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1. 发明申请

US20160245786A1 LIPID BIOMARKERS OF HEALTHY AGEING 审中-公开
标题翻译：健康老化的脂肪生物标志物
公开(公告)号：US20160245786A1
公开(公告)日：2016-08-25
申请号：US15028244
申请日：2014-11-05
申请人： NESTEC S.A.
发明人： Sebastiano Collino , Ivan Montoliu Roura , Françios-Pierre Martin , Fiona Camille Beguelin , Serge André Dominique Rezzi
IPC分类号： G01N33/487
CPC分类号： G01N33/487 , G01N33/6893 , G01N33/92 , G01N2405/00 , G01N2405/02 , G01N2405/04 , G01N2405/08 , G01N2560/00 , G01N2570/00 , G01N2800/50 , G01N2800/52
摘要： In one aspect there is provided a method for predicting a risk of unhealthy ageing in a subject, comprising: (a) determining a level of two or more lipid biomarkers in a sample from the subject, wherein the biomarkers are selected from two or more of the following groups: (i) a triacylglycerol (TAG) from TAG (46:5) to TAG (54:3); (ii) an ether phosphatidylcholine (PC-O) from PC-O(28:0) to PC-O(38:6); (iii) a sphingomyelin (SM) from SM (33:1) to SM(50:1); (iv) a phosphatidylcholine (PC) from PC (32:1) to PC (40:5); (v) a phosphatidylinositol (PI) from PI (36:1) to PI (38:3); (vi) a phosphatidylethanolamine (PE) from PE (36:2) to PE (38:4); and (b) comparing the levels of the biomarkers in the sample to reference values; wherein the levels of the biomarkers in the sample compared to the reference values are indicative of the risk of unhealthy ageing in the subject.
摘要翻译：一方面，提供了一种用于预测受试者中不健康衰老风险的方法，其包括：（a）测定来自所述受试者的样品中两种或更多种脂质生物标志物的水平，其中所述生物标志物选自以下组：（i）TAG（46:5）至TAG（54:3）的三酰基甘油（TAG）; （ii）从PC-O（28:0）到PC-O（38:6）的醚磷脂酰胆碱（PC-O）; （iii）SM（33：1）至SM（50：1）的鞘磷脂（SM）; （iv）从PC（32:1）到PC（40:5）的磷脂酰胆碱（PC）; （v）PI（36：1）至PI（38：3）的磷脂酰肌醇（PI）; （vi）从PE（36:2）到PE（38:4）的磷脂酰乙醇胺（PE）; 和（b）将样品中生物标志物的水平与参考值进行比较; 其中与参考值相比，样品中的生物标志物的水平表明受试者中不健康老化的风险。

2. 发明授权

US10648991B2 Biomarkers for epicardial adipose tissue 有权
公开(公告)号：US10648991B2
公开(公告)日：2020-05-12
申请号：US15102490
申请日：2014-12-09
申请人： Nestec S.A.
发明人： Fiona Camille Beguelin , Sebastiano Collino , Françios-Pierre Martin , Ivan Montoliu Roura , Max Scherer
IPC分类号： G01N33/92 , A23L33/00 , G09B19/00
摘要： A method for predicting the level of epicardial adipose tissue (EAT) in a subject comprising: (a) determining a level of one or more lipid biomarkers in a sample from the subject, wherein the biomarkers are selected from the following: (i) phosphatidylcholine (PC) [16:1/16:1] (ii) diacylglycerol (DAG) [42:8] (iii) phosphatidylethanolamine-ether (PE-O) [32:5] (iv) phosphatidylcholine (PC) [18:0/22:5] (v) phosphatidylinositol (PI) [18:0/16:1] (vi) phosphatidylglycerol (PG) [20:3/20:3] (vii) phosphatidylglycerol (PG) [22:5/18:1] (b) comparing the levels of the biomarkers in the sample to reference values; wherein the levels of the biomarkers in the sample compared to the reference values are indicative of levels of EAT fat in the subject.

3. 发明申请

US20160305968A1 BIOMARKERS FOR EPICARDIAL ADIPOSE TISSUE 审中-公开
标题翻译：生物标志物用于EPICARDIAL ADIPOSE组织
公开(公告)号：US20160305968A1
公开(公告)日：2016-10-20
申请号：US15102490
申请日：2014-12-09
申请人： NESTEC S.A.
发明人： Fiona Camille Beguelin , Sebastiano Collino , Françios-Pierre Martin , Ivan Montoliu Roura , Max Scherer
IPC分类号： G01N33/92 , G09B19/00
CPC分类号： G01N33/92 , A23L33/30 , A23V2002/00 , G01N2405/00 , G01N2405/04 , G01N2570/00 , G01N2800/324 , G01N2800/50 , G09B19/00 , G09B19/0092
摘要： A method for predicting the level of epicardial adipose tissue (EAT) in a subject comprising: (a) determining a level of one or more lipid biomarkers in a sample from the subject, wherein the biomarkers are selected from the following: (i) phosphatidylcholine (PC) [16:1/16:1] (ii) diacylglycerol (DAG) [42:8] (iii) phosphatidylethanolamine-ether (PE-O) [32:5] (iv) phosphatidylcholine (PC) [18:0/22:5] (v) phosphatidylinositol (PI) [18:0/16:1] (vi) phosphatidylglycerol (PG) [20:3/20:3] (vii) phosphatidylglycerol (PG) [22:5/18:1] (b) comparing the levels of the biomarkers in the sample to reference values; wherein the levels of the biomarkers in the sample compared to the reference values are indicative of levels of EAT fat in the subject.
摘要翻译：一种用于预测受试者心包脂肪组织（EAT）水平的方法，包括：（a）确定来自受试者的样品中一种或多种脂质生物标志物的水平，其中所述生物标志物选自以下：（i）磷脂酰胆碱（PC）[16：1/16：1]（ii）二酰基甘油（DAG）[42:8]（iii）磷脂酰乙醇胺 - 醚（PE-O）[32：5]（iv）磷脂酰胆碱（PC）（v）磷脂酰肌醇（PI）[18：0/16：1]（vi）磷脂酰甘油（PG）[20：3/20：3]（vii）磷脂酰甘油（PG）[22：5 / 18：1]（b）将样品中生物标志物的水平与参考值进行比较; 其中与参考值相比，样品中生物标志物的水平指示受试者中EAT脂肪的水平。

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