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1. 发明授权

US06777427B2 Tetrahydroquinoline compounds 失效
标题翻译：四氢喹啉化合物
公开(公告)号：US06777427B2
公开(公告)日：2004-08-17
申请号：US10380589
申请日：2003-03-13
申请人： Motonori Miyakawa , Seiji Amano , Misa Kamei , Keigo Hanada , Kazuyuki Furuya , Noriko Yamamoto
发明人： Motonori Miyakawa , Seiji Amano , Misa Kamei , Keigo Hanada , Kazuyuki Furuya , Noriko Yamamoto
IPC分类号： A61K3147
CPC分类号： C07D215/233 , A61K31/47 , C07D215/36 , C07D215/42 , C07D215/44 , C07D215/48 , C07D401/04 , C07F7/1804
摘要： Tetrahydroquinoline compounds of general formula (I) or pharmacologically acceptable salts thereof, which have a specific and strong binding affinity for AR, exhibit AR agonism or antagonism, have therapeutic effects on AR-mediated diseases, particularly by not acting excessively on the prostate as AR agonists, but by showing potent action on skeletal muscle tissue and bone tissue; and pharmaceutical compositions comprising the compounds or the salts as active ingredients:
摘要翻译：对AR具有特异性和强结合亲和力的通式（I）的四氢喹啉化合物或其药理学上可接受的盐表现出AR激动作用或拮抗作用，对AR介导的疾病具有治疗作用，特别是通过不作为过度作用于AR的前列腺激动剂，但通过显示对骨骼肌组织和骨组织的有效作用; 以及包含所述化合物或所述盐作为活性成分的药物组合物：

2. 发明申请

US20060128737A1 Androgen receptor agonists 审中-公开
标题翻译：雄激素受体激动剂
公开(公告)号：US20060128737A1
公开(公告)日：2006-06-15
申请号：US10518405
申请日：2003-06-19
申请人： Motonori Miyakawa , Yuji Sumita , Kazuyuki Furuya , Kiyonoshin Ichikawa , Noriko Yamamoto , Seiji Amano , Hiroaki Nejishima , Keigo Hanada
发明人： Motonori Miyakawa , Yuji Sumita , Kazuyuki Furuya , Kiyonoshin Ichikawa , Noriko Yamamoto , Seiji Amano , Hiroaki Nejishima , Keigo Hanada
IPC分类号： A61K31/4741 , A61K31/473 , C07D491/02
CPC分类号： C07D263/58 , A61K31/473 , A61K31/4741 , A61K31/497 , C07D215/18 , C07D215/48 , C07D221/16 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D491/04
摘要： The present invention provides nonsteroidal tetrahydroquinoline derivatives of general formula (I) or salts thereof: (R1, R2, X, Y, Z and m are as defined in claim 1) which show no excessive action on the prostate but show a particularly potent androgen receptor agonistic action on skeletal muscle tissue and bone tissue, as well as pharmaceuticals comprising such derivatives or their salts as active ingredients.
摘要翻译：本发明提供通式（I）的非甾族四氢喹啉衍生物或其盐：（R 1，R 2，X，Y，Z和m如权利要求中所定义） 1），其对前列腺没有过度作用，但对骨骼肌组织和骨组织表现出特别有效的雄激素受体激动作用，以及包含这些衍生物或其盐作为活性成分的药物。

3. 发明授权

US07037919B1 Tetrahydroquinoline derivatives 失效
标题翻译：四氢喹啉衍生物
公开(公告)号：US07037919B1
公开(公告)日：2006-05-02
申请号：US10110636
申请日：2000-10-06
申请人： Keigo Hanada , Kazuyuki Furuya , Kiyoshi Inoguchi , Motonori Miyakawa , Naoya Nagata
发明人： Keigo Hanada , Kazuyuki Furuya , Kiyoshi Inoguchi , Motonori Miyakawa , Naoya Nagata
IPC分类号： A61K31/473 , A61K31/4741 , A61K31/4745 , C07D221/06 , C07D491/048
CPC分类号： C07D221/16
摘要： Tetrahydroquinoline derivatives of general formula (I) or salts thereof, having a specific and strong binding affinity for AR and exhibiting AR agonism or antagonism; and pharmaceutical compositions containing the derivatives or the salts.
摘要翻译：通式（I）的四氢喹啉衍生物或其盐对AR具有特异性和强结合亲和力并表现出AR激动作用或拮抗作用; 和含有衍生物或盐的药物组合物。

