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1. 发明申请

US20100099654A1 FATTY ACID ESTERS OF GLUCOCORTICOIDS AS ANTI-INFLAMMATORY AND ANTI-CANCER AGENTS 有权
标题翻译：作为抗炎剂和抗癌剂的葡萄糖苷的脂肪酸
公开(公告)号：US20100099654A1
公开(公告)日：2010-04-22
申请号：US12531214
申请日：2008-03-13
申请人： Myhren Finn , Marit Liland Sandvold , Ole Henrik Eriksen , Steinar Hagen
发明人： Myhren Finn , Marit Liland Sandvold , Ole Henrik Eriksen , Steinar Hagen
IPC分类号： A61K31/56 , C07J3/00 , C07J71/00 , A61P11/00 , A61P35/00 , A61P29/00
CPC分类号： C07J31/006 , C07J71/0031
摘要： The present invention relates to certain unsaturated fatty acid derivatives of therapeutically active glucocorticoides-fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents and pharmaceutical formulations containing them.
摘要翻译：本发明涉及作为抗炎剂和抗癌剂的糖皮质激素的治疗活性的糖皮质激素 - 脂肪酸酯的某些不饱和脂肪酸衍生物和含有它们的药物制剂。

2. 发明授权

US09428540B2 Fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents 有权
标题翻译：糖皮质激素的脂肪酸酯作为抗炎剂和抗癌剂
公开(公告)号：US09428540B2
公开(公告)日：2016-08-30
申请号：US12531214
申请日：2008-03-13
申请人： Finn Myhren , Marit Liland Sandvold , Ole Henrik Eriksen , Steinar Hagen
发明人： Finn Myhren , Marit Liland Sandvold , Ole Henrik Eriksen , Steinar Hagen
IPC分类号： A61K31/335 , C07J71/00 , C07J31/00
CPC分类号： C07J31/006 , C07J71/0031
摘要： The present invention relates to certain unsaturated fatty acid derivatives of therapeutically active glucocorticoides-fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer agents and pharmaceutical formulations containing them.
摘要翻译：本发明涉及作为抗炎剂和抗癌剂的糖皮质激素的治疗活性的糖皮质激素 - 脂肪酸酯的某些不饱和脂肪酸衍生物和含有它们的药物制剂。

3. 发明授权

US08349834B2 Dioxolane derivates for the treatment of cancer 有权
标题翻译：二恶烷衍生物用于治疗癌症
公开(公告)号：US08349834B2
公开(公告)日：2013-01-08
申请号：US12305338
申请日：2006-12-07
申请人： Finn Myhren , Marit Liland Sandvold , Steinar Hagen , Ole Henrik Eriksen
发明人： Finn Myhren , Marit Liland Sandvold , Steinar Hagen , Ole Henrik Eriksen
IPC分类号： A01N43/64 , A01N43/66 , A61K31/53 , C07F9/02 , C07D473/00
CPC分类号： C07D405/04
摘要： This invention relates to certain unsaturated fatty acid derivatives of therapeutically active 1,3-dioxolane nucleoside analogues and to pharmaceutical formulations containing them. The said derivatives fall within formula (I). Compounds of formula (I) can be used in the treatment of a cancerous disease, including solid tumors and haematological cancers such as leukaemias, lymphomas and multiple myelomas.
摘要翻译：本发明涉及治疗活性1,3-二氧戊环核苷类似物的某些不饱和脂肪酸衍生物和含有它们的药物制剂。所述衍生物属于式（I）。式（I）化合物可用于治疗癌性疾病，包括实体瘤和血液病，如白血病，淋巴瘤和多发性骨髓瘤。

4. 发明申请

US20100062996A1 DIOXOLANE DERIVATES FOR THE TREATMENT OF CANCER 有权
标题翻译：用于治疗癌症的二恶唑衍生物
公开(公告)号：US20100062996A1
公开(公告)日：2010-03-11
申请号：US12305338
申请日：2006-12-07
申请人： Finn Myhren , Marit Liland Sandvold , Steinar Hagen , Ole Henrik Eriksen
发明人： Finn Myhren , Marit Liland Sandvold , Steinar Hagen , Ole Henrik Eriksen
IPC分类号： A61K31/7068 , C07H19/06 , A61P35/00
CPC分类号： C07D405/04
摘要： This invention relates to certain unsaturated fatty acid derivatives of therapeutically active 1,3-dioxolane nucleoside analogues and to pharmaceutical formulations containing them. The said derivatives are referred to as “Compounds of formula (I)” herein. Compounds of formula (I) can be used in the treatment of a cancerous disease. Treatment of both solid tumours and haematological cancers such as leukaemias, lymphomas and multiple myelomas are included.
摘要翻译：本发明涉及治疗活性1,3-二氧戊环核苷类似物的某些不饱和脂肪酸衍生物和含有它们的药物制剂。所述衍生物在本文中称为“式（I）的化合物”。式（I）化合物可用于治疗癌性疾病。包括实体肿瘤和血液学癌症如白血病，淋巴瘤和多发性骨髓瘤的治疗。

