09-13
申请人： NEUROSCIENCES RES FOUND , FLEISCHER JASON G , SZATMARY BOTOND , HUTSON DONALD B , MOORE DOUGLAS A , SNOOK JAMES A , EDELMAN GERALD M , KRICHMAR JEFFREY
发明人： FLEISCHER JASON G , SZATMARY BOTOND , HUTSON DONALD B , MOORE DOUGLAS A , SNOOK JAMES A , EDELMAN GERALD M , KRICHMAR JEFFREY
IPC分类号： G06N3/02
CPC分类号： G06N3/0427 , G05B13/027 , G05B15/02 , G05B2219/39292 , G05B2219/39385 , G06K9/00664 , G06N3/02
摘要： A hybrid control system for a robot can include a neuronal control portion and a non-neuronal control portion.
摘要翻译：用于机器人的混合控制系统可以包括神经元控制部分和非神经元控制部分。

6. 发明申请

WO0153538A3 METHOD FOR FUNCTIONAL MAPPING OF AN ALZHEIMER'S DISEASE GENE NETWORK AND FOR IDENTIFYING THERAPEUTIC AGENTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
标题翻译：阿尔茨海默病基因组网络的功能定位方法和鉴定治疗阿尔茨海默病的治疗药物的方法
公开(公告)号：WO0153538A3
公开(公告)日：2003-02-20
申请号：PCT/US0102332
申请日：2001-01-23
申请人： NEUROSCIENCES RES FOUND , GREENSPAN RALPH J , EDELMAN GERALD M
发明人： GREENSPAN RALPH J , EDELMAN GERALD M
IPC分类号： A01K67/033 , C07H21/04 , C07K14/47 , C12Q1/68 , C07K14/435 , C12N15/10 , G01N33/50
CPC分类号： A01K67/0339 , A01K2217/075 , A01K2227/706 , A01K2267/0312 , C07K14/4711 , C12Q1/68 , C12Q1/6827
摘要： The present invention provides a novel genetic method for mapping a network of functional gene interactions relating to Alzheimer's disease. Further provided by the invention is a screening method for identifying therapeutic agents for treating Alzheimer's disease.
摘要翻译：本发明提供了一种用于绘制与阿尔茨海默病有关的功能基因相互作用网络的新型遗传方法。本发明进一步提供的是用于鉴定治疗阿尔茨海默氏病的治疗剂的筛选方法。

7. 发明公开

EP1969513A4 BRAIN-BASED DEVICE HAVING A CEREBELLAR MODEL FOR PREDICTIVE MOTOR CONTROL 审中-公开
标题翻译：用小脑模型预测电机控制基于大脑的设备
公开(公告)号：EP1969513A4
公开(公告)日：2010-05-05
申请号：EP06848895
申请日：2006-12-27
申请人： NEUROSCIENCES RES FOUND
发明人： MCKINSKY JEFFREY L , EDELMAN GERALD M , KRICHMAR JEFFREY L
IPC分类号： G06N3/00 , G06N3/04
CPC分类号： G06N3/04 , G05B13/026 , G05B13/04 , G06N3/004 , G06N3/02
摘要： A mobile brain-based device (BBD) includes a mobile platform with sensors and effectors, which is guided by a simulated nervous system that is an analogue of the cerebellar areas of the brain used for predictive motor control to determine interaction with a real-world environment. The simulated nervous system has neural areas including precerebellum nuclei (PN), Purkinje cells (PC), deep cerebellar nuclei (DCN) and an inferior olive (IO) for predicting turn and velocity control of the BBD during movement in a real-world environment. The BBD undergoes training and testing, and the simulated nervous system learns and performs control functions, based on a delayed eligibility trace learning rule.

