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1. 发明专利

JP2001137329A BIO-TISSUE FOR TENDON OR LIGAMENT AND METHOD OF MANUFACTURING IT 失效
公开(公告)号：JP2001137329A
公开(公告)日：2001-05-22
申请号：JP32375399
申请日：1999-11-15
申请人： NAT INST RES INORGANIC MAT , TAKI CHEMICAL , NOF CORP
发明人： TANAKA JUNZO , KIKUCHI MASANORI , FUKUZAKI HIRONOBU , YAMAGUCHI ISAMU , KATO KENJI , SONODA KENSAKU
IPC分类号： A61L27/00 , A61F2/08 , A61L27/32 , A61L27/36 , A61L27/50
摘要： PROBLEM TO BE SOLVED: To provide a bio-tissue for tendon or ligament which is expected to quickly stick to a bone after a surgical operation and to recover a patient in an early stage due to its superior biocompatibility and a manufacturing method by which the bio-tissue can be manufactured easily in a short period. SOLUTION: A bio-tissue for tendon or ligament contains a tissue substrate for tendon or ligament and a calcium phosphate compound which is fixed to at least the surface of the substrate. A method of manufacturing the bio-tissue includes a step of generating and fixing the calcium phosphate compound by alternately dipping the substrate in a calcium solution and a phosphoric acid solution.

2. 发明专利

JP2001054564A VITAL MATERIAL 失效
公开(公告)号：JP2001054564A
公开(公告)日：2001-02-27
申请号：JP23034899
申请日：1999-08-17
申请人： NAT INST RES INORGANIC MAT , KAWASUMI LAB INC , TAKI CHEMICAL
发明人： TANAKA JUNZO , KIKUCHI MASANORI , MIYAMOTO KIMIHIRO , SUWA SHUJI , ICHIKAWA SHUNJI , YOKOYAMA ETSURO , AKINO SOICHI , OKADA TAKAO , IMAMURA YUKARI
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To obtain a material which has excellent biocompatibility and is effective for reproduction of the tissue having adequate strength and degradation rate by forming a vital material containing calcium phosphate and a lactic acid/glycolic acid/εcaprolatone copolymer. SOLUTION: The vital material is formed of the structure in which the calcium phosphate is coordinated with the carbonyl group of the lactic acid/ glycolic acid/ε-caprolatone copolymer and, therefore, adjusts the in-vivo degradability and vital tissue derivability of the calcium phosphate, thereby greatly accelerating the vital tissue derivability. While the shapes of the vital tissue to be rebuilt are intricate in general, various kinds of the materials from flexibility to high strength are molded by adjusting the tissue and molecular weight of the lactic acid/glycolic acid/εcaprolatone copolymer and, therefore, the vital material is not deformed by the oppression of the tissue and the fixation in tight contact with the tissue is possible. Also, the adjustment to the decomposition rate suitable for the damage of application parts is possible and, therefore, the rapid tissue restoration is made possible without the hindrance of the reproduction of the vital tissue.

