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1. 发明授权

US4443614A Triarylmethane derivatives 失效
标题翻译：三芳基甲烷衍生物
公开(公告)号：US4443614A
公开(公告)日：1984-04-17
申请号：US162659
申请日：1980-06-24
申请人： Mitsuru Kondo , Kiyoshi Yasui , Makoto Miyake , Hiroshi Iwasaki , Tetsuo Shiraishi
发明人： Mitsuru Kondo , Kiyoshi Yasui , Makoto Miyake , Hiroshi Iwasaki , Tetsuo Shiraishi
IPC分类号： C07D209/08 , B41M5/136 , B41M5/145 , B41M5/30 , B41M5/323 , B41M5/327 , C07C67/00 , C07C227/00 , C07C227/02 , C07C229/52 , C07C229/64 , C07D209/20 , C07D239/70 , C07D295/155 , C07D307/885 , C07D405/04 , C07D455/04 , C09B11/00 , C09B11/26 , C07D209/04
CPC分类号： C07D455/04 , B41M5/1366 , B41M5/145 , B41M5/327 , C07D209/20 , C07D239/70 , C07D295/155 , C07D307/885 , B41M5/323
摘要： A process is described for preparing triarylmethane derivatives of a high purity in an extremely high yield from 3-phenylphthalide derivatives and aniline derivatives or indole derivatives with Friedel-Crafts type catalyst or Friedel-Crafts type catalyst and an oxidizing agent.
摘要翻译：描述了一种由Friedel-Crafts型催化剂或Friedel-Crafts型催化剂和氧化剂从3-苯基苯酞衍生物和苯胺衍生物或吲哚衍生物以极高产率制备高纯度三芳基甲烷衍生物的方法。

2. 发明授权

US4439610A Process for preparing triarylmethane derivatives 失效
标题翻译：三芳基甲烷衍生物的制备方法
公开(公告)号：US4439610A
公开(公告)日：1984-03-27
申请号：US774613
申请日：1977-03-04
申请人： Mitsuru Kondo , Kiyoshi Yasui , Makoto Miyake , Hiroshi Iwasaki , Tetsuo Shiraishi
发明人： Mitsuru Kondo , Kiyoshi Yasui , Makoto Miyake , Hiroshi Iwasaki , Tetsuo Shiraishi
IPC分类号： C07D209/08 , B41M5/136 , B41M5/145 , B41M5/30 , B41M5/323 , B41M5/327 , C07C67/00 , C07C227/00 , C07C227/02 , C07C229/52 , C07C229/64 , C07D209/20 , C07D239/70 , C07D295/155 , C07D307/885 , C07D405/04 , C07D455/04 , C09B11/00 , C09B11/26 , C07D209/04 , C07D307/77
CPC分类号： C07D455/04 , B41M5/1366 , B41M5/145 , B41M5/327 , C07D209/20 , C07D239/70 , C07D295/155 , C07D307/885 , B41M5/323
摘要： A process is described for preparing triarylmethane derivatives of a high purity in an extremely high yield from 3-phenylphthalide derivatives and aniline derivatives or indole derivatives with Friedel-Crafts type catalyst or Friedel-Crafts type catalyst and an oxidizing agent.
摘要翻译：描述了一种由Friedel-Crafts型催化剂或Friedel-Crafts型催化剂和氧化剂从3-苯基苯酞衍生物和苯胺衍生物或吲哚衍生物以极高产率制备高纯度三芳基甲烷衍生物的方法。

