专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07935706B2 Nitrogen-containing heterocycle derivatives substituted with cyclic group 失效
标题翻译：用环状基团取代的含氮杂环衍生物
公开(公告)号：US07935706B2
公开(公告)日：2011-05-03
申请号：US12278412
申请日：2007-02-21
申请人： Moriyasu Masui , Makoto Adachi , Hidenori Mikamiyama , Akira Matsumura , Naoki Tsuno
发明人： Moriyasu Masui , Makoto Adachi , Hidenori Mikamiyama , Akira Matsumura , Naoki Tsuno
IPC分类号： A61K31/497
CPC分类号： C07D209/08 , C07D209/34 , C07D215/38 , C07D235/08 , C07D235/26 , C07D249/18 , C07D263/58 , C07D277/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , C07D513/04
摘要： It was found out that the nitrogen-containing heterocyclic derivative represented by the formula (I) specifically binds to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist.A compound represented by: wherein Z is N or CR1, A1 is a nitrogen-containing aromatic monocyclic group which is optionally substituted, a nitrogen-containing aromatic fused cyclic group which is optionally substituted etc., A2 is an aromatic hydrocarbon cyclic group or an aromatic heterocyclic group, each optionally having a substituent, R1, R2, Ra, Rb, Rc and Rd are each independently hydrogen, hydroxy, etc., w is 2 or 3, t is 1 or 2, X is —(CR3R4)m-, —CO(CR3R4)n-, —CONR5(CR3R4)n- etc., m is an integer of 1 to 4, n is an integer of 0 to 4, R3 and R4 are each independently hydrogen, halogen, hydroxy etc., and R5 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：发现由式（I）表示的含氮杂环衍生物特异性结合NR1 / NR2B的受体，并用作NR2B受体拮抗剂。由下式表示的化合物：其中Z为N或CR1，A1为任选取代的含氮芳族单环基团，任选取代的含氮芳族稠合环基等，A2为芳族烃环基或芳族杂环基，各自任选具有取代基，R 1，R 2，R a，R b，R c和R d各自独立地为氢，羟基等，w为2或3，t为1或2，X为 - （CR 3 R 4）m - ，-CO（CR 3 R 4）n - ， - CONR 5（CR 3 R 4）n - 等，m为1〜4的整数，n为0〜4的整数，R 3和R 4各自独立地为氢，卤素，羟基等 R5为氢或低级烷基，或其药学上可接受的盐或溶剂合物。

2. 发明申请

US20110172415A1 NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP 审中-公开
标题翻译：用循环集团取代的含氮杂环衍生物（NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES WITH CYCLIC GROUP
公开(公告)号：US20110172415A1
公开(公告)日：2011-07-14
申请号：US13050465
申请日：2011-03-17
申请人： Moriyasu Masui , Makoto Adachi , Hidenori Mikamiyama , Akira Matsumura , Naoki Tsuno
发明人： Moriyasu Masui , Makoto Adachi , Hidenori Mikamiyama , Akira Matsumura , Naoki Tsuno
IPC分类号： C07D498/04 , C07D401/12 , C07D405/12 , C07D401/06 , C07D401/14 , C07D405/14 , C07D403/12 , C07D417/14 , C07D417/12 , C07D471/04 , C07D295/185 , C07D413/12
CPC分类号： C07D209/08 , C07D209/34 , C07D215/38 , C07D235/08 , C07D235/26 , C07D249/18 , C07D263/58 , C07D277/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , C07D513/04
摘要： It was found out that the nitrogen-containing heterocyclic derivative represented by the formula (I) specifically binds to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist.A compound represented by: wherein Z is N or CR1, A1 is a nitrogen-containing aromatic monocyclic group which is optionally substituted, a nitrogen-containing aromatic fused cyclic group which is optionally substituted etc., A2 is an aromatic hydrocarbon cyclic group or an aromatic heterocyclic group, each optionally having a substituent, R1, R2, Ra, Rb, Rc and Rd are each independently hydrogen, hydroxy, etc., w is 2 or 3, t is 1 or 2, X is —(CR3R4)m-, —CO(CR3R4)n-, —CONR5(CR3R4)n- etc., m is an integer of 1 to 4, n is an integer of 0 to 4, R3 and R4 are each independently hydrogen, halogen, hydroxy etc., and R5 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：发现由式（I）表示的含氮杂环衍生物特异性结合NR1 / NR2B的受体，并用作NR2B受体拮抗剂。由下式表示的化合物：其中Z为N或CR1，A1为任选取代的含氮芳族单环基团，任选取代的含氮芳族稠合环基等，A2为芳族烃环基或芳族杂环基，各自任选具有取代基，R 1，R 2，R a，R b，R c和R d各自独立地为氢，羟基等，w为2或3，t为1或2，X为 - （CR 3 R 4）m - ，-CO（CR 3 R 4）n - ， - CONR 5（CR 3 R 4）n - 等，m为1〜4的整数，n为0〜4的整数，R 3和R 4各自独立地为氢，卤素，羟基等 R5为氢或低级烷基，或其药学上可接受的盐或溶剂合物。

