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1. 发明申请

US20090270455A1 Therapeutic agent for intestinal diseases and visceral pain 审中-公开
标题翻译：肠道疾病和内脏痛的治疗剂
公开(公告)号：US20090270455A1
公开(公告)日：2009-10-29
申请号：US12458317
申请日：2009-07-08
申请人： Munetaka Tokumasu , Masaki Hashimoto , Tetsuo Yano , Hideki Matsumoto , Shinichi Fujita , Tetsuya Seki , Sayaka Asari , Naoyuki Fukuchi , Kazuyoshi Takahashi , Masataka Shoji
发明人： Munetaka Tokumasu , Masaki Hashimoto , Tetsuo Yano , Hideki Matsumoto , Shinichi Fujita , Tetsuya Seki , Sayaka Asari , Naoyuki Fukuchi , Kazuyoshi Takahashi , Masataka Shoji
IPC分类号： A61K31/454 , A61P1/00
CPC分类号： A61K31/454
摘要： The present invention relates to a therapeutic agent for irritable bowel syndrome of diarrhea type, ulcerative colitis, visceral pain or abdominal pain, which contains a compound of the following formula and which has 5-HT7 receptor antagonistic effect or an analogue thereof; and this therapeutic agent has an excellent therapeutic effect and a high safety:
摘要翻译：本发明涉及含有下式化合物，具有5-HT7受体拮抗作用或其类似物的腹泻型肠易激综合征，溃疡性结肠炎，内脏痛或腹痛的治疗剂。该治疗剂具有优异的治疗效果和高安全性：

2. 发明申请

US20050148632A1 Therapeutic agent for intestinal diseases and visceral pain 审中-公开
标题翻译：肠道疾病和内脏痛的治疗剂
公开(公告)号：US20050148632A1
公开(公告)日：2005-07-07
申请号：US11052735
申请日：2005-02-07
申请人： Munetaka Tokumasu , Masaki Hashimoto , Tetsuo Yano , Hideki Matsumoto , Shinichi Fujita , Tetsuya Seki , Sayaka Asari , Naoyuki Fukuchi , Kazuyoshi Takahashi , Masataka Shoji
发明人： Munetaka Tokumasu , Masaki Hashimoto , Tetsuo Yano , Hideki Matsumoto , Shinichi Fujita , Tetsuya Seki , Sayaka Asari , Naoyuki Fukuchi , Kazuyoshi Takahashi , Masataka Shoji
IPC分类号： A61K31/445 , A61K31/454 , A61P1/00 , A61P1/04 , A61P29/00 , A61P43/00
CPC分类号： A61K31/454
摘要： The present invention relates to a therapeutic agent for irritable bowel syndrome of diarrhea type, ulcerative colitis, visceral pain or abdominal pain, which contains a compound of the following formula and which has 5-HT7 receptor antagonistic effect or an analogue thereof; and this therapeutic agent has an excellent therapeutic effect and a high safety:
摘要翻译：本发明涉及含有下式化合物，具有5-HT7受体拮抗作用或其类似物的腹泻型肠易激综合征，溃疡性结肠炎，内脏痛或腹痛的治疗剂。该治疗剂具有优异的治疗效果和高安全性：

3. 发明申请

US20070021460A1 Novel piperidine derivative 失效
标题翻译：新型哌啶衍生物
公开(公告)号：US20070021460A1
公开(公告)日：2007-01-25
申请号：US10557353
申请日：2004-05-19
申请人： Shingo Makino , Naoyuki Fukuchi , Sayaka Asari , Masaki Hashimoto , Tetsuo Yano , Youji Yamada , Munetaka Tokumasu , Masataka Shoji , Itsuya Tanabe , Shinichi Fujita , Hideki Matsumoto
发明人： Shingo Makino , Naoyuki Fukuchi , Sayaka Asari , Masaki Hashimoto , Tetsuo Yano , Youji Yamada , Munetaka Tokumasu , Masataka Shoji , Itsuya Tanabe , Shinichi Fujita , Hideki Matsumoto
IPC分类号： C07D211/26 , C07D211/28 , A61K31/445
CPC分类号： C07D211/70
摘要： The present invention provides a piperidine derivative represented by the following formula or analogs thereto, which are used for agents for treating or preventing various diseases related to 5-HT7.
摘要翻译：本发明提供由下式表示的哌啶衍生物或其类似物，其用于治疗或预防与5-HT7相关的各种疾病的药剂。