3. 发明授权

US4045458A Process for preparing triarylmethane derivatives 失效
标题翻译：三芳基甲烷衍生物的制备方法
公开(公告)号：US4045458A
公开(公告)日：1977-08-30
申请号：US699584
申请日：1976-06-24
申请人： Mitsura Kondo , Kiyoshi Yasui , Makoto Miyake , Hiroshi Iwasaki , Tetsuo Shiraishi
发明人： Mitsura Kondo , Kiyoshi Yasui , Makoto Miyake , Hiroshi Iwasaki , Tetsuo Shiraishi
IPC分类号： C07D209/08 , B41M5/136 , B41M5/145 , B41M5/30 , B41M5/323 , B41M5/327 , C07C67/00 , C07C227/00 , C07C227/02 , C07C229/52 , C07C229/64 , C07D209/20 , C07D239/70 , C07D295/155 , C07D307/885 , C07D405/04 , C07D455/04 , C09B11/00 , C09B11/26
CPC分类号： C07D455/04 , B41M5/1366 , B41M5/145 , B41M5/327 , C07D209/20 , C07D239/70 , C07D295/155 , C07D307/885 , B41M5/323
摘要： A process is described for preparing triarylmethane derivatives of a high purity in an extremely high yield from 3-phenylphthalide derivatives and aniline derivatives or indole derivatives with Friedel-Crafts type catalyst or Friedel-Crafts type catalyst and an oxidizing agent.
摘要翻译：描述了一种由Friedel-Crafts型催化剂或Friedel-Crafts型催化剂和氧化剂从3-苯基苯酞衍生物和苯胺衍生物或吲哚衍生物以极高产率制备高纯度三芳基甲烷衍生物的方法。

4. 发明授权

US4323700A Process for preparing benzophenone derivatives 失效
标题翻译：制备二苯甲酮衍生物的方法
公开(公告)号：US4323700A
公开(公告)日：1982-04-06
申请号：US73108
申请日：1979-09-06
申请人： Mitsuru Kondo , Hiroshi Iwasaki , Kiyoshi Yasui , Makoto Miyake
发明人： Mitsuru Kondo , Hiroshi Iwasaki , Kiyoshi Yasui , Makoto Miyake
IPC分类号： C07C65/32 , B41M5/145 , B41M5/327 , C07C51/00 , C07C67/00 , C07C201/00 , C07C205/57 , C07C205/61 , C07C229/52 , C07C229/66 , C07D307/885 , C07D493/10 , C09B11/00 , C09B11/24 , C09B11/26 , C09B11/28 , G03G9/09 , C07C59/76
CPC分类号： G03G9/0928 , B41M5/145 , B41M5/327 , C07D307/885 , C07D493/10 , C09B11/245
摘要： A process is described for preparing benzophenone derivatives of a high purity in an extremely high yield from 3-phenylphthalide derivatives with the use of at least one oxidizing agent.
摘要翻译：描述了一种使用至少一种氧化剂从3-苯基苯酞衍生物制备高纯度二苯甲酮衍生物的方法。

5. 发明申请

US20050101590A1 Antipruritics 审中-公开
标题翻译：止痒药
公开(公告)号：US20050101590A1
公开(公告)日：2005-05-12
申请号：US10504955
申请日：2003-02-18
申请人： Kiyoshi Yasui , Yasuhide Morioka , Kohji Hanasaki
发明人： Kiyoshi Yasui , Yasuhide Morioka , Kohji Hanasaki
IPC分类号： A61K31/00 , A61K31/426 , A61K31/435 , A61K31/436 , A61K31/4375 , A61K31/4412 , A61K31/4439 , A61K31/4523 , A61K31/4704 , A61K31/4709 , A61K31/4745 , A61K31/506 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/547 , A61P17/04 , C07D213/69 , C07D213/70 , C07D213/75 , C07D213/82 , C07D215/38 , C07D215/54 , C07D217/26 , C07D221/04 , C07D221/12 , C07D221/22 , C07D263/46 , C07D277/18 , C07D279/06 , C07D279/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D405/14 , C07D411/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D455/06 , C07D471/04 , C07D493/04 , C07D513/04 , C07D513/10 , A61K31/554 , A61K31/425
CPC分类号： C07D213/69 , A61K31/00 , A61K31/255 , A61K31/426 , A61K31/435 , A61K31/436 , A61K31/4375 , A61K31/4412 , A61K31/4439 , A61K31/4523 , A61K31/4704 , A61K31/4709 , A61K31/4745 , A61K31/506 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/547 , C07D213/70 , C07D213/75 , C07D213/82 , C07D215/38 , C07D215/54 , C07D217/26 , C07D221/04 , C07D221/12 , C07D221/22 , C07D263/46 , C07D277/18 , C07D279/06 , C07D279/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D405/14 , C07D411/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D455/06 , C07D471/04 , C07D493/04 , C07D513/04 , C07D513/10
摘要： It is intended to provide antipruritics (drugs to control itching, antiitch agents and drugs to stop itching). It is found out that a compound having an agonistic activity to the cannabinoid receptor shows an antipruritics effect.
摘要翻译：旨在提供止痒药（用于控制瘙痒的药物，止痒剂和药物以阻止瘙痒）。发现对大麻素受体具有激动作用的化合物显示出止痒作用。

