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1. 发明申请

WO2018119152A1 SYNTHESIS OF BIOPRODUCTS FROM LIGNIN-DERIVED AROMATICS BY GENETICALLY MODIFIED MICROORGANISMS 审中-公开
公开(公告)号：WO2018119152A1
公开(公告)日：2018-06-28
申请号：PCT/US2017/067737
申请日：2017-12-20
申请人： NATIONAL TECHNOLOGY & ENGINEERING SOLUTIONS OF SANDIA, LLC (NTESS) , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BATTELLE MEMORIAL INSTITUTE (FOR MANAGEMENT AND OPERATION OF PACIFIC NORTHWEST NATIONAL LABORATORY)
发明人： GLADDEN, John M. , SKERKER, Jeffrey M. , KEASLING, Jay D. , KIRBY, James , YAEGASHI, Junko
IPC分类号： C12P5/00 , C12P1/02 , C08L97/02 , C07G1/00
摘要： The present invention provides for a method of converting a depolymerized lignin aromatic compound into a bioproduct, comprising: (a) providing a composition comprising a depolymerized lignin aromatic compound, optionally a depolymerized cellulose, and optionally a depolymerized hemicellulose, and (b) introducing a genetically modified microorganism to the composition, wherein the genetically modified microorganism is capable of converting the depolymerized lignin aromatic compound into a bioproduct; such that the depolymerized lignin aromatic compound is converted into a bioproduct.

2. 发明申请

WO2007024718A2 GENETICALLY MODIFIED HOST CELLS AND USE OF SAME FOR PRODUCING ISOPRENOID COMPOUNDS 审中-公开
标题翻译：遗传修饰的宿主细胞及其用于生产类异戊烯化合物的用途
公开(公告)号：WO2007024718A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/032406
申请日：2006-08-17
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , SHIBA, Yoichiro , KIRBY, James , PARADISE, Eric M. , KEASLING, Jay D.
发明人： SHIBA, Yoichiro , KIRBY, James , PARADISE, Eric M. , KEASLING, Jay D.
IPC分类号： C12P21/06 , C12N1/18
CPC分类号： C12P23/00
摘要： The present invention provides genetically modified eukaryotic host cells exhibiting increased activity levels of one or more enzymes that generate precursors to be utilized by the mevalonate pathway enzymes, increased activity levels of one or more mevalonate pathway enzymes, prenyl transferase, and/or decreased levels of squalene synthase activity; such cells are useful for producing isoprenoid compounds. The present invention provides genetically modified eukaryotic host cells that produce higher levels of acetyl-CoA than a control cell; such cells are useful for producing a variety of products, including isoprenoid compounds. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.
摘要翻译：本发明提供了遗传修饰的真核宿主细胞，其表现出增加一种或多种酶的活性水平，所述酶产生甲羟戊酸途径酶所利用的前体，一种或多种甲羟戊酸途径酶的活性水平增加，异戊二烯基和/或降低的角鲨烯合酶活性水平; 这样的细胞可用于生产类异戊二烯化合物。本发明提供了与对照细胞相比产生更高水平的乙酰-CoA的基因修饰的真核宿主细胞; 这种细胞可用于生产各种产品，包括类异戊二烯化合物。提供了在受试基因修饰的真核宿主细胞中产生类异戊二烯化合物或类异戊二烯前体的方法。该方法通常涉及在促进高水平类异戊二烯或类异戊二烯前体化合物产生的条件下培养受试基因修饰的宿主细胞。

3. 发明公开

EP1778831A1 GENETICALLY MODIFIED HOST CELLS AND USE OF SAME FOR PRODUCING ISOPRENOID COMPOUNDS 有权
标题翻译：遗传修饰的宿主细胞及其使用产生类异戊二烯组合物
公开(公告)号：EP1778831A1
公开(公告)日：2007-05-02
申请号：EP05775484.8
申请日：2005-07-21
申请人： The Regents of the University of California
发明人： KEASLING, Jay D. , PARADISE, Eric M. , KIRBY, James
IPC分类号： C12N1/15 , C12N1/16 , C12N1/18 , C12N5/10 , C12N15/10 , C12N15/31 , C12N15/12 , C12N15/63 , C12N15/64
CPC分类号： C12P5/007 , C12N9/0006 , C12N9/1085 , C12N9/88 , C12N15/81 , C12P23/00 , C12Y101/01034 , C12Y205/01092 , C12Y402/03024
摘要： The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.