8. 发明公开

EP1934894A4 HYBRID CONTROL DEVICE 审中-公开
标题翻译：混合动力控制装置
公开(公告)号：EP1934894A4
公开(公告)日：2010-05-26
申请号：EP06803361
申请日：2006-09-13
申请人： NEUROSCIENCES RES FOUND
发明人： FLEISCHER JASON G , SZATMARY BOTOND , HUTSON DONALD B , MOORE DOUGLAS A , SNOOK JAMES A , EDELMAN GERALD M , KRICHMAR JEFFREY
IPC分类号： G06N3/02 , G05B13/02 , G06N3/04
CPC分类号： G06N3/0427 , G05B13/027 , G05B15/02 , G05B2219/39292 , G05B2219/39385 , G06K9/00664 , G06N3/02
摘要： A brain-based device (BBD) for moving in a real-world environment has sensors that provide data about the environment, actuators to move the BBD, and a hybrid controller which includes a neural controller having a simulated nervous system being a model of selected areas of the human brain and a non-neural controller based on a computational algorithmic network. The neural controller and non-neural controller interact with one another to control movement of the BBD.

9. 发明公开

EP0800649A4 INHIBITION OF GLIAL CELL PROLIFERATION 失效
标题翻译：神经胶质细胞增殖的抑制
公开(公告)号：EP0800649A4
公开(公告)日：2000-01-26
申请号：EP95944317
申请日：1995-12-11
申请人： SCRIPPS RESEARCH INST , NEUROSCIENCES RES FOUND
发明人： EDELMAN GERALD M , CROSSIN KATHRYN L , SPORNS OLAF , KRUSHEL LESLIE
IPC分类号： A61K38/00 , C07K14/705 , C07K16/28 , G01N33/50 , G01N33/68 , G01N33/53 , A01N37/18 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： G01N33/5044 , A61K38/00 , C07K14/70503 , C07K16/2803 , C07K2317/73 , G01N33/5008 , G01N33/5011 , G01N33/5058 , G01N33/5091 , G01N33/6896
摘要： Methods and compositions are disclosed that are useful for the inhibition of glial cell proliferation by means of binding inhibiting agents to neural cell adhesion (N-CAM) molecules present on the cell surface. Such inhibiting agents can be peptides, monoclonal antibodies, polyclonal antibodies, Fab' fragments, and the like.

10. 发明公开

EP1763811A4 MOBILE BRAIN-BASED DEVICE FOR USE IN A REAL WORLD ENVIRONMENT 审中-公开
标题翻译：移动的基于大脑设备用在真实世界环境
公开(公告)号：EP1763811A4
公开(公告)日：2010-04-21
申请号：EP05735603
申请日：2005-04-14
申请人： NEUROSCIENCES RES FOUND
发明人： SETH ANIL K , MCKINSTRY JEFFREY L , EDELMAN GERALD M , KRICHMAR JEFFREY L
IPC分类号： G06N3/00 , G06F3/01 , G06F19/00 , G06K9/62 , G06N3/04
CPC分类号： G06F15/18 , G06F3/015 , G06K9/629 , G06N3/004 , G06N3/049 , G16H50/50
摘要： A mobile brain-based device BBD includes a mobile base equipped with sensors and effectors (Neurally Organized Mobile Adaptive Device or NOMAD), which is guided by a simulated nervous system that is an analogue of cortical and sub-cortical areas of the brain required for visual processing, decision-making, reward, and motor responses. These simulated cortical and sub-cortical areas are reentrantly connected and each area contains neuronal units representing both the mean activity level and the relative timing of the activity of groups of neurons. The brain-based device BBD learns to discriminate among multiple objects with shared visual features, and associated "target" objects with innately preferred auditory cues. Globally distributed neuronal circuits that correspond to distinct objects in the visual field of NOMAD 10 are activated.; These circuits, which are constrained by a reentrant neuroanatomy and modulated by behavior and synaptic plasticity, result in successful discrimination of objects. The brain-based device BBD is moveable, in a rich real-world environment involving continual changes in the size and location of visual stimuli due to self-generated or autonomous, movement, and shows that reentrant connectivity and dynamic synchronization provide an effective mechanism for binding the features of visual objects so as to reorganize object features such as color, shape and motion while distinguishing distinct objects in the environment.

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