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1. 发明申请

US20090104702A1 Attenuated chimeric flavivirus bearing attenuated Japanese encephalitis virus gene as backbone 失效
标题翻译：具有减毒的日本脑炎病毒基因的减毒嵌合黄病毒作为骨架
公开(公告)号：US20090104702A1
公开(公告)日：2009-04-23
申请号：US12292518
申请日：2008-11-20
申请人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
发明人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
IPC分类号： C12N15/87 , C12N15/11 , C12N15/00 , C12N7/00
CPC分类号： A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24134 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
摘要翻译：含有编码日本脑炎病毒的衣壳蛋白，膜前蛋白质和非结构蛋白质的核苷酸序列的核酸分子和编码第二黄病毒的包膜蛋白的核苷酸序列，其中编码的核苷酸序列日本脑炎病毒的膜前蛋白质和/或非结构蛋白质含有产生一种或多种减弱病毒的氨基酸突变的核苷酸突变。

2. 发明授权

US07749734B2 Attenuated chimeric flavivirus bearing attenuated Japanese encephalitis virus gene as backbone 失效
标题翻译：具有减毒的日本脑炎病毒基因的减毒嵌合黄病毒作为骨架
公开(公告)号：US07749734B2
公开(公告)日：2010-07-06
申请号：US11793277
申请日：2005-12-22
申请人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
发明人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
IPC分类号： C12N7/01 , A61K39/12
CPC分类号： A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24134 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
摘要翻译：含有编码日本脑炎病毒的衣壳蛋白，膜前蛋白质和非结构蛋白质的核苷酸序列的核酸分子和编码第二黄病毒的包膜蛋白的核苷酸序列，其中编码的核苷酸序列日本脑炎病毒的膜前蛋白质和/或非结构蛋白质含有产生一种或多种减弱病毒的氨基酸突变的核苷酸突变。

3. 发明授权

US08492532B2 Attenuated chimeric flavivirus bearing attenuated japanese encephalitis virus gene as backbone 失效
标题翻译：减毒的日本脑炎病毒基因的减毒嵌合黄病毒为骨架
公开(公告)号：US08492532B2
公开(公告)日：2013-07-23
申请号：US12292518
申请日：2008-11-20
申请人： Kouichi Morita , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
发明人： Kouichi Morita , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
IPC分类号： C12N7/00 , A61K39/12
CPC分类号： A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24134 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
摘要翻译：含有编码日本脑炎病毒的衣壳蛋白，膜前蛋白质和非结构蛋白质的核苷酸序列的核酸分子和编码第二黄病毒的包膜蛋白的核苷酸序列，其中编码的核苷酸序列日本脑炎病毒的膜前蛋白质和/或非结构蛋白质含有产生一种或多种减弱病毒的氨基酸突变的核苷酸突变。

4. 发明申请

US20080138363A1 Attenuated Chimeric Flavivirus Bearing Attenuated Japanese Encephalitis Virus Gene as Backbone 失效
标题翻译：减毒的嵌合黄病毒携带减毒的日本脑炎病毒基因作为骨干
公开(公告)号：US20080138363A1
公开(公告)日：2008-06-12
申请号：US11793277
申请日：2005-12-22
申请人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
发明人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
IPC分类号： A61K39/12 , C12N15/40 , C12N15/00 , C12N7/04
CPC分类号： A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24134 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
摘要翻译：含有编码日本脑炎病毒的衣壳蛋白，膜前蛋白质和非结构蛋白质的核苷酸序列的核酸分子和编码第二黄病毒的包膜蛋白的核苷酸序列，其中编码的核苷酸序列日本脑炎病毒的膜前蛋白质和/或非结构蛋白质含有产生一种或多种减弱病毒的氨基酸突变的核苷酸突变。

5. 发明授权

US08507339B2 BiCMOS device 有权
标题翻译： BiCMOS器件
公开(公告)号：US08507339B2
公开(公告)日：2013-08-13
申请号：US12950178
申请日：2010-11-19
申请人： Shinichi Miyake , Kazuaki Tsunoda
发明人： Shinichi Miyake , Kazuaki Tsunoda
IPC分类号： H01L21/8238
CPC分类号： H01L21/8249 , H01L27/0623
摘要： In a BiCMOS device, a device isolation film separating the bipolar transistor region from the MOS region is taller than the substrate at least where it contacts the bipolar transistor region, and is preferably taller than the same layer where it contacts the MOS transistor region. This makes it possible to maintain the processing accuracy of a MOS transistor while stabilizing the diode current characteristics of the bipolar transistor.
摘要翻译：在BiCMOS器件中，将双极晶体管区域与MOS区域分开的器件隔离膜至少在与双极晶体管区域接触的地方比衬底高，并且优选地与与MOS晶体管区域接触的相同层高。这使得可以在稳定双极晶体管的二极管电流特性的同时保持MOS晶体管的处理精度。

