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1. 发明授权

US4962096A Heterocyclic glycerol derivatives and their use as anti-hypertensive agents 失效
标题翻译：杂环甘油衍生物及其作为抗高血压剂的用途
公开(公告)号：US4962096A
公开(公告)日：1990-10-09
申请号：US172581
申请日：1988-03-24
申请人： Mitsuo Masaki , Hiromitsu Takeda , Toshiro Kamishiro , Masao Yamamoto
发明人： Mitsuo Masaki , Hiromitsu Takeda , Toshiro Kamishiro , Masao Yamamoto
IPC分类号： C07F9/10 , C07F9/572 , C07F9/576 , C07F9/58 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/6539
CPC分类号： C07F9/60 , C07F9/10 , C07F9/5722 , C07F9/5725 , C07F9/5765 , C07F9/582 , C07F9/592 , C07F9/595 , C07F9/62 , C07F9/6539
摘要： A novel glycerol derivative which is effective to reduce blood pressure has the formula: ##STR1## wherein R.sup.1 is an alkyl group having 10-22 carbon atoms, R.sup.2 is lower acyl, benzoyl, aryl, mono-, di- or triarylalkyl, alkyl, cycloalkyl, or cycloalkylalkyl; Q is substituted or unsubstituted alkylene containing 1-4 carbon atoms, l is 0 or 1; Y is a nitrogen-containing heterocyclic group or a nitrogen-containing bridged heterocyclic group (--(Q).sub.l -- is attached to a carbon atom contained in a hetero-ring of the heterocyclic group) in which Y is the bridged heterocyclic group where l is 0; and each of R.sup.5, R.sup.6 and R.sup.7 is hydrogen, lower alkyl, aryl or aralkyl.

2. 发明授权

US5053402A Certain glyceryl phosphate-cyclic ammonium compounds useful for treating hypertension 失效
标题翻译：某些用于治疗高血糖症的糖果 - 磷酸循环氨基甲酸酯化合物
公开(公告)号：US5053402A
公开(公告)日：1991-10-01
申请号：US438996
申请日：1989-11-22
申请人： Mitsuo Masaki , Hiromitsu Takeda , Toshiro Kamishiro , Masao Yamamoto
发明人： Mitsuo Masaki , Hiromitsu Takeda , Toshiro Kamishiro , Masao Yamamoto
IPC分类号： A61K31/685 , A61P7/02 , A61P9/12 , C07F9/10 , C07F9/553 , C07F9/572 , C07F9/59
CPC分类号： C07F9/5532 , C07F9/10 , C07F9/5725 , C07F9/595
摘要： A glycerol derivative which is effective to reduce blood pressure and has the formula: ##STR1## wherein R.sup.1 is an alkyl group having 10-22 carbon atoms, R.sup.2 is a lower acyl group or benzoyl, each of R.sup.3 and R.sup.4 independently is hydrogen or a straight or branched chain alkyl group having 1-6 carbon atoms; each of R.sup.5, R.sup.6 and R.sup.7 independently is hydrogen, a straight or branched chain alkyl group having 1-6 carbon atoms, an aryl group or an aralkyl group; and each of m and n independently is 0 or a positive integer under the condition of m+n=2-8.
摘要翻译：一种有效降低血压的甘油衍生物，具有下式：其中R1是具有10-22个碳原子的烷基，R2是低级酰基或苯甲酰基，R3和R4各自独立地是氢或一个具有1-6个碳原子的直链或支链烷基; R5，R6和R7各自独立地为氢，具有1-6个碳原子的直链或支链烷基，芳基或芳烷基; 在m + n = 2-8的条件下，m和n各自独立地为0或正整数。

