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1. 发明授权

US08986449B2 Device and a method for promoting crystallisation 有权
标题翻译：装置和促进结晶的方法
公开(公告)号：US08986449B2
公开(公告)日：2015-03-24
申请号：US12303132
申请日：2007-06-27
申请人： Morten Sommer
发明人： Morten Sommer
IPC分类号： C30B35/00 , C30B29/58 , B01L3/00 , C30B7/00
CPC分类号： C30B29/58 , B01L3/502738 , B01L2200/0605 , B01L2300/041 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0688 , B01L2400/0694 , C30B7/00 , C30B35/00 , Y10T117/10
摘要： The invention relates to a microfluidic device for promoting crystallization of target molecules, such as proteins. The device comprises a solid structure with a top face and an opposite bottom face and with a least one liquid channel. The liquid channel comprises a target molecule solution inlet and at least two precipitant inlets. The target molecule solution inlet is in liquid communication with each of the precipitant inlets through the liquid channel. The liquid channel comprises a branching channel section adjacent to the target molecule solution inlet, crystallization channel sections adjacent to the respective precipitant inlets and flow break channel sections arranged between the branching channel section and each of the crystallization channel sections. The liquid channel is branched from 1 to X in the branching channel section, wherein X is the number of crystallization channel sections, and the flow break channel sections comprise a flow break arrangement capable of breaking up the liquid communication between said respective branching channel section and crystallization channel sections.
摘要翻译：本发明涉及用于促进目标分子如蛋白质结晶的微流体装置。该装置包括具有顶面和相对底面以及至少一个液体通道的固体结构。液体通道包括靶分子溶液入口和至少两个沉淀剂入口。目标分子溶液入口通过液体通道与每个沉淀剂入口液体连通。液体通道包括与目标分子溶液入口相邻的分支通道部分，与相应的沉淀剂入口相邻的结晶通道部分和布置在分支通道部分和每个结晶通道部分之间的流动断裂通道部分。液体通道在分支通道部分中从1分支到X，其中X是结晶通道部分的数量，并且流动断裂通道部分包括能够破坏所述相应分支通道部分和结晶通道部分。

2. 发明申请

US20120020850A1 CRYSTALLIZATION SYSTEM AND METHOD FOR PROMOTING CRYSTALLIZATION 审中-公开
标题翻译：用于促进结晶的结晶系统和方法
公开(公告)号：US20120020850A1
公开(公告)日：2012-01-26
申请号：US13202952
申请日：2010-02-23
申请人： Morten Sommer
发明人： Morten Sommer
IPC分类号： G01N33/50 , B23P11/00 , B01D9/00
CPC分类号： B01L3/50853 , B01L2300/0829 , B01L2300/0887 , C30B7/00 , C30B35/00 , Y10T29/49826
摘要： A crystallization system includes a well plate and a cover for the well plate, at least one of the well plate and said cover includes at least a transparent window. The well plate including at least one well comprising a bottom surface including a first essentially planar bottom surface section and a second essentially planar bottom surface section in a first bottom plane and a well border wall provided by a well border edge surrounding the planar bottom surface section: The cover includes a first essentially planar top surface section in a first top plane adapted to face the first essentially planar bottom surface section. The first and the second essentially planar bottom surface sections are totally or partly separated by a liquid barrier, provided by one or more of a low tension surface barrier, a ridge and an indentation. A method of producing the crystallization system includes providing a bottom plate, a perforated plate and a cover, mounting the bottom plate to the perforated plate to provide a well plate including a plurality of wells each having a bottom surface. The system is simple and cost effective to produce and simple to handle.
摘要翻译：结晶系统包括井板和用于井板的盖，井板和所述盖中的至少一个至少包括透明窗。所述井板包括至少一个井，所述井包括底表面，所述井底表面包括第一基本平坦的底表面区段和在第一底部平面中的第二基本上平面的底表面部分以及由围绕所述平坦底表面部分的井口边缘边缘提供的井口边界壁盖子包括适于面对第一基本平坦的底表面部分的第一顶部平面中的第一基本平坦的顶部表面部分。第一和第二基本上平面的底表面部分由液体屏障全部或部分地分开，该液体屏障由低压表面屏障，脊和凹陷中的一个或多个提供。一种生产结晶系统的方法包括提供底板，多孔板和盖，将底板安装到多孔板上，以提供一个井板，该井板包括多个具有底面的孔。该系统生产简单，成本低廉，操作简单。