4. 发明授权

US08927493B2 Promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue 有权
标题翻译：肌腱 - 骨连接组织或韧带 - 骨连接组织再生的启动子
公开(公告)号：US08927493B2
公开(公告)日：2015-01-06
申请号：US13123091
申请日：2009-10-08
申请人： Katsuro Tomita , Hiroyuki Tsuchiya , Katsuhiko Kitaoka , Junsuke Nakase , Keigo Hanada , Kunio Matsumoto
发明人： Katsuro Tomita , Hiroyuki Tsuchiya , Katsuhiko Kitaoka , Junsuke Nakase , Keigo Hanada , Kunio Matsumoto
IPC分类号： A61K38/18 , C07K14/475 , A61P19/00 , A61P19/04 , A61K48/00
CPC分类号： A61K38/1833 , A61K48/00 , C07K14/4753
摘要： An object of the present invention is to provide a drug for promoting the regeneration of tendon-bone junction tissue or ligament-bone junction tissue. The present invention relates to a promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue including the following (1) or (2) as an active ingredient: (1) the following (1-a), (1-b), or (1-c) (1-a) HGF protein, (1-b) a partial peptide of HGF protein, the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, (1-c) a salt of (1-a) or (1-b); (2) DNA including the following (2-a), (2-b), or (2-c), (2-a) DNA encoding HGF protein, (2-b) DNA encoding a partial peptide of HGF protein, the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, (2-c) DNA encoding a protein or a peptide, the protein or the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, and the DNA hybridizing with DNA comprising a base sequence complementary to (2-a) or (2-b) under a stringent condition.
摘要翻译：本发明的目的是提供一种用于促进腱 - 骨连接组织或韧带 - 骨连接组织的再生的药物。本发明涉及包含以下（1）或（2）作为活性成分的腱 - 骨连接组织或韧带 - 骨连接组织再生促进剂：（1）以下（1-a），（1- b）或（1-c）（1-a）HGF蛋白，（1-b）HGF蛋白的部分肽，所述肽具有促进腱 - 骨连接组织或韧带 - 骨连接组织再生的作用，（1-c）（1-a）或（1-b）的盐; （2）包含以下（2-a），（2-b）或（2-c），（2-a）编码HGF蛋白的DNA的DNA，（2-b）编码HGF蛋白的部分肽的DNA，该肽具有促进腱 - 骨连接组织或韧带 - 骨连接组织再生的作用，（2-c）编码蛋白质或肽的DNA，所述蛋白质或肽具有促进腱 - 骨连接再生的作用组织或韧带 - 骨连接组织，以及在严格条件下与包含与（2-a）或（2-b）互补的碱基序列的DNA杂交的DNA。

5. 发明授权

US5350743A Bisphosphonic acid derivatives, as bone resorption inhibitors 失效
标题翻译：双膦酸衍生物，作为骨吸收抑制剂
公开(公告)号：US5350743A
公开(公告)日：1994-09-27
申请号：US831965
申请日：1992-02-06
申请人： Yoshitaka Ohishi , Makoto Tamura , Mitsuo Hayashida , Satoru Ikegami , Yoshiyuki Hiyama , Takao Awa , Kiyonoshin Ichikawa , Kiyoshi Nomiyama , Keigo Hanada , Mitsuo Mimura
发明人： Yoshitaka Ohishi , Makoto Tamura , Mitsuo Hayashida , Satoru Ikegami , Yoshiyuki Hiyama , Takao Awa , Kiyonoshin Ichikawa , Kiyoshi Nomiyama , Keigo Hanada , Mitsuo Mimura
IPC分类号： C07F9/572 , C07F9/576 , C07F9/59 , C07F9/6558 , A61K31/675
CPC分类号： C07F9/5765 , C07F9/5721 , C07F9/591 , C07F9/65583
摘要： A bisphosphonic acid derivative of the formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein A is ##STR2## each of R.sup.3 and R.sup.4, which may be the same or different, is (i) a hydrogen atom, (ii) a C.sub.1-6 alkyl group, a C.sub.2-6 alkenyl group, a C.sub.2-6 alkynyl group, a C.sub.1-6 alkyl-carbonyl group, a C.sub.2-6 alkenyl-carbonyl group, a C.sub.2-6 alkynyl-carbonyl group R.sup.5 and R.sup.6, which may be the same or different, is a hydrogen atom, a hydroxyl group, a halogen atom, a cyano group, a carbamoyl group, an aralkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted amino group, a C.sub.1-6 alkyl group, a C.sub.2-6 alkenyl group, a C.sub.2-6 alkynyl group;each of m and n is 0 or a positive integer, provided that (m+n) is from 2 to 5; andR is a hydrogen atom, a C.sub.1-8 alkyl group or a C.sub.7-15 aralkyl group.
摘要翻译：式（I）的双膦酸衍生物或其药学上可接受的盐：氨或不同的是（i）氢原子，（ii）C 1-6烷基，C 2-6烯基，C 2-6 炔基，C 1-6烷基 - 羰基，C 2-6烯基羰基，C 2-6炔基 - 羰基R 5和R 6可以相同或不同，为氢原子，羟基，卤素原子，氰基，氨基甲酰基，芳烷基，取代或未取代的苯基，取代或未取代的氨基，C 1-6烷基，C 2-6烯基，C 2-6炔基 ; m和n分别为0或正整数，条件是（m + n）为2至5; 且R为氢原子，C1-8烷基或C7-15芳烷基。

