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1. 发明申请

US20080152615A1 Composition for Adjuvant Containing Poly-Gamma-Glutamic Acid 审中-公开
标题翻译：含有多糖 - 谷氨酸的佐剂组合物
公开(公告)号：US20080152615A1
公开(公告)日：2008-06-26
申请号：US11817021
申请日：2005-12-06
申请人： Moon-Hee Sung , Chul-Joong Kim , Ha Ryoung Poo , Seung Pyo Hong , Jong Soo Lee , Ji Youn Kim
发明人： Moon-Hee Sung , Chul-Joong Kim , Ha Ryoung Poo , Seung Pyo Hong , Jong Soo Lee , Ji Youn Kim
IPC分类号： A61K39/02 , A61K39/12
CPC分类号： A61K39/39 , A61K2039/55516
摘要： The present invention relates to a composition for an immunopotentiator (adjuvant) containing poly-gamma-glutamic acid and a composition for a vaccine containing the immunopotentiator, and more particularly, to an immunopotentiator containing poly-gamma-glutamic acid capable of enhancing antibody production rate by administering it to an animal together with antigen having low immunogenicity, and a composition for a vaccine containing the immunopotentiator and antigen. The inventive adjuvant has almost no toxicity and side effects, and show high antibody titer even when it is used with antigen having poor immunogenicity, so it can be used by adding to medical composition including preventive or curative vaccine for non-contagious chronic diseases as well as cancer, especially prostatic carcinoma, colon carcinoma, lung cancer, breast cancer, ovarian cancer, head and neck cancer, pudendum cancer, bladder cancer, brain tumor and glioma.
摘要翻译：本发明涉及含有聚-γ-谷氨酸的免疫增强剂（佐剂）组合物和含有免疫增强剂的疫苗组合物，更具体地说，涉及含有能够提高抗体产生率的聚-γ-谷氨酸的免疫增强剂通过将其与抗免疫原性低的抗原一起施用于动物，以及含有免疫增强剂和抗原的疫苗组合物。本发明的佐剂几乎没有毒副作用，即使与抗免疫原性差的抗原一起使用也显示出高的抗体效价，因此可以通过添加包含用于非传染性慢性疾病的预防或治疗性疫苗的医药组合物作为癌症，特别是前列腺癌，结肠癌，肺癌，乳腺癌，卵巢癌，头颈癌，pudendum癌，膀胱癌，脑肿瘤和胶质瘤。

2. 发明授权

US07871816B2 Vector for anti-HPV vaccine and transformed microorganism by the vector 有权
标题翻译：载体用于抗HPV疫苗和转化的微生物载体
公开(公告)号：US07871816B2
公开(公告)日：2011-01-18
申请号：US11939546
申请日：2007-11-13
申请人： Moon-Hee Sung , Ha Ryoung Poo , Jong Soo Lee , Chang Min Jung , Seung Pyo Hong , Chul-Joong Kim , Sue-nie Park , Hyun-mi Pyo
发明人： Moon-Hee Sung , Ha Ryoung Poo , Jong Soo Lee , Chang Min Jung , Seung Pyo Hong , Chul-Joong Kim , Sue-nie Park , Hyun-mi Pyo
IPC分类号： C12N1/20 , C12N15/00
CPC分类号： C07K14/005 , A61K39/0011 , A61K2039/523 , C12N7/00 , C12N2710/20022 , C12N2730/10122 , C12N2830/008
摘要： Expression vectors that can efficiently produce virion capsid protein, tumor-associated protein of human papillomavirus on a microbial surface. Bacterial strains harboring such surface display vectors, and the use of the bacterial strains or their extracts or purified products as complex vaccines, are also described. The surface display vectors contain one or more than two genes selected from among pgsB, pgsC and pgsA, encoding a poly-χ-glutamic acid synthetase complex (pgsBCA) of a Bacillus sp. strain, and genes that encode virion capsid proteins, tumor-associated proteins of human papillomavirus. Methods for preparing the foregoing vectors, vaccines and transformed microorganisms are also described.
摘要翻译：可以有效地产生病毒体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白在微生物表面上的表达载体。还描述了携带这种表面显示载体的细菌菌株，以及细菌菌株或其提取物或纯化产物作为复合疫苗的用途。表面显示载体含有选自pgsB，pgsC和pgsA中的一种或多于两种的基因，编码芽孢杆菌属的多χ-谷氨酸合成酶复合物（pgsBCA）。菌株和编码病毒载体衣壳蛋白，人乳头瘤病毒的肿瘤相关蛋白的基因。还描述了制备前述载体，疫苗和转化的微生物的方法。