4. 发明授权

US07683077B2 Piperidine derivative 失效
标题翻译：哌啶衍生物
公开(公告)号：US07683077B2
公开(公告)日：2010-03-23
申请号：US10557353
申请日：2004-05-19
申请人： Shingo Makino , Naoyuki Fukuchi , Sayaka Asari , Masaki Hashimoto , Tetsuo Yano , Youji Yamada , Munetaka Tokumasu , Masataka Shoji , Itsuya Tanabe , Shinichi Fujita , Hideki Matsumoto
发明人： Shingo Makino , Naoyuki Fukuchi , Sayaka Asari , Masaki Hashimoto , Tetsuo Yano , Youji Yamada , Munetaka Tokumasu , Masataka Shoji , Itsuya Tanabe , Shinichi Fujita , Hideki Matsumoto
IPC分类号： A61K31/445 , C07D211/08 , C07D211/22 , C07D211/20
CPC分类号： C07D211/70
摘要： The present invention provides a piperidine derivative represented by the following formula or analogs thereto, which are used for agents for treating or preventing various diseases related to 5-HT7.
摘要翻译：本发明提供由下式表示的哌啶衍生物或其类似物，其用于治疗或预防与5-HT7相关的各种疾病的药剂。

5. 发明申请

US20050076398A1 Animal model of chronic stress diseases and method for producing the same 审中-公开
标题翻译：慢性应激疾病动物模型及其制备方法
公开(公告)号：US20050076398A1
公开(公告)日：2005-04-07
申请号：US10998832
申请日：2004-11-30
申请人： Kazuyoshi Takahashi , Miroslav Smriga , Masaki Hashimoto , Tetsuo Yano , Hisayuki Uneyama , Kunio Torii
发明人： Kazuyoshi Takahashi , Miroslav Smriga , Masaki Hashimoto , Tetsuo Yano , Hisayuki Uneyama , Kunio Torii
IPC分类号： A01K67/02 , A61K49/00 , A61P25/00 , A61P43/00 , G01N33/50 , A01K67/027
CPC分类号： G01N33/5088 , A01K67/02 , A61K49/0008
摘要： The present invention provides animal model of chronic stress diseases produced by feeding lysine deficient diet to the animals and a method for producing the animal model. The effect of medicine on chronic stress diseases can be judged with the animal model. Effective compounds in preventing chronic stress diseases and/or treating patients suffering from chronic stress diseases can be screened by using the animal model.
摘要翻译：本发明提供通过向动物喂养赖氨酸缺乏饮食而产生的慢性应激疾病的动物模型和用于生产动物模型的方法。药物对慢性应激疾病的影响可以用动物模型来判断。可以通过使用动物模型来筛选预防慢性应激疾病和/或治疗患有慢性应激疾病的患者的有效化合物。

6. 发明授权

US08168669B2 Therapeutic agent for inflammatory bowel disease and TNF-α production inhibitor 有权
标题翻译：炎症性肠病和TNF-α产生抑制剂的治疗剂
公开(公告)号：US08168669B2
公开(公告)日：2012-05-01
申请号：US12491698
申请日：2009-06-25
申请人： Hideki Matsumoto , Tomohisa Okutsu , Tomoko Takeda , Hideki Suzuki , Tetsuo Yano , Masaki Hashimoto , Miho Ono , Manabu Suzuki
发明人： Hideki Matsumoto , Tomohisa Okutsu , Tomoko Takeda , Hideki Suzuki , Tetsuo Yano , Masaki Hashimoto , Miho Ono , Manabu Suzuki
IPC分类号： A61K31/197 , A61K31/4172 , A61K31/4184
CPC分类号： A61K31/198 , A61K31/405 , A61K31/4172 , Y02A50/411 , A61K2300/00
摘要： Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-α production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.
摘要翻译：公开了用于治疗或预防炎症性肠病的药剂。还公开了抑制TNF-α产生的药剂。包含至少一种选自赖氨酸，组氨酸，苯丙氨酸，甲硫氨酸，色氨酸，谷氨酰胺，甘氨酸，半胱氨酸，胱氨酸和苏氨酸的氨基酸的炎症性肠病治疗或预防剂，所述氨基酸以每日0.1〜4000mg / kg; 和包含选自组氨酸，苯丙氨酸和色氨酸的氨基酸的TNF-α产生抑制剂，所述氨基酸以每天0.1至4000mg / kg的剂量施用。