3. 发明授权

US5183811A Glycerol derivative and anti-hypertensive agent 失效
标题翻译：甘油衍生物和抗高血压药
公开(公告)号：US5183811A
公开(公告)日：1993-02-02
申请号：US554343
申请日：1990-07-19
申请人： Mitsuo Masaki , Hiromitsu Takeda , Toshiro Kamishiro , Masao Yamamoto
发明人： Mitsuo Masaki , Hiromitsu Takeda , Toshiro Kamishiro , Masao Yamamoto
IPC分类号： C07F9/10 , C07F9/572 , C07F9/576 , C07F9/58 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/6539
CPC分类号： C07F9/582 , C07F9/10 , C07F9/5722 , C07F9/5725 , C07F9/5765 , C07F9/592 , C07F9/595 , C07F9/60 , C07F9/62 , C07F9/6539
摘要： A novel glycerol derivative which is effective to reduce blood pressure has the formula: ##STR1## wherein R.sup.1 is an alkyl group having 10-22 carbon atoms, R.sup.2 is lower acyl, benzoyl, aryl, mono-, di- or triarylalkyl, alkyl, cycloalkyl, or cycloalkylalkyl; Q is substituted or unsubstituted alkylene containing 1-4 carbon atoms, l is 0 or 1; Y is a nitrogen-containing heterocyclic group or a nitrogen-containing bridged heterocyclic group (--(Q).sub.l -- is attached to a carbon atom contained in a hetero-ring of the heterocyclic group) in which Y is the bridged heterocyclic group where l is 0; and each of R.sup.5, R.sup.6 and R.sup.7 is hydrogen, lower alkyl, aryl or aralkyl.
摘要翻译：有效降低血压的新型甘油衍生物具有下式：其中R1是具有10-22个碳原子的烷基，R2是低级酰基，苯甲酰基，芳基，单 - ，三 - 芳基烷基，烷基，环烷基或环烷基烷基; Q是取代或未取代的含有1-4个碳原子的亚烷基，l是0或1; Y是含氮杂环基或含氮桥接杂环基（ - （Q）1-连接到杂环基杂环中含有的杂原子上的碳原子），其中Y是桥连杂环基，其中l 是0; R 5，R 6和R 7各自为氢，低级烷基，芳基或芳烷基。

4. 发明授权

US5070089A Therapeutic agent for liver disease and piperazine derivatives 失效
标题翻译：用于肝病和哌嗪衍生物的治疗剂
公开(公告)号：US5070089A
公开(公告)日：1991-12-03
申请号：US302552
申请日：1989-01-26
申请人： Mitsuo Masaki , Tomio Yamakawa , Masaru Satoh , Hiromitsu Takeda , Yasushi Yoshino , Hitoshi Matsukura
发明人： Mitsuo Masaki , Tomio Yamakawa , Masaru Satoh , Hiromitsu Takeda , Yasushi Yoshino , Hitoshi Matsukura
IPC分类号： C07D295/21 , C07D317/60 , C07H15/26
CPC分类号： C07D295/21 , C07D317/60 , C07H15/26
摘要： A therapeutic agent for liver disease containing as an active ingredient a piperazine derivative having the formula: ##STR1## wherein, A represents a phenyl, p-benzoquinonyl or cumarinyl group which may have at least one substituent selected from the group consisting of halogen, alkyl, fluoroalkyl, formyl, alkoxycarbonyl, acyl, hydroxy, alkoxy, acyloxy, glycosyloxy, amino, alkylamino, mercapto, alkylthio and nitro; B represents a single bond or a straight chain alkylene group containing 1-4 carbon atoms which may have at least one substituent selected from the group consisting of alkyl, aryl, aralkyl, hydroxy and oxo; R represents an atom or a group selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, alkyl, cycloalkyl, aralkyl and aryl; and n is 2 or 3, or its pharmaceutically acceptable salt is disclosed.

5. 发明授权

US4891433A Process for the preparation of dibenzothiepin derivative 失效
标题翻译：二苯并噻吩衍生物的制备方法
公开(公告)号：US4891433A
公开(公告)日：1990-01-02
申请号：US102981
申请日：1987-09-30
申请人： Mitsuo Masaki , Hiromitsu Takeda , Naoya Moritoh , Toshihiro Takahashi
发明人： Mitsuo Masaki , Hiromitsu Takeda , Naoya Moritoh , Toshihiro Takahashi
IPC分类号： C07C323/62 , C07D337/14
CPC分类号： C07C323/62 , C07D337/14
摘要： A novel process for the preparation of 2-(10,11-dihydro-10-oxodibenzo[b, f]thiepin-2-yl)propionic acid which shows high anti-inflammatory and analgetic action is disclosed. The process starts from a propiophenone derivative having the formula (II): ##STR1## wherein R.sup.1 is hydrogen or a lower alkyl group, which is once converted into a haloacetal compound via a halo-ketone compound, and then converted into the desired dibenzothiepin derivative through a combination of rearrangement, hydrolysis and ring closure in variable sequences.
摘要翻译：公开了一种制备显示出高抗炎和止痛作用的2-（10,11-二氢-10-氧代二苯并[b，f]硫杂-2-基）丙酸的新方法。该方法从具有式（II）的苯丙酮衍生物开始：其中R1是氢或低级烷基，其通过卤代酮化合物一度转化为卤代缩醛化合物，然后转化为通过可变序列的重排，水解和闭环的组合，所需的二苯并噻吩衍生物。