3. 发明授权

US07049097B2 Antibiotics-independent vector for constant high-expression and method for gene expression using the same 失效
标题翻译：用于恒定高表达的抗生素无关载体和使用其的基因表达方法
公开(公告)号：US07049097B2
公开(公告)日：2006-05-23
申请号：US10221349
申请日：2002-01-11
申请人： Moon Hee Sung , Seung Goo Lee , Seung Pyo Hong , Eun Ja Yoon , Yoon Ho Choi , Ha Ryoung Poo
发明人： Moon Hee Sung , Seung Goo Lee , Seung Pyo Hong , Eun Ja Yoon , Yoon Ho Choi , Ha Ryoung Poo
IPC分类号： C12P21/00 , C12N15/61 , C12N15/63 , C12N9/90 , C12N1/21
CPC分类号： C12N15/65
摘要： An antibiotic-independent vector for stable vector maintenance and high protein expression and a method for gene expression using this vector are disclosed. The stable maintenance of the vector is due to expression of a glutamic acid racemase to complement a D-glutamic acid auxotroph. No antibiotics, such as ampicillin, are necessary for the stable maintenance of this vector.
摘要翻译：公开了一种用于稳定载体维持和高蛋白表达的抗生素非依赖载体和使用该载体的基因表达方法。载体的稳定维持是由于表达谷氨酸消旋酶以补充D-谷氨酸营养缺陷型。不需要抗生素如氨苄青霉素来稳定维持该载体。

4. 发明授权

US09228190B2 Vector for constitutive high-level expression containing REPe mutant gene 有权
标题翻译：含有REPe突变基因的组成型高水平表达载体
公开(公告)号：US09228190B2
公开(公告)日：2016-01-05
申请号：US13143918
申请日：2010-01-07
申请人： Moon-Hee Sung , Seung Pyo Hong , A Ri Jang
发明人： Moon-Hee Sung , Seung Pyo Hong , A Ri Jang
IPC分类号： C12N15/00 , C12P21/06 , C12N1/20 , C12N15/70 , C07K14/195 , C12N15/74
CPC分类号： C12N15/70 , C07K14/195 , C12N15/746
摘要： A vector for constitutively expressing a high level of a target protein, and more particularly a RepE mutant protein containing a deletion of 21 amino acids in the C-terminal region of a RepE protein and a vector for constitutively expressing a high level of a target protein, which comprises a gene encoding the mutant protein. The constitutive high-level expression vector can stably express a high level of a target protein. Also, the surface expression vector can express a target protein on the surface of recombinant microorganisms while constitutively expressing a high level of the target protein, and thus will be useful for construction of an antigen for vaccines.
摘要翻译：用于组成型表达高水平靶蛋白的载体，更具体地，在RepE蛋白的C-末端区域中含有21个氨基酸缺失的RepE突变蛋白和用于组成型表达高水平靶蛋白的载体，其包含编码突变蛋白的基因。组成型高水平表达载体可稳定表达高水平的靶蛋白。此外，表面表达载体可以在重组微生物的表面上表达靶蛋白，同时组成型表达高水平的靶蛋白，因此可用于构建疫苗抗原。

