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1. 发明授权

US07638133B2 Recombinant BCG vaccine 失效
标题翻译：重组BCG疫苗
公开(公告)号：US07638133B2
公开(公告)日：2009-12-29
申请号：US10524586
申请日：2003-08-13
申请人： Mitsuo Honda , Kazuhiro Matsuo , Masaru Kanekiyo , Duanthanorm Promkhatkaew
发明人： Mitsuo Honda , Kazuhiro Matsuo , Masaru Kanekiyo , Duanthanorm Promkhatkaew
IPC分类号： A61K39/02 , A61K39/04
CPC分类号： C07K14/005 , A61K39/04 , A61K2039/523 , C07K16/1054 , C12N15/67 , C12N2740/16222
摘要： A recombinant BCG vaccine being transformed with an expression vector that has a polynucleotide encoding a foreign antigenic protein, wherein the polynucleotide is a modified one in which the third position of each codon is substituted with G or C without a change of an amino acid. This recombinant BCG vaccine has an excellent expression rate of antigenic protein and, as a result, capable of inducing a sufficient immune response against target infectious disease, cancer, or the like at the same dose as that of the typical BCG vaccine.
摘要翻译：用编码外源抗原蛋白的多核苷酸的表达载体转化的重组BCG疫苗，其中所述多核苷酸是其中每个密码子的第三位被G或C替代而不改变氨基酸的修饰的。该重组BCG疫苗具有优异的抗原性蛋白的表达率，因此能够以与典型的BCG疫苗相同的剂量诱导针对目标感染性疾病，癌症等的足够的免疫应答。

2. 发明申请

US20090060954A1 Recombinant BCG Vaccine 失效
标题翻译：重组BCG疫苗
公开(公告)号：US20090060954A1
公开(公告)日：2009-03-05
申请号：US12230847
申请日：2008-09-05
申请人： Mitsuo Honda , Kazuhiro Matsuo , Masaru Kanekiyo , Duanthanorm Promkhatkaew
发明人： Mitsuo Honda , Kazuhiro Matsuo , Masaru Kanekiyo , Duanthanorm Promkhatkaew
IPC分类号： A61K39/04 , A61P31/04 , A61P37/04
CPC分类号： C07K14/005 , A61K39/04 , A61K2039/523 , C07K16/1054 , C12N15/67 , C12N2740/16222
摘要： A recombinant BCG vaccine being transformed with an expression vector that has a polynucleotide encoding a foreign antigenic protein, wherein the polynucleotide is a modified one in which the third position of each codon is substituted with G or C without a change of an amino acid. This recombinant BCG vaccine has an excellent expression rate of antigenic protein and, as a result, capable of inducing a sufficient immune response against target infectious disease, cancer, or the like at the same dose as that of the typical BCG vaccine.
摘要翻译：用编码外源抗原蛋白的多核苷酸的表达载体转化的重组BCG疫苗，其中所述多核苷酸是其中每个密码子的第三位被G或C替代而不改变氨基酸的修饰的。该重组BCG疫苗具有优异的抗原性蛋白的表达率，因此能够以与典型的BCG疫苗相同的剂量诱导针对目标感染性疾病，癌症等的足够的免疫应答。

3. 发明授权

US07670610B2 Recombinant BCG vaccine 失效
标题翻译：重组BCG疫苗
公开(公告)号：US07670610B2
公开(公告)日：2010-03-02
申请号：US12230847
申请日：2008-09-05
申请人： Mitsuo Honda , Kazuhiro Matsuo , Masaru Kanekiyo , Duanthanorm Promkhatkaew
发明人： Mitsuo Honda , Kazuhiro Matsuo , Masaru Kanekiyo , Duanthanorm Promkhatkaew
IPC分类号： A61K39/02 , A61K39/04
CPC分类号： C07K14/005 , A61K39/04 , A61K2039/523 , C07K16/1054 , C12N15/67 , C12N2740/16222
摘要： A recombinant BCG vaccine being transformed with an expression vector that has a polynucleotide encoding a foreign antigenic protein, wherein the polynucleotide is a modified one in which the third position of each codon is substituted with G or C without a change of an amino acid. This recombinant BCG vaccine has an excellent expression rate of antigenic protein and, as a result, capable of inducing a sufficient immune response against target infectious disease, cancer, or the like at the same dose as that of the typical BCG vaccine.
摘要翻译：用编码外源抗原蛋白的多核苷酸的表达载体转化的重组BCG疫苗，其中所述多核苷酸是其中每个密码子的第三位被G或C替代而不改变氨基酸的修饰的。该重组BCG疫苗具有优异的抗原性蛋白的表达率，因此能够以与典型的BCG疫苗相同的剂量诱导针对目标感染性疾病，癌症等的足够的免疫应答。

