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1. 发明申请

WO2005042028A3 IL-13 CONJUGATED TO AN IMMUNOGEN AND USES THEREOF 审中-公开
公开(公告)号：WO2005042028A3
公开(公告)日：2005-05-12
申请号：PCT/US2004/035093
申请日：2004-10-25
申请人： NEOPHARM, INC. , AHMAD, Imran , JAMIL, Haris , AHMAD, Ateeq
发明人： AHMAD, Imran , JAMIL, Haris , AHMAD, Ateeq
IPC分类号： C07K16/24 , A61K47/48 , A61P11/06 , A61P35/00 , A61P31/00
摘要： The invention provides a method for inducing an immune response against a disease in a human, which method comprises providing a conjugate comprising a portion of interleukin 13 (IK-13) fused to an immunogen, and administering the conjugate to the human, whereupon an immune response to the disease is induced. The invention also provides a method for treating a disease in a human, which method comprises preparing an antibody raised against a conjugate comprising a portion of IL-13 fused to an immunogen, and administering the antibody to the human, whereupon the disease is treated.

2. 发明申请

WO2003102011A1 METHOD FOR DETERMINING OLIGONUCLEOTIDE CONCENTRATION 审中-公开
标题翻译：确定寡核苷酸浓度的方法
公开(公告)号：WO2003102011A1
公开(公告)日：2003-12-11
申请号：PCT/US2003/016874
申请日：2003-05-29
申请人： NEOPHARM, INC. , AHMAD, Ateeq , KHAN, Sumsullah , AHMAD, Imran
发明人： AHMAD, Ateeq , KHAN, Sumsullah , AHMAD, Imran
IPC分类号： C07H21/04
CPC分类号： C12N15/101
摘要： The invention provides a simple, sensitive method to determine the concentration of oligonucleotides in biological matrices, such as plasma. The method involves obtaining a biological specimen containing a concentration of an oligonucleotide, removing an amount of protein from the sample, subjecting the sample to a chromatographic separation, and analyzing the eluant for the amount of oligonucleotide by mass spectrometry. The assay provides a reliable measure of the concentration of oligonucleotide in the concentration range of about 5 to about 10,000 ng/mL of sample.
摘要翻译：本发明提供了一种简单，灵敏的方法来确定生物基质如血浆中寡核苷酸的浓度。该方法包括获得含有寡核苷酸浓度的生物样品，从样品中除去一定量的蛋白质，对样品进行色谱分离，并通过质谱法分析洗脱液的量。该测定提供了在约5至约10,000ng / mL样品浓度范围内寡核苷酸浓度的可靠测量。

3. 发明申请

WO2008127358A2 AQUEOUS SYSTEMS FOR THE PREPARATION OF LIPID-BASED PHARMACEUTICAL COMPOUNDS; COMPOSITIONS, METHODS, AND USES THEREOF 审中-公开
标题翻译：用于制备基于脂质的药物化合物的水性体系; 组合物，方法和用途
公开(公告)号：WO2008127358A2
公开(公告)日：2008-10-23
申请号：PCT/US2007/080984
申请日：2007-10-10
申请人： JINA PHARMACEUTICALS, INC. , ALI, Shoukath, M. , AHMAD, Moghis, U. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Imran
发明人： ALI, Shoukath, M. , AHMAD, Moghis, U. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A61K9/127
CPC分类号： A61K47/28 , A61K9/0019 , A61K9/1075 , A61K9/127 , A61K9/1617 , A61K9/1682 , A61K9/19 , A61K9/5123 , A61K31/337 , A61K31/436 , A61K31/704 , A61K31/7048 , A61K47/10 , A61K47/24 , A61K47/541 , A61K47/554 , Y02A50/409
摘要： The present invention relates to a methods of preparing active compounds complexed with lipids using aqueous systems that are free of organic solvents, and methods of using the complexes, e.g., in treating a disease in a subject. In some embodiments, the present invention comprises a composition comprising a complex comprising at least one active compound, e.g., a polyene antibiotic, an immunosuppressant agent such as tacrolimus or a taxane or taxane derivative, and one or more lipids. In some embodiments, the present invention provides a method comprising preparing a composition comprising a lipid complex comprising at least one active compound and at least one lipid and administering the composition to a subject. In certain embodiments the subject is a mammal. In certain preferred embodiments, the subject is human.
摘要翻译：本发明涉及使用不含有机溶剂的水性体系制备与脂质络合的活性化合物的方法，以及使用该络合物的方法，例如用于治疗受试者中的疾病的方法。在一些实施方案中，本发明包含组合物，其包含含有至少一种活性化合物（例如多烯抗生素），免疫抑制剂（例如他克莫司或紫杉烷或紫杉烷衍生物）和一种或多种脂质的复合物。在一些实施方案中，本发明提供一种方法，其包括制备包含脂质复合物的组合物，所述脂质复合物包含至少一种活性化合物和至少一种脂质，并将所述组合物施用于受试者在某些实施方案中，受试者是哺乳动物。在某些优选的实施方案中，受试者是人。