5. 发明申请

US20110312030A1 CONSISTENT HIGH EXPRESSION VECTOR CONTAINING REP E MUTATED GENE 有权
标题翻译：一致性高表达载体含有突变基因
公开(公告)号：US20110312030A1
公开(公告)日：2011-12-22
申请号：US13143918
申请日：2010-01-07
申请人： Moon-Hee Sung , Seung Pyo Hong , A Ri Jang
发明人： Moon-Hee Sung , Seung Pyo Hong , A Ri Jang
IPC分类号： C12P21/00 , C07K14/00 , C12N1/21 , C12N15/70 , C12N15/11 , C12N15/74
CPC分类号： C12N15/70 , C07K14/195 , C12N15/746
摘要： A vector for constitutively expressing a high level of a target protein, and more particularly a RepE mutant protein containing a deletion of 21 amino acids in the C-terminal region of a RepE protein and a vector for constitutively expressing a high level of a target protein, which comprises a gene encoding the mutant protein. The constitutive high-level expression vector can stably express a high level of a target protein. Also, the surface expression vector can express a target protein on the surface of recombinant microorganisms while constitutively expressing a high level of the target protein, and thus will be useful for construction of an antigen for vaccines.
摘要翻译：用于组成型表达高水平靶蛋白的载体，更具体地，在RepE蛋白的C-末端区域中含有21个氨基酸缺失的RepE突变蛋白和用于组成型表达高水平靶蛋白的载体，其包含编码突变蛋白的基因。组成型高水平表达载体可稳定表达高水平的靶蛋白。此外，表面表达载体可以在重组微生物的表面上表达靶蛋白，同时组成型表达高水平的靶蛋白，因此可用于构建疫苗抗原。

6. 发明授权

US07345122B2 High stereospecific polybutylene polymer and highly active process for preparation thereof 有权
标题翻译：高立体特异性聚丁烯聚合物和高活性的制备方法
公开(公告)号：US07345122B2
公开(公告)日：2008-03-18
申请号：US10569411
申请日：2004-03-31
申请人： Seung Pyo Hong , Min Kyu Park , Deok Kyeong Kim , Seok Joong Hwang
发明人： Seung Pyo Hong , Min Kyu Park , Deok Kyeong Kim , Seok Joong Hwang
IPC分类号： C08F2/38 , C08F110/08
CPC分类号： C08F110/08 , C08F10/00 , Y10S526/905 , C08F4/6565 , C08F4/651 , C08F2500/15 , C08F2500/03 , C08F2500/04 , C08F2500/12 , C08F2500/08
摘要： Disclosed is a process for the preparation of a high stereospecific (isotactic) polybutylene polymer comprising the step of polymerizing a reactive monomer, 1-butene, which is used or is not used as a solvent, in the presence of catalyst and inert gas. According to the present invention, it is possible to prepare a high stereospecific polybutylene polymer in much higher activity than that of any other known processes for the preparation of a high stereospecific polybutylene polymer. The high stereospecific polybutylene polymer according to the present invention is a homopolymer of 1-butene, or a copolymer containing a-olefin and up to 40% by weight of a comonomer, wherein titanium in the catalyst residues is not detected in the ppm level, stereospecificity (Isotactic Index, mmmm %) determined by 13C-NMR is 96 or more, molecular weight distribution (Mw/Mn) is 3-6, and molecular weight distribution (Mw/Mn) can be controlled to 8 or more.
摘要翻译：公开了一种制备高立体定向（全同立构）聚丁烯聚合物的方法，包括在催化剂和惰性气体存在下使用或不用作溶剂的反应性单体1-丁烯聚合的步骤。根据本发明，可以制备比用于制备高立体特异性聚丁烯聚合物的任何其它已知方法高的立体特异性聚丁烯聚合物活性高得多。根据本发明的高立体特异性聚丁烯聚合物是1-丁烯的均聚物或含有α-烯烃的共聚物和至多40重量％的共聚单体的共聚单体，其中催化剂残余物中的钛在ppm水平上未检测到，通过13 C-NMR测定的立体定向性（全同立构指数mmmm％）为96以上，分子量分布（Mw / Mn）为3-6，分子量分布（Mw / Mn）可以为控制在8以上。