3. 发明申请

US20090062261A1 NITROGEN-CONTAINING HETEROCYCLE DERIVATIVES SUBSTITUTED WITH CYCLIC GROUP 失效
标题翻译：采用循环组合的含氮杂环衍生物
公开(公告)号：US20090062261A1
公开(公告)日：2009-03-05
申请号：US12278412
申请日：2007-02-21
申请人： Moriyasu Masui , Makoto Adachi , Hidenori Mikamiyama , Akira Matsumura , Naoki Tsuno
发明人： Moriyasu Masui , Makoto Adachi , Hidenori Mikamiyama , Akira Matsumura , Naoki Tsuno
IPC分类号： A61K31/4545 , C07D401/04 , C07D211/44 , C07D211/08 , C07D295/104 , C07D413/12 , C07D401/06 , A61K31/454 , A61K31/496 , C07D413/14 , C07D401/14 , A61K31/551 , A61K31/538 , A61K31/451 , A61K31/495
CPC分类号： C07D209/08 , C07D209/34 , C07D215/38 , C07D235/08 , C07D235/26 , C07D249/18 , C07D263/58 , C07D277/68 , C07D401/06 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , C07D513/04
摘要： It was found out that the nitrogen-containing heterocyclic derivative represented by the formula (I) specifically binds to a receptor of NR1/NR2B, and is used as a NR2B receptor antagonist.A compound represented by: wherein Z is N or CR1, A1 is a nitrogen-containing aromatic monocyclic group which is optionally substituted, a nitrogen-containing aromatic fused cyclic group which is optionally substituted etc., A2 is an aromatic hydrocarbon cyclic group or an aromatic heterocyclic group, each optionally having a substituent, R1, R2, Ra, Rb, Rc and Rd are each independently hydrogen, hydroxy, etc., w is 2 or 3, t is 1 or 2, X is —(CR3R4)m-, —CO(CR3R4)n-, —CONR5(CR3R4)n- etc., m is an integer of 1 to 4, n is an integer of 0 to 4, R3 and R4 are each independently hydrogen, halogen, hydroxy etc., and R5 is hydrogen or lower alkyl, or a pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：发现由式（I）表示的含氮杂环衍生物特异性结合NR1 / NR2B的受体，并用作NR2B受体拮抗剂。由下式表示的化合物：其中Z为N或CR1，A1为任选取代的含氮芳族单环基团，任选取代的含氮芳族稠合环基等，A2为芳族烃环基或芳族杂环基，各自任选具有取代基，R 1，R 2，R a，R b，R c和R d各自独立地为氢，羟基等，w为2或3，t为1或2，X为 - （CR 3 R 4）m - ，-CO（CR 3 R 4）n - ， - CONR 5（CR 3 R 4）n - 等，m为1〜4的整数，n为0〜4的整数，R 3和R 4各自独立地为氢，卤素，羟基等 R5为氢或低级烷基，或其药学上可接受的盐或溶剂合物。

