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1. 发明申请

WO2016205637A2 DETECTION OF CEREBROSPINAL FLUID 审中-公开
标题翻译：检测骨髓液
公开(公告)号：WO2016205637A2
公开(公告)日：2016-12-22
申请号：PCT/US2016/038062
申请日：2016-06-17
申请人： NEUROLOGICAL SURGERY, P.C. , RENSSELAER POLYTECHNIC INSTITUTE
发明人： KWON, Seok-Joon , LINHARDT, Robert, J. , DORDICK, Jonathan, S. , SONSTEIN, William, J. , ZHANG, Fuming
IPC分类号： G01N33/573
CPC分类号： G01N33/68 , G01N2333/79
摘要： The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample comprising removing sialo-transferrin and selectively detecting or measuring asialo-transferrin in the biological sample.
摘要翻译：本发明包括用于检测生物样品中脑脊液（CSF）的存在的方法和测试条，包括去除唾液酸转运蛋白并选择性地检测或测量生物样品中的脱唾液酸转铁蛋白。

2. 发明公开

EP3311142A2 DETECTION OF CEREBROSPINAL FLUID 有权转让
标题翻译：脑脊液的检测
公开(公告)号：EP3311142A2
公开(公告)日：2018-04-25
申请号：EP16812516.9
申请日：2016-06-17
申请人： Neurological Surgery, P.C. , Rensselaer Polytechnic Institute
发明人： KWON, Seok-Joon , LINHARDT, Robert, J. , DORDICK, Jonathan, S. , SONSTEIN, William, J. , ZHANG, Fuming
IPC分类号： G01N21/78 , G01N33/566
CPC分类号： G01N33/68 , G01N33/54306 , G01N33/558 , G01N2333/79
摘要： The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample comprising removing sialo-transferrin and selectively detecting or measuring asialo-transferrin in the biological sample.

3. 发明公开

EP1794590A2 ENHANCED STABILITY OF PROTEINS IMMOBILIZED ON NANOPARTICLES 有权
标题翻译：在纳米颗粒上固定的蛋白质稳定性增强
公开(公告)号：EP1794590A2
公开(公告)日：2007-06-13
申请号：EP05858100.0
申请日：2005-09-07
申请人： RENSSELAER POLYTECHNIC INSTITUTE
发明人： KARAJANAGI, Sandeep, S. , DORDICK, Jonathan, S. , ASURI, Prashanth , KANE, Ravindra, S.
IPC分类号： G01N33/53 , C12N9/00
CPC分类号： G01N33/54346 , B82Y15/00 , C12Q1/001 , G01N33/587 , G01N33/588
摘要： This invention is directed to the application of a previously unknown property of nanomaterials - its ability to enhance protein activity and stability at high temperatures, in organic solvents, and in polymer composites. Nanomaterials such as single-walled carbon nanotubes (SWNTs) can significantly enhance enzyme function and stability in strongly denaturing environments. Experimental results and theoretical analysis reveal that the enhancement in stability is a result of the curvature of these nanoscale materials, which suppresses unfavorable protein-protein interactions. The enhanced stability is also exploited in the preparation of highly stable and active nanocomposite films that resist nonspecific protein absorption, i.e., inhibit fouling of the films. The protein-nanoparticles conjugates represent a new generation of highly selective, active, and stable catalytic materials. Furthermore, the ability to enhance protein function by interfacing them with nanomaterials has a profound impact on applications ranging from biosensing, diagnostics, vaccines, drug delivery, and biochips, to novel hybrid materials that integrate biotic and abiotic components.