7. 发明申请

US20090052900A1 MULTI-FUNCTION REMOTE CONTROLLER AND METHOD OF CONTROLLING THE SAME 审中-公开
标题翻译：多功能遥控器及其控制方法
公开(公告)号：US20090052900A1
公开(公告)日：2009-02-26
申请号：US12109622
申请日：2008-04-25
申请人： Seung Pyo Hong
发明人： Seung Pyo Hong
IPC分类号： H04B10/00
CPC分类号： G08C23/04 , G08C2201/71
摘要： A multi-function remote controller includes a transmitter to transmit a wireless control signal corresponding to one selected from among a first mode via an infrared diode, in which a user manipulates the remote controller with one hand to manipulate a television, and a second mode, in which the user manipulates a video game unit with two hands. The transmitter turns a rotatable lever equipped with the infrared diode to set the first mode or the second mode according to a characteristic of an appliance to be controlled. The transmitter sets the remote controller in the first mode if a protrusion of the rotatable lever does not make contact with a mode selecting switch, and sets the remote controller in the second mode if the protrusion of the rotatable lever makes contact with the mode selecting switch due to the rotation of the rotatable lever, thereby simplifying components to set each mode using one hand or two hands.
摘要翻译：多功能遥控器包括发射器，用于通过红外二极管传输对应于从第一模式中选择的一个的无线控制信号，其中用户用一只手操纵遥控器来操纵电视机;以及第二模式，其中用户用双手操纵视频游戏单元。变送器转动配备有红外二极管的可旋转杆，以根据要控制的器具的特性来设置第一模式或第二模式。如果可旋转杆的突起不与模式选择开关接触，则发射器将遥控器设置在第一模式中，并且如果可旋转杆的突起与模式选择开关接触，则将遥控器设置在第二模式由于可旋转杆的旋转，由此简化部件以使用一只手或两只手来设定每个模式。

8. 发明授权

US07056989B2 Polyalkylaromaticsilsesquioxane and preparation method thereof 失效
公开(公告)号：US07056989B2
公开(公告)日：2006-06-06
申请号：US10386936
申请日：2003-03-13
申请人： Seung Sang Hwang , Soon Man Hong , Eung Chan Lee , Seung Pyo Hong
发明人： Seung Sang Hwang , Soon Man Hong , Eung Chan Lee , Seung Pyo Hong
IPC分类号： C08G77/04 , C08G77/06
CPC分类号： C08G77/04 , C08G77/24
摘要： Highly regular and well-defined structured polyorganosilsesquioxane polymer with superior heat resistance, combustion resistance and flexibility, wherein same or different kinds of substituents are bonded alternately, and the preparation method thereof. The polyorganosilsesquioxane prepared according to the present invention has a small molecular weight distribution and a high molecular weight, and is soluble in organic solvents because a three-dimensional network structure is not formed during the preparative condensation polymerization. Polyalkylaromaticsilsesquioxane obtained from the preparing method of the present invention is a useful heat-resistant material. It can be used as a heat-resistant coating agent, a protective coating agent of optical fiber, a coating material for resistor, heat-resistant paint, an adhesive and a releasing agent for precise molding. Also, it can be used for the semiconductor protective layer, interlayer dielectrics for semiconductor integration (e.g. LSI), new heat-resistant photoresist, and functional photonics materials.