4. 发明申请

WO2017100655A1 MONOTERPENE-PRODUCING GENETICALLY MODIFIED HOST CELLS AND METHODS OF USE OF SAME 审中-公开
标题翻译：单壁碳纳米管生成基因修饰的宿主细胞及其使用方法
公开(公告)号：WO2017100655A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065944
申请日：2016-12-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： DENBY, Charles M. , KEASLING, Jay D. , KIRBY, James , LI, Rachel Alexandra
IPC分类号： C12N9/04
CPC分类号： C12P5/007 , C12N9/88 , C12P7/04 , C12Y402/03025
摘要： The present disclosure provides a genetically modified host cell capable of producing linalool (or 3,7-dimethylocta-1,6-dien-3-ol).
摘要翻译：本公开提供了能够生产里哪醇（或3,7-二甲基辛-1,6-二烯-3-醇）的遗传修饰的宿主细胞。

5. 发明申请

WO2006014837A1 GENETICALLY MODIFIED HOST CELLS AND USE OF SAME FOR PRODUCING ISOPRENOID COMPOUNDS 审中-公开
标题翻译：遗传修饰的宿主细胞及其用于生产异噻唑类化合物的用途
公开(公告)号：WO2006014837A1
公开(公告)日：2006-02-09
申请号：PCT/US2005/026190
申请日：2005-07-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , KIRBY, James , KEASLING, Jay D. , PARADISE, Eric M.
发明人： KIRBY, James , KEASLING, Jay D. , PARADISE, Eric M.
IPC分类号： C12N1/15
CPC分类号： C12P5/007 , C12N9/0006 , C12N9/1085 , C12N9/88 , C12N15/81 , C12P23/00 , C12Y101/01034 , C12Y205/01092 , C12Y402/03024
摘要： The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.
摘要翻译：本发明提供了产生类异戊二烯前体或类异戊二烯化合物的遗传修饰的真核宿主细胞。受试者遗传修饰的宿主细胞包括甲羟戊酸途径酶中的一种或多种的增加的活性水平，异戊烯转移酶活性水平增加和角鲨烯合酶活性水平降低。提供了用于在受试者遗传修饰的真核宿主细胞中产生类异戊二烯化合物或类异戊二烯前体的方法。所述方法通常涉及在促进产生高水平的类异戊二烯或类异戊二烯前体化合物的条件下培养受试者遗传修饰的宿主细胞。

6. 发明授权

EP1778831B1 GENETICALLY MODIFIED HOST CELLS AND USE OF SAME FOR PRODUCING ISOPRENOID COMPOUNDS 有权
标题翻译：遗传修饰的宿主细胞及其使用产生类异戊二烯组合物
公开(公告)号：EP1778831B1
公开(公告)日：2012-05-23
申请号：EP05775484.8
申请日：2005-07-21
申请人： The Regents of The University of California
发明人： KEASLING, Jay D. , PARADISE, Eric M. , KIRBY, James
IPC分类号： C12N1/15 , C12N1/16 , C12N1/18 , C12N5/10 , C12N15/10 , C12N15/31 , C12N15/12 , C12N15/63 , C12N15/64
CPC分类号： C12P5/007 , C12N9/0006 , C12N9/1085 , C12N9/88 , C12N15/81 , C12P23/00 , C12Y101/01034 , C12Y205/01092 , C12Y402/03024
摘要： The present invention provides genetically modified eukaryotic host cells that produce isoprenoid precursors or isoprenoid compounds. A subject genetically modified host cell comprises increased activity levels of one or more of mevalonate pathway enzymes, increased levels of prenyltransferase activity, and decreased levels of squalene synthase activity. Methods are provided for the production of an isoprenoid compound or an isoprenoid precursor in a subject genetically modified eukaryotic host cell. The methods generally involve culturing a subject genetically modified host cell under conditions that promote production of high levels of an isoprenoid or isoprenoid precursor compound.

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