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1. 发明授权

US06342364B1 Cholesterol sensor and method of determining cholesterol 有权
标题翻译：胆固醇传感器和胆固醇测定方法
公开(公告)号：US06342364B1
公开(公告)日：2002-01-29
申请号：US09831091
申请日：2001-05-03
申请人： Motokazu Watanabe , Keiko Yugawa , Shiro Nankai
发明人： Motokazu Watanabe , Keiko Yugawa , Shiro Nankai
IPC分类号： C12Q160
CPC分类号： C12Q1/60 , C12Q1/005 , G01N33/92 , G01N2800/044 , Y10S435/817
摘要： The present invention provides a sensor that electrochemically determines cholesterol in low density lipoprotein by only one feed of a sample. The sensor has: an electrode system that is mounted on an electrically insulating base plate and includes at least a working electrode and a counter electrode; an enzyme layer formed on the base plate with the electrode system; and a reagent layer that is arranged before the enzyme layer in a sample solution supply path to the electrode system. The enzyme layer includes at least an oxidoreductase and an electron mediator. The reagent layer includes a reagent that depresses reactivity of cholesterol in lipoproteins other than the low density lipoprotein with the oxidoreductase, for example, a reagent that attaches to lipoproteins other than the low density lipoprotein to form a water-soluble complex.
摘要翻译：本发明提供一种传感器，其通过仅一种样品的进料电化学地测定低密度脂蛋白中的胆固醇。传感器具有：电极系统，其安装在电绝缘基板上，并且至少包括工作电极和对电极; 在所述基板上形成有电极系的酶层; 以及被配置在所述酶层之前的试剂溶液供给到所述电极系统的路径中的试剂层。酶层至少包含氧化还原酶和电子介体。试剂层包括抑制低密度脂蛋白以外的脂蛋白中的胆固醇与氧化还原酶的反应性的试剂，例如附着于低密度脂蛋白以外的脂蛋白的试剂，形成水溶性络合物。

2. 发明授权

US07005048B1 Glucose sensor 有权
标题翻译：葡萄糖传感器
公开(公告)号：US07005048B1
公开(公告)日：2006-02-28
申请号：US09807692
申请日：2000-10-02
申请人： Motokazu Watanabe , Keiko Yugawa , Toshihiko Yoshioka , Shiro Nankai , Junko Nakayama , Shoji Miyazaki , Hideyuki Baba
发明人： Motokazu Watanabe , Keiko Yugawa , Toshihiko Yoshioka , Shiro Nankai , Junko Nakayama , Shoji Miyazaki , Hideyuki Baba
IPC分类号： G01N27/327
CPC分类号： C12Q1/006
摘要： The present invention provides a high-performance glucose sensor having excellent storage stability and an improved response characteristic. This sensor comprises: an electrically insulating base plate; an electrode system including at least a working electrode and a counter electrode formed on the base plate; and a reaction layer containing at least pyrrolo-quinoline quinone dependent glucose dehydrogenase, formed in contact with or in the vicinity of the electrode system, and the reaction layer contains at least one kind of additive selected from the group consisting of gluconic acid and salts thereof.
摘要翻译：本发明提供一种具有优异的储存稳定性和改善的响应特性的高性能葡萄糖传感器。该传感器包括：电绝缘基板; 电极系统，其至少包括形成在所述基板上的工作电极和对电极; 和至少含有与电极体系接触或附近形成的吡咯并喹啉醌依赖型葡萄糖脱氢酶的反应层，反应层含有选自葡萄糖酸及其盐的至少一种添加剂。