4. 发明申请

WO2012122493A1 LIPID BASED CLOPIDOGREL COMPOSITIONS, METHODS, AND USES 审中-公开
标题翻译：基于脂质的胶体组合物，方法和用途
公开(公告)号：WO2012122493A1
公开(公告)日：2012-09-13
申请号：PCT/US2012/028530
申请日：2012-03-09
申请人： JINA PHARMACEUTICALS, INC. , ALI, Shoukath M. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Moghis U. , AHMAD, Imran
发明人： ALI, Shoukath M. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Moghis U. , AHMAD, Imran
IPC分类号： A61K9/20 , A01N43/42 , A61K31/44
CPC分类号： A61K9/10 , A61K9/1075 , A61K31/44 , A61K47/24
摘要： The present invention relates to a methods of preparing clopidogrel complexed with lipids using aqueous systems that are free of organic solvents, and methods of using the complexes, e.g., in treating a disease in a subject. In some embodiments, the present invention provides a method comprising preparing a composition comprising a lipid complex comprising clopidogrel and at least one lipid and administering the composition to a subject. In certain embodiments the subject is a mammal. In certain preferred embodiments, the subject is human.
摘要翻译：本发明涉及使用不含有机溶剂的水性体系制备与脂质复合的氯吡格雷的方法，以及使用复合物例如治疗受试者疾病的方法。在一些实施方案中，本发明提供了包括制备包含含有氯吡格雷和至少一种脂质的脂质复合物并将组合物给予受试者的组合物的方法。在某些实施方案中，受试者是哺乳动物。在某些优选实施方案中，受试者是人。

5. 发明申请

WO2008070463A2 ENDOXIFEN METHODS AND COMPOSITIONS 审中-公开
标题翻译：内切酶方法和组合物
公开(公告)号：WO2008070463A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/085443
申请日：2007-11-21
申请人： JINA PHARMACEUTICALS, INC. , AHMAD, Ateeq , ALI, Shoukath, M. , AHMAD, Moghis, U. , SHEIKH, Saifuddin , AHMAD, Imran
发明人： AHMAD, Ateeq , ALI, Shoukath, M. , AHMAD, Moghis, U. , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A61K31/35
CPC分类号： A61K31/138 , A61K9/0014 , A61K9/127 , A61K9/19 , A61K31/35 , C07D309/10
摘要： The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of breast cancer and other breast diseases and diseases susceptible to endoxifen. In particular, the compositions of the present invention include liposomes, complexes, vesicles, emulsions, micelles and mixed micelles of endoxifen in which the compositions further contain any of a variety of neutral or charged lipids and desirably, cholesterol and cholesterol derivatives, sterols, Z - and E - guggulsterones, phospholipids, fatty acids, vitamin D, and vitamin E. The present invention also provides methods of preparing endoxifen. The present invention provides methods for treating and preventing breast cancer and other breast related diseases by administrating novel formulations or compositions comprising a therapeutically effective amount of endoxifen.
摘要翻译：本发明提供了含有内皮素的内含物，制剂和脂质体的组合物，这些药剂和制剂的制备方法，以及用于治疗乳腺癌和其它乳腺疾病和对内给药易感染的疾病的制剂和制剂的用途。特别地，本发明的组合物包括脂质体，复合物，囊泡，乳剂，胶束和内皮素的混合胶束，其中所述组合物还含有任何多种中性或带电荷的脂质，并且期望地，胆固醇和胆固醇衍生物，甾醇，Z - 和 - 尤努尔酮，磷脂，脂肪酸，维生素D和维生素E.本发明还提供了内皮素的制备方法。本发明提供了通过施用包含治疗有效量的内皮素的新制剂或组合物来治疗和预防乳腺癌和其它乳腺相关疾病的方法。