4. 发明申请

WO2007001355A2 ENHANCED STABILITY OF PROTEINS IMMOBILIZED ON NANOPARTICLES 审中-公开
标题翻译：增强纳米粒子固定蛋白质的稳定性
公开(公告)号：WO2007001355A2
公开(公告)日：2007-01-04
申请号：PCT/US2005/031652
申请日：2005-09-07
申请人： RENSSELAER POLYTECHNIC INSTITUTE , DORDICK, Jonathan, S. , KANE, Ravindra, S. , ASURI, Prashanth , KARAJANAGI, Sandeep, S.
发明人： DORDICK, Jonathan, S. , KANE, Ravindra, S. , ASURI, Prashanth , KARAJANAGI, Sandeep, S.
IPC分类号： G01N33/53 , C12N9/00
CPC分类号： G01N33/54346 , B82Y15/00 , C12Q1/001 , G01N33/587 , G01N33/588
摘要： This invention is directed to the application of a previously unknown property of nanomaterials - its ability to enhance protein activity and stability at high temperatures, in organic solvents, and in polymer composites. Nanomaterials such as single-walled carbon nanotubes (SWNTs) can significantly enhance enzyme function and stability in strongly denaturing environments. Experimental results and theoretical analysis reveal that the enhancement in stability is a result of the curvature of these nanoscale materials, which suppresses unfavorable protein-protein interactions. The enhanced stability is also exploited in the preparation of highly stable and active nanocomposite films that resist nonspecific protein absorption, i.e., inhibit fouling of the films. The protein-nanoparticles conjugates represent a new generation of highly selective, active, and stable catalytic materials. Furthermore, the ability to enhance protein function by interfacing them with nanomaterials has a profound impact on applications ranging from biosensing, diagnostics, vaccines, drug delivery, and biochips, to novel hybrid materials that integrate biotic and abiotic components.
摘要翻译：本发明涉及以前未知的纳米材料性质的应用 - 其在高温下，在有机溶剂中和在聚合物复合材料中增强蛋白质活性和稳定性的能力。纳米材料如单壁碳纳米管（SWNT）可以显着增强强力变性环境中的酶功能和稳定性。实验结果和理论分析表明，稳定性的提高是这些纳米材料的曲率的结果，其抑制不利的蛋白质 - 蛋白质相互作用。增强的稳定性也被用于制备高度稳定和活性的纳米复合膜，其抵抗非特异性蛋白质吸收，即抑制膜的结垢。蛋白质 - 纳米颗粒共轭体代表新一代高选择性，活性和稳定的催化材料。此外，通过与纳米材料接口来增强蛋白质功能的能力对从生物传感，诊断，疫苗，药物递送和生物芯片到包含生物和非生物成分的新型杂交材料的应用具有深远的影响。

5. 发明公开

EP1943330A2 THREE-DIMENSIONAL CELLULAR ARRAY CHIP AND PLATFORM FOR TOXICOLOGY ASSAYS 审中-公开
标题翻译：元胞阵列芯片和平台进行毒理学测试安排
公开(公告)号：EP1943330A2
公开(公告)日：2008-07-16
申请号：EP06836660.8
申请日：2006-10-31
申请人： RENSSELAER POLYTECHNIC INSTITUTE
发明人： LEE, Moo-Yeal , KUMAR, R., Anand , CLARK, Douglas, S. , DORDICK, Jonathan, S.
IPC分类号： C12M3/00 , H01L51/00
CPC分类号： G01N33/5014 , B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/0065 , B01J2219/00659 , B01J2219/00664 , B01J2219/00743 , C12N2503/00 , C12N2533/54
摘要： The present invention is directed to a screening platform employing a miniaturized three-dimensional cell chip for high-throughput toxicology screening of test and lead compounds, prodrugs, drugs and P-450 generated drug metabolites. To this end, the three-dimensional cell chip, employs human cells encapsulated in a matrix (e.g., collagen or alginate gels) in volumes as small as 10 nL arrayed on a functionalized substrates (e.g., glass microscope slides) for spatially addressable screening against multiple test compounds. With the present platform, over 3,000 cell-matrix islands may be spotted providing for simultaneous screening against multiple compounds at multiple doses and in high replicate.