6. 发明授权

US08518880B2 Therapeutic agent for spinal cord injuries 有权
标题翻译：脊髓损伤治疗剂
公开(公告)号：US08518880B2
公开(公告)日：2013-08-27
申请号：US12548881
申请日：2009-08-27
申请人： Hideyuki Okano , Yoshiaki Toyama , Masaya Nakamura , Akio Iwanami , Kazuya Kitamura , Toshikazu Nakamura , Hiroshi Funakoshi , Keigo Hanada
发明人： Hideyuki Okano , Yoshiaki Toyama , Masaya Nakamura , Akio Iwanami , Kazuya Kitamura , Toshikazu Nakamura , Hiroshi Funakoshi , Keigo Hanada
IPC分类号： A61K38/18
CPC分类号： A61K38/1833 , A61K9/0004 , A61K9/0024 , A61K9/0085 , A61K9/146 , A61K9/2063 , A61K9/5026 , A61K9/5031
摘要： Disclosed is a therapeutic agent effective for the fundamental treatment of a spinal cord injury and a demyelinating disease. Specifically disclosed are a therapeutic agent for a spinal cord injury and a therapeutic agent for a demyelinating disease, each of which comprises an HGF protein as an active ingredient.
摘要翻译：公开了一种有效治疗脊髓损伤和脱髓鞘疾病的治疗剂。具体公开了用于脊髓损伤的治疗剂和脱髓鞘疾病的治疗剂，其各自包含HGF蛋白作为活性成分。

7. 发明申请

US20090233863A1 HGF PREPARATION 有权
标题翻译： HGF制剂
公开(公告)号：US20090233863A1
公开(公告)日：2009-09-17
申请号：US12432651
申请日：2009-04-29
申请人： Kiichi Adachi , Keigo Hanada
发明人： Kiichi Adachi , Keigo Hanada
IPC分类号： A61K38/18
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/06 , A61K9/19 , A61K38/1833 , A61K47/183
摘要： The present invention relates to an HGF preparation comprising HGF and purified sucrose. The HGF preparation is characterized by being stable even after a long-term storage.
摘要翻译：本发明涉及包含HGF和纯化蔗糖的HGF制剂。 HGF制剂的特征在于即使在长期储存之后也是稳定的。

8. 发明授权

US08461112B2 HGF preparation 有权
标题翻译： HGF制剂
公开(公告)号：US08461112B2
公开(公告)日：2013-06-11
申请号：US12432651
申请日：2009-04-29
申请人： Kiichi Adachi , Keigo Hanada
发明人： Kiichi Adachi , Keigo Hanada
IPC分类号： A61K38/18
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/06 , A61K9/19 , A61K38/1833 , A61K47/183
摘要： The present invention relates to an HGF preparation comprising HGF and purified sucrose. The HGF preparation is characterized by being stable even after a long-term storage.
摘要翻译：本发明涉及包含HGF和纯化蔗糖的HGF制剂。 HGF制剂的特征在于即使在长期储存后也是稳定的。

