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1. 发明申请

US20050247893A1 Apparatus and method for transporting radiopharmaceuticals 有权
标题翻译：用于运输放射性药物的装置和方法
公开(公告)号：US20050247893A1
公开(公告)日：2005-11-10
申请号：US11184291
申请日：2005-07-18
申请人： Monty Fu , Bing Zhu
发明人： Monty Fu , Bing Zhu
IPC分类号： G21F5/018
CPC分类号： G21F5/018 , A61M5/1785 , G21Y2002/501 , G21Y2004/30 , Y10T29/49826 , Y10T29/49904
摘要： A method and apparatus for transporting radiopharmaceuticals. Typically, the apparatus is a two-part assembly, each part having an exterior shell, a radiation shield and a non-porous lining. Additionally, the assembled apparatus has a sealed internal chamber suitable for carrying a syringe or a sharps container containing a syringe. The internal chamber of the radiopharmaceutical pig is lined with a non-porous lining, typically a durable plastic, that prevents contamination of the radiopharmaceutical doses, the radiation shield, or the environment. Additionally, the non-porous lining can be quickly and easily cleaned and sterilized, avoiding the often difficult, to impossible, task of cleaning and sterilizing the radiation shield of the radiopharmaceutical pig. The non-porous lining is surrounded by a radiation shield that is typically comprised of elemental lead. The radiation shield prevents radiation from the radiopharmaceutical from contaminating the user or environment. The radiation shield is surrounded by an exterior shell that absorbs impact and prevents the radiopharmaceutical pig from breaking. Additionally, the exterior shell prevents environmental exposure to the potentially hazardous material of the radiation shield. Generally, a method of transporting a radiopharmaceutical by filling the container with a radiopharmaceutical, inserting the container into the internal chamber of the radiopharmaceutical pig having a non-porous lining, and assembling the radiopharmaceutical pig so the that the container is in the internal chamber and is encapsulated by the radiation shield, is also provided.
摘要翻译：用于运输放射性药物的方法和装置。通常，该设备是两部分组件，每个部件具有外壳，辐射屏蔽和无孔衬里。此外，组装的装置具有适于携带注射器或含有注射器的锐器容器的密封内部腔室。放射性药物猪的内部室内衬有无孔衬里，通常是耐用的塑料，其防止放射性药物剂量，辐射屏蔽或环境的污染。此外，无孔衬里可以快速且容易地清洁和消毒，避免了对放射性药物猪的辐射屏蔽进行清洁和消毒的常常困难的，不可能的任务。无孔衬里由通常由元素铅构成的辐射屏蔽围绕。辐射屏蔽防止放射性药物的辐射污染用户或环境。辐射屏蔽被外壳包围，吸收冲击并防止放射性药物猪破裂。此外，外壳防止环境暴露于辐射屏蔽层的潜在危险物质。通常，通过用放射性药剂填充容器来输送放射性药物的方法，将容器插入具有无孔衬里的放射性药物猪的内部室中，并且组装放射性药物猪使得容器处于内部室中，被辐射屏蔽封装，也被提供。

2. 发明授权

US09289468B2 Fusion protein comprising circularly permuted form of trail/Apo2L, coding gene and use thereof 有权
标题翻译：融合蛋白包含循环形式的小鼠/ Apo2L，编码基因及其用途
公开(公告)号：US09289468B2
公开(公告)日：2016-03-22
申请号：US14344289
申请日：2011-09-16
申请人： Shifang Yang , Junsheng Cui , Bing Zhu , Peng Wei
发明人： Shifang Yang , Junsheng Cui , Bing Zhu , Peng Wei
IPC分类号： A61K38/16 , A61K38/12 , A61K38/00 , A61P35/00 , A61P35/02 , C07K1/00 , C07K14/00 , C07K17/00 , C07K16/00 , C12N1/20 , C12N15/00 , A61K39/00 , A61K39/385 , A61K38/17 , C07K14/715 , C07K14/47 , C07K14/525 , C12N15/63 , C12N15/62 , C07K14/705 , A61K45/06 , C07K14/52
CPC分类号： A61K38/1761 , A61K38/00 , A61K45/06 , C07K14/47 , C07K14/4747 , C07K14/52 , C07K14/525 , C07K14/70575 , C07K14/7151 , C07K2319/21 , C07K2319/33 , C12N15/62 , C12N15/63
摘要： Provided is a fusion protein comprising circularly permuted form of TRAIL, and the fusion protein contains circularly permuted form of TRAIL and oligopeptides located at the N-terminus and/or C-terminus of the permuted form. The oligopeptides contain a repeating sequence consisting of 3-10 histidines. The components of the circularly permuted form of TRAIL from N-terminus to C-terminus are: (a) amino acids 135-281 of TRAIL, (b) a linker, and (c) amino acids 121-135 of TRAIL or amino acids 114-135 of TRAIL or amino acids 95-135 of TRAIL or any fragments of amino acids 95-135 of TRAIL containing amino acids 121-135 of TRAIL. Also provided is a method for treating cancer by using the fusion protein.
摘要翻译：提供了包含循环形式的TRAIL的融合蛋白，并且融合蛋白包含位于置换形式的N末端和/或C末端的循环形式的TRAIL和寡肽。寡肽含有由3-10组氨酸组成的重复序列。从N末端到C末端的循环形式的TRAIL的组分是：（a）TRAIL的氨基酸135-281，（b）接头，和（c）TRAIL或氨基酸的氨基酸121-135 TRAIL的114-135或TRAIL的氨基酸95-135或含有TRAIL的第121-135位氨基酸的TRAIL的任何氨基酸95-135的片段。还提供了通过使用融合蛋白治疗癌症的方法。