4. 发明授权

US5394276A Method and apparatus for two-channel recording of video signals 失效
标题翻译：用于视频信号双通道录像的方法和装置
公开(公告)号：US5394276A
公开(公告)日：1995-02-28
申请号：US49589
申请日：1993-04-20
申请人： Makoto Adachi
发明人： Makoto Adachi
IPC分类号： H04N5/92 , H04N7/015 , H04N9/797 , H04N9/81 , H04N5/78
CPC分类号： H04N9/7973 , Y10S348/91
摘要： A video signal recording apparatus is provided with first and second channels for transmitting an input video signal. The first channel has a line memory for conducting a 1H delay on data and a time-base-extension line memory for conducting time base extension on the data with the 1H delay. The data subjected to the time base extension undergoes D/A conversion to be an output of the first channel. On the other hand, the second channel does not have a line memory for a 1H delay, and the video signal without delay is subjected to time base extension and undergoes D/A conversion to be an output of the second channel. In the arrangement, odd lines and even lines respectively contained in adjoining two frames in each channel are reversed such that in a certain frame, odd lines of the input video signal are transmitted through the first channel with even lines through the second channel. In the next frame, even lines are transmitted through the first channel with odd lines through the second channel. Thus, influences on the reproduced picture due to the difference of circuit characteristics is averaged and the perception to unevenness of color or brightness is avoided.
摘要翻译：视频信号记录装置具有用于发送输入视频信号的第一和第二信道。第一通道具有用于在数据上进行1H延迟的行存储器和用于对1H延迟的数据进行时基扩展的时基扩展线存储器。经过时基扩展的数据经历D / A转换为第一通道的输出。另一方面，第二通道不具有用于1H延迟的行存储器，并且没有延迟的视频信号经受时基扩展，并且经历D / A转换为第二通道的输出。在这种布置中，分别包含在每个通道中的相邻两个帧中的奇数行和偶数行被反转，使得在某个帧中，输入视频信号的奇数行通过第二通道的偶数行通过第一通道传输。在下一帧中，偶数行通过第二通道以奇数行通过第一通道传输。因此，由于电路特性的差异对对再现图像的影响被平均，并且避免了对颜色或亮度的不均匀性的感知。

5. 发明授权

US4569331A Solar heat powered plant 失效
标题翻译：太阳能热力发电厂
公开(公告)号：US4569331A
公开(公告)日：1986-02-11
申请号：US559248
申请日：1983-12-08
申请人： Tatsuo Tani , Sinji Sawata , Tadayoshi Tanaka , Koichi Sakuta , Yuuji Nagata , Yasushi Eto , Makoto Adachi , Yasunori Matsurra
发明人： Tatsuo Tani , Sinji Sawata , Tadayoshi Tanaka , Koichi Sakuta , Yuuji Nagata , Yasushi Eto , Makoto Adachi , Yasunori Matsurra
IPC分类号： F24S90/00 , F24D11/00 , F24D17/00
CPC分类号： F24D11/003 , Y02B10/20
摘要： In a solar heat powered plant according to the present invention, hot water is normally circulated through a hot-water tank, a low-temperature-side heat load unit, a return tank, a low-temperature-side heat exchanger, and again through the hot-water tank, in the order named, under the condition in which first and second valves are opened and closed, respectively. On the other hand, in warming up the hot-water tank, the first and second valves are closed and opened, respectively, so that the hot water is circulated between the hot-after tank and the low-temperature-side heat exchanger, through a by-pass pipe. Thus, the warming up of the hot-water tank can be achieved in a short time.
摘要翻译：在本发明的太阳能热力发电设备中，热水通常循环通过热水箱，低温侧热负荷单元，回流箱，低温侧热交换器，再次通过分别在第一和第二阀门打开和关闭的条件下按照命名的顺序排列热水箱。另一方面，在对热水箱进行预热时，第一和第二阀分别关闭并打开，使得热水在热水箱和低温侧热交换器之间循环，通过旁路管。因此，可以在短时间内实现热水箱的升温。