9. 发明申请

US20110312887A1 PROMOTER FOR REGENERATION OF TENDON-BONE JUNCTION TISSUE OR LIGAMENT-BONE JUNCTION TISSUE 有权
标题翻译：胫骨结扎组织或骨结缔组织再生的促进剂
公开(公告)号：US20110312887A1
公开(公告)日：2011-12-22
申请号：US13123091
申请日：2009-10-08
申请人： Katsuro Tomita , Hiroyuki Tsuchiya , Katsuhiko Kitaoka , Junsuke Nakase , Keigo Hanada , Kunio Matsumoto
发明人： Katsuro Tomita , Hiroyuki Tsuchiya , Katsuhiko Kitaoka , Junsuke Nakase , Keigo Hanada , Kunio Matsumoto
IPC分类号： A61K38/18 , A61P19/04 , C12N15/63 , A61K31/713 , C07K14/475 , C12N15/12
CPC分类号： A61K38/1833 , A61K48/00 , C07K14/4753
摘要： An object of the present invention is to provide a drug for promoting the regeneration of tendon-bone junction tissue or ligament-bone junction tissue. The present invention relates to a promoter for regeneration of tendon-bone junction tissue or ligament-bone junction tissue including the following (1) or (2) as an active ingredient: (1) the following (1-a), (1-b), or (1-c) (1-a) HGF protein, (1-b) a partial peptide of HGF protein, the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, (1-c) a salt of (1-a) or (1-b); (2) DNA including the following (2-a), (2-b), or (2-c), (2-a) DNA encoding HGF protein, (2-b) DNA encoding a partial peptide of HGF protein, the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, (2-c) DNA encoding a protein or a peptide, the protein or the peptide having an effect of promoting regeneration of tendon-bone junction tissue or ligament-bone junction tissue, and the DNA hybridizing with DNA comprising a base sequence complementary to (2-a) or (2-b) under a stringent condition.
摘要翻译：本发明的目的是提供一种用于促进腱 - 骨连接组织或韧带 - 骨连接组织的再生的药物。本发明涉及包含以下（1）或（2）作为活性成分的腱 - 骨连接组织或韧带 - 骨连接组织再生促进剂：（1）以下（1-a），（1- b）或（1-c）（1-a）HGF蛋白，（1-b）HGF蛋白的部分肽，所述肽具有促进腱 - 骨连接组织或韧带 - 骨连接组织再生的作用，（1-c）（1-a）或（1-b）的盐; （2）包含以下（2-a），（2-b）或（2-c），（2-a）编码HGF蛋白的DNA的DNA，（2-b）编码HGF蛋白的部分肽的DNA，该肽具有促进腱 - 骨连接组织或韧带 - 骨连接组织再生的作用，（2-c）编码蛋白质或肽的DNA，所述蛋白质或肽具有促进腱 - 骨连接再生的作用组织或韧带 - 骨连接组织，以及在严格条件下与包含与（2-a）或（2-b）互补的碱基序列的DNA杂交的DNA。

10. 发明授权

US06833354B1 Agent for the treatment of bone diseases 失效
标题翻译：用于治疗骨病的药剂
公开(公告)号：US06833354B1
公开(公告)日：2004-12-21
申请号：US08197678
申请日：1994-02-17
申请人： Keigo Hanada , Yoshiyuki Hiyama , Makoto Tamura
发明人： Keigo Hanada , Yoshiyuki Hiyama , Makoto Tamura
IPC分类号： A61K3818
CPC分类号： A61K38/1825 , C07K14/503
摘要： An object of the present invention is to provide a novel agent for the treatment of bone diseases which can shorten a period for curing various fractures including acceleration of bone formation for bone defect, can improve bone strength of united bones and can also improve reduced bone strength accompanied by various diseases. The agent comprises as an effective ingredient a basic fibroblast growth factor and/or its analogue.
摘要翻译：本发明的目的是提供一种用于治疗骨疾病的新型药剂，其能够缩短固化各种骨折的期间，包括加速骨形成骨骼的骨骼，可以提高骨骼的骨强度，并且还可以提高骨骼强度的降低伴有各种疾病。该药剂包含碱性成纤维细胞生长因子和/或其类似物作为有效成分。

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