3. 发明授权

US07666989B2 Recombinant protein having an anti-cancer effect, its encoding gene and uses thereof 有权
标题翻译：具有抗癌作用的重组蛋白，其编码基因及其用途
公开(公告)号：US07666989B2
公开(公告)日：2010-02-23
申请号：US10577535
申请日：2003-11-03
申请人： Bing Zhu
发明人： Bing Zhu
IPC分类号： C07K14/00
CPC分类号： C07K14/4703 , A61K38/00 , C07K14/70575
摘要： The present invention discloses a recombinant protein having an anti-cancer effect, its encoding gene and uses thereof. The recombinant protein having an anti-cancer effect provided by the present invention is one selected from the group consisting of: 1) a protein having the amino acid sequence of SEQ ID No:2 shown in the sequence listing; 2) a protein derived from SEQ ID No:2, which has a sequence homology of more than 90% with SEQ ID No:2 and which has the same activity as that of SEQ ID No:2; 3) a protein derived from SEQ ID No:2, which is obtained by adding or deleting 15 or less amino acid residues at the N-terminus of the amino acid sequence of SEQ ID No:2, and which has the same activity as that of SEQ ID No:2; 4) a protein derived from SEQ ID No:2, which is obtained by adding or deleting 15 or less amino acid residues at the C-terminus of the amino acid sequence of SEQ ID No:2, and which has the same activity as that of SEQ ID No:2; 5) a protein derived from SEQ ID No:2, which is obtained by substitution, deletion, or addition of one or several amino acid residues in the amino acid sequence of SEQ ID No:2, and which has the same activity as that of SEQ ID No:2. The medicament containing above recombinant protein as active component has significant selective inhibitory effect on tumor cells, and does not induce apoptosis of normal tissue cells, and has important applicable value.
摘要翻译：本发明公开了具有抗癌作用的重组蛋白，其编码基因及其用途。本发明提供的具有抗癌效果的重组蛋白质选自：1）具有序列表所示的SEQ ID No：2的氨基酸序列的蛋白质; 2）衍生自SEQ ID No：2的蛋白质，其与SEQ ID No：2具有大于90％的序列同源性，并且具有与SEQ ID No：2具有相同的活性; 3）衍生自SEQ ID No：2的蛋白质，其通过在SEQ ID No：2的氨基酸序列的N末端添加或缺失15个或更少的氨基酸残基而获得，并且具有与该序列具有相同的活性 SEQ ID No：2; 4）衍生自SEQ ID No：2的蛋白质，其通过在SEQ ID No：2的氨基酸序列的C末端添加或缺失15个或更少的氨基酸残基获得，并且具有与SEQ ID No：2具有相同的活性 SEQ ID No：2; 5）衍生自SEQ ID No：2的蛋白质，其通过在SEQ ID No：2的氨基酸序列中的一个或几个氨基酸残基的取代，缺失或添加获得，并且具有与 SEQ ID No：2。含有上述重组蛋白作为活性成分的药物对肿瘤细胞具有显着的选择性抑制作用，不诱导正常组织细胞凋亡，具有重要的适用价值。