6. 发明授权

US5574030A N-aminoalkyl-substituted nitrogen-containing five membered heterocyclic compounds 失效
标题翻译： N-氨基烷基取代的含氮五元杂环化合物
公开(公告)号：US5574030A
公开(公告)日：1996-11-12
申请号：US91219
申请日：1993-07-13
申请人： Mitsuo Masaki , Norihisa Miyake , Atsushi Tendo , Hiromitsu Takeda , Michiko Ishida , Haruhiko Shinozaki
发明人： Mitsuo Masaki , Norihisa Miyake , Atsushi Tendo , Hiromitsu Takeda , Michiko Ishida , Haruhiko Shinozaki
IPC分类号： C07D263/16 , C07D263/20 , C07D263/22 , C07D263/44 , C07D265/32 , C07D277/14 , C07D413/04 , C07D413/06 , C07D233/32 , A61K31/505 , A61K31/54 , C07D233/42
CPC分类号： C07D263/16 , C07D263/20 , C07D263/22 , C07D263/44 , C07D265/32 , C07D277/14 , C07D413/04 , C07D413/06
摘要： Disclosed are new alkylenediamine derivatives of the following formula which are effective for treatment of dysuria are disclosed: ##STR1## wherein R.sup.1 is hydrogen, alkyl, or a substituted or unsubstituted phenyl, naphthyl or aromatic heterocyclic group; R.sup.2 is a substituted or unsubstituted phenyl, naphthyl or aromatic heterocyclic group; R.sup.3 and R.sup.4 represent hydrogen, alkyl, aralkyl or aryl; or R.sup.3 and R.sup.4 are combined to form one of substituted or unsubstituted 5- to 7-membered heterocyclic groups; X is oxygen, sulfur or imino; Y is oxygen or sulfur; Z is --CH.sub.2 --, --CO-- or --CS--; m is an integer of 0-4; n is an integer of 0-4; r is 0 or 1; and p and q represent an integer of 0-5 provided that p plus q is 1-5.
摘要翻译：公开了对治疗排尿困难有效的下式的新的亚烷基二胺衍生物：其中R 1是氢，烷基或取代或未取代的苯基，萘基或芳族杂环基; R2是取代或未取代的苯基，萘基或芳族杂环基; R3和R4代表氢，烷基，芳烷基或芳基; 或R 3和R 4组合以形成取代或未取代的5至7元杂环基团之一; X是氧，硫或亚氨基; Y是氧或硫; Z是-CH 2 - ， - CO-或-CS-; m为0-4的整数; n是0-4的整数; r为0或1; p和q表示0〜5的整数，只要p + q为1-5。

7. 发明授权

US5446146A Piperazine derivative having substituted phenyl groups 失效
标题翻译：具有取代苯基的哌嗪衍生物
公开(公告)号：US5446146A
公开(公告)日：1995-08-29
申请号：US255120
申请日：1994-06-07
申请人： Mitsuo Masaki , Tomio Yamakawa , Masaru Satoh , Hiromitsu Takeda , Yasushi Yoshino , Hitoshi Matsukura
发明人： Mitsuo Masaki , Tomio Yamakawa , Masaru Satoh , Hiromitsu Takeda , Yasushi Yoshino , Hitoshi Matsukura
IPC分类号： C07D295/21 , C07D317/60 , C07H15/26 , C07D243/08 , C07D295/194
CPC分类号： C07D295/21 , C07D317/60 , C07H15/26
摘要： A therapeutic agent for liver disease containing as an active ingredient a piperazine derivative having the formula: ##STR1## wherein, A represents a phenyl, p-benzoquinonyl or cumarinyl group which may have at least one substituent selected from the group consisting of halogen, alkyl, fluoroalkyl, formyl, alkoxycarbonyl, acyl, hydroxy, alkoxy, acyloxy, glycosyloxy, amino, alkylamino, mercapto, alkylthio and nitro; B represents a single bond or a straight chain alkylene group containing 1-4 carbon atoms which may have at least one substituent selected from the group consisting of alkyl, aryl, aralkyl, hydroxy and oxo; R represents an atom or a group selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, alkyl, cycloalkyl, aralkyl and aryl; and n is 2 or 8, or its pharmaceutically acceptable salt is diclosed.
摘要翻译：含有下列通式的哌嗪衍生物作为活性成分的肝病治疗剂：其中，A表示可具有至少一个取代基的苯基，对苯醌或类似的基团，所述取代基选自卤素，烷基氟烷基，甲酰基，烷氧基羰基，酰基，羟基，烷氧基，酰氧基，糖氧基，氨基，烷基氨基，巯基，烷硫基和硝基; B表示单键或含有1-4个碳原子的直链亚烷基，其可以具有至少一个选自烷基，芳基，芳烷基，羟基和氧代的取代基; R表示选自氢，碱金属，碱土金属，烷基，环烷基，芳烷基和芳基的原子或基团。并且n为2或8，或其药学上可接受的盐被包围。