5. 发明授权

US06420028B1 Coated polymer article and its use 有权
标题翻译：涂层聚合物制品及其用途
公开(公告)号：US06420028B1
公开(公告)日：2002-07-16
申请号：US09446672
申请日：1999-12-22
申请人： Steinar Hagen , Rune Ringberg , Geir Fonnum
发明人： Steinar Hagen , Rune Ringberg , Geir Fonnum
IPC分类号： B32B516
CPC分类号： B01J20/287 , B01J20/267 , B01J20/3208 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3251 , B01J2220/54 , Y10T428/2991 , Y10T428/2998 , Y10T428/31913 , Y10T428/31928
摘要： A polymer article having structure (I), where P comprises the basic polymer and groups —L—CH(—X(R1)p)—CH2(—Y(R2)p); L is a part of a pending group utilized for introducing —X(R1)p and —Y(R2)p; X and Y are halogen, N, S and O; R1 is hydrogen, alkyl, acyl or R2 when X is N, O or S; R2 is hydrogen, alkyl, alkylaryl or arylalkyl in which the alkyl part may contain 1-18 carbons, or —R3(—NH—CR4═O)q or —R3(—NH2)q, —CR4═O or poly alkyloxy that may have been terminally acylated or alkylated; p is an integer 0-3, with the provisos a) p depends on X being halogen, O, S or N, and b) that if several groups R2 are present they may be identical or different; R3 is alkyl, —O-alkyl, hydroxyalkyl, phenylalkyl, with up to 18 carbon atoms in the alkyl part, and R4 is C1-18 alkyl. q is an integer>O representing that one or more hydrogens in R3 may have been replaced with —NH2 or —NH—CR4═O. The polymer article may be used as a chromatography separation medium or in solide phase oligonucleotide synthesis.
摘要翻译：具有结构（I）的聚合物制品，其中P包含碱性聚合物和基团-L-CH（-X（R 1）p）-CH 2（-Y（R 2）p）; L是用于引入-X（R1）p和-Y（R2）p的待决基团的一部分; X和Y是卤素，N，S和O; 当X为N，O或S时，R1为氢，烷基，酰基或R2; R2是氢，烷基，烷基芳基或芳烷基，其中烷基部分可以含有1-18个碳，或-R3（-NH-CR4 = O）q或-R3（-NH2）q，-CR4 = O或聚烷氧基，其中可能已被终止酰化或烷基化; p是0-3的整数，条件是a）p取决于X是卤素，O，S或N，和b）如果存在几个基团R2，它们可以相同或不同; R3是烷基，烷基，-O-烷基，羟基烷基，苯基烷基，在烷基部分具有至多18个碳原子，R4是C1-18烷基。 q是整数> O，表示R3中的一个或多个氢可以被-NH 2或-NH-CR 4 = O代替。聚合物制品可用作色谱分离介质或溶剂相寡核苷酸合成。

6. 发明授权

US06569911B1 Manufacturing method and article produced by the method 失效
标题翻译：该方法制作方法和制作方法
公开(公告)号：US06569911B1
公开(公告)日：2003-05-27
申请号：US09743296
申请日：2001-03-05
申请人： Torunn Arntsen , Jan Roger Karlson , Geir Fonnum , Steinar Hagen
发明人： Torunn Arntsen , Jan Roger Karlson , Geir Fonnum , Steinar Hagen
IPC分类号： C08J936
CPC分类号： B01J20/28042 , B01D15/08 , B01D15/361 , B01D15/3804 , B01J20/28004 , B01J20/28016 , B01J20/28078 , G01N2030/528
摘要： A method of manufacturing a support media from a cross-linked polymerisate based on vinyl compounds, and exhibiting residual vinyl groups. The characteristic feature of the method is that the polymerisate is subjected to a heating step that preferably is carried out under reduced access of oxygen. The use of the support media is also described.
摘要翻译：一种由基于乙烯基化合物的交联聚合物制备载体介质并显示残余乙烯基的方法。该方法的特征在于聚合物经受加热步骤，优选在氧气的进入下进行。还描述了使用支持介质。

7. 发明申请

US20070135436A1 Chemical compounds 审中-公开
标题翻译：化合物
公开(公告)号：US20070135436A1
公开(公告)日：2007-06-14
申请号：US11305344
申请日：2005-12-19
申请人： Finn Myhren , Marit Sandvold , Steinar Hagen , Ole Eriksen
发明人： Finn Myhren , Marit Sandvold , Steinar Hagen , Ole Eriksen
IPC分类号： A61K31/522 , A61K31/52 , A61K31/53 , A61K31/513 , C07D473/12 , C07D407/02
CPC分类号： C07D405/04
摘要： This invention relates to certain unsaturated fatty acid derivatives of therapeutically active 1,3-dioxolane nucleoside analogues and to pharmaceutical formulations containing them. The said derivatives are referred to as “Compounds of formula I” herein. Compounds of formula I can be used in the treatment of a cancerous disease. Treatment of both solid tumours and haematological cancers such as leukaemias, lymphomas and multiple myelomas are included.
摘要翻译：本发明涉及治疗活性1,3-二氧戊环核苷类似物的某些不饱和脂肪酸衍生物和含有它们的药物制剂。所述衍生物在本文中称为“式I化合物”。式I化合物可用于治疗癌性疾病。包括实体肿瘤和血液学癌症如白血病，淋巴瘤和多发性骨髓瘤的治疗。

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