6. 发明授权

US4160784A Process for the production of o-aminophenyl ketone derivatives 失效
标题翻译：制备邻氨基苯基酮衍生物的方法
公开(公告)号：US4160784A
公开(公告)日：1979-07-10
申请号：US770037
申请日：1977-02-18
申请人： Tsutomu Sugasawa , Tatsuo Toyoda , Makoto Adachi , Kazuyuki Sasakura
发明人： Tsutomu Sugasawa , Tatsuo Toyoda , Makoto Adachi , Kazuyuki Sasakura
IPC分类号： C07C225/22 , C07C67/00 , C07C241/00 , C07C251/24 , C07F5/02 , C07C85/18
CPC分类号： C07F5/022
摘要： O-Aminophenyl ketone derivatives are regio-specifically prepared by reacting an aniline unsubstituted in at least one ortho position with a nitrile in the presence of boron trihalogenide to introduce a substituted iminomethyl into the ortho position of said aniline and hydrolyzing the resulting iminomethyl compound.
摘要翻译：通过在三卤代硼存在下使至少一个邻位未取代的苯胺与腈反应来引入O-氨基苯基酮衍生物，以将取代的亚氨基甲基引入所述苯胺的邻位并水解所得的亚氨基甲基化合物。

7. 发明申请

US20100123728A1 MEMORY ACCESS CONTROL CIRCUIT AND IMAGE PROCESSING SYSTEM 有权
标题翻译：存储器访问控制电路和图像处理系统
公开(公告)号：US20100123728A1
公开(公告)日：2010-05-20
申请号：US12608322
申请日：2009-10-29
申请人： Akihiro KAWAHARA , Makoto Adachi , Kouji Nishikawa , Masayuki Nakamura , Motonobu Mamiya , Kae Yamashita
发明人： Akihiro KAWAHARA , Makoto Adachi , Kouji Nishikawa , Masayuki Nakamura , Motonobu Mamiya , Kae Yamashita
IPC分类号： G06F13/00 , G06F12/16
CPC分类号： G09G5/397 , G09G5/363 , G09G5/393
摘要： A memory access control circuit includes a first internal register, an address transmitting unit that sets a state of the first internal register to a first state to transmit a first address and sets a state of the first internal register to a second state to transmit a second address, a second internal register, a data receiving unit that sets a state of the second internal register to a third state to receive first data corresponding to the first address, performs data processing on the first data without delay, sets a state of the second internal register to a fourth state to receive second data corresponding to the second address, and performs data processing on the second data after delaying the second data by a given delay time, a first backup unit and a second backup unit.
摘要翻译：存储器访问控制电路包括第一内部寄存器，地址发送单元，其将第一内部寄存器的状态设置为第一状态以发送第一地址，并将第一内部寄存器的状态设置为第二状态，以发送第二内部寄存器地址，第二内部寄存器，数据接收单元，其将第二内部寄存器的状态设置为第三状态，以接收对应于第一地址的第一数据，对延迟的第一数据执行数据处理，设置第二内部寄存器的状态内部寄存器到第四状态以接收对应于第二地址的第二数据，并且在延迟给定延迟时间的第二数据之后对第二数据执行数据处理，第一备份单元和第二备份单元。

8. 发明授权

US06756376B1 Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities 失效
标题翻译：具有sPLA2抑制活性的三环唑烷衍生物
公开(公告)号：US06756376B1
公开(公告)日：2004-06-29
申请号：US10129658
申请日：2002-05-09
申请人： Masahiro Fuji , Tetsuo Okada , Makoto Adachi
发明人： Masahiro Fuji , Tetsuo Okada , Makoto Adachi
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein E is N or C—R4; G is N or C—R25; R1 is a carbocyclic group, heterocyclic group or the like; one of R3 and R4 is —(L2)-(acidic group), the other is a hydrogen atom, wherein L2 is a group connecting with an acid group; A ring is optionally substituted 5-8 membered cyclohexane ring or cyclohexene ring; R24 and R25 are a hydrogen atom or the like, its prodrug, their pharmaceutically acceptable salt, or hydrate thereof.
摘要翻译：本发明提供具有sPLA2抑制活性的化合物。式（I）表示的化合物：其中E为N或C-R 4; G是N或C-R 25; R 1是碳环基，杂环基等; R 3和R 4中的一个是 - （L 2） - （酸性基团），另一个是氢原子，其中L 2是与酸基连接的基团; 环是任选取代的5-8元环己烷环或环己烯环; R 24和R 25是氢原子等，其前药，其药学上可接受的盐或水合物。