7. 发明申请

US20080108684A1 THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASE AND TNF-ALFA PRODUCTION INHIBITOR 审中-公开
标题翻译：炎症性皮肤病和TNF-ALFA生产抑制剂治疗剂
公开(公告)号：US20080108684A1
公开(公告)日：2008-05-08
申请号：US11968343
申请日：2008-01-02
申请人： HIDEKI MATSUMOTO , Tomohisa Okutsu , Tomoko Takeda , Hideki Suzuki , Tetsuo Yano , Masaki Hashimoto , Miho Ono , Manabu Suzuki
发明人： HIDEKI MATSUMOTO , Tomohisa Okutsu , Tomoko Takeda , Hideki Suzuki , Tetsuo Yano , Masaki Hashimoto , Miho Ono , Manabu Suzuki
IPC分类号： A61K31/4172 , A61K31/405 , A61K31/198
CPC分类号： A61K31/198 , A61K31/405 , A61K31/4172 , Y02A50/411 , A61K2300/00
摘要： Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-α production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.
摘要翻译：公开了用于治疗或预防炎症性肠病的药剂。还公开了抑制TNF-α产生的药剂。包含至少一种选自赖氨酸，组氨酸，苯丙氨酸，甲硫氨酸，色氨酸，谷氨酰胺，甘氨酸，半胱氨酸，胱氨酸和苏氨酸的氨基酸的炎症性肠病治疗或预防剂，所述氨基酸以每日0.1〜4000mg / kg; 和包含选自组氨酸，苯丙氨酸和色氨酸的氨基酸的TNF-α产生抑制剂，所述氨基酸以每天0.1至4000mg / kg的剂量施用。

8. 发明申请

US20100076044A1 THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASE AND TNF-ALPHA PRODUCTION INHIBITOR 有权
标题翻译：炎症性皮肤病和TNF-ALPHA生产抑制剂的治疗剂
公开(公告)号：US20100076044A1
公开(公告)日：2010-03-25
申请号：US12491698
申请日：2009-06-25
申请人： Hideki MATSUMOTO , Tomohisa Okutsu , Tomoko Takeda , Hideki Suzuki , Tetsuo Yano , Masaki Hashimoto , Miho Ono , Manabu Suzuki
发明人： Hideki MATSUMOTO , Tomohisa Okutsu , Tomoko Takeda , Hideki Suzuki , Tetsuo Yano , Masaki Hashimoto , Miho Ono , Manabu Suzuki
IPC分类号： A61K31/197 , A61K31/405 , A61K31/4164 , A61P1/00
CPC分类号： A61K31/198 , A61K31/405 , A61K31/4172 , Y02A50/411 , A61K2300/00
摘要： Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-α production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.
摘要翻译：公开了用于治疗或预防炎症性肠病的药剂。还公开了抑制TNF-α产生的药剂。包含至少一种选自赖氨酸，组氨酸，苯丙氨酸，甲硫氨酸，色氨酸，谷氨酰胺，甘氨酸，半胱氨酸，胱氨酸和苏氨酸的氨基酸的炎症性肠病治疗或预防剂，所述氨基酸以每日0.1〜4000mg / kg; 和包含选自组氨酸，苯丙氨酸和色氨酸的氨基酸的TNF-α产生抑制剂，所述氨基酸以每天0.1至4000mg / kg的剂量施用。