4. 发明授权

US08467862B2 Systems and methods related to ST segment monitoring by an implantable medical device 有权
标题翻译：通过植入式医疗装置与ST段监测相关的系统和方法
公开(公告)号：US08467862B2
公开(公告)日：2013-06-18
申请号：US13049805
申请日：2011-03-16
申请人： Jay Snell , Bing Zhu , Katie Hoberman , Harish Krishnaswamy
发明人： Jay Snell , Bing Zhu , Katie Hoberman , Harish Krishnaswamy
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/7264
摘要： Cardiac activity is sensed over a plurality of heart beats defining a beat set. For each beat in the set, it is determined whether the beat is a non-classified beat (e.g., paced beat, a beat outside of a specified heart rate range or a PVC), or a classified beat. For each classified beat, it is determined whether the beat is a non-detect beat, a minor beat or a major beat. Counts of classified beats, non-classified beats, major beats, minor beats, and non-detect beats are maintained. The beat set is declared to be one of a non-classified set, a major set, a minor set or a non-detect set based on the relative counts of classified beats, non-classified beats, major beats, minor beats, and non-detect beats. Over a period of time, counts of beat-set types are maintained and entry into and exit from ST episodes are determined based on these beat-set counts.
摘要翻译：在定义拍子组的多个心跳上感测到心脏活动。对于集合中的每个节拍，确定节拍是否是非分类节拍（例如，节奏拍子，指定心率范围或PVC之外的节拍）或分类节拍。对于每个分类的节拍，确定节拍是否是非检测节拍，小节奏或主要节拍。维持分类节拍，非分类节拍，主要节拍，次要节拍和非检测节拍的数量。基于分类节拍，非分类节拍，主要节拍，次要节拍和非节奏组合的相对计数，节拍组被宣布为非分类集，主要集，未成年集或未检测集之一。检测节拍在一段时间内，基于这些节拍设置计算确定节拍类型的计数，并且进入和退出ST剧集。

5. 发明授权

US08331797B2 Polarization-controlled encoding method, encoder, and quantum key distribution system 有权
标题翻译：极化控制编码方法，编码器和量子密钥分配系统
公开(公告)号：US08331797B2
公开(公告)日：2012-12-11
申请号：US10588042
申请日：2004-08-19
申请人： Zhengfu Han , Bing Zhu , Xiaofan Mo , Guangcan Guo
发明人： Zhengfu Han , Bing Zhu , Xiaofan Mo , Guangcan Guo
IPC分类号： H04B10/04 , H04B10/00
CPC分类号： H04L9/0858
摘要： The invention relates to a polarization-controlled encoding method, encoder and quantum key distribution system, which is characterized in that polarization maintaining light path or 90 degree rotation Faraday mirror are used inside the encoder to keep the polarization of the output pulses same, and that in the quantum key distribution system employing the polarization-controlled encoder the pulse emitted from transmitter is unidirectional-transmitted to receiver and then quantum key distribution is implemented using interference in the pulses according to the quantum key distribution protocol. The quantum key distribution system using the polarization-controlled encoder of the invention has the ability of avoiding the wiretapping to transmitter, receiver and quantum channel. Detection units each of which separates reversed photon from other photons are added at the out port of the transmitter and the in port of receiver, respectively, so that Trojan horse is prevented from entering and photons with phase modulated information are prevented from leaving the safe area in receiver. Unconditionally safe key distribution can be accomplished by using the quantum key distribution system of the invention.
摘要翻译：本发明涉及一种偏振控制编码方法，编码器和量子密钥分发系统，其特征在于在编码器内部使用偏振保持光路或90度旋转法拉第镜，以保持输出脉冲的极化相同，在使用偏振控制编码器的量子密钥分配系统中，从发射机发射的脉冲是单向传输到接收机，然后根据量子密钥分配协议在脉冲中使用干扰来实现量子密钥分配。使用本发明的偏振控制编码器的量子密钥分发系统具有避免对发射机，接收机和量子信道的窃听的能力。检测单元分别将反向光子与其他光子分离，分别在发射机的出口和接收机的入口端口分别加入，防止特洛伊木马进入，防止具有相位调制信息的光子离开安全区域在接收器。通过使用本发明的量子密钥分发系统可以实现无条件的安全密钥分发。