6. 发明授权

EP1794590B1 ENHANCED STABILITY OF PROTEINS IMMOBILIZED ON NANOPARTICLES 有权
标题翻译：在纳米颗粒上固定的蛋白质稳定性增强
公开(公告)号：EP1794590B1
公开(公告)日：2014-02-26
申请号：EP05858100.0
申请日：2005-09-07
申请人： RENSSELAER POLYTECHNIC INSTITUTE
发明人： KARAJANAGI, Sandeep, S. , DORDICK, Jonathan, S. , ASURI, Prashanth , KANE, Ravindra, S. , VERTEGEL, Alexey A. , SIEGEL, Richard W.
IPC分类号： A61K9/16 , A61K9/14 , G01N33/543 , G01N33/58 , C12Q1/00
CPC分类号： G01N33/54346 , B82Y15/00 , C12Q1/001 , G01N33/587 , G01N33/588

7. 发明申请

WO2011154829A2 SHEATHED NANOTUBE FIBER AND METHOD OF FORMING SAME 审中-公开
公开(公告)号：WO2011154829A2
公开(公告)日：2011-12-15
申请号：PCT/IB2011/001401
申请日：2011-06-20
申请人： RENSSELAER POLYTECHNIC INSTITUTE , MIYAUCHI, Minoru , MIAO, Jianjun , SIMMONS, Trevor, J. , LEE, Jong-Won , DOHERTY, Thomas, V. , DORDICK, Jonathan, S. , LINHARDT, Robert, J.
发明人： MIYAUCHI, Minoru , MIAO, Jianjun , SIMMONS, Trevor, J. , LEE, Jong-Won , DOHERTY, Thomas, V. , DORDICK, Jonathan, S. , LINHARDT, Robert, J.
IPC分类号： H01B3/48 , H01B5/06
CPC分类号： B82Y30/00 , D01D5/0007 , D01F1/09 , D01F2/02 , D01F8/02 , H01G9/02 , H01G11/52 , Y02E60/13 , Y10T428/2918
摘要： Embodiments of the invention provide a cellulose- sheathed carbon nanotube fiber. One aspect of the invention provides a sheathed nanotube fiber comprising: a carbon nanotube fiber; and a cellulose sheath extending co-axially along at least a first portion of a length of the carbon nanotube fiber. Another aspect of the invention provides a method of forming a sheathed carbon nanotube fiber, the method comprising: co-electrospinning a carbon nanotube fiber gel core within a cellulose solution sheath.
摘要翻译：本发明的实施方案提供一种纤维素包覆的碳纳米管纤维。本发明的一个方面提供一种护套纳米管纤维，其包含：碳纳米管纤维; 以及沿所述碳纳米管纤维的长度的至少第一部分同轴延伸的纤维素护套。本发明的另一方面提供了一种形成护套碳纳米管纤维的方法，所述方法包括：在纤维素溶液鞘内共同静电纺丝碳纳米管纤维凝胶芯。

8. 发明申请

WO2003038404A3 IN VITRO METABOLIC ENGINEERING ON MICROSCALE DEVICES 审中-公开
公开(公告)号：WO2003038404A3
公开(公告)日：2003-05-08
申请号：PCT/US2002/035281
申请日：2002-11-01
申请人： RENSSELAER POLYTECHNIC INSTITUTE , UNIVERSITY OF MINNESOTA , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： DORDICK, Jonathan, S. , SRINIVASAN, Aravind , KIM, Jungbae , SHERMAN, David, H. , CLARK, Douglas, S.
IPC分类号： C12P1/00
摘要： Disclosed herein is a microfluidics device that can be used to prepare natural products and their analogs. The device comprises the enzymes of a biosynthetic pathway immobilized thereon and a means for sequentially directing a starting material and each ensuing reaction product to the enzymes of the biosynthetic pathway in the order corresponding to the steps of the biosynthetic pathway. The device can thus be used to prepare the natural product using the natural starting material of the biosynthetic pathway or analogs of the natural product using an unnatural starting material. Alternatively, artificial pathways can be created by immobilizing an appropriate selection of enzymes on the device in an order whereby each subsequent enzyme can catalyze a reaction with the product of the prior enzyme. Novel chemical entities can be prepared from these artificial pathways.