3. 发明申请

US20050072670A1 Biosensor 审中-公开
标题翻译：生物传感器
公开(公告)号：US20050072670A1
公开(公告)日：2005-04-07
申请号：US10478283
申请日：2002-12-27
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： C12Q1/00 , C12Q1/60 , G01N27/403 , G01N33/487 , G01N33/49 , G01N27/26
CPC分类号： C12Q1/001 , C12Q1/006 , C12Q1/60 , G01N27/3272
摘要： In order to provide a biosensor with high accuracy and excellent response where plasma obtained by filtration of blood rapidly arrives at an electrode system, in a biosensor comprising: an insulating base plate; an electrode system having a working electrode and a counter electrode which are provided on the base plate; a reaction layer including at least oxidoreductase and an electron mediator; a sample solution supply pathway which includes the electrode system and the reaction layer and has an inlet and an air aperture; a sample solution supply part for introducing a sample solution, which is in position apart from the sample solution supply pathway; and a first filter which is disposed between the sample solution supply pathway and the sample solution supply part for filtering the sample solution, where the filtrate filtered with the first filter is supplied into the sample solution supply pathway due to capillary action, the direction in which the sample solution passes through the first filter and the direction in which the filtrate passes through the sample solution supply pathway are made cross at right angles.
摘要翻译：为了提供具有高精度和优异响应的生物传感器，其中通过过滤血液获得的血液迅速到达电极系统，在生物传感器中包括：绝缘基板; 具有设置在基板上的工作电极和对置电极的电极系统; 至少包含氧化还原酶和电子介体的反应层; 包括电极系统和反应层并具有入口和空气孔的样品溶液供应路径; 用于引入样品溶液的样品溶液供应部件，其处于离样品溶液供给路径的位置; 以及第一过滤器，其设置在样品溶液供给路径和样品溶液供给部之间，用于过滤样品溶液，其中用第一过滤器过滤的滤液由于毛细作用而被供给到样品溶液供给通道中，其中样品溶液通过第一过滤器，滤液通过样品溶液供应通道的方向被成直角交叉。

4. 发明授权

US06706232B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06706232B2
公开(公告)日：2004-03-16
申请号：US10363589
申请日：2003-03-04
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Takahiro Nakaminami , Shin Ikeda , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/001
摘要： There is provided a cholesterol sensor with high-accuracy and excellent response, whose object to be measured is whole blood, where plasma with hemocytes therein filtered can rapidly reach an electrode system. In a biosensor where plasma with hemocytes therein filtered with a filter is sucked into a sample solution supply pathway due to capillarity, there are formed: a first pressing part for holding a primary side portion of the filter from the bottom; a second pressing part for holding a secondary side portion of the filter from the top and the bottom; a third pressing part for holding the central portion of the filter from the top; and a void for surrounding the filter between the second pressing part and third pressing part.
摘要翻译：提供了具有高精度和优异反应的胆固醇传感器，其被测量对象是全血，其中血细胞在其中被过滤的血浆可以快速地达到电极系统。在生物传感器中，其中用过滤器过滤血细胞的血浆由于毛细作用而被吸入样品溶液供应通道中，形成有：从底部保持过滤器的初级侧部分的第一按压部分; 用于从顶部和底部保持过滤器的次级侧部分的第二按压部分; 用于从顶部保持过滤器的中心部分的第三按压部分; 以及用于围绕第二按压部和第三按压部之间的过滤器的空隙。

5. 发明授权

US06416641B1 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US06416641B1
公开(公告)日：2002-07-09
申请号：US09328511
申请日：1999-06-09
申请人： Shin Ikeda , Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
发明人： Shin Ikeda , Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/001
摘要： The present invention relates to a biosensor comprising a working electrode base plate 11, a counter electrode base plate 14 and a reagent layer containing at least an enzyme and an electron mediator, wherein a working electrode 12 disposed on the working electrode base plate and a counter electrode 15 disposed on the counter electrode base plate are positioned so as to mutually face and a terminal of a measuring device can be brought in contact with terminals 13, 16 of both electrodes from through-holes 25, 24. Such a biosensor can produce highly reliable and accurate measuring results with only a small amount of a sample.
摘要翻译：本发明涉及一种生物传感器，其包括工作电极基板11，对电极基板14和至少含有酶和电子介体的试剂层，其中设置在工作电极底板上的工作电极12和反电极配置在对置电极基板上的电极15被定位成相互面对，并且测量装置的端子可以从通孔25,24与两个电极的端子13,16接触。这种生物传感器可以高度生产可靠和准确的测量结果，只有少量的样品。