6. 发明申请

WO2010135703A2 ENDOXIFEN METHODS AND COMPOSITIONS IN THE TREATMENT OF MAMMALIAN DISEASES 审中-公开
标题翻译：内分泌方法和组合物治疗马马里兰病
公开(公告)号：WO2010135703A2
公开(公告)日：2010-11-25
申请号：PCT/US2010/035852
申请日：2010-05-21
申请人： JINA PHARMACEUTICALS, INC. , AHMAD, Ateeq , ALI, Shoukath, M. , AHMAD, Moghis, U. , SHEIKH, Saifuddin , AHMAD, Imran
发明人： AHMAD, Ateeq , ALI, Shoukath, M. , AHMAD, Moghis, U. , SHEIKH, Saifuddin , AHMAD, Imran
CPC分类号： A61K9/06 , A61K9/0014 , A61K9/08 , A61K9/19 , A61K31/138 , Y02A50/409
摘要： The present invention provides compositions containing endoxifen, formulations and liposomes of endoxifen, methods of preparation of such agents and formulations, and use of such agents and formulations for the treatment of a subject having or at risk for psychiatric and neurodegenerative diseases, infectious diseases, fertility disorders, osteoporosis, osteoarthritis, and/or cardiovascular diseases. Specifically, the present invention relates to compositions comprising endoxifen for use in the treatment of such disorders or predisposition to such disorders, for use in manufacture of medicaments for treating such disorders, and methods comprising use of such compositions in such treatments.
摘要翻译：本发明提供了含有内皮素的内含物，制剂和脂质体的组合物，这些药剂和制剂的制备方法，以及这些药剂和制剂用于治疗患有精神和神经退行性疾病，感染性疾病，生育能力或有风险的受试者的用途疾病，骨质疏松症，骨关节炎和/或心血管疾病。具体地说，本发明涉及包含用于治疗这种疾病或易患这种疾病的内给素的组合物，用于制备用于治疗这种病症的药物，以及包括在这种治疗中使用这些组合物的方法。

7. 发明申请

WO2008058156A3 GUGGULPHOSPHOLIPID METHODS AND COMPOSITIONS 审中-公开
公开(公告)号：WO2008058156A3
公开(公告)日：2008-05-15
申请号：PCT/US2007/083832
申请日：2007-11-06
申请人： JINA PHARMACEUTICALS INC. , AHMAD, Moghis, U. , ALI, Shoukath, M. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Imran
发明人： AHMAD, Moghis, U. , ALI, Shoukath, M. , AHMAD, Ateeq , SHEIKH, Saifuddin , AHMAD, Imran
IPC分类号： A01N65/00 , A61K36/328
摘要： The present invention relates to the methods for preparing synthetic guggulphospholipids, their fatty acid analogues and other bioactiv molecules. The present invention relates to E-guggulsterone and Z- guggulsterone or mixture of E- and Z-guggulsterones. The present invention also provides a novel method for the preparation of E-guggulsterol and Z- guggulsterol or mixture of E-and Z-guggulsterols from a mixture of E- and Z- guggulsterones. The present invention further relates to guggulphospholipids and other bioactive molecules incorporated into complexes such as liposomes, complexes, emulsions, vesicles, micelles, and mixed micelles, which can include othe active agents, such as hydrophobic or hydrophilic drugs for use, e.g., in treatment of human and animal diseases.

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