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1. 发明授权

US08989839B2 Method and apparatus for diagnosis of tumor activity using tumor interstitial fluid pressure 有权
标题翻译：使用肿瘤间质液压力诊断肿瘤活动的方法和装置
公开(公告)号：US08989839B2
公开(公告)日：2015-03-24
申请号：US13585784
申请日：2012-08-14
申请人： Mordechay Schlesinger , Long Jian Liu , James R. Ewing , Stephen L. Brown
发明人： Mordechay Schlesinger , Long Jian Liu , James R. Ewing , Stephen L. Brown
IPC分类号： A61B5/03 , A61B5/055 , A61B5/00
CPC分类号： A61B5/03 , A61B5/0059
摘要： A scanning apparatus, is used to effect multiple images of a tumor in which a contrast agent has been localized as a detectable marker over a selected time to map the change in the imaged marker. The rate of change in the imaged marker and/or contrast intensity of the dyed tissues is used to assess tumor aggressiveness and as an early predictor of response to cancer therapy. In particular, following the marking of tumor or cancerous tissues by the initial localization of an imageable contrast agent, the rate of change in the volume and/or area of the imaged marker is used to provide an indication of tumor interstitial fluid pressure (TIFP).
摘要翻译：扫描装置用于在所选择的时间内使造影剂已经被定位为可检测标记的肿瘤的多个图像以映射成像的标记物的变化。使用染色组织的成像标记和/或对比度强度的变化率来评估肿瘤侵袭性，并且作为对癌症治疗反应的早期预测因子。特别地，在通过可成像造影剂的初始定位来标记肿瘤或癌组织之后，使用成像标记物的体积和/或面积的变化率来提供肿瘤间质液压力（TIFP）的指示，。

2. 发明申请

US20140051981A1 METHOD AND APPARATUS FOR DIAGNOSIS OF TUMOR ACTIVITY USING TUMOR INTERSTITIAL FLUID PRESSURE 有权
标题翻译：使用肿瘤间质液体压力诊断肿瘤活性的方法和装置
公开(公告)号：US20140051981A1
公开(公告)日：2014-02-20
申请号：US13585784
申请日：2012-08-14
申请人： Mordechay Schlesinger , Long Jian Liu , James R. Ewing , Stephen L. Brown
发明人： Mordechay Schlesinger , Long Jian Liu , James R. Ewing , Stephen L. Brown
IPC分类号： A61B5/03
CPC分类号： A61B5/03 , A61B5/0059
摘要： A scanning apparatus, is used to effect multiple images of a tumor in which a contrast agent has been localized as a detectable marker over a selected time to map the change in the imaged marker. The rate of change in the imaged marker and/or contrast intensity of the dyed tissues is used to assess tumor aggressiveness and as an early predictor of response to cancer therapy. In particular, following the marking of tumor or cancerous tissues by the initial localization of an imageable contrast agent, the rate of change in the volume and/or area of the imaged marker is used to provide an indication of tumor interstitial fluid pressure (TIFP).
摘要翻译：扫描装置用于在所选择的时间内使造影剂已经被定位为可检测标记的肿瘤的多个图像以映射成像的标记物的变化。使用染色组织的成像标记和/或对比度强度的变化率来评估肿瘤侵袭性，并且作为对癌症治疗反应的早期预测因子。特别地，在通过可成像造影剂的初始定位来标记肿瘤或癌组织之后，使用成像标记物的体积和/或面积的变化率来提供肿瘤间质液压力（TIFP）的指示，。

3. 发明申请

US20100198054A1 MRI ESTIMATION OF CONTRAST AGENT CONCENTRATION USING A NEURAL NETWORK APPROACH 有权
标题翻译： MRI使用神经网络方法估算对比剂浓度
公开(公告)号：US20100198054A1
公开(公告)日：2010-08-05
申请号：US12600750
申请日：2008-05-19
申请人： James R. Ewing , Hassan Bagher-Ebadian
发明人： James R. Ewing , Hassan Bagher-Ebadian
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/7267
摘要： The invention comprises systems, methods, and apparatus to correlate changes in MRI data with CA concentration, using an adaptive neural network In MRI techniques, CAs are used to estimate vascular properties such as blood flow, blood volume, and transfer constant of tissue microvessels However, the relationship between the contrast in the MRI image and the contrast agent concentration is not linear, instead depending on factors such as the nature of the sequence, the nature of the tissue, and the tissue concentration of contrast agent, and thus limiting the reliability of vascular properties using MRI
摘要翻译：本发明包括使用自适应神经网络将MRI数据的变化与CA浓度相关联的系统，方法和装置。在MRI技术中，CA用于估计血管特性，例如血流量，血液体积和组织微血管的传递常数。然而 MRI图像中的对比度与造影剂浓度之间的关系不是线性的，而是取决于诸如序列的性质，组织的性质和造影剂的组织浓度等因素，从而限制了可靠性的血管性质使用MRI