4. 发明申请

US20060210586A1 Recombination bcg vaccine 失效
标题翻译：重组bcg疫苗
公开(公告)号：US20060210586A1
公开(公告)日：2006-09-21
申请号：US10524586
申请日：2003-08-13
申请人： Mitsuo Honda , Kazuhiro Matsuo , Masaru Kanekiyo
发明人： Mitsuo Honda , Kazuhiro Matsuo , Masaru Kanekiyo
IPC分类号： A61K39/02 , C12N15/74
CPC分类号： C07K14/005 , A61K39/04 , A61K2039/523 , C07K16/1054 , C12N15/67 , C12N2740/16222
摘要： A recombinant BCG vaccine being transformed with an expression vector that has a polynucleotide encoding a foreign antigenic protein, wherein the polynucleotide is a modified one in which a third position of each codon is substituted with G or C without a change of an amino acid. This recombinant BCG vaccine has an excellent expression rate of antigenic protein and, as a result, capable of inducing a sufficient immune response against target infectious disease, cancer, or the like at the same dose as that of the typical BCG vaccine.
摘要翻译：用编码外源抗原蛋白的多核苷酸的表达载体转化的重组BCG疫苗，其中所述多核苷酸是其中每个密码子的第三个位置被G或C取代而不改变氨基酸的修饰的。该重组BCG疫苗具有优异的抗原性蛋白的表达率，因此能够以与典型的BCG疫苗相同的剂量诱导针对目标感染性疾病，癌症等的足够的免疫应答。

5. 发明申请

US20050123561A1 Radio lan access authentication system 审中-公开
标题翻译：无线局域网接入认证系统
公开(公告)号：US20050123561A1
公开(公告)日：2005-06-09
申请号：US10515253
申请日：2002-11-20
申请人： Mitsuo Honda , Kazuhiro Matsuo , Yasuyuki Izumi
发明人： Mitsuo Honda , Kazuhiro Matsuo , Yasuyuki Izumi
IPC分类号： A61K39/00 , A61P31/00 , A61P31/18 , C07K14/155 , A61K39/12
CPC分类号： C07K14/005 , A61K39/0011 , A61K2039/523 , A61K2039/545 , C12N2740/15022
摘要： This invention provides a recombinant BCG vaccine transformed by an expression vector having polynucleotide coding for exogenous antigenic protein, characterized in that, the BCG vaccine is used for initial antigen stimulus in immune induction by plural antigen stimulations and also provides a method for the immune induction where the initial antigen stimulus is carried out by the said BCG vaccine and one or more additional antigenic stimulation(s) is/are carried out by non-BCG vaccine expressing the same antigenic protein.
摘要翻译：本发明提供了一种通过表达载体转化的重组BCG疫苗，该表达载体具有编码外源抗原蛋白的多核苷酸，其特征在于，通过多次抗原刺激将BCG疫苗用于免疫诱导中的初始抗原刺激，并提供免疫诱导方法初始抗原刺激由所述BCG疫苗进行，一个或多个另外的抗原刺激由表达相同抗原蛋白的非BCG疫苗进行。