3. 发明申请

US20050205005A1 Microfluidic protein crystallography 有权
标题翻译：微流体蛋白晶体学
公开(公告)号：US20050205005A1
公开(公告)日：2005-09-22
申请号：US11006522
申请日：2004-12-06
申请人： Carl Hansen , Morten Sommer , Stephen Quake
发明人： Carl Hansen , Morten Sommer , Stephen Quake
IPC分类号： C30B1/00 , C30B7/00 , C30B35/00
CPC分类号： C30B7/14 , B01J19/0046 , B01J2219/00286 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/0059 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/0472 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , C30B7/00 , C30B7/10 , C30B29/58 , C30B35/00 , C40B40/10 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0028 , F16K99/0057 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , G01N2013/003 , Y10T117/10 , Y10T117/1004 , Y10T117/1008 , Y10T117/1024
摘要： The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.
摘要翻译：使用微流体结构可实现蛋白质结晶的高通量筛选。在一个实施方案中，集成的组合混合芯片允许精确计量试剂以快速产生大量潜在的结晶条件，并在芯片上观察到可能的晶体形成。在替代实施方案中，微流体结构可用于探索特定蛋白质结晶剂组合的相空间条件，从而确定有希望的条件并允许随后的聚焦尝试以获得晶体生长。

4. 发明申请

US20090264632A1 DEVICE AND A METHOD FOR PROMOTING CRYSTALLISATION 有权
标题翻译：装置和促进结晶的方法
公开(公告)号：US20090264632A1
公开(公告)日：2009-10-22
申请号：US12303132
申请日：2007-06-27
申请人： Morten Sommer
发明人： Morten Sommer
IPC分类号： C07K1/30 , B01D9/00 , C07H1/06 , C07H21/00
CPC分类号： C30B29/58 , B01L3/502738 , B01L2200/0605 , B01L2300/041 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0688 , B01L2400/0694 , C30B7/00 , C30B35/00 , Y10T117/10
摘要： The invention relates to a microfluidic device for promoting crystallisation of target molecules, such as proteins. The device comprises a solid structure with a top face and an opposite bottom face and with a least one liquid channel. The liquid channel comprises a target molecule solution inlet and at least two precipitant inlets. The target molecule solution inlet is in liquid communication with each of the precipitant inlets through the liquid channel. The liquid channel comprises a branching channel section adjacent to the target molecule solution inlet, crystallisation channel sections adjacent to the respective precipitant inlets and flow break channel sections arranged between the branching channel section and each of the crystallization channel sections. The liquid channel is branched from 1 to X in the branching channel section, wherein X is the number of crystallisation channel sections, and the flow break channel sections comprise a flow break arrangement capable of breaking up the liquid communication between said respective branching channel section and crystallisation channel sections.
摘要翻译：本发明涉及用于促进目标分子如蛋白质结晶的微流体装置。该装置包括具有顶面和相对底面以及至少一个液体通道的固体结构。液体通道包括靶分子溶液入口和至少两个沉淀剂入口。目标分子溶液入口通过液体通道与每个沉淀剂入口液体连通。液体通道包括与目标分子溶液入口相邻的分支通道部分，与相应的沉淀剂入口相邻的结晶通道部分和布置在分支通道部分和每个结晶通道部分之间的流动断裂通道部分。液体通道在分支通道部分中从1分支到X，其中X是结晶通道部分的数量，并且流动断裂通道部分包括能够分解所述相应分支通道部分和结晶通道部分。

5. 发明授权

US07459022B2 Microfluidic protein crystallography 有权
标题翻译：微流体蛋白晶体学
公开(公告)号：US07459022B2
公开(公告)日：2008-12-02
申请号：US11006522
申请日：2004-12-06
申请人： Carl L. Hansen , Morten Sommer , Stephen R. Quake
发明人： Carl L. Hansen , Morten Sommer , Stephen R. Quake
IPC分类号： C30B7/14
CPC分类号： C30B7/14 , B01J19/0046 , B01J2219/00286 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/0059 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/0472 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , C30B7/00 , C30B7/10 , C30B29/58 , C30B35/00 , C40B40/10 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0028 , F16K99/0057 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , G01N2013/003 , Y10T117/10 , Y10T117/1004 , Y10T117/1008 , Y10T117/1024
摘要： The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.
摘要翻译：使用微流体结构可实现蛋白质结晶的高通量筛选。在一个实施例中，集成的组合混合芯片允许精确计量试剂以快速产生大量潜在的结晶条件，并且在芯片上观察到可能的晶体形成。在替代实施方案中，微流体结构可用于探索特定蛋白质结晶剂组合的相空间条件，从而确定有希望的条件并允许随后的聚焦尝试以获得晶体生长。