9. 发明申请

US20120329846A1 THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASE AND TNF-ALPHA PRODUCTION INHIBITOR 审中-公开
标题翻译：炎症性皮肤病和TNF-ALPHA生产抑制剂的治疗剂
公开(公告)号：US20120329846A1
公开(公告)日：2012-12-27
申请号：US13431183
申请日：2012-03-27
申请人： Hideki Matsumoto , Tomohisa Okutsu , Tomoko Takeda , Hideki Suzuki , Tetsuo Yano , Masaki Hashimoto , Miho Ono , Manabu Suzuki
发明人： Hideki Matsumoto , Tomohisa Okutsu , Tomoko Takeda , Hideki Suzuki , Tetsuo Yano , Masaki Hashimoto , Miho Ono , Manabu Suzuki
IPC分类号： A61K31/198 , C07D233/64 , C07C323/58 , C07D209/16 , C07C229/24 , A61P29/00 , C07C229/36 , A61K31/4172 , A61K31/195 , A61K31/405 , A61P1/00 , C07C229/26 , C07C229/08
CPC分类号： A61K31/198 , A61K31/405 , A61K31/4172 , Y02A50/411 , A61K2300/00
摘要： Disclosed is an agent for use in the treatment or prevention of inflammatory bowel disease. Also disclosed is an agent for inhibiting the production of TNF-α. A therapeutic or prophylactic agent for inflammatory bowel disease comprising at least one amino acid selected from the group consisting of lysine, histidine, phenylalanine, methionine, tryptophan, glutamine, glycine, cysteine, cystine and threonine, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day; and a TNF-α production inhibitor comprising an amino acid selected from the group consisting of histidine, phenylalanine and tryptophan, the amino acid being administered at a dose of 0.1 to 4000 mg/kg per day.
摘要翻译：公开了用于治疗或预防炎症性肠病的药剂。还公开了抑制TNF-α产生的药剂。包含至少一种选自赖氨酸，组氨酸，苯丙氨酸，甲硫氨酸，色氨酸，谷氨酰胺，甘氨酸，半胱氨酸，胱氨酸和苏氨酸的氨基酸的炎症性肠病治疗或预防剂，所述氨基酸以每日0.1〜4000mg / kg; 和包含选自组氨酸，苯丙氨酸和色氨酸的氨基酸的TNF-α产生抑制剂，所述氨基酸以每天0.1至4000mg / kg的剂量施用。

10. 发明申请

US20070249717A1 PREVENTIVE/THERAPEUTIC AGENT FOR VISCERAL PAIN 审中-公开
标题翻译：用于粘膜疼痛的预防/治疗剂
公开(公告)号：US20070249717A1
公开(公告)日：2007-10-25
申请号：US11740541
申请日：2007-04-26
申请人： Tetsuo Yano , Masaki Hashimoto , Smriga Miroslav , Hisayuki Uneyama , Kunio Torii
发明人： Tetsuo Yano , Masaki Hashimoto , Smriga Miroslav , Hisayuki Uneyama , Kunio Torii
IPC分类号： A61K31/198
CPC分类号： A61K31/198 , A23L33/175
摘要： The present invention provides an agent for the prophylaxis or treatment of visceral pain associated with gastrointestinal tract diseases, which contains lysine. Using the prophylactic or therapeutic agent, gastrointestinal tract diseases accompanying visceral pain, such as intestinal disorder, irritable bowel syndrome, functional dyspepsia, gastro esophageal disease, functional abdominal pain syndrome, ulcerative colitis and Crohn's disease and the like can be lo treated or prevented. In addition, pharmaceutical agent, food and drink and dietary supplement for the prophylaxis or treatment of visceral pain associated with such gastrointestinal tract diseases are provided. They are highly effective for visceral pain associated with gastrointestinal tract diseases as compared to existing pharmaceutical agents, show reduced side effects, and are highly effective.
摘要翻译：本发明提供了用于预防或治疗与包含赖氨酸的胃肠道疾病相关的内脏疼痛的药剂。使用预防或治疗剂，可以治疗或预防伴随内脏痛，诸如肠障，肠易激综合征，功能性消化不良，胃食管疾病，功能性腹痛综合征，溃疡性结肠炎和克罗恩病等的胃肠道疾病。此外，还提供了用于预防或治疗与这种胃肠道疾病相关的内脏痛的药剂，食物和饮料和膳食补充剂。与现有的药剂相比，它们与胃肠道疾病相关的内脏痛具有高度的效果，显示出减少的副作用，并且是非常有效的。

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