3. 发明专利

JP2001026408A COMBINED MATERIAL OF CHITOSAN AND CALCIUM PHOSPHATE AND ITS PRODUCTION 失效
公开(公告)号：JP2001026408A
公开(公告)日：2001-01-30
申请号：JP20148099
申请日：1999-07-15
申请人： NAT INST RES INORGANIC MAT , TAKI CHEMICAL
发明人： TANAKA JUNZO , KIKUCHI MASANORI , AKINO SOICHI , FUKUZAKI HIRONOBU , YAMAGUCHI ISAMU
IPC分类号： A61L27/00 , C01B25/32 , C08B37/08 , C09C1/02
摘要： PROBLEM TO BE SOLVED: To obtain a combined material excellent in biocompatibility, strength and flexibility by adding phosphoric acid to a chitosan liquid, adding the obtained liquid to a water-soluble calcium salt solution to produce precipitates and subjecting the produced precipitates to hydrothermal treatment to adhere calcium phosphate crystals whose C axes are oriented onto the chitosan. SOLUTION: Chitosan having 10,000-1,000,000 weight average molecular weight is dissolved in an acid such as acetic acid to obtain the chitosan liquid having around 0.01-30 wt.% chitosan concentration. Phosphoric acid or a water-soluble phosphate is added to this chitosan liquid, preferably, using the phosphoric acid solution of around 0.1-65% (in terms of P2O5) by around 0.1-420% based on the chitosan. This mixed liquid is added to the water-soluble calcium salt solution of about 0.05-30% (in terms of CaO) or CaO suspension so that CaO is 80-140% based on P2O5. The produced precipitates are dehydrated or dried to recover them and, if necessary, they are subjected to hydrothermal treatment at about 50-200 deg.C to obtain the combined material in which calcium phosphate crystals, whose C axes have less than 50 deg. orientation angle, are adhered onto the chitosan by 99/1-1/99 ratio.

4. 发明专利

JPH10127751A LACTIC ACID COMPLEX AND ITS MANUFACTURE 失效
公开(公告)号：JPH10127751A
公开(公告)日：1998-05-19
申请号：JP28882296
申请日：1996-10-30
申请人： DAINIPPON INK & CHEMICALS , NAT INST RES INORGANIC MAT
发明人： SHIKATA NORIKI , KAKIZAWA YASUTOSHI , TANAKA JUNZO , SUETSUGU YASUSHI , KIKUCHI MASANORI
IPC分类号： A61C8/00 , A61B17/00 , A61B17/58 , A61B17/88 , A61K47/30 , A61L27/00 , A61L31/00
摘要： PROBLEM TO BE SOLVED: To enhance the preserving stability and thermal stability and equipping a bone inducing ability, bone transmissive ability, and pharmaceutical agent sustained releasing property by containing in a specific weight proportion a lactic acid or a polymeride of lactic acid and a hydroxy-carboxylic acid and a deactivated polymerizing catalyst and calcium phosphate. SOLUTION: A lactic acid or polymeride A of lactic acid and a hydroxy- carboxylic acid is subjected to a deactivating process with a chelating agent or an acidic phosphoric acid ester. This inhibits decomposition of polymerides and production of lactides caused by the polymerizing catalyst, to lead to enhancement of the thermal stability. A complex body of lactic acid series is formed which contains this polymeride A and a compound B of calcium phosphate series with the ratio by weight A/B ranging 99:1 to 1:99. A too large content of polymeride A relative to the compound B reduces the modules of elasticity, while a too small makes difficult to mix and knead. Thuds a bending strength, pharmaceutical agent sustained releasing property, and tissue affinity equivalent to those of a cortex bone are obtained.

5. 发明专利

JPH04202020A PRODUCTION OF FINE POWDER OF PEROVSKITE TYPE COMPOUND 失效
公开(公告)号：JPH04202020A
公开(公告)日：1992-07-22
申请号：JP33272690
申请日：1990-11-29
申请人： NAT INST RES INORGANIC MAT
发明人： HANEDA HAJIME , TERADA HIROMI , SHIRASAKI SHINICHI , MIHASHI TAKEFUMI , TANAKA JUNZO
IPC分类号： C01G49/00 , C01G45/00 , C01G51/00 , C01G53/00
摘要： PURPOSE:To increase a specific surface area by subjecting water-soluble salts of constituent elements to alkali neutralization in an aq. medium in the presence of an oxidizing agent, depositing the hydroxides, converting them into carbonates with blown CO2 and calcining the resulting precursor. CONSTITUTION:Water-soluble salts of a rare earth element such as Y and a transition metal such as Co are dissolved in water in about 1:1 molar ratio of Y:Co to prepare a mixed aq. soln. An alkaline earth metal such as Ca may be substd. for part of the rare earth element and the water-soluble salts may be chlorides, nitrates, sulfates or acetates. H2O2 or other oxidizing agent enough to oxidize divalent metal ions present in the aq. soln. to trivalent ions at the time of deposition and NaOH or other alkali are added to the aq. soln. to obtain a slurry of hydroxides by neutralization. This slurry is heated to about 80 deg.C, aged and cooled, the hydroxides are converted into carbonates at pH9.5-7.0 by blowing CO2 and the resulting precursor is separated by filtration, washed, dried and fired to obtain fine powder of a perovskite type compd. represented by a formula ABO3 (where A is a rare earth element, an alkaline earth metal may be substd. for part of the rare earth element and B is Co, Ni, Fe or Mn as a transition metal).