9. 发明申请

WO2003038404A2 IN VITRO METABOLIC ENGINEERING ON MICROSCALE DEVICES 审中-公开
标题翻译：在微型设备中的体外代谢工程
公开(公告)号：WO2003038404A2
公开(公告)日：2003-05-08
申请号：PCT/US2002/035281
申请日：2002-11-01
申请人： RENSSELAER POLYTECHNIC INSTITUTE , UNIVERSITY OF MINNESOTA , UNIVERSITY OF CALIFORNIA AT BERKELEY
发明人： DORDICK, Jonathan, S. , SRINIVASAN, Aravind , KIM, Jungbae , SHERMAN, David, H. , CLARK, Douglas, S.
IPC分类号： G01N
CPC分类号： B01J19/0093 , B01J19/0046 , B01J2219/00317 , B01J2219/00364 , B01J2219/00497 , B01J2219/00527 , B01J2219/00533 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00691 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , B01J2219/00835 , B01J2219/00837 , B01J2219/0086 , B01L3/5027 , B01L3/5085 , B01L2300/069 , B01L2300/0819 , B01L2300/0829
摘要： Disclosed herein is a microfluidics device that can be used to prepare natural products and their analogs. The device comprises the enzymes of a biosynthetic pathway immobilized thereon and a means for sequentially directing a starting material and each ensuing reaction product to the enzymes of the biosynthetic pathway in the order corresponding to the steps of the biosynthetic pathway. The device can thus be used to prepare the natural product using the natural starting material of the biosynthetic pathway or analogs of the natural product using an unnatural starting material. Alternatively, artificial pathways can be created by immobilizing an appropriate selection of enzymes on the device in an order whereby each subsequent enzyme can catalyze a reaction with the product of the prior enzyme. Novel chemical entities can be prepared from these artificial pathways.
摘要翻译：本文公开了可用于制备天然产物及其类似物的微流体装置。该装置包括固定在其上的生物合成途径的酶和按照与生物合成途径的步骤相应的顺序将原料和每个随后的反应产物顺序地引导到生物合成途径的酶的装置。因此，该装置可以用于使用天然起始物质的天然产物或天然产物的类似物使用非天然原料制备天然产物。或者，可以通过以适当顺序的酶固定适当选择的酶在装置上来产生人工途径，其中每个随后的酶可以催化与先前酶的产物的反应。这些人造途径可以制备新的化学物质。

10. 发明公开

EP3198038A1 COMPOSITIONS AND METHODS TO MODULATE CELL ACTIVITY 审中-实审
标题翻译：调节细胞活性的组合物和方法
公开(公告)号：EP3198038A1
公开(公告)日：2017-08-02
申请号：EP15843730.1
申请日：2015-09-22
申请人： The Rockefeller University , Rensselaer Polytechnic Institute
发明人： STANLEY, Sarah , FRIEDMAN, Jeffrey , DORDICK, Jonathan, S. , SAUER, Jeremy
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： A61K48/005 , A61K9/51 , A61K38/28 , A61K47/541 , A61K47/549 , A61K47/55 , A61K47/6929 , A61K48/00 , A61K48/0075 , A61N2/00 , A61N2/004 , A61N5/025 , A61P3/08 , C07K14/705 , C12N15/86 , C12N2710/10343 , C12N2800/30 , G01N33/5005 , G01N33/6854 , G01N33/6872 , G01N2800/042
摘要： The present invention provides methods and compositions for the remote control of cell function based on the use of a magnetic field to excite paramagnetic nanoparticles targeted to specific cell types. The cell type of interest expresses an ion channel wherein excitation of the paramagnetic nanoparticles results in a physical change that is transduced into a cellular response. Such cellular responses may include, for example, increases in gene expression resulting in production of one or more physiologically active proteins. The expression of such proteins can be used to treat a variety of different inherited or acquired diseases or disorders in a subject.
摘要翻译：本发明提供了基于使用磁场来激发靶向特定细胞类型的顺磁纳米颗粒来远程控制细胞功能的方法和组合物。感兴趣的细胞类型表达离子通道，其中顺磁纳米颗粒的激发导致被转导成细胞应答的物理变化。这样的细胞应答可以包括例如基因表达的增加，导致产生一种或多种生理活性蛋白质。这种蛋白质的表达可以用于治疗受试者中的各种不同的遗传性或获得性疾病或病症。

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