8. 发明授权

US5852006A N-aminoalkyl-substituted nitrogen-containing six membered heterocyclic compounds 失效
标题翻译： N-氨基烷基取代的含氮六元杂环化合物
公开(公告)号：US5852006A
公开(公告)日：1998-12-22
申请号：US725247
申请日：1996-10-04
申请人： Mitsuo Masaki , Norihisa Miyake , Atsushi Tendo , Hiromitsu Takeda , Michiko Ishida , Haruhiko Shinozaki
发明人： Mitsuo Masaki , Norihisa Miyake , Atsushi Tendo , Hiromitsu Takeda , Michiko Ishida , Haruhiko Shinozaki
IPC分类号： C07D263/16 , C07D263/20 , C07D263/22 , C07D263/44 , C07D265/32 , C07D413/06 , C07D265/30 , A61K31/535 , A61K31/54 , C07D279/12
CPC分类号： C07D263/16 , C07D263/20 , C07D263/22 , C07D263/44 , C07D265/32 , C07D413/06
摘要： Disclosed are new alkylenediamine derivatives of the following formula which are effective for treatment of dysuria are disclosed: ##STR1## wherein R.sup.1 is hydrogen, alkyl, or a substituted or unsubstituted phenyl, naphthyl or aromatic heterocyclic group; R.sup.2 is a substituted or unsubstituted phenyl, naphthyl or aromatic heterocyclic group; R.sup.3 and R.sup.4 represent hydrogen, alkyl, aralkyl or aryl; or R.sup.3 and R.sup.4 are combined to form one of substituted or unsubstituted 5- to 7-membered heterocyclic groups; X is oxygen, sulfur or imino; Y is oxygen or sulfur; Z is --CH.sub.2 --, --CO-- or --CS--; m is an integer of 0-4; n is an integer of 0-4; r is 0 or 1; and p and q represent an integer of 0-5 provided that p plus q is 1-5.
摘要翻译：公开了对治疗排尿困难有效的下式的新的亚烷基二胺衍生物：其中R 1是氢，烷基或取代或未取代的苯基，萘基或芳族杂环基; R2是取代或未取代的苯基，萘基或芳族杂环基; R3和R4代表氢，烷基，芳烷基或芳基; 或R 3和R 4组合以形成取代或未取代的5至7元杂环基团之一; X是氧，硫或亚氨基; Y是氧或硫; Z是-CH 2 - ， - CO-或-CS-; m为0-4的整数; n是0-4的整数; r为0或1; p和q表示0〜5的整数，只要p + q为1-5。