6. 发明专利

JP2001198208A CALCIUM PHOSPHATE TYPE BIOCOMPATIBLE CERAMIC SINTERED BODY AND METHOD OF MANUFACTURING THE SAME 失效
公开(公告)号：JP2001198208A
公开(公告)日：2001-07-24
申请号：JP2000010943
申请日：2000-01-19
申请人： NAT INST RES INORGANIC MAT , TOSHIBA CERAMICS CO , TOSHIBA DENKO KK
发明人： TANAKA JUNZO , KIKUCHI MASANORI , IKOMA TOSHIYUKI , HOJO AKIMICHI , IMURA KOICHI , UEMOTO HIDEO , YAMAZAKI HIROSHI , KINOSHITA MASAMI , MINOWA NOBUAKI
IPC分类号： A61C13/08 , A61C13/00 , A61K6/838 , A61L27/00 , A61L31/00 , A61K6/033
摘要： PROBLEM TO BE SOLVED: To improve the initial adhesion cells and tissues. SOLUTION: A calcium phosphate biocompatible sintered body is constituted by modifying the surface of a sintered object with metal ions (e.g.; zinc ions) to arrange a polymer (e.g.; collagen) accelerating the regenerative growth of a bone on the surface of the sintered body.

7. 发明专利

JP2000302567A CALCIUM PHOSPHATE POROUS SINTERED COMPACT AND ITS PRODUCTION 失效
公开(公告)号：JP2000302567A
公开(公告)日：2000-10-31
申请号：JP10557999
申请日：1999-04-13
申请人： TOSHIBA CERAMICS CO , NAT INST RES INORGANIC MAT , TOSHIBA DENKO KK
发明人： IMURA KOICHI , UEMOTO HIDEO , HOJO AKIMICHI , TANAKA JUNZO , KIKUCHI MASANORI , SUETSUGU YASUSHI , YAMAZAKI HIROSHI , KINOSHITA MASAMI , MINOWA NOBUAKI
IPC分类号： A61L27/00 , A61K6/838 , A61L27/12 , A61L27/56 , C01B25/32 , C04B35/447 , C04B38/06 , C04B38/10 , A61K6/033
摘要： PROBLEM TO BE SOLVED: To improve mechanical strength and bio-affinity by specifying porosity, diameter of the communicating part between pores and three-point bending strength of a calcium phosphate sintere compact having a porous structure. SOLUTION: This calucium phosphate porous sintered body, having porous characteristics that the porosity is in the range of 55 to 90%, spherical pores are communicated with one another over the whole porous body, an average diameter of communicating parts between pores is not less than 50 μm, pore diameters are not less than 150 μm and the three-point bending strength is >=5 MPa, is obtained by dispersing or dissolving calcium phosphate powder and a curable organic material capable of being cured by cross-linking polymerization into a solvent to obtain a slurry, adding a foaming agent to the slurry, foaming the slurry by stirring or introducing gas into the slurry until the volume of the slurry becomes a prescribed volume to obtain a slurry in the foamed state, further adding a cross-linking agent and/or a cross-linking initiator to the resultant slurry, after mixing, pouring the slurry into a mold, subjecting the slurry to cross-linking polymerization and curing to obtain a formed body, drying the obtained formed body and finally sintering the dried formed body.