4. 发明授权

US09370316B2 MRI estimation of contrast agent concentration using a neural network approach 有权
标题翻译：使用神经网络方法对造影剂浓度的MRI估计
公开(公告)号：US09370316B2
公开(公告)日：2016-06-21
申请号：US12600750
申请日：2008-05-19
申请人： James R. Ewing , Hassan Bagher-Ebadian
发明人： James R. Ewing , Hassan Bagher-Ebadian
IPC分类号： A61B5/055 , A61B5/00
CPC分类号： A61B5/055 , A61B5/7267
摘要： The invention comprises systems, methods, and apparatus to correlate changes in MRI data with CA concentration, using an adaptive neural network In MRI techniques, CAs are used to estimate vascular properties such as blood flow, blood volume, and transfer constant of tissue microvessels However, the relationship between the contrast in the MRI image and the contrast agent concentration is not linear, instead depending on factors such as the nature of the sequence, the nature of the tissue, and the tissue concentration of contrast agent, and thus limiting the reliability of vascular properties using MRI.
摘要翻译：本发明包括使用自适应神经网络将MRI数据的变化与CA浓度相关联的系统，方法和装置。在MRI技术中，CA用于估计血管特性，例如血流量，血液体积和组织微血管的传递常数。然而 MRI图像中的对比度与造影剂浓度之间的关系不是线性的，而是取决于诸如序列的性质，组织的性质和造影剂的组织浓度等因素，从而限制了可靠性的血管性质使用MRI。

5. 发明申请

US20140167756A1 SEALED MAGIC ANGLE SPINNING NUCLEAR MAGNETIC RESONANCE PROBE AND PROCESS FOR SPECTROSCOPY OF HAZARDOUS SAMPLES 有权
标题翻译：密封魔术角旋转核磁共振探测和有害样品光谱的过程
公开(公告)号：US20140167756A1
公开(公告)日：2014-06-19
申请号：US14106441
申请日：2013-12-13
申请人： Herman M. Cho , Nancy M. Washton , Karl T. Mueller , Jesse A. Sears, JR. , Mark R. Townsend , James R. Ewing
发明人： Herman M. Cho , Nancy M. Washton , Karl T. Mueller , Jesse A. Sears, JR. , Mark R. Townsend , James R. Ewing
IPC分类号： G01R33/30 , G01R33/44
CPC分类号： G01R33/307 , G01N24/08 , G01N24/084 , G01R33/30 , G01R33/465
摘要： A magic-angle-spinning (MAS) nuclear magnetic resonance (NMR) probe is described that includes double containment enclosures configured to seal and contain hazardous samples for analysis. The probe is of a modular design that ensures containment of hazardous samples during sample analysis while preserving spin speeds for superior NMR performance and convenience of operation.
摘要翻译：描述了魔角旋转（MAS）核磁共振（NMR）探针，其包括双重密封外壳，其被配置为密封和容纳用于分析的危险样品。该探头采用模块化设计，可确保在样品分析过程中容纳危险样品，同时保留旋转速度以获得卓越的NMR性能和操作方便性。

6. 发明授权

US4585994A Nuclear magnetic resonance imaging system 失效
标题翻译：核磁共振成像系统
公开(公告)号：US4585994A
公开(公告)日：1986-04-29
申请号：US514169
申请日：1983-07-15
申请人： James R. Ewing
发明人： James R. Ewing
IPC分类号： G01R33/20 , A61B5/055 , A61B10/00 , G01R33/38 , G01R33/385 , G01R33/421 , G12B17/02 , H01F7/20
CPC分类号： G01R33/381 , G01R33/421
摘要： A nuclear magnetic resonance imaging system comprising a high field solenoidal magnet providing a uniform static magnetic field surrounding a subject, an RF coil surrounding the subject, a receiver coil surrounding the subject, and a cylindrical shell of magnetic material surrounding the magnet and the RF and receiver coils. The shell is positioned such that the wall thereof lies in the area of the field of the magnet where the shell's permeability is substantially at a maximum for the imposed field such that the shell functions to substantially confine the field of the magnet to an area about the shell and the environment is not adversely affected and no additional protection is required surrounding the system.
摘要翻译：一种核磁共振成像系统，包括提供围绕对象的均匀静磁场的高场螺线管磁体，围绕对象的RF线圈，围绕对象的接收器线圈和围绕磁体和RF的磁性材料的圆柱形外壳，以及接收线圈。外壳被定位成使得其壁位于磁体领域的区域中，其中外壳的磁导率基本上在施加的场地处于最大值，使得壳体基本上将磁体的磁场限制在围绕磁体的区域外壳和环境不会受到不利影响，并且在系统周围不需要额外的保护。

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