6. 发明申请

US20080145657A1 Process for Producing Metallic Ultrafine Powder 有权
标题翻译：生产金属超细粉的工艺
公开(公告)号：US20080145657A1
公开(公告)日：2008-06-19
申请号：US11793424
申请日：2005-12-22
申请人： Hiroshi Igarashi , Takayuki Matsumura , Shinichi Miyake
发明人： Hiroshi Igarashi , Takayuki Matsumura , Shinichi Miyake
IPC分类号： B32B15/02 , B22F9/22
CPC分类号： B22F9/22 , B22F9/28 , B22F2998/00 , F23D14/22 , F23D14/32 , F23D14/78 , Y02E20/344 , Y10T428/2982 , B22F1/0048 , B22F1/0018
摘要： A process for producing metallic ultra-fine powder, which can use a raw material which is spread over a wide range, and control freely the grain size of the metallic powder to be produced, at low cost and high safety. The process for producing the metallic ultra fine powder consists of using a burner and a furnace which can generate a high temperature reductive atmosphere, and an apparatus for separating gas which is generated in the furnace from powder to recover the powder. The burner has a function of blowing a powdery metallic compound as a raw material into a high temperature reductive flame. The raw material powder is efficiently heated in airflow of a high temperature reductive flame, thereby being reduced rapidly into metallic ultra-fine powder. At this time, the grain size of the metallic ultra-fine powder is controlled by adjusting the oxygen ratio (i.e. the ratio of amount of the burning-assist gas supplied to the burner to the amount of the burning-assist gas required for completely burning the fuel).
摘要翻译：一种生产金属超细粉末的方法，其可以使用在宽范围内分散的原料，并且以低成本和高安全性自由地控制待生产的金属粉末的晶粒尺寸。金属超细粉末的制造方法由使用能够产生高温还原气氛的燃烧器和炉子构成，以及用于从炉中产生的气体从粉末中分离以回收粉末的装置。燃烧器具有将作为原料的粉末状金属化合物吹入高温还原火焰的功能。原料粉末在高温还原火焰气流中被有效地加热，从而迅速地被还原成金属超细粉末。此时，通过调节氧比（即，供给燃烧器的燃烧辅助气体的量与完全燃烧所需的燃烧辅助气体的量的比例）来控制金属超细粉末的粒径燃料）。

7. 发明授权

US5743930A Apparatus for producing inorganic spherical particles 失效
标题翻译：用于生产无机球形颗粒的装置
公开(公告)号：US5743930A
公开(公告)日：1998-04-28
申请号：US788335
申请日：1997-01-27
申请人： Shinichi Miyake , Takeru Yajima
发明人： Shinichi Miyake , Takeru Yajima
IPC分类号： B01J2/00 , B01J2/16 , C01B33/12 , B29B9/00
CPC分类号： B01J2/16
摘要： The apparatus for manufacturing inorganic spherical particles according to the present invention consists of a vertical sphering furnace, a sphering burner disposed at the top of the furnace, a particle outflow pipe through which spherical particles formed in the furnace are drawn out therefrom and an air inflow pipe for introducing air for carrying the spherical particles toward the opening of the particle outflow pipe; wherein the particle outflow pipe and the air inflow pipe are arranged to oppose each other horizontally at a lower position of the furnace. The opening diameter of the particle outflow pipe is designed to be larger than that of the air inflow pipe.
摘要翻译：根据本发明的无机球形颗粒的制造装置包括垂直气相炉，设置在炉顶部的气泡燃烧器，将从炉中形成的球形颗粒从其中排出的颗粒流出管和空气流入用于将用于将球形颗粒携带的空气朝向颗粒流出管的开口的管道; 其中，所述颗粒流出管和所述空气流入管在所述炉的下部位置处水平相对地配置。颗粒流出管的开口直径设计成大于空气流入管的开口直径。

