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2. 发明授权

US08148386B2 Agent for the prevention and treatment of prostatic hyperplasia comprising pyrazolopyrimidinone compound 有权
标题翻译：用于预防和治疗包含吡唑并嘧啶酮化合物的前列腺增生的药剂
公开(公告)号：US08148386B2
公开(公告)日：2012-04-03
申请号：US12244432
申请日：2008-11-24
申请人： Jae Young Yu , Seul Min Choi , Kyung Koo Kang , Byoung Ok Ahn , Moohi Yoo
发明人： Jae Young Yu , Seul Min Choi , Kyung Koo Kang , Byoung Ok Ahn , Moohi Yoo
IPC分类号： A01N43/90
CPC分类号： A61K31/519
摘要： The present invention relates to an agent for preventing and treating benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) associated with BPH and a relaxant for relaxing urethral smooth muscle or prostatic smooth muscle comprising a pyrazolopyrimidinone compound as an effective ingredient. The agent in accordance with the present invention can provide nitric oxides by inhibiting the activity of PDE-5 that decomposes c-GMP, and the provided nitric oxides relax the urethral smooth muscle or the prostatic smooth muscle to lower the intraurethral pressure (IUP), thus treating BPH and LUTS associated with BPH. Furthermore, the time required for reaching a maximum blood concentration is shorter and the half-life is longer than the other PDE-5 inhibitors, thus reducing the frequency of administration. Moreover, the agent of the invention causing few side effects can be efficiently used as a safe drug.
摘要翻译：本发明涉及用于预防和治疗与BPH相关的良性前列腺增生症（BPH）和下尿路症状（LUTS）的药剂和用于缓解包含吡唑嘧啶酮化合物作为有效成分的尿道平滑肌或前列腺平滑肌的松弛剂。根据本发明的药剂可以通过抑制分解c-GMP的PDE-5的活性来提供一氧化氮，并且所提供的一氧化氮使尿道平滑肌或前列腺平滑肌松弛以降低尿道内压（IUP），从而治疗与BPH相关的BPH和LUTS。此外，达到最大血液浓度所需的时间更短，半衰期比其他PDE-5抑制剂长，从而降低给药频率。此外，本发明的副作用少的药剂可以有效地用作安全药物。

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