9. 发明申请

US20070218280A1 Boride Nanoparticle-Containing Fiber and Textile Product That Uses the Same 审中-公开
标题翻译：含硼纳米粒子的纤维和纺织产品使用相同
公开(公告)号：US20070218280A1
公开(公告)日：2007-09-20
申请号：US11631162
申请日：2004-07-15
申请人： Kayo Yabuki , Kenichi Fujita , Hiromitsu Takeda , Kenji Adachi
发明人： Kayo Yabuki , Kenichi Fujita , Hiromitsu Takeda , Kenji Adachi
IPC分类号： D02G3/02 , B32B9/00
CPC分类号： D01F1/10 , D01F1/106 , D04B1/16 , Y10T428/249921 , Y10T428/256 , Y10T428/2916
摘要： An object is to provide a fiber that absorbs heat with good efficiency, has excellent transparency and heat-retaining properties, and does not compromise the design characteristics of a textile product, and to provide a textile product in which the fiber is used. Hexaboride nanoparticles, a dispersion medium, and a dispersion agent for dispersing the nanoparticles are mixed together. The mixture is dispersed and dried to obtain a dispersion powder. The resulting dispersion powder is added to thermoplastic resin pellets, uniformly mixed, and thereafter melted and kneaded to obtain a master batch containing a heat-absorbing component. The master batch containing a heat-absorbing component is mixed with a similarly prepared master batch to which inorganic nanoparticles has not been added, and the mixture is melted, spun, and drawn to manufacture a multifilament yarn. The multifilament yarn is cut to fabricate staples, and the staples are used to manufacture a spun yarn having heat-absorbing effects. The spun yarn is used to obtain a knitted product having heat-retaining properties.
摘要翻译：本发明的目的是提供一种能够以高效率吸收热量的纤维，具有优异的透明性和保温性，并且不损害纺织品的设计特性，并提供使用纤维的纺织品。六硼化物纳米颗粒，分散介质和分散纳米颗粒的分散剂混合在一起。将混合物分散并干燥，得到分散粉末。将所得分散体粉末加入到热塑性树脂颗粒中，均匀混合，然后熔融和捏合，得到含有吸热组分的母料。将含有吸热成分的母料与未加入无机纳米颗粒的类似制备的母料混合，并将该混合物熔融，纺丝和拉伸以制造复丝纱线。复丝纱线被切割以制造订书钉，并且订书钉用于制造具有吸热效果的细纱。使用细纱来获得具有保温性的针织物。

10. 发明授权

US06060154A Coating liquid for selective permeable membrane, selective permeable membrane and selective permeable multilayered membrane 失效
标题翻译：选择性渗透膜，选择性渗透膜和选择性渗透性多层膜的涂布液
公开(公告)号：US06060154A
公开(公告)日：2000-05-09
申请号：US951166
申请日：1997-10-15
申请人： Kenji Adachi , Hiromitsu Takeda , Hiroko Kuno
发明人： Kenji Adachi , Hiromitsu Takeda , Hiroko Kuno
IPC分类号： C03C17/00 , C03C17/34 , C09D7/12 , B32B5/16 , B32B9/00
CPC分类号： C09D7/1266 , C03C17/007 , C03C17/34 , C09D7/1216 , C03C2217/475 , C08K3/22 , C08K3/28 , Y10T428/25 , Y10T428/256
摘要： A coating solution for forming a selectively transmitting film which is effective for cutting off ultraviolet radiation in a wide range of wavelengths up to about 400 nm, maintains its stability and effect for a long time, has also a power of cutting off heat rays and a controlled transmittance of visible light, has any desired color produced by the addition of fine particles of an appropriate inorganic substance, and is applicable to glass in any existing building, or the like by a simple and inexpensive method using an appropriately selected binder, and a selectively transmitting film and a selectively transmitting multilayer film which are formed from the solution. The solution is a dispersion of fine particles having an average diameter of 100 nm or less of at least one of ruthenium oxide, titanium nitride, tantalum nitride, titanium silicide, molybdenum silicide, lanthanum boride, iron oxide and iron hydroxide oxide. It may also contain at least one of the alkoxides of silicon, zirconium, titanium and aluminum, and partially hydrolyzed polymers of those alkoxides, or a synthetic resin as a binder. The selectively transmitting film is formed by coating a base material with the solution, and hardening it. The selectively transmitting multilayer film has another film formed on the selectively transmitting film and containing at least one of the alkoxides of silicon, zirconium, titanium and aluminum, partially hydrolyzed polymers of those alkoxides, and a synthetic resin.
摘要翻译：用于形成选择性透射膜的涂布溶液具有切断高达约400nm的宽波长范围内的紫外线辐射，长时间保持其稳定性和效果的选择性透射膜，还具有切断热射线的功能和受控的可见光透射率，具有通过添加合适的无机物质的微粒而产生的所需颜色，并且可以通过使用适当选择的粘合剂的简单廉价的方法适用于任何现有建筑物中的玻璃等，以及选择性地透射膜和由溶液形成的选择性透射多层膜。该溶液是氧化钌，氮化钛，氮化钽，硅化钛，硅化钼，硼化镧，氧化铁和氢氧化铁氧化物中的至少一种平均直径为100nm以下的微粒子的分散液。它还可以含有硅，锆，钛和铝的至少一种醇，以及这些醇盐的部分水解聚合物，或作为粘合剂的合成树脂。选择透射膜通过用溶液涂覆基材并使其硬化而形成。选择性透射多层膜具有形成在选择性透射膜上并含有硅，锆，钛和铝的至少一种，这些醇盐的部分水解的聚合物和合成树脂中的至少一种的另一膜。

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