9. 发明授权

US06703385B1 Tricyclic compounds having sPLA2-inhibitory activities 失效
标题翻译：具有sPLA2抑制活性的三环化合物
公开(公告)号：US06703385B1
公开(公告)日：2004-03-09
申请号：US10031443
申请日：2002-01-22
申请人： Mitsuaki Ohtani , Masahiro Fuji , Makoto Adachi , Tomoyuki Ogawa
发明人： Mitsuaki Ohtani , Masahiro Fuji , Makoto Adachi , Tomoyuki Ogawa
IPC分类号： A61K3133
CPC分类号： C07D471/04
摘要： The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocyclic groups or the like; R2 is COCONH2 or the like; Q1 is a nitrogen atom or C—R4; one of R3 and R4 is —(L2)-(acidic group) wherein L2 is a group connecting with an acid group and the length of the connecting groups 1 to 5 atoms, and the other is a hydrogen atom; R21 and R22 are hydrogen atoms or the like; X is —CR23R24— or the like wherein R23 and R24 are hydrogen atoms or the like; Y is —CR25R26— or the like wherein R25 and R26 are hydrogen atoms or the like; Z is CH2 or the like; a broken line ( - - - ) represents the presence or absence of a bond, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.
摘要翻译：本发明提供具有sPLA2抑制活性的化合物。式（I）表示的化合物：其中R 1为（a）C 1至C 20烷基，C 2至C 20烯基，C 2至C 20炔基，碳环基，杂环基或类似物; R 2是COCONH 2等; Q 1是氮原子或C-R 4; R 3和R 4之一是 - （L 2） - （酸性基团）其中L 2是与酸基连接的基团和连接基团的长度为1至5个原子，以及另一个是氢原子; R 21和R 22是氢原子等; X是-CR 23 R 24 - 等，其中R 23和R 24是氢原子等; Y是-CR 25 R 26 - 等，其中R 25和R 26是氢原子等; Z是CH 2等; 虚线（ - - - ）表示键的存在或不存在，其前体药物，其药学上可接受的盐或溶剂合物。

10. 发明授权

US06472389B1 Pyrrolo[1,2-b] pyridazine derivatives having sPLA2 inhibitory effect 失效
标题翻译：具有sPLA2抑制作用的吡咯并[1,2-b]哒嗪衍生物
公开(公告)号：US06472389B1
公开(公告)日：2002-10-29
申请号：US09673413
申请日：2000-10-18
申请人： Mitsuaki Ohtani , Masahiro Fuji , Yoshikazu Fukui , Makoto Adachi
发明人： Mitsuaki Ohtani , Masahiro Fuji , Yoshikazu Fukui , Makoto Adachi
IPC分类号： A61K315025
CPC分类号： C07D487/04
摘要： The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein R1 is —(L1)—R6 wherein L1 is a divalent linking group of 1 to 18 atoms or the like, and R6 is a carbocyclic ring substituted by at least one non-interfering substituent or the like; R2 is C1 to C3 alkyl or the like; R3 is —(L2)-(acidic group); R4 and R5 are hydrogen atoms, non-interfering substituents, carbocyclic groups or the like; X is independently oxygen atom of sulfur atom; and RA is —C(═X)—C(═X)—NH2 or the like; the prodrugs thereof, their pharmaceutically acceptable salts, or their solvates, and a composition for inhibiting sPLA2 containing them as effective ingredients.
摘要翻译：本发明提供具有sPLA2抑制活性的化合物。式（I）表示的化合物：其中R1为 - （L1）-R6，其中L1为1至18个原子的二价连接基团等，R6为被至少一个非干扰取代基等取代的碳环; R2是C1-C3烷基等; R3是 - （L2） - （酸性基团）; R4和R5是氢原子，非干扰取代基，碳环基团等; X独立地是硫原子的氧原子; RA为-C（= X）-C（= X）-NH 2等; 其前体药物，其药学上可接受的盐或其溶剂合物，以及用于抑制含有它们作为有效成分的sPLA2的组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式