8. 发明授权

US5106584A Cell selecting apparatus 失效
标题翻译：细胞选择装置
公开(公告)号：US5106584A
公开(公告)日：1992-04-21
申请号：US437287
申请日：1989-11-16
申请人： Hiroyasu Funakubo , Shinichi Miyake , Yoshikazu Nishiwaki
发明人： Hiroyasu Funakubo , Shinichi Miyake , Yoshikazu Nishiwaki
IPC分类号： C12M1/00 , C12M1/32 , C12M1/34 , G01N33/48 , G01N33/577 , G01N35/02
CPC分类号： G01N35/028 , C12M23/04 , C12M23/50 , C12M33/04 , C12M41/36 , C12M41/46 , C12M47/04 , Y10T436/113332
摘要： A cell selecting apparatus which has an extracting and injection section, a tray transport section, a cultivating section, a cell selecting section, and a controller for controlling each section according to the operating conditions which are inputted therein. This arrangement makes it possible to select and isolate the desired cells or microorganisms from mixtures of different types of cells or microorganisms, for example, those which are capable of proliferating over short periods of time and producing antibodies or secretions, from a liquid culture of cells.
摘要翻译：具有提取和注射部分的细胞选择装置，托盘传送部分，培养部分，细胞选择部分和用于根据输入其中的操作条件控制每个部分的控制器。这种布置使得可以从不同类型的细胞或微生物的混合物中选择和分离所需的细胞或微生物，例如能够在短时间内能够增殖并产生抗体或分泌物的细胞或微生物从细胞的液体培养物。

9. 发明申请

US20110256250A1 Process for producing metallic ultrafine powder 审中-公开
公开(公告)号：US20110256250A1
公开(公告)日：2011-10-20
申请号：US13067780
申请日：2011-06-27
申请人： Hiroshi Igarashi , Takayuki Matsumura , Shinichi Miyake
发明人： Hiroshi Igarashi , Takayuki Matsumura , Shinichi Miyake
IPC分类号： B22F9/02 , F23C99/00
CPC分类号： B22F9/22 , B22F9/28 , B22F2998/00 , F23D14/22 , F23D14/32 , F23D14/78 , Y02E20/344 , Y10T428/2982 , B22F1/0048 , B22F1/0018
摘要： A process for producing metallic ultra-fine powder, which can use a raw material which is spread over a wide range, and control freely the grain size of the metallic powder to be produced, at low cost and high safety. The process for producing the metallic ultra fine powder consists of using a burner and a furnace which can generate a high temperature reductive atmosphere, and an apparatus for separating gas which is generated in the furnace from powder to recover the powder. The burner has a function of blowing a powdery metallic compound as a raw material into a high temperature reductive flame. The raw material powder is efficiently heated in airflow of a high temperature reductive flame, thereby being reduced rapidly into metallic ultra-fine powder. At this time, the grain size of the metallic ultra-fine powder is controlled by adjusting the oxygen ratio (i.e. the ratio of amount of the burning-assist gas supplied to the burner to the amount of the burning-assist gas required for completely burning the fuel).

10. 发明授权

US07787984B2 Sphering apparatus and operating method thereof 有权
标题翻译：悬挂装置及其操作方法
公开(公告)号：US07787984B2
公开(公告)日：2010-08-31
申请号：US12066752
申请日：2005-09-22
申请人： Yoshiyuki Hagiwara , Shinichi Miyake
发明人： Yoshiyuki Hagiwara , Shinichi Miyake
IPC分类号： G06F19/00 , C03B13/14 , C03B9/00
CPC分类号： C01B33/12
摘要： A sphering apparatus includes a sphering furnace on a body of which a plurality of adhesion preventing air-introducing holes is formed and at a lower position of which a carrier air-introducing hole and a carrier air-withdrawing hole are formed; an air blower introducing both an adhesion preventing air and a carrier air; a first pipe one end of which is connected to a discharging part of the air blower and the other end of which is biforked, one biforked end being connected to the carrier air-introducing hole and the other biforked end being connected to a manifold bundling the plurality of adhesion preventing air-introducing holes; a first damper provided in any one of two pipes in the biforked part of the first pipe; a cyclone connected to the carrier air-withdrawing hole through a second pipe; and a bag filter connected to the cyclone through a third pipe.
摘要翻译：悬挂装置包括在其上形成有多个防粘连空气引入孔的主体上的气相炉，并且在其下部形成有载体空气引入孔和载体抽吸孔; 引入防粘气体和载气的鼓风机; 第一管一端连接到鼓风机的排放部分并且另一端被分叉，一个分叉端连接到载体空气引入孔，另一个分叉端连接到歧管多个防粘附空气导入孔; 设置在第一管道的分叉部分中的两个管道中的任一个中的第一阻尼器; 通过第二管连接到载体抽气孔的旋风分离器; 以及通过第三管连接到旋风分离器的袋式过滤器。

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