6. 发明授权

US08691010B2 Microfluidic protein crystallography 有权
标题翻译：微流体蛋白晶体学
公开(公告)号：US08691010B2
公开(公告)日：2014-04-08
申请号：US13087697
申请日：2011-04-15
申请人： Carl L. Hansen , Morten Sommer , Stephen R. Quake
发明人： Carl L. Hansen , Morten Sommer , Stephen R. Quake
IPC分类号： C30B7/10
CPC分类号： C30B7/14 , B01J19/0046 , B01J2219/00286 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/0059 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/0472 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , C30B7/00 , C30B7/10 , C30B29/58 , C30B35/00 , C40B40/10 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0028 , F16K99/0057 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , G01N2013/003 , Y10T117/10 , Y10T117/1004 , Y10T117/1008 , Y10T117/1024
摘要： The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.
摘要翻译：使用微流体结构可实现蛋白质结晶的高通量筛选。在一个实施方案中，集成的组合混合芯片允许精确计量试剂以快速产生大量潜在的结晶条件，并在芯片上观察到可能的晶体形成。在替代实施方案中，微流体结构可用于探索特定蛋白质结晶剂组合的相空间条件，从而确定有希望的条件并允许随后的聚焦尝试以获得晶体生长。

7. 发明申请

US20090168066A1 MICROFLUIDIC PROTEIN CRYSTALLOGRAPHY 有权
标题翻译：微流感蛋白晶体学
公开(公告)号：US20090168066A1
公开(公告)日：2009-07-02
申请号：US12326741
申请日：2008-12-02
申请人： Carl L. Hansen , Morten Sommer , Stephen R. Quake
发明人： Carl L. Hansen , Morten Sommer , Stephen R. Quake
IPC分类号： G01N21/59 , G06F17/18
CPC分类号： C30B7/14 , B01J19/0046 , B01J2219/00286 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/0059 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/0472 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , C30B7/00 , C30B7/10 , C30B29/58 , C30B35/00 , C40B40/10 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0028 , F16K99/0057 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , G01N2013/003 , Y10T117/10 , Y10T117/1004 , Y10T117/1008 , Y10T117/1024
摘要： The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.
摘要翻译：使用微流体结构可实现蛋白质结晶的高通量筛选。在一个实施方案中，集成的组合混合芯片允许精确计量试剂以快速产生大量潜在的结晶条件，并在芯片上观察到可能的晶体形成。在替代实施方案中，微流体结构可用于探索特定蛋白质结晶剂组合的相空间条件，从而确定有希望的条件并允许随后的聚焦尝试以获得晶体生长。

8. 发明授权

US08652417B2 Crystallization media 有权
标题翻译：结晶介质
公开(公告)号：US08652417B2
公开(公告)日：2014-02-18
申请号：US13010298
申请日：2011-01-20
申请人： Morten Sommer
发明人： Morten Sommer
IPC分类号： G01N33/00
CPC分类号： C30B29/58 , C30B7/00
摘要： A set of crystallization solutions includes a plurality of crystallization solutions of Crystallization Solution Set I, a plurality of crystallization solutions of Crystallization Solution Set II or a plurality of crystallization solutions of Crystallization Solution Set III.
摘要翻译：一组结晶溶液包括结晶溶液组I的多个结晶溶液，结晶溶液组II的多个结晶溶液或结晶溶液组III的多个结晶溶液。