6. 发明授权

US08187606B2 HPV antigen fusion protein vaccine compositions and uses thereof 有权
标题翻译： HPV抗原融合蛋白疫苗组合物及其用途
公开(公告)号：US08187606B2
公开(公告)日：2012-05-29
申请号：US12446382
申请日：2007-10-19
申请人： Bing Zhu , Shifang Yang , Junsheng Cui
发明人： Bing Zhu , Shifang Yang , Junsheng Cui
IPC分类号： A61K39/00
CPC分类号： A61K39/12 , A61K2039/585 , A61K2039/6031 , C07K14/005 , C07K14/4725 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12N2710/20034
摘要： The present invention provides a fusion protein comprising an immunostimulatory polypeptide and a mutant E7 protein of a human papilloma virus. The present invention also provides a gene encoding the fusion protein, expression vectors containing the gene, a pharmaceutical composition comprising the fusion protein, a method for treating or preventing a human papilloma virus related disease by using the fusion protein and uses of the fusion protein in the preparation of a medicament for the treatment or prevention of the human papilloma virus related disease.
摘要翻译：本发明提供了包含免疫刺激多肽和人乳头瘤病毒的突变E7蛋白的融合蛋白。本发明还提供了编码融合蛋白的基因，含有该基因的表达载体，包含该融合蛋白的药物组合物，通过使用融合蛋白治疗或预防人乳头状瘤病毒相关疾病的方法以及融合蛋白的用途制备用于治疗或预防人乳头状瘤病毒相关疾病的药物。

7. 发明申请

US20080037998A1 Polarization-Controlled Encoding Method, Encoder, And Quantum Key Distribution System 有权
标题翻译：极化控制编码方法，编码器和量子密钥分配系统
公开(公告)号：US20080037998A1
公开(公告)日：2008-02-14
申请号：US10588042
申请日：2004-08-19
申请人： Han Zhengfu , Bing Zhu , Xiaofan Mo , Guangcan Guo
发明人： Han Zhengfu , Bing Zhu , Xiaofan Mo , Guangcan Guo
IPC分类号： H04L9/08
CPC分类号： H04L9/0858
摘要： The invention relates to a polarization-controlled encoding method, encoder and quantum key distribution system, which is characterized in that polarization maintaining light path or 90 degree rotation Faraday mirror are used inside the encoder to keep the polarization of the output pulses same, and that in the quantum key distribution system employing the polarization-controlled encoder the pulse emitted from transmitter is unidirectional-transmitted to receiver and then quantum key distribution is implemented using interference in the pulses according to the quantum key distribution protocol. The quantum key distribution system using the polarization-controlled encoder of the invention has the ability of avoiding the wiretapping to transmitter, receiver and quantum channel. Detection units each of which separates reversed photon from other photons are added at the out port of the transmitter and the in port of receiver, respectively, so that Trojan horse is prevented from entering and photons with phase modulated information are prevented from leaving the safe area in receiver. Unconditionally safe key distribution can be accomplished by using the quantum key distribution system of the invention.
摘要翻译：本发明涉及一种偏振控制编码方法，编码器和量子密钥分发系统，其特征在于在编码器内部使用偏振保持光路或90度旋转法拉第镜，以保持输出脉冲的极化相同，在使用偏振控制编码器的量子密钥分配系统中，从发射机发射的脉冲是单向传输到接收机，然后根据量子密钥分配协议在脉冲中使用干扰来实现量子密钥分配。使用本发明的偏振控制编码器的量子密钥分发系统具有避免对发射机，接收机和量子信道的窃听的能力。检测单元分别将反向光子与其他光子分离，分别在发射机的出口和接收机的入口端口分别加入，防止特洛伊木马进入，防止具有相位调制信息的光子离开安全区域在接收器。通过使用本发明的量子密钥分发系统可以实现无条件的安全密钥分发。

8. 发明申请

US20070014573A1 Exchange structure and a method of connection configuration between the optical networks 审中-公开
标题翻译：交换结构和光网络之间的连接配置方法
公开(公告)号：US20070014573A1
公开(公告)日：2007-01-18
申请号：US10570181
申请日：2003-09-01
申请人： Xueqin Wei , Bing Zhu , Zhifeng Wang
发明人： Xueqin Wei , Bing Zhu , Zhifeng Wang
IPC分类号： H04B10/20
CPC分类号： H04B10/271 , H04B10/27 , H04B10/275
摘要： The invention discloses an interconnection structure and a method for configuring path between the optical networks. The optical network includes a first network and a second network, the first network and the second network each has a number of nodes, a first node of the first network connects with a third node of the second network, a second node of the first network connects with a fourth node of the second network. The method comprises the steps of: setting-up a first path between one of the first node and the second node and another node of the first network; and at least by one link of the link between the first node and the third node and that between the second node and the fourth node, and by the first path, said another node of the first network communicates for path with another node of the second network. By the dual-node interconnection structure and the path configuration shceme of this invention between a ring network and a mesh network, and between mesh networks, the respective advantages of the ring network and the mesh metwork in regard to protection and restoration can be combined effectively, and the existing internetworking schemes between the rings are also compatible.
摘要翻译：本发明公开了一种用于配置光网络之间的路由的互连结构和方法。光网络包括第一网络和第二网络，第一网络和第二网络各自具有多个节点，第一网络的第一节点与第二网络的第三节点连接，第一网络的第二节点与第二网络的第四节点连接。该方法包括以下步骤：在第一节点和第二节点之一以及第一网络的另一个节点之间建立第一路径; 以及所述第一节点和所述第三节点之间的链路以及所述第二节点和所述第四节点之间的链路的至少一个链路，并且通过所述第一路径，所述第一网络的所述另一个节点与所述第二节点的另一个节点进行通信网络。通过环形网络和网状网络之间以及网状网络之间的本发明的双节点互连结构和路径配置，可以有效地组合环网和网状网络在保护和恢复方面的各自优点，并且环之间的现有互联方案也是兼容的。