6. 发明授权

US5885580A Anti-AIDS secretory recombinant BCG vaccine 失效
标题翻译：抗艾滋病分泌型重组BCG疫苗
公开(公告)号：US5885580A
公开(公告)日：1999-03-23
申请号：US972089
申请日：1997-11-17
申请人： Kazuhiro Matsuo , Yoshitomo Chujo , Akihiro Yamazaki , Mitsuo Honda , Shudo Yamazaki , Hiromichi Tasaka
发明人： Kazuhiro Matsuo , Yoshitomo Chujo , Akihiro Yamazaki , Mitsuo Honda , Shudo Yamazaki , Hiromichi Tasaka
IPC分类号： A61K39/00 , A61P31/18 , C07K14/16 , C07K14/35 , C07K14/47 , A61K38/00 , A61K39/02 , C07H21/04
CPC分类号： C07K14/005 , C07K14/35 , C07K14/473 , A61K39/00 , C07K2319/00 , C12N2740/16122
摘要： A vaccine containing Mycobacterium bovis BCG which secretes a fusion protein to be obtained by inserting a foreign antigen peptide into the molecular surface of a secretory protein, a carrier, having a signal peptide. BCG constituting the present invention secretes a fusion protein to be obtained by inserting a foreign antigen peptide into the molecular surface of an .alpha.-antigen derived from mycobacteria. Said fusion protein has significantly increased antigenicity and immunogenicity. Therefore, when it is inoculated into animals, it is efficiently recognized by B cells which recognize said antigen, thereby effectively inducing the production of an antibody to said antigen. When said BCG itself is inoculated into animals, it continuously secretes said fusion protein in the bodies of the animals while continuously propagating therein. Therefore, said BCG is an extremely useful vaccine.
摘要翻译：含有牛分枝杆菌BCG的疫苗，其分泌通过将外源抗原肽插入分泌蛋白的分子表面，具有信号肽的载体获得的融合蛋白。构成本发明的BCG分泌通过将异源抗原肽插入来自分枝杆菌的α-不锈钢的分子表面而获得的融合蛋白。所述融合蛋白具有显着增加的抗原性和免疫原性。因此，当将其接种到动物体内时，可以有效地识别识别所述抗原的B细胞，从而有效地诱导产生抗原的抗体。当所述BCG本身被接种到动物中时，它连续地分布在动物体内的所述融合蛋白，同时连续传播。因此，所述BCG是非常有用的疫苗。

7. 发明授权

US5858369A Anti-acids secretory recombinant BCG vaccine 失效
标题翻译：抗分泌重组BCG疫苗
公开(公告)号：US5858369A
公开(公告)日：1999-01-12
申请号：US975699
申请日：1997-11-21
申请人： Kazuhiro Matsuo , Yoshitomo Chujo , Akihiro Yamazaki , Mitsuo Honda , Shudo Yamazaki , Hiromichi Tasaka
发明人： Kazuhiro Matsuo , Yoshitomo Chujo , Akihiro Yamazaki , Mitsuo Honda , Shudo Yamazaki , Hiromichi Tasaka
IPC分类号： A61K39/00 , A61P31/18 , C07K14/16 , C07K14/35 , C07K14/47 , A61K38/00 , A61K39/02 , C07H21/04
CPC分类号： C07K14/005 , C07K14/35 , C07K14/473 , A61K39/00 , C07K2319/00 , C12N2740/16122
摘要： A vaccine containing Mycobacterium bovis BCG which secretes a fusion protein to be obtained by inserting a foreign antigen peptide into the molecular surface of a secretory protein, a carrier, having a signal peptide. BCG constituting the present invention secretes a fusion protein to be obtained by inserting a foreign antigen peptide into the molecular surface of an .alpha.-antigen derived from mycobacteria. Said fusion protein has significantly increased antigenicity and immunogenicity. Therefore, when it is inoculated into animals, it is efficiently recognized by B cells which recognize said antigen, thereby effectively inducing the production of an antibody to said antigen. When said BCG itself is inoculated into animals, it continuously secretes said fusion protein in the bodies of the animals while continuously propagating therein. Therefore, said BCG is an extremely useful vaccine.
摘要翻译：含有牛分枝杆菌BCG的疫苗，其分泌通过将外源抗原肽插入分泌蛋白的分子表面，具有信号肽的载体获得的融合蛋白。构成本发明的BCG分泌通过将异源抗原肽插入来自分枝杆菌的α-不锈钢的分子表面而获得的融合蛋白。所述融合蛋白具有显着增加的抗原性和免疫原性。因此，当将其接种到动物体内时，可以有效地识别识别所述抗原的B细胞，从而有效地诱导产生抗原的抗体。当所述BCG本身被接种到动物中时，它连续地分布在动物体内的所述融合蛋白，同时连续传播。因此，所述BCG是非常有用的疫苗。

