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1. 发明申请

WO2017201352A1 MRNA COMBINATION THERAPY FOR THE TREATMENT OF CANCER 审中-公开
标题翻译： MRNA联合治疗癌症的研究
公开(公告)号：WO2017201352A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/033425
申请日：2017-05-18
申请人： MODERNATX, INC.
发明人： FREDERICK, Joshua , HEWITT, Susannah , BAI, Ailin , HOGE, Stephen , PRESNYAK, Vladimir , MCFADYEN, Iain , BENENATO, Kerry , KUMARASINGHE, Ellalahewage Sathyajith
IPC分类号： A61K39/395 , C12N15/11 , C07K14/54 , C07K14/705
摘要： The present disclosure relates to the use of nucleic acid (e.g., mRNA) combination therapies for the treatment of cancer. The disclosure provides compositions, and methods for their preparation, manufacture, and therapeutic use, wherein those compositions comprise at least two polynucleotides (e.g., mRNAs) in combination wherein the at least two polynucleotides are selected from the group consisting of (i) a polynucleotide encoding an immune response primer (e.g., IL23), (ii) a polynucleotide encoding an immune response co-stimulatory signal (e.g., OX40L), (iii) a polynucleotide encoding a checkpoint inhibitor (e.g., an anti CTLA-4 antibody), and, (iv) a combination thereof. The therapeutic methods disclosed herein comprise, e.g., the administration of a combination therapy disclosed herein for the treatment of cancer, e.g., by reducing the size of a tumor or inhibiting the growth of a tumor, in a subject in need thereof. In some aspects, the combination therapies disclosed herein disclosed are administered intratumorally.
摘要翻译：本公开涉及核酸（例如，mRNA）组合疗法在治疗癌症中的用途。本公开内容提供了用于其制备，制造和治疗用途的组合物和方法，其中所述组合物包含至少两种多核苷酸（例如mRNA），其中所述至少两种多核苷酸选自（i）多核苷酸编码免疫应答引物（例如IL23），（ii）编码免疫应答共刺激信号（例如OX40L）的多核苷酸，（iii）编码检查点抑制剂（例如抗CTLA-4抗体）的多核苷酸，和（iv）其组合。本文公开的治疗方法包括例如在有此需要的受试者中施用本文公开的用于治疗癌症的组合疗法，例如通过减小肿瘤的大小或抑制肿瘤的生长。在一些方面，本文公开的组合疗法在肿瘤内施用。

2. 发明申请

WO2017201350A1 POLYNUCLEOTIDES ENCODING INTERLEUKIN-12 (IL12) AND USES THEREOF 审中-公开
标题翻译：编码白细胞介素-12（IL12）的多核苷酸及其用途
公开(公告)号：WO2017201350A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/033422
申请日：2017-05-18
申请人： MODERNATX, INC.
发明人： FREDERICK, Joshua , HEWITT, Susannah , BAI, Ailin , HOGE, Stephen , PRESNYAK, Vladimir , MCFADYEN, Iain , BENENATO, Kerry , KUMARASINGHE, Ellalahewage Sathyajith
IPC分类号： A61K38/20 , C07K14/54 , C12N15/67
摘要： The present disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human interleukin-12 (IL12), functional fragments thereof, and fusion proteins comprising IL12. In some embodiments, the open reading frame is sequence-optimized. In particular embodiments, the disclosure provides sequence-optimized polynucleotides comprising nucleotides encoding the polypeptide sequence of human IL12, or sequences having high sequence identity with those sequence optimized polynucleotides.
摘要翻译：本公开涉及包含编码人白细胞介素-12（IL12）的连接核苷的开放阅读框，其功能片段和包含IL12的融合蛋白的多核苷酸。在一些实施方案中，开放阅读框是序列优化的。在具体的实施方案中，本公开提供了包含编码人IL12的多肽序列的核苷酸或与那些序列优化的多核苷酸具有高度序列同一性的序列的序列优化的多核苷酸。

