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1. 发明授权

US07604982B2 High-throughput screening method for intergrin antagonist and new peptide screened therefrom 失效
标题翻译：用于整合蛋白拮抗剂的高通量筛选方法和从其筛选的新肽
公开(公告)号：US07604982B2
公开(公告)日：2009-10-20
申请号：US10566532
申请日：2004-11-26
申请人： Moon-Hi Han , In-Cheol Kang , Yoon-Suk Lee , Soo-Ik Chang
发明人： Moon-Hi Han , In-Cheol Kang , Yoon-Suk Lee , Soo-Ik Chang
IPC分类号： C12M3/00
CPC分类号： G01N33/54366 , C07K7/06 , C40B30/04 , G01N33/6842 , G01N2333/70546 , G01N2333/70557 , G01N2500/02
摘要： The present invention relates to the screening method of antagonistic material of integrin using the protein chip and useful peptides screened thereby. The protein chip used in the present invention is unique substrate coated with new material, calixarene derivative, which can keep uniform and high activities of proteins. Integrin receptor protein is arrayed high densely on the chip, and materials (protein, peptide, small molecules and so on) specifically inhibiting the binding of ligand can be screened therewith. The integrins used in the present invention are integrin av f3 3 and integrin a1, b j3 3, and new antagonistic peptides screened from peptide library have high binding affinity.
摘要翻译：本发明涉及使用蛋白质芯片的整联蛋白拮抗物质的筛选方法和由此筛选的有用肽。用于本发明的蛋白质芯片是用新材料，杯芳烃衍生物涂覆的独特的底物，其可以保持蛋白质的均匀和高活性。整合素受体蛋白在芯片上高密度排列，可以筛选特异性抑制配体结合的材料（蛋白质，肽，小分子等）。本发明中使用的整联蛋白是整合素av f3 3和整联蛋白a1，b j3 3，从肽文库筛选的新拮抗肽具有高结合亲和力。

2. 发明申请

US20070249061A1 High-Throughput Screening Method for Intergrin Antagonist and New Peptide Screened Therefrom 失效
标题翻译：用于整合蛋白拮抗剂和新肽筛选的高通量筛选方法
公开(公告)号：US20070249061A1
公开(公告)日：2007-10-25
申请号：US10566532
申请日：2004-11-26
申请人： Moon-Hi Han , In-Cheol Kang , Yoon-Suk Lee , Soo-Ik Chang
发明人： Moon-Hi Han , In-Cheol Kang , Yoon-Suk Lee , Soo-Ik Chang
IPC分类号： A61K48/00 , G01N33/68
CPC分类号： G01N33/54366 , C07K7/06 , C40B30/04 , G01N33/6842 , G01N2333/70546 , G01N2333/70557 , G01N2500/02
摘要： The present invention relates to the screening method of antagonistic material of integrin using the protein chip and useful peptides screened thereby. The protein chip used in the present invention is unique substrate coated with new material, calixarene derivative, which can keep uniform and high activities of proteins. Integrin receptor protein is arrayed high densely on the chip, and materials (protein, peptide, small molecules and so on) specifically inhibiting the binding of ligand can be screened therewith. The integrins used in the present invention are integrin av f3 3 and integrin a1, b j3 3, and new antagonistic peptides screened from peptide library have high binding affinity.
摘要翻译：本发明涉及使用蛋白质芯片的整联蛋白拮抗物质的筛选方法和由此筛选的有用肽。用于本发明的蛋白质芯片是用新材料，杯芳烃衍生物涂覆的独特的底物，其可以保持蛋白质的均匀和高活性。整合素受体蛋白在芯片上高密度排列，可以筛选特异性抑制配体结合的材料（蛋白质，肽，小分子等）。本发明中使用的整联蛋白是整合素av f3 3和整联蛋白a1，b j3 3，从肽文库筛选的新拮抗肽具有高结合亲和力。