8. 发明申请

US20050053620A1 Recombinant vaccinia virus vaccine 审中-公开
标题翻译：重组痘苗病毒疫苗
公开(公告)号：US20050053620A1
公开(公告)日：2005-03-10
申请号：US10495974
申请日：2001-11-20
申请人： Mitsuo Honda , Kazuhiro Matsuo , Takeaki Ohsu , Tatsuo Miyamura , Yoshiharu Matsuura , Koji Ishii , Kenzo Kato
发明人： Mitsuo Honda , Kazuhiro Matsuo , Takeaki Ohsu , Tatsuo Miyamura , Yoshiharu Matsuura , Koji Ishii , Kenzo Kato
IPC分类号： A61K39/00 , C07K14/16 , C12N7/01 , C12N7/08 , C12N15/49 , C12N15/863 , A61K39/12 , C12N7/00
CPC分类号： C12N7/00 , A61K39/00 , A61K2039/5256 , A61K2039/53 , C07K14/005 , C12N15/86 , C12N2710/24043 , C12N2740/16122
摘要： The invention provides a recombinant vaccinia virus strain DIs that possesses a polynucleotide encoding a foreign antigenic protein in the non-essential gene region of the chromosome DNA and expresses the antigenic protein; and provides a highly-safe, vaccinia virus vaccine containing the recombinant virus strain DIs as the active ingredient. The invention also provides a method of using the vaccinia virus strain DIs as a vector for protein expression.
摘要翻译：本发明提供了一种重组痘苗病毒株DIs，其具有编码染色体DNA非必需基因区域中外源抗原蛋白的多核苷酸并表达该抗原蛋白; 并提供含有重组病毒株DIs作为活性成分的高度安全的痘苗病毒疫苗。本发明还提供了使用痘苗病毒株DIs作为蛋白质表达载体的方法。

9. 发明授权

US08791521B2 Semiconductor device and method of manufacturing the same 有权
标题翻译：半导体装置及其制造方法
公开(公告)号：US08791521B2
公开(公告)日：2014-07-29
申请号：US13423664
申请日：2012-03-19
申请人： Koji Nakahara , Kazuhiro Matsuo , Masayuki Tanaka , Hirofumi Iikawa
发明人： Koji Nakahara , Kazuhiro Matsuo , Masayuki Tanaka , Hirofumi Iikawa
IPC分类号： H01L29/788
CPC分类号： H01L27/11521 , H01L29/42324 , H01L29/7881
摘要： A semiconductor device includes an interelectrode insulating film formed between a charge storage layer and a control electrode layer. The interelectrode insulating film is formed in a first region above an upper surface of an element isolation insulating film, a second region along a sidewall of the charge storage layer, and a third region above an upper surface of the charge storage layer. The interelectrode insulating film includes a first stack including a first silicon nitride film or a high dielectric constant film interposed between a first and a second silicon oxide film or a second stack including a second high dielectric constant film and a third silicon oxide film, and a second silicon nitride film formed between the control electrode layer and the first or the second stack. The second silicon nitride film is relatively thinner in the third region than in the first region.
摘要翻译：半导体器件包括在电荷存储层和控制电极层之间形成的电极间绝缘膜。电极间绝缘膜形成在元件隔离绝缘膜的上表面上方的第一区域，沿着电荷存储层的侧壁的第二区域和电荷存储层的上表面上方的第三区域。电极间绝缘膜包括：第一堆叠，其包括介于第一和第二氧化硅膜之间的第一氮化硅膜或高介电常数膜，或包括第二高介电常数膜和第三氧化硅膜的第二堆叠，形成在控制电极层和第一或第二堆叠之间的第二氮化硅膜。在第三区域中，第二氮化硅膜比第一区域相对薄。

10. 发明授权

US08525252B2 Nonvolatile semiconductor memory device and method of fabricating the same 有权
公开(公告)号：US08525252B2
公开(公告)日：2013-09-03
申请号：US13233788
申请日：2011-09-15
申请人： Kenichiro Toratani , Masayuki Tanaka , Kazuhiro Matsuo
发明人： Kenichiro Toratani , Masayuki Tanaka , Kazuhiro Matsuo
IPC分类号： H01L29/792
CPC分类号： H01L29/792 , G11C16/0466 , H01L21/28282 , H01L27/11568 , H01L27/11582 , H01L29/4234 , H01L29/66833 , H01L29/7926
摘要： According to one embodiment, a nonvolatile semiconductor memory device includes a semiconductor region, a tunnel insulator provided above the semiconductor region, a charge storage insulator provided above the tunnel insulator, a block insulator provided above the charge storage insulator, a control gate electrode provided above the block insulator, and an interface region including a metal element, the interface region being provided at one interface selected from between the semiconductor region and the tunnel insulator, the tunnel insulator and the charge storage insulator, the charge storage insulator and the block insulator, and the block insulator and the control gate electrode.

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