3. 发明申请

WO2017201325A8 COMBINATIONS OF MRNAS ENCODING IMMUNE MODULATING POLYPEPTIDES AND USES THEREOF 审中-公开
公开(公告)号：WO2017201325A8
公开(公告)日：2017-11-23
申请号：PCT/US2017/033395
申请日：2017-05-18
申请人： MODERNATX, INC.
发明人： FREDERICK, Joshua , HEWITT, Susannah , BAI, Ailin , HOGE, Stephen , PRESNYAK, Vladimir , MCFADYEN, lAIN , BENENATO, Kerry , KUMARASINGHE, Ellalahewage Sathyajith
IPC分类号： C07K14/54 , A61K48/00 , C07K14/545 , C07K14/705
摘要： The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL- 36-gamma) polypeptide), and an immune response co- stimulatory signal polypeptide (e.g., an OX40L polypeptide).

4. 发明申请

WO2017201325A1 COMBINATIONS OF MRNAS ENCODING IMMUNE MODULATING POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译：编码免疫调节多肽的MRNA的组合及其用途
公开(公告)号：WO2017201325A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/033395
申请日：2017-05-18
申请人： MODERNATX, INC.
发明人： FREDERICK, Joshua , HEWITT, Susannah , BAI, Ailin , HOGE, Stephen , PRESNYAK, Vladimir , MCFADYEN, lAIN , BANENATO, Kerry , KUMARASINGHE, Ellalahewage, Sathyajith
IPC分类号： C07K14/54 , A61K48/00 , C07K14/545 , C07K14/705
摘要： The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL- 36-gamma) polypeptide), and an immune response co- stimulatory signal polypeptide (e.g., an OX40L polypeptide).
摘要翻译：本公开涉及用于编码免疫反应性引物多肽（例如白细胞介素23（IL-23））的免疫调节多核苷酸（例如，mRNA）的组合的制备，制造和治疗用途的组合物和方法。多肽或白细胞介素36γ（IL-36-γ）多肽）和免疫应答共刺激信号多肽（例如OX40L多肽）。

5. 发明公开

EP3458474A1 COMBINATIONS OF MRNAS ENCODING IMMUNE MODULATING POLYPEPTIDES AND USES THEREOF 有权转让
公开(公告)号：EP3458474A1
公开(公告)日：2019-03-27
申请号：EP17727999.9
申请日：2017-05-18
申请人： Modernatx, Inc.
发明人： FREDERICK, Joshua , HEWITT, Susannah , BAI, Ailin , HOGE, Stephen , PRESNYAK, Vladimir , MCFADYEN, lAIN , BENENATO, Kerry , KUMARASINGHE, Ellalahewage, Sathyajith
IPC分类号： C07K14/54 , A61K48/00 , C07K14/545 , C07K14/705

6. 发明公开

EP3458092A1 MRNA COMBINATION THERAPY FOR THE TREATMENT OF CANCER 无效转让
公开(公告)号：EP3458092A1
公开(公告)日：2019-03-27
申请号：EP17728002.1
申请日：2017-05-18
申请人： Modernatx, Inc.
发明人： FREDERICK, Joshua , HEWITT, Susannah , BAI, Ailin , HOGE, Stephen , PRESNYAK, Vladimir , MCFADYEN, Iain , BENENATO, Kerry , KUMARASINGHE, Ellalahewage Sathyajith
IPC分类号： A61K39/395 , C12N15/11 , C07K14/54 , C07K14/705

7. 发明公开

EP3458083A1 POLYNUCLEOTIDES ENCODING INTERLEUKIN-12 (IL12) AND USES THEREOF 有权转让
公开(公告)号：EP3458083A1
公开(公告)日：2019-03-27
申请号：EP17726458.7
申请日：2017-05-18
申请人： Modernatx, Inc.
发明人： FREDERICK, Joshua , HEWITT, Susannah , BAI, Ailin , HOGE, Stephen , PRESNYAK, Vladimir , MCFADYEN, Iain , BENENATO, Kerry , KUMARASINGHE, Ellalahewage Sathyajith
IPC分类号： A61K38/20 , C07K14/54 , C12N15/67

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