8. 发明专利

JPH10179715A BIOADAPTABLE COMPOSITE 失效
公开(公告)号：JPH10179715A
公开(公告)日：1998-07-07
申请号：JP21101297
申请日：1997-08-05
申请人： DAINIPPON INK & CHEMICALS , NAT INST RES INORGANIC MAT
发明人： SHIKATA NORIKI , KAKIZAWA YASUTOSHI , TANAKA JUNZO , SUETSUGU YASUSHI , KIKUCHI MASANORI
IPC分类号： A61K47/32 , A61L27/00 , A61L29/00 , A61L31/00
摘要： PROBLEM TO BE SOLVED: To obtain a bioadaptable composite which is useful as materials for the living bodies, such as substitution materials, joining materials and restoring materials for bones of animals inclusive of man, materials for medical treatment apparatus, such as skin terminals and catheters, and slowly medicine- releasable base materials. SOLUTION: This bioadaptable composite consists of a lactic acid-based polyester having a weight average mol.wt. of 20000 to 400000 and calcium phosphate. The weight ratio of the calcium phosphate to the lactic acid-based polyester is 99:1 to 1:99. The grain size of the calcium phosphate is 0.1 to 300μm and holes of a diameter of 10 to 1000μm exist in the composite. The lactic acid-based polyester which includes the structural units derived from a chelating agent and/or acidic phosphates and has the weight average mol.wt. of 20000 to 400000 is preferably used.

9. 发明专利

JPH06151118A MANUFACTURE OF NONLINEAR RESISTOR 失效
公开(公告)号：JPH06151118A
公开(公告)日：1994-05-31
申请号：JP31407992
申请日：1992-10-29
申请人： NAT INST RES INORGANIC MAT
发明人： HISHIDA SHUNICHI , HANEDA HAJIME , WATANABE AKIO , TANAKA JUNZO
IPC分类号： H01C7/10 , H01C17/00 , H01L21/265
摘要： PURPOSE:To provide the manufacture of a nonlinear resistor which is applicable to a hybrid IC to accurately control the distribution and the quantity of a barrier layer producting nonlinear resistance and also to deal with the demand for the miniaturization of elements. CONSTITUTION:This manufacture is characterized in that accelerated metal for forming a barrier layer and oxygen are injected together into strontium titanate compound made up into semiconductor which includes strontium titanate or the other alkali earth metal having strontium titanate as a main body by the method of ion implantation, thereby forming a barrier layer. For an agent for making up into semiconductor, a component including at least one kind or more of niobium, tantalum, tungsten, yttrium and rare metal is taken up. Bismuth is preferable to metal ions for forming a barrier and used for the absorption of the surge of an electric circuit, the removal of noise, the prevention of spark discharge and the like.

10. 发明专利

JP2000005298A METHOD FOR MANUFACTURING APATITE-COATING ORGANIC MATERIAL 失效
公开(公告)号：JP2000005298A
公开(公告)日：2000-01-11
申请号：JP18829598
申请日：1998-06-17
申请人： NAT INST RES INORGANIC MAT , NITTA GELATIN KK
发明人： TANAKA JUNZO , RI SOKUN , SATO KIMIYASU , KIKUCHI MASANORI , MORIMURA MASAHIRO , NAKATANI SHINICHI , BANDAI YOSHINOBU
IPC分类号： A61L27/00
摘要： PROBLEM TO BE SOLVED: To form an apatite layer under moderate conditions by soaking an organic material having a hydrophilic group in a solution including at least phosphate ion, calcium ion, and an organic acid to precipitate apatite on the surface of the organic material. SOLUTION: An organic acid is included in a solution including at least phosphate ion and calcium ion. A rate of forming apatite is increased to start precipitation. A polybasic acid such as citric acid having more than two carboxy groups is used as the organic acid. A substrate including an organic material having a hydrophilic group, such as at least collagen and/or cellulose, is soaked in the aqueous solution. The apatite is precipitated along collagen fibers of the surface of the organic material thereby to obtain an apatite layer under moderate conditions.

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