9. 发明授权

US09029085B2 Assays and other reactions involving droplets 有权
标题翻译：测定和其他涉及液滴的反应
公开(公告)号：US09029085B2
公开(公告)日：2015-05-12
申请号：US12529926
申请日：2008-03-07
申请人： Jeremy Agresti , Liang-Yin Chu , David A. Weitz , Jin-Woong Kim , Amy Rowat , Morten Sommer , Gautam Dantas , George Church
发明人： Jeremy Agresti , Liang-Yin Chu , David A. Weitz , Jin-Woong Kim , Amy Rowat , Morten Sommer , Gautam Dantas , George Church
IPC分类号： C12Q1/68 , C12P19/34 , B01J13/00 , B01F3/08 , B01F13/00
CPC分类号： C12P19/34 , B01F3/0807 , B01F3/0811 , B01F13/0062 , B01F13/0071 , B01F2215/0037 , B01J13/0052 , B01J13/0065 , B01L3/502784 , C12Q1/6834 , C12Q1/6848 , C12Q1/686 , G01N15/1404 , G01N2015/1006
摘要： The present invention generally relates to droplets and/or emulsions, such as multiple emulsions. In some cases, the droplets and/or emulsions may be used in assays, and in certain embodiments, the droplet or emulsion may be hardened to form a gel. In some aspects, a heterogeneous assay can be performed using a gel. For example, a droplet may be hardened to form a gel, where the droplet contains a cell, DNA, or other suitable species. The gel may be exposed to a reactant, and the reactant may interact with the gel and/or with the cell, DNA, etc., in some fashion. For example, the reactant may diffuse through the gel, or the hardened particle may liquefy to form a liquid state, allowing the reactant to interact with the cell. As a specific example, DNA contained within a gel particle may be subjected to PCR (polymerase chain reaction) amplification, e.g., by using PCR primers able to bind to the gel as it forms. As the DNA is amplified using PCR, some of the DNA will be bound to the gel via the PCR primer. After the PCR reaction, unbound DNA may be removed from the gel, e.g., via diffusion or washing. Thus, a gel particle having bound DNA may be formed in one embodiment of the invention.
摘要翻译：本发明通常涉及液滴和/或乳液，例如多重乳液。在一些情况下，液滴和/或乳液可用于测定中，并且在某些实施方案中，液滴或乳液可被硬化以形成凝胶。在一些方面，可以使用凝胶进行异质测定。例如，液滴可以被硬化以形成凝胶，其中液滴包含细胞，DNA或其它合适的物质。凝胶可以暴露于反应物，并且反应物可以以某种方式与凝胶和/或与细胞，DNA等相互作用。例如，反应物可以扩散通过凝胶，或者硬化的颗粒可以液化以形成液体状态，允许反应物与细胞相互作用。作为具体实例，包含在凝胶颗粒内的DNA可以进行PCR（聚合酶链式反应）扩增，例如通过使用能够在形成凝胶时结合凝胶的PCR引物。当使用PCR扩增DNA时，一些DNA将通过PCR引物与凝胶结合。 PCR反应后，未结合的DNA可以从凝胶中去除，例如通过扩散或洗涤。因此，可以在本发明的一个实施方案中形成具有结合DNA的凝胶颗粒。

10. 发明申请

US20110306522A1 MICROFLUIDIC PROTEIN CRYSTALLOGRAPHY 有权
标题翻译：微流感蛋白晶体学
公开(公告)号：US20110306522A1
公开(公告)日：2011-12-15
申请号：US13087697
申请日：2011-04-15
申请人： Carl L. Hansen , Morten Sommer , Stephen R. Quake
发明人： Carl L. Hansen , Morten Sommer , Stephen R. Quake
IPC分类号： C40B60/12
CPC分类号： C30B7/14 , B01J19/0046 , B01J2219/00286 , B01J2219/00355 , B01J2219/00378 , B01J2219/00396 , B01J2219/00398 , B01J2219/00439 , B01J2219/005 , B01J2219/00527 , B01J2219/0059 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00659 , B01J2219/00704 , B01J2219/00707 , B01J2219/00722 , B01J2219/00725 , B01J2219/00756 , B01L3/06 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/54 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/10 , B01L2300/0681 , B01L2300/0861 , B01L2300/123 , B01L2300/14 , B01L2300/18 , B01L2400/0472 , B01L2400/0481 , B01L2400/0655 , B01L2400/0688 , C30B7/00 , C30B7/10 , C30B29/58 , C30B35/00 , C40B40/10 , F04B43/043 , F16K99/0001 , F16K99/0015 , F16K99/0028 , F16K99/0057 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , G01N2013/003 , Y10T117/10 , Y10T117/1004 , Y10T117/1008 , Y10T117/1024
摘要： The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potential crystallization conditions, with possible crystal formations observed on chip. In an alternative embodiment, the microfluidic structures may be utilized to explore phase space conditions of a particular protein crystallizing agent combination, thereby identifying promising conditions and allowing for subsequent focused attempts to obtain crystal growth.
摘要翻译：使用微流体结构可实现蛋白质结晶的高通量筛选。在一个实施方案中，集成的组合混合芯片允许精确计量试剂以快速产生大量潜在的结晶条件，并在芯片上观察到可能的晶体形成。在替代实施方案中，微流体结构可用于探索特定蛋白质结晶剂组合的相空间条件，从而确定有希望的条件并允许随后的聚焦尝试以获得晶体生长。

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