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    • 5. 发明授权
    • Optical module manufacturing and testing systems and methods
    • 光模块制造和测试系统及方法
    • US08233215B2
    • 2012-07-31
    • US12542899
    • 2009-08-18
    • Jun Bao
    • Jun Bao
    • H04B10/08H04B10/17G02B6/46
    • H01S3/06704
    • The present disclosure relates to streamlining optical module and/or subassembly development, manufacturing, and testing through introducing a memory component within a module and/or subassembly that is utilized with a host module for system calibration and/or configuration. In an exemplary embodiment, the present invention can streamline optical amplifier (EDFA) module and/or subassembly development, manufacturing, and testing. The present invention includes an optical module/sub-assembly without control circuitry, i.e. a “dumb module”, but with a memory that is used to load relevant data from a supplier. This data is utilized to calibrate, test, and configure the optical module/sub-assembly in a host module. The host module includes control circuitry to access this memory in the optical module/sub-assembly and to calibrate, test, configure, and control the optical module/sub-assembly. Advantageously, this additional memory reduces manufacturing time without the disadvantage of adding complexity in the optical module/sub-assembly.
    • 本公开涉及通过在与主机模块一起用于系统校准和/或配置的模块和/或子组件中引入存储器组件来简化光学模块和/或子组件开发,制造和测试。 在示例性实施例中,本发明可以简化光放大器(EDFA)模块和/或子组件开发,制造和测试。 本发明包括没有控制电路的光学模块/子组件,即“哑模块”,但是具有用于从供应商加载相关数据的存储器。 该数据用于校准,测试和配置主机模块中的光模块/子组件。 主机模块包括用于访问光学模块/子组件中的该存储器并且校准,测试,配置和控制光学模块/子组件的控制电路。 有利地,该附加存储器减少了制造时间,而没有增加光学模块/子组件的复杂性的缺点。
    • 6. 发明申请
    • Fusion Protein Inhibiting Osteoclast Formation, Preparation Method and Medicine Compositions Thereof
    • 融合蛋白抑制破骨细胞形成,制备方法和药物组合物
    • US20110243944A1
    • 2011-10-06
    • US13123235
    • 2009-09-29
    • Jun BaoHaiming ChenDaocheng Zhu
    • Jun BaoHaiming ChenDaocheng Zhu
    • A61K39/395C07H21/04C07K19/00C12P21/02A61P19/08A61P19/10
    • C07K14/70575A61K38/00C07K2319/30
    • The present invention provides a coding gene having the nucleic acid sequence shown as SEQ ID NO:1 and the fusion protein RIG (SEQ ID NO:2) that inhibits osteoclast formation. The present invention also provides the preparation method for the fusion protein RIG as well as synthetic oligo-nucleotide primers, plasmids and host cells used in the method and a medicine having the above fusion protein RIG as active ingredient. The fusion protein RIG in present invention is derived from humanized immunoglobulin and RANKL with a flexible hinge region. RIG can cross link the cell surface receptor RANK and Fcγ 1 to induce a cytosolic inhibitory signal leading to the inhibition of osteoclast formation. The fusion protein RIG in present invention can play an essential role in treating osteoporosis and bone resorption diseases caused by tumor metastasis.
    • 本发明提供具有SEQ ID NO:1所示的核酸序列和抑制破骨细胞形成的融合蛋白RIG(SEQ ID NO:2)的编码基因。 本发明还提供了融合蛋白RIG的制备方法以及该方法中使用的合成寡核苷酸引物,质粒和宿主细胞以及具有上述融合蛋白RIG作为活性成分的药物。 本发明的融合蛋白RIG衍生自具有柔性铰链区的人源化免疫球蛋白和RANKL。 RIG可以将细胞表面受体RANK和Fcγ1交联以诱导抑制破骨细胞形成的细胞溶质抑制信号。 本发明的融合蛋白RIG可以在治疗由肿瘤转移引起的骨质疏松症和骨吸收疾病中发挥重要作用。
    • 10. 发明授权
    • Systems and methods reducing coherence effect in narrow line-width light sources
    • 系统和方法降低窄线宽光源的相干效应
    • US09140624B2
    • 2015-09-22
    • US13541146
    • 2012-07-03
    • Jun BaoMichael Haidar ShahineHua JiaoJean-Luc Archambault
    • Jun BaoMichael Haidar ShahineHua JiaoJean-Luc Archambault
    • G01N21/55G01M11/00
    • G01M11/3118G01N21/55
    • Systems and methods are described for reducing coherence effect in narrow line-width light sources through various modulation techniques. The systems and methods can include a narrow line-width laser source with a thermoelectric cooler thermally coupled thereto and a controller communicatively coupled to the thermoelectric cooler. The controller is configured to provide a varied input signal to the thermoelectric cooler to reduce coherence of the narrow line-width laser source by artificially broadening the narrow line-width on a time averaged basis. The systems and methods can also include direct modulation of the narrow line-width laser source. The systems and methods can include a narrow line-width Optical Time Domain Reflectometer (OTDR). The systems and methods can also include direct modulation of the narrow line-width laser source with or without the varied input signal to the thermoelectric cooler.
    • 描述了通过各种调制技术降低窄线宽光源的相干效应的系统和方法。 该系统和方法可以包括具有热耦合到其上的热电冷却器的窄线宽激光源和通信地耦合到热电冷却器的控制器。 控制器被配置为向热电冷却器提供变化的输入信号,以通过以时间平均的方式人为地加宽窄线宽来减小窄线宽激光源的相干性。 系统和方法还可以包括对窄线宽激光源的直接调制。 系统和方法可以包括窄线宽光时域反射计(OTDR)。 这些系统和方法还可以包括对具有或不具有到热电冷却器的变化的输入信号的窄线宽激光源的直接调制。