6. 发明授权

US06776888B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06776888B2
公开(公告)日：2004-08-17
申请号：US10089289
申请日：2002-03-26
申请人： Tomohiro Yamamoto , Miwa Hasegawa , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Tomohiro Yamamoto , Miwa Hasegawa , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/004 , G01N27/3272
摘要： The present invention provides a biosensor that enables highly-accurate measurement of a sample solution including a solid component like hemocytes and has a little variation in response. The biosensor includes: an insulating base plate, an electrode system having at least a working electrode and a counter electrode provided on the base plate, a cover member that is combined with the base plate to define a sample solution supply pathway for leading a sample solution from a sample supply unit to the electrode system, a reaction reagent system including at least an oxidation-reduction enzyme and an electron mediator, and a filter disposed between the electrode system and the sample supply unit in the sample solution supply pathway. The biosensor has a space that encircles surface of the filter in an area from one end of the filter close to the sample supply unit to the other end of the filter close to the electrode system. This arrangement effectively prevents the solid component like hemocytes from flowing into the electrode system without being filtered out by the filter.
摘要翻译：本发明提供一种生物传感器，其能够高精度地测量包含像血细胞这样的固体成分的样品溶液，并且响应性变化很小。生物传感器包括：绝缘基板，至少具有工作电极和设置在基板上的对电极的电极系统，与基板结合以限定用于引导样品溶液的样品溶液供给路径的盖构件从样品供给单元到电极系统，至少包含氧化还原酶和电子介体的反应试剂系统，以及设置在样品溶液供给路径中的电极系统和样品供给单元之间的过滤器。生物传感器具有在过滤器的一端靠近样品供给单元的一个区域中的过滤器的表面周围到靠近电极系统的过滤器的另一端的空间。这种布置有效地防止诸如血细胞的固体组分流入电极系统而不被过滤器过滤掉。

7. 发明授权

US06383819B1 Method for determining cholesterol and sensor applicable to the same 有权
标题翻译：胆固醇和传感器的测定方法
公开(公告)号：US06383819B1
公开(公告)日：2002-05-07
申请号：US09492979
申请日：2000-01-27
申请人： Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
发明人： Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N33543
CPC分类号： G01N27/3272 , G01N33/92 , G01N2800/044 , G01N2800/52 , Y10S435/803 , Y10S435/814 , Y10S435/817 , Y10S435/962 , Y10S435/973 , Y10S436/806 , Y10S436/815 , Y10S436/824 , Y10S436/825 , Y10T436/25375 , Y10T436/255
摘要： The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high density lipoprotein, low density lipoprotein, very low density lipoprotein and chylomicron, and (b) measuring cholesterol levels in the high density lipoprotein, very low density lipoprotein and chylomicron in the sample, wherein the cholesterol level in the low density lipoprotein is determined by subtracting a value obtained in step (b) from a value obtained in step (a). The present invention enables concurrent determination of cholesterol level in low density lipoprotein and total cholesterol level, facilitating acquisition of two types of biological information at a time.
摘要翻译：本公开涉及一种用于测定低密度脂蛋白胆固醇的方法，包括以下步骤：（a）测量含有至少高密度脂蛋白，低密度脂蛋白，极低密度脂蛋白和乳糜微粒的样品中的总胆固醇水平，和（b）测量样品中高密度脂蛋白，极低密度脂蛋白和乳糜微粒中的胆固醇水平，其中通过从步骤（a）中获得的值减去步骤（b）中获得的值来确定低密度脂蛋白中的胆固醇水平。本发明能够同时测定低密度脂蛋白和总胆固醇水平的胆固醇水平，便于一次获取两种生物信息。