6. 发明授权

US06294669B1 Crystalline substance of cefditoren pivoxyl and the production of the same 有权
标题翻译：头孢托仑的新型结晶物质及其生产
公开(公告)号：US06294669B1
公开(公告)日：2001-09-25
申请号：US09269109
申请日：1999-03-19
申请人： Kiyoshi Yasui , Masahiro Onodera , Masamichi Sukegawa , Tatsuo Watanabe , Yuichi Yamamoto , Yasushi Murai , Katsuharu Iinuma
发明人： Kiyoshi Yasui , Masahiro Onodera , Masamichi Sukegawa , Tatsuo Watanabe , Yuichi Yamamoto , Yasushi Murai , Katsuharu Iinuma
IPC分类号： C07D50124
CPC分类号： C07D501/00
摘要： As a novel substance is provided such a new, crystalline substance of Cefditoren povoxyl which has a high purity and an enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving amorphous substance of Cefditoren pivoxyl in an anhydrous, first organic solvent capable of dissolving said amorphous substance well therein, and steps of replacing the first organic solvent component of the resulting solution by an anhydrous alkanol of 1 to 5 carbon atoms as a second organic solvent, in such a manner that the firstly prepared solution of Cefditoren pivoxyl in the first organic solvent is mixed with a volume of the alkanol and then is concentrated below 15° C. under reduced pressure, and so on. Thereby, the process proceeds so as to produce a solution containing 50 mg/ml to 250 mg/ml of Cefditoren pivoxyl dissolved in the alkanol alone. From the latter solution, crystals of Cefditoren pivoxyl are induced to deposit by addition of water at a temperature of 0-10° C. The resulting admixture of the concentrated solution of Cefditoren pivoxyl in alkanol with added water and the deposited Cefditoren pivoxyl is then agitated 10° C. or below, to effect a complete crystallization of Cefditoren pivoxyl.
摘要翻译：作为一种新物质，提供了这样一种具有高纯度和增加的储存热稳定性的新型头孢托仑聚氧乙烯醚的结晶物质。这种结晶的头孢托仑新戊基可以通过包括以下步骤的方法来制备，所述方法包括将能够将所述无定形物质溶解在其中的无水的第一有机溶剂中溶解新戊酰氧基甲基头孢托仑的无定形物质，以及将所得溶液的第一有机溶剂组分置换为将具有1至5个碳原子的无水链烷醇作为第二有机溶剂，使得将首先制备的在第一有机溶剂中的新戊酰氧基头孢托仑的溶液与一定体积的链烷醇混合，然后在15℃以下浓缩减压等。由此，进行处理，从而产生溶解在单独的链烷醇中的含有50mg / ml〜250mg / ml的新戊酰氧基甲基头孢地托仑的溶液。从后一种溶液中，通过在0-10℃的温度下，通过加入水诱导新戊酸头孢托仑的晶体沉淀。然后搅拌所得的新戊酰氧基甲基头孢地托仑在链烷醇中与加入的水的混合物和沉积的新戊糖酯 10℃或更低，以实现新戊酰氧基甲基头孢托仑的完全结晶。