9. 发明申请

US20060277509A1 SYSTEM AND METHOD FOR ANALYZING POWER CONSUMPTION OF ELECTRONIC DESIGN UNDERGOING EMULATION OR HARDWARE BASED SIMULATION ACCELERATION 有权
标题翻译：用于分析基于仿真或硬件仿真加速的电子设计功耗的系统和方法
公开(公告)号：US20060277509A1
公开(公告)日：2006-12-07
申请号：US11422314
申请日：2006-06-05
申请人： Tung-sun Tung , Tsair-Chin Lin , Bing Zhu
发明人： Tung-sun Tung , Tsair-Chin Lin , Bing Zhu
IPC分类号： G06F17/50
CPC分类号： G06F17/5022 , G06F17/5027 , G06F2217/78
摘要： The invention described here is the methods of using a hardware-based functional verification system to mimic a design under test (DUT), under intended application environment and software, to record or derive the transition activities of all circuits of the DUT, then calculate the total or partial power consumption during the period of interest. The period of interest is defined by the user in terms of “events” which are the arbitrary states of the DUT. Furthermore, the user can specify the number of sub-divisions required between events thus vary the apparent resolution of the power consumption profile.
摘要翻译：这里描述的发明是使用基于硬件的功能验证系统在预期的应用环境和软件下模拟被测设计（DUT）来记录或导出DUT的所有电路的转换活动的方法，然后计算在兴趣期间的全部或部分功耗。感兴趣的时期由用户根据DUT的任意状态的“事件”定义。此外，用户可以指定事件之间所需的子分割的数量，从而改变功耗简档的视在分辨率。

10. 发明申请

US20140317222A1 Data Storage Method, Device and Distributed Network Storage System 有权
标题翻译：数据存储方法，设备和分布式网络存储系统
公开(公告)号：US20140317222A1
公开(公告)日：2014-10-23
申请号：US13818360
申请日：2012-02-15
申请人： Hui Li , Xianxia Huang , Hanxu Hou , Tai Zhou , Bing Zhu , Changmin Chen , Jingbang Zhou
发明人： Hui Li , Xianxia Huang , Hanxu Hou , Tai Zhou , Bing Zhu , Changmin Chen , Jingbang Zhou
IPC分类号： H04L29/08
CPC分类号： H04L67/1097 , G06F11/1092 , H03M13/033 , H03M13/1515 , H04L67/1095
摘要： A method, device and system disclosed used in storage technique, comprising: splitting a file of size M into k blocks, that is to say, each block is of size M/k; issuing the above k blocks across k different storage nodes in the distributed network storage system in a distributed manner; using the k blocks, constructing n−k independent blocks via linear coding method, and satisfying the property that any k of the n encoded blocks can be used to reconstruct the original data in the file, which means the linear coding method is a kind of Maximum-Distance Separable (MDS) code; distribute the n−k encoded blocks to the rest n−k different storage codes in the distributed network storage systems.
摘要翻译：一种在存储技术中使用的方法，装置和系统，包括：将大小为M的文件分割成k个块，也就是说，每个块的大小为M / k; 以分布式方式在分布式网络存储系统中的k个不同存储节点上发布上述k个块; 使用k个块，通过线性编码方法构造n-k个独立块，并满足n个编码块的任何k可以用于重构文件中的原始数据的属性，这意味着线性编码方法是一种最大距离可分离（MDS）代码; 将n-k个编码块分布到分布式网络存储系统中的其余n-k个不同存储码。

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