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1. 发明授权

US06962694B1 Cytolysis of target cells by superantigen conjugates inducing T-cell activation 失效
标题翻译：通过诱导T细胞活化的超抗原共轭物对靶细胞进行细胞溶解
公开(公告)号：US06962694B1
公开(公告)日：2005-11-08
申请号：US09463470
申请日：1998-07-21
申请人： Morten Soegaard , Lars Abrahmsen , Peter Lando , Goran Forsberg , Terje Kalland , Mikael Dohlsten
发明人： Morten Soegaard , Lars Abrahmsen , Peter Lando , Goran Forsberg , Terje Kalland , Mikael Dohlsten
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/085 , A61K39/385 , A61K39/395 , A61K45/00 , A61K47/48 , A61P35/00 , A61P37/00 , C07K14/31 , C07K14/47 , C07K14/715 , C07K16/00 , C07K19/00 , C12N5/10
CPC分类号： C07K14/47 , A61K47/642 , A61K47/6801 , A61K47/6813 , A61K47/6829 , A61K47/6863 , C07K2319/035
摘要： A method for inactivating target cells in the presence of T cells by bringing the two types of cells in contact with a superantigen (SAG) in the presence of an immune modulator, characterized in that at least one of the superantigen and the immune modulator is in the form of a conjugate between a “free” superantigen (Sag) and a moiety targeting the conjugate to the target cells. A superantigen conjugate complying with the formula (1) (T)x(Sag)y(IM)z; a) T is a targeting moiety, Sag corresponds to a free superantigen, IM is an immune modulator that is not a superantigen and T, Sag and IM are linked together via organic linkers B; b) x, y and z are integers that typically are selected among 0-10 and represent the number of moieties T, Sag and IM, respectively, in a given conjugate molecule, with the provision that y>0 and also one or both of x and z>0. The superantigen conjugate is preferably a triple fusion protein. A targeted immune modulator, characterized in that it is a conjugate between a targeting moiety (T″′) and a modified immune modulator (IM″′). The conjugate complies with a formula analogous to formula (1) except for the imperative presence of the modified immune modulator. A superantigen moiety may be present. A DNA molecule encoding a superantigen and an immune modulator.
摘要翻译：一种通过在免疫调节剂存在下使两种类型的细胞与超抗原（SAG）接触而在T细胞存在下灭活靶细胞的方法，其特征在于，超抗原和免疫调节剂中的至少一种在 “自由”超抗原（Sag）与靶向靶细胞靶向缀合物的部分之间的缀合物的形式。符合公式（1）（T）的超抗原缀合物（S）（S））（IM）z a）T是靶向部分，Sag对应于游离超抗原，IM是不是超抗原的免疫调节剂，T，Sag和IM通过有机接头B连接在一起; b）x，y和z是通常在0-10中选择并且分别代表给定共轭分子中部分T，Sag和IM的数目的整数，其规定y> 0，并且还包括一个或两个 x和z> 0。超抗原缀合物优选为三重融合蛋白。靶向免疫调节剂，其特征在于它是靶向部分（T“'”和修饰的免疫调节剂（IM“）之间的缀合物。该缀合物符合类似于式（1）的式，除了修饰的免疫调节剂的命令性存在。可能存在超抗原部分。编码超抗原和免疫调节剂的DNA分子。

2. 发明申请

US20050226885A1 Cytolysis of target cells by superantigen conjugates inducing T-cell activation 审中-公开
标题翻译：通过诱导T细胞活化的超抗原共轭物对靶细胞进行细胞溶解
公开(公告)号：US20050226885A1
公开(公告)日：2005-10-13
申请号：US11023086
申请日：2004-12-27
申请人： Morten Soegaard , Lars Abrahmsen , Peter Lando , Goran Forsberg , Terje Kalland , Mikael Dohlsten
发明人： Morten Soegaard , Lars Abrahmsen , Peter Lando , Goran Forsberg , Terje Kalland , Mikael Dohlsten
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/085 , A61K39/385 , A61K39/395 , A61K45/00 , A61K47/48 , A61P35/00 , A61P37/00 , C07K14/31 , C07K14/47 , C07K14/715 , C07K16/00 , C07K19/00 , C12N5/10
CPC分类号： C07K14/47 , A61K47/642 , A61K47/6801 , A61K47/6813 , A61K47/6829 , A61K47/6863 , C07K2319/035
摘要： A method for inactivating target cells in the presence of T cells by bringing the two types of cells in contact with a superantigen (SAG) in the presence of an immune modulator, characterized in that at least one of the superantigen and the immune modulator is in the form of a conjugate between a “free” superantigen (Sag) and a moiety targeting the conjugate to the target cells. A superantigen conjugate complying with the formula (1): (T)x(Sag)y(IM)z; a) T is a targeting moiety, Sag corresponds to a free superantigen, IM is an immune modulator that is not a superantigen and T, Sag and IM are linked together via organic linkers B; b) x, y and z are integers that typically are selected among 0-10 and represent the number of moieties T, Sag and IM, respetively, in a given conjugate molecule, with the provision that y>0 and also one or both of x and z>0. The superantigen conjugate is preferably a triple fusion protein. A targeted immune modulator, characterized in that it is a conjugate between a targeting moiety (T′″) and a modified immune modulator (IM′″). The conjugate complies with a formula analogous to formula (I) except for the imperative presence of the modified immune modulator. A superantigen moiety may be present. A DNA molecule encoding a superantigen and an immune modulator.
摘要翻译：一种通过在免疫调节剂存在下使两种类型的细胞与超抗原（SAG）接触而在T细胞存在下灭活靶细胞的方法，其特征在于，超抗原和免疫调节剂中的至少一种在 “自由”超抗原（Sag）与靶向靶细胞靶向缀合物的部分之间的缀合物的形式。符合式（1）的超抗原共轭：（T）X（Sag）Y（IM）z a）T是靶向部分，Sag对应于游离超抗原，IM是不是超抗原的免疫调节剂，T，Sag和IM通过有机接头B连接在一起; b）x，y和z是通常在0-10中选择的整数，并且在给定的共轭分子中分别表示部分T，Sag和IM的数目，其规定y> 0，并且还包括一个或两个 x和z> 0。超抗原缀合物优选为三重融合蛋白。靶向免疫调节剂，其特征在于它是靶向部分（T“'”和修饰的免疫调节剂（IM“）之间的缀合物。除了修饰的免疫调节剂的命令存在之外，缀合物符合类似于式（I）的式。可能存在超抗原部分。编码超抗原和免疫调节剂的DNA分子。

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