8. 发明授权

US06966977B2 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06966977B2
公开(公告)日：2005-11-22
申请号：US10350139
申请日：2003-01-24
申请人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Miwa Hasegawa , Tomohiro Yamamoto , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： C12Q1/00 , G01N33/487 , G01N33/49 , G01N33/543 , G01N27/327
CPC分类号： C12Q1/004 , G01N27/3272
摘要： A sensor including an insulating base plate; an electrode system, provided on the base plate, having a measuring electrode and a counter electrode; a reaction layer including at least an oxidoreductase and an electron mediator; a sample solution supply pathway including the electrode system and the reaction layer; and a sample supply unit, wherein the sensor is so structured that, between the sample supply unit and the sample solution supply pathway, there is provided a filter having a function to filter out hemocytes and having a cross-sectional area larger than an opening of the sample solution supply pathway, and that plasma of a blood with hemocytes thereof having been filtered out is sucked into the inside of the sample solution supply pathway owing to capillary phenomena.
摘要翻译：一种传感器，包括绝缘基板; 设置在基板上的具有测量电极和对电极的电极系统; 至少包含氧化还原酶和电子介体的反应层; 包括电极系统和反应层的样品溶液供给路径; 以及样本供应单元，其中所述传感器的结构使得在所述样品供应单元和所述样品溶液供应通道之间提供过滤器，所述过滤器具有过滤出血细胞并且具有大于所述样品供应单元的开口的横截面积样品溶液供给路径，由于毛细血管现象，血液中已经滤出血细胞的血浆被吸入到样品溶液供给路径的内部。

9. 发明授权

US06762062B2 Method of determining cholesterol and sensor applicable to the same 失效
标题翻译：测定胆固醇和传感器的方法适用于此
公开(公告)号：US06762062B2
公开(公告)日：2004-07-13
申请号：US09961930
申请日：2001-09-24
申请人： Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
发明人： Motokazu Watanabe , Toshihiko Yoshioka , Shiro Nankai
IPC分类号： G01N3353
CPC分类号： G01N27/3272 , G01N33/92 , G01N2800/044 , G01N2800/52 , Y10S435/803 , Y10S435/814 , Y10S435/817 , Y10S435/962 , Y10S435/973 , Y10S436/806 , Y10S436/815 , Y10S436/824 , Y10S436/825 , Y10T436/25375 , Y10T436/255
摘要： The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high density lipoprotein, low density lipoprotein, very low density lipoprotein and chylomicron, and (b) measuring cholesterol levels in the high density lipoprotein, very low density lipoprotein and chylomicron in the sample, wherein the cholesterol level in the low density lipoprotein is determined by subtracting a value obtained in the step (b) from a value obtained in the step (a). The present invention enables concurrent determination of cholesterol level in low density lipoprotein and total cholesterol level, facilitating acquisition of two types of biological information at a time.
摘要翻译：本公开涉及一种用于测定低密度脂蛋白胆固醇的方法，包括以下步骤：（a）测量含有至少高密度脂蛋白，低密度脂蛋白，极低密度脂蛋白和乳糜微粒的样品中的总胆固醇水平，和（b）测量样品中高密度脂蛋白，极低密度脂蛋白和乳糜微粒中的胆固醇水平，其中通过从步骤（a）中获得的值减去步骤（b）中获得的值来确定低密度脂蛋白中的胆固醇水平）。本发明能够同时测定低密度脂蛋白和总胆固醇水平的胆固醇水平，便于一次获取两种生物信息。

10. 发明授权

US06740215B1 Biosensor 失效
标题翻译：生物传感器
公开(公告)号：US06740215B1
公开(公告)日：2004-05-25
申请号：US09959571
申请日：2001-10-30
申请人： Takahiro Nakaminami , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
发明人： Takahiro Nakaminami , Motokazu Watanabe , Shin Ikeda , Shiro Nankai
IPC分类号： G01N27327
CPC分类号： C12Q1/005
摘要： A biosensor comprising an electrically insulating base plate, an electrode system containing a working electrode and a counter electrode disposed on the base plate, and a reagent system comprising at least an oxidoreductase, a hydrophilic polymer and an electron mediator, wherein the reagent system further comprises a substance having a function to convert an organic product generated by direct reaction of a substrate to be measured with the oxidoreductase to another compound.
摘要翻译：一种生物传感器，包括电绝缘基板，包含工作电极的电极系统和设置在基板上的对电极，以及至少包含氧化还原酶，亲水性聚合物和电子介体的试剂系统，其中所述试剂系统还包括具有将待测基质与氧化还原酶直接反应产生的有机产物转化为其他化合物的功能的物质。

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