3. 发明申请

US20120264942A1 METHOD FOR SCREENING OSTEOPONTIN INHIBITOR AND INHIBITOR OBTAINED FROM THE METHOD 审中-公开
标题翻译：用于筛选由该方法获得的骨钙素抑制剂和抑制剂的方法
公开(公告)号：US20120264942A1
公开(公告)日：2012-10-18
申请号：US13296049
申请日：2011-11-14
申请人： In-Cheol Kang , Eung-Yoon Kim , Young-Jin Choi
发明人： In-Cheol Kang , Eung-Yoon Kim , Young-Jin Choi
IPC分类号： C40B30/02 , C07D417/04 , C07C49/83
CPC分类号： G01N33/6893 , C07C50/32 , C07C2602/28 , C07D417/04 , G01N33/566 , G01N33/6845 , G01N2333/70557 , G01N2500/02 , G01N2800/108
摘要： Provided is a compound found by screening a material for inhibiting an osteopontin, in which the material for inhibiting the osteopontin can increase effectiveness as an excellent material for inhibiting an osteoporosis.
摘要翻译：提供通过筛选抑制骨桥蛋白的材料而发现的化合物，其中用于抑制骨桥蛋白的材料可以提高作为抑制骨质疏松症的优异材料的有效性。

4. 发明授权

US06537551B2 Anti-tumor agent comprising salmosin as an active ingredient 有权
标题翻译：抗肿瘤剂包括沙莫沙星作为活性成分
公开(公告)号：US06537551B2
公开(公告)日：2003-03-25
申请号：US09776268
申请日：2001-02-02
申请人： Doo-Sik Kim , Kwang Hoe Chung , In-Cheol Kang
发明人： Doo-Sik Kim , Kwang Hoe Chung , In-Cheol Kang
IPC分类号： A61K3900
CPC分类号： C07K14/46 , A61K38/00 , A61K48/00
摘要： The present invention relates to an anti-tumor agent comprising Salmosin which is a novel disintegrin containing Arg-Gly-Asp (RGD) sequence and derived from venom of Korean snake, Agkistrodon halys brevicaudus, as an active ingredient. Salmosin is a disintegrin which blocks the function of &agr;v&bgr;3 integrin and strongly inhibits tumor angiogenesis, tumor metastasis as well as growth of solid tumor. Salmosin does not exhibit cytotoxicity within an effective dose range where tumor growth is efficiently suppressed without any untoward effect on preexisting blood vessels and normal angiogenesis. Accordingly, Salmosin can be applied for the development of potent anti-tumor drugs which are effective for various types of cancers.
摘要翻译：本发明涉及含有Salmosin的抗肿瘤剂，其为含有Arg-Gly-Asp（RGD）序列的新型去整合素，其衍生自作为活性成分的韩国蛇（Agkistrodon halys brevicaudus）的毒液。 Salmosin是一种阻断alphavbeta3整合素功能的解体蛋白，强烈抑制肿瘤血管生成，肿瘤转移以及实体瘤的生长。 Salmosin在有效剂量范围内不显示细胞毒性，其中肿瘤生长被有效抑制，而对预先存在的血管和正常血管生成没有任何不利影响。因此，Salmosin可用于开发对各种类型的癌症有效的有效的抗肿瘤药物。

5. 发明申请

US20120101284A1 METHOD FOR SCREENING INHIBITOR FOR INHIBITING INTERACTION BETWEEN BETA-AMYLOID PEPTIDE AND VEGF AND INHIBITOR SEARCHED BY THE SAME 审中-公开
标题翻译：用于筛选抑制剂以抑制β-淀粉样蛋白与VEGF之间的相互作用的方法和由其搜索的抑制剂
公开(公告)号：US20120101284A1
公开(公告)日：2012-04-26
申请号：US13379213
申请日：2010-06-15
申请人： In-Cheol Kang , Chan-Won Park
发明人： In-Cheol Kang , Chan-Won Park
IPC分类号： C07D493/04 , C07D407/10 , C40B30/02
CPC分类号： C07D493/04 , G01N2333/4709 , G01N2500/00 , G01N2800/2821
摘要： There is provided a compound found by screening a material for inhibiting a binding between a beta-amyloid 1-42 peptide and VEGF165, in which the inhibition material screened according to the present invention can improve effectiveness as a material for treating Alzheimer's disease.
摘要翻译：提供了通过筛选抑制β-淀粉样蛋白1-42肽与VEGF165之间的结合的材料而发现的化合物，其中根据本发明筛选的抑制材料可以提高作为治疗阿尔茨海默氏病的材料的有效性。

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