7. 发明申请

US20080312292A1 Antipruritics 审中-公开
标题翻译：止痒药
公开(公告)号：US20080312292A1
公开(公告)日：2008-12-18
申请号：US12010740
申请日：2008-01-29
申请人： Kiyoshi Yasui , Yasuhide Morioka , Kohji Hanasaki
发明人： Kiyoshi Yasui , Yasuhide Morioka , Kohji Hanasaki
IPC分类号： A61K31/4412 , A61K31/435
CPC分类号： C07D213/69 , A61K31/00 , A61K31/255 , A61K31/426 , A61K31/435 , A61K31/436 , A61K31/4375 , A61K31/4412 , A61K31/4439 , A61K31/4523 , A61K31/4704 , A61K31/4709 , A61K31/4745 , A61K31/506 , A61K31/5377 , A61K31/54 , A61K31/541 , A61K31/5415 , A61K31/547 , C07D213/70 , C07D213/75 , C07D213/82 , C07D215/38 , C07D215/54 , C07D217/26 , C07D221/04 , C07D221/12 , C07D221/22 , C07D263/46 , C07D277/18 , C07D279/06 , C07D279/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D405/14 , C07D411/12 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D455/06 , C07D471/04 , C07D493/04 , C07D513/04 , C07D513/10
摘要： It is intended to provide antipruritics (drugs to control itching, antiitch agents and drugs to stop itching). It is found out that a compound having an agonistic activity to the cannabinoid receptor shows an antipruritics effect.
摘要翻译：旨在提供止痒药（用于控制瘙痒的药物，止痒剂和药物以阻止瘙痒）。发现对大麻素受体具有激动作用的化合物显示出止痒作用。

8. 发明授权

US06441162B2 Crystalline substance of cefditoren pivoxyl and the production of the same 有权
标题翻译：头孢托仑的新型结晶物质及其生产
公开(公告)号：US06441162B2
公开(公告)日：2002-08-27
申请号：US09854462
申请日：2001-05-15
申请人： Kiyoshi Yasui , Masahiro Onodera , Masamichi Sukegawa , Tatsuo Watanabe , Yuichi Yamamoto , Yasushi Murai , Katsuharu Iinuma
发明人： Kiyoshi Yasui , Masahiro Onodera , Masamichi Sukegawa , Tatsuo Watanabe , Yuichi Yamamoto , Yasushi Murai , Katsuharu Iinuma
IPC分类号： C07D50124
CPC分类号： C07D501/00
摘要： A crystalline substance of Cefditoren pivoxyl is provided which has a high purity and enhanced thermal stability on storage. This crystalline Cefditoren pivoxyl may be prepared by a process comprising a step of dissolving an amorphous form of Cefditoren pivoxyl in an anhydrous, first organic solvent capable of dissolving said amorphous form well therein, and steps of replacing the first organic solvent component of the resulting solution by an anhydrous alkanol of 1 to 5 carbon atoms as a second organic solvent, in such a manner that the firstly prepared solution of Cefditoren pivoxyl in the first organic solvent is mixed with a volume of the alkanol and then is concentrated below 15° C. under reduced pressure, and so on. Thereby, the process proceeds so as to produce a solution containing 50 mg/ml to 250 mg/ml of Cefditoren pivoxyl dissolved in the alkanol alone. From the latter solution, crystals of Cefditoren pivoxyl are induced to deposit by addition of water at a temperature of 0-10° C. The resulting admixture of the concentrated solution of Cefditoren pivoxyl in alkanol with added water and the deposited Cefditoren pivoxyl is then agitated 10° C. or below, to effect a complete crystallization of Cefditoren pivoxyl.
摘要翻译：提供了新戊酸头孢托仑的结晶物质，其具有高纯度和增强的储存热稳定性。这种结晶的头孢托仑新戊基可以通过包括以下步骤的方法来制备，该方法包括将无定形形式的新戊酰氧基头孢托仑溶解在能够将所述无定形形式溶解在其中的无水第一有机溶剂中，以及将所得溶液的第一有机溶剂组分通过具有1至5个碳原子的无水链烷醇作为第二有机溶剂，使得将首先制备的在第一有机溶剂中的新戊酰氧基头孢托仑的溶液与一定体积的链烷醇混合，然后浓缩至15℃以下。减压下等。由此，进行处理，从而产生溶解在单独的链烷醇中的含有50mg / ml〜250mg / ml的新戊酰氧基甲基头孢地托仑的溶液。从后一种溶液中，通过在0-10℃的温度下，通过加入水诱导新戊酸头孢托仑的晶体沉淀。然后搅拌所得的新戊酰氧基甲基头孢地托仑在链烷醇中与加入的水的混合物和沉积的新戊糖酯 10℃或更低，以实现新戊酰氧基甲基头孢托仑的完全结晶。

