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1. 发明公开

EP2657702A1 ANALYTICAL DEVICE AND ANALYTICAL METHOD 审中-公开
标题翻译：分析装置和分析方法
公开(公告)号：EP2657702A1
公开(公告)日：2013-10-30
申请号：EP11850209.5
申请日：2011-12-22
申请人： NEC Soft, Ltd.
发明人： HORII Katsunori , KATOU Shintarou , AKITOMI Jou , WAGA Iwao
IPC分类号： G01N33/543 , G01N21/78 , G01N27/327 , G01N27/416 , G01N33/53 , C12N15/115
CPC分类号： C12Q1/68 , C12N15/111 , C12N2310/16 , C12N2320/10 , C12Q1/6834 , G01N33/54306 , C12Q2525/205 , C12Q2563/131
摘要： The present invention provides a technique capable of simply analyzing a target to be analyzed. An analytical device of the present invention includes a basal plate; a nucleic acid element; and a detection section of detecting a signal. The nucleic acid element and the detection section are arranged on the basal plate. The nucleic acid element includes a first nucleic acid molecule and a second nucleic acid molecule. The first nucleic acid molecule is a nucleic acid molecule capable of binding to a target. The second nucleic acid molecule is a nucleic acid molecule capable of binding to streptavidin. When the target does not bind to the first nucleic acid molecule, a binding capacity of the second nucleic acid molecule to the streptavidin is inactivated. When the target binds to the first nucleic acid molecule, a binding capacity of the second nucleic acid molecule to the streptavidin is activated. The detection section detects binding between the second nucleic acid molecule and the streptavidin. The target is bound to the first nucleic acid molecule, so that the streptavidin is bound to the second nucleic acid molecule. Thus, the target can be analyzed through detecting the binding between the second nucleic acid molecule and the streptavidin using the detection device.
摘要翻译：本发明提供了一种能够简单地分析要分析的目标的技术。本发明的分析装置包括基板; 核酸元件; 以及检测信号的检测部分。核酸元件和检测部分布置在基板上。核酸元件包括第一核酸分子和第二核酸分子。第一核酸分子是能够结合靶标的核酸分子。第二核酸分子是能够结合链霉抗生物素蛋白的核酸分子。当靶标不结合第一核酸分子时，第二核酸分子与链霉抗生物素蛋白的结合能力失活。当靶标结合第一核酸分子时，第二核酸分子与链霉抗生物素蛋白的结合能力被激活。检测部分检测第二核酸分子与链霉抗生物素蛋白之间的结合。靶标与第一核酸分子结合，使得链霉抗生物素蛋白与第二核酸分子结合。因此，可以通过使用检测装置检测第二核酸分子与链霉抗生物素蛋白之间的结合来分析靶。

2. 发明公开

EP2489734A1 NUCLEIC ACID MOLECULE HAVING AFFINITY WITH IgG ANTIBODY DERIVED FROM RODENT, BINDING AGENT, DETECTION REAGENT, AND DETECTION KIT 审中-公开
标题翻译：具有亲和性的核酸分子，具有IgG抗体FROM NAGER，粘合剂，检测试剂和鉴定
公开(公告)号：EP2489734A1
公开(公告)日：2012-08-22
申请号：EP09848504.8
申请日：2009-08-21
申请人： NEC Soft, Ltd.
发明人： TAKENAKA Hiromi , YOSHIDA Yoshihito , HORII Katsunori , FURUICHI Makio , YAGI Hirotaka , AKITOMI Jou , YAMAGUCHI Mineko , KATOU Shintarou , NISHIKATA Kensaku , WAGA Iwao
IPC分类号： C12N15/09 , G01N33/53 , G01N33/566
CPC分类号： G01N33/6854 , C12N15/115 , C12N2310/16 , G01N33/5308
摘要： The present invention is to provide a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or superior to that of an antibody, a binder using the nucleic acid molecule, a detection reagent, and a detection kit. The nucleic acid molecule of the present invention has a binding affinity to a rodent-derived IgG antibody and has a dissociation constant of 1 µM or less. The binder for a rodent-derived IgG antibody of the present invention includes the nucleic acid molecule of the present invention. The detection reagent for detecting a rodent-derived IgG antibody of the present invention includes the binder for a rodent-derived IgG antibody of the present invention. The detection kit for detecting a rodent-derived IgG antibody of the present invention includes the detection reagent for detecting a rodent-derived IgG antibody of the present invention.
摘要翻译：本发明是提供一种具有对啮齿动物来源的IgG抗体，可以制备比抗体更容易的结合亲和力的核酸分子，并具有结合亲和力等于或优于没有抗体的，粘合剂使用核酸分子，检测试剂和检测试剂盒。本发明的核酸分子具有至啮齿类动物衍生的IgG抗体的结合亲和力，并且具有的解离常数1微米或更小的。用于本发明的啮齿动物来源的IgG抗体的粘合剂包括本发明的核酸分子。用于检测本发明的啮齿动物来源的IgG抗体的检测试剂包括用于本发明的啮齿动物来源的IgG抗体的粘合剂。用于检测本发明的啮齿动物来源的IgG抗体的检测试剂盒包括用于检测本发明的啮齿动物来源的IgG抗体的检测试剂。

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