9. 发明授权

US09441017B2 Water-soluble polypeptides comprised of repeat modules, method for preparing the same and method for a target-specific polypeptide and analysis of biological activity thereof 有权
标题翻译：由重复模块组成的水溶性多肽，其制备方法和靶特异性多肽的方法及其生物活性的分析
公开(公告)号：US09441017B2
公开(公告)日：2016-09-13
申请号：US14005536
申请日：2012-03-22
申请人： Hak Sung Kim , Dong Sup Kim , Sang Chul Lee , Byung Chul Lee , Ji Eun Han , Joong Jae Lee , Keun Wan Park , Seung Pyo Hong
发明人： Hak Sung Kim , Dong Sup Kim , Sang Chul Lee , Byung Chul Lee , Ji Eun Han , Joong Jae Lee , Keun Wan Park , Seung Pyo Hong
IPC分类号： C07K14/195 , C07K14/705 , G01N33/50 , G06F19/16 , C12Q1/68 , C07K14/46 , C12N15/70
CPC分类号： C07K14/195 , C07K14/46 , C07K14/461 , C07K14/705 , C07K2319/35 , C07K2319/70 , C12N15/70 , C12Q1/6897 , G01N33/5023 , G06F19/16
摘要： The present invention relates to a soluble polypeptide comprised of repeat modules. More particularly, the present invention relates to a soluble fusion polypeptide of the N-terminal domain of internalin and LRR (Leucine rich repeat) family protein, a method for preparing the polypeptide, a vector comprising a nucleic acid sequence encoding the polypeptide, a host cell comprising the vector, a method for producing a solubility and folding-improved fusion polypeptide by expressing the vector in the host cell, and a method for improving the solubility and folding of the fusion polypeptide. Further, the present invention relates to a method for preparing the polypeptide bound with a specific target and analyzing the efficacy of the soluble polypeptide.
摘要翻译：本发明涉及由重复模块组成的可溶性多肽。更具体地说，本发明涉及内源蛋白和LRR（富含亮氨酸重复）家族蛋白质的N-末端结构域的可溶性融合多肽，制备该多肽的方法，包含编码该多肽的核酸序列的载体，宿主包含载体的细胞，通过在宿主细胞中表达载体产生溶解性和折叠改良的融合多肽的方法，以及改善融合多肽的溶解性和折叠的方法。此外，本发明涉及制备与特异性靶标结合的多肽的方法，并分析可溶性多肽的功效。

10. 发明申请

US20140088292A1 Water-Soluble Polypeptides Comprised of Repeat Modules, Method for Preparing the Same and Method for a Target-Specific Polypeptide and Analysis of Biological Activity Thereof 有权
标题翻译：由重复模块组成的水溶性多肽，其制备方法及靶向特异性多肽的方法及其生物活性分析
公开(公告)号：US20140088292A1
公开(公告)日：2014-03-27
申请号：US14005536
申请日：2012-03-22
申请人： Hak Sung Kim , Dong Sup Kim , Sang Chul Lee , Byung Chul Lee , Ji Eun Han , Joong Jae Lee , Keun Wan Park , Seung Pyo Hong
发明人： Hak Sung Kim , Dong Sup Kim , Sang Chul Lee , Byung Chul Lee , Ji Eun Han , Joong Jae Lee , Keun Wan Park , Seung Pyo Hong
IPC分类号： C07K14/195 , C07K14/705 , G01N33/50 , G06F19/16 , C12Q1/68
CPC分类号： C07K14/195 , C07K14/46 , C07K14/461 , C07K14/705 , C07K2319/35 , C07K2319/70 , C12N15/70 , C12Q1/6897 , G01N33/5023 , G06F19/16
摘要： The present invention relates to a soluble polypeptide comprised of repeat modules. More particularly, the present invention relates to a soluble fusion polypeptide of the N-terminal domain of internalin and LRR (Leucine rich repeat) family protein, a method for preparing the polypeptide, a vector comprising a nucleic acid sequence encoding the polypeptide, a host cell comprising the vector, a method for producing a solubility and folding-improved fusion polypeptide by expressing the vector in the host cell, and a method for improving the solubility and folding of the fusion polypeptide. Further, the present invention relates to a method for preparing the polypeptide bound with a specific target and analyzing the efficacy of the soluble polypeptide.
摘要翻译：本发明涉及由重复模块组成的可溶性多肽。更具体地说，本发明涉及内源蛋白和LRR（富含亮氨酸重复）家族蛋白质的N-末端结构域的可溶性融合多肽，制备该多肽的方法，包含编码该多肽的核酸序列的载体，宿主包含载体的细胞，通过在宿主细胞中表达载体产生溶解性和折叠改良的融合多肽的方法，以及改善融合多肽的溶解性和折叠的方法。此外，本发明涉及制备与特异性靶标结合的多肽的方法，并分析可溶性多肽的功效。

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