9. 发明授权

US06486149B2 Composition comprising a crystallographically stable, amorphous cephalosporin and processes for the preparation thereof 有权
公开(公告)号：US06486149B2
公开(公告)日：2002-11-26
申请号：US09991694
申请日：2001-11-26
申请人： Masahiro Onodera , Masamichi Sukegawa , Kiyoshi Yasui , Tatsuo Watanabe , Toyomi Sato , Yasushi Murai , Katsuharu Iinuma
发明人： Masahiro Onodera , Masamichi Sukegawa , Kiyoshi Yasui , Tatsuo Watanabe , Toyomi Sato , Yasushi Murai , Katsuharu Iinuma
IPC分类号： A61K31545
CPC分类号： C07D501/00 , A61K9/146 , A61K31/545 , A61K31/546 , Y10S514/96
摘要： Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren pivoxil substance with a water soluble high-molecular additive. These compositions can be produced by dissolving crystalline Cefditoren pivoxil substance and the water-soluble high-molecular additive in an aqueous solution of an acid, then neutralizing the resultant solution, to co-precipitate the product, and drying the thus precipitated product, followed by recovering the product in the form of the above-mentioned particles.

10. 发明授权

US06342493B1 Crystallographically stable amorphous cephalosporin compositions and process for producing the same 有权
标题翻译：晶体学稳定的无定型头孢菌素组合物及其制备方法
公开(公告)号：US06342493B1
公开(公告)日：2002-01-29
申请号：US09582937
申请日：2000-07-07
申请人： Masahiro Onodera , Masamichi Sukegawa , Kiyoshi Yasui , Tatsuo Watanabe , Toyomi Sato , Yasushi Murai , Katsuharu Iinuma
发明人： Masahiro Onodera , Masamichi Sukegawa , Kiyoshi Yasui , Tatsuo Watanabe , Toyomi Sato , Yasushi Murai , Katsuharu Iinuma
IPC分类号： A61K31545
CPC分类号： C07D501/00 , A61K9/146 , A61K31/545 , A61K31/546 , Y10S514/96
摘要： Processes are provided for the preparation of orally administrable, yellow and powdery compositions essentially consisting of particles composed of a homogeneous mixture of an amorphous Cefditoren pivoxil substance with a water soluble high-molecular additive. These compositions can be produced by dissolving crystalline Cefditoren pivoxil substance and the water-soluble high-molecular additive in an aqueous solution of an acid, then neutralizing the resultant solution, to co-precipitate the product, and drying the thus precipitated product, followed by recovering the product in the form of the above-mentioned particles.
摘要翻译：提供了制备可口服的黄色和粉末状组合物的方法，其基本上由由无定形头孢托仑匹酯与水溶性高分子添加剂的均匀混合物组成的颗粒组成。这些组合物可以通过将结晶性匹戊头孢托仑物质和水溶性高分子添加剂溶解在酸的水溶液中，然后中和所得溶液，使产物共沉淀并干燥沉淀的产物，然后以上述颗粒的形式回收产物。

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