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1. 发明授权

US6115513A Information input method and apparatus using a target pattern and an access indication pattern 失效
标题翻译：使用目标图案和访问指示图案的信息输入方法和装置
公开(公告)号：US6115513A
公开(公告)日：2000-09-05
申请号：US971319
申请日：1997-11-17
申请人： Mitsuhiro Miyazaki , Hiroshi Usuda , Motohiro Kobayashi
发明人： Mitsuhiro Miyazaki , Hiroshi Usuda , Motohiro Kobayashi
IPC分类号： G06F3/14 , G06F3/00 , G06F3/033 , G06F3/048 , G06F13/00 , G06T1/00 , G06K9/20 , G06K9/00
CPC分类号： G06F3/0426
摘要： An information input method and interface, which can easily be operated without direct awareness of hardware, are provided. Image recognition is performed with an image recognition unit on image information obtained from imaging a target pattern on an object surface and an access indication pattern created by a user. The input patterns are created with an image pickup unit. The target pattern is associated with corresponding information stored in a storage unit. An access indication input which specifies a subset of the information is generated by performing image recognition on the access indication pattern. A control operation corresponding to the access indication input is performed in response to the access indication input by a control unit.
摘要翻译：提供了一种信息输入方法和接口，可以在没有硬件意识的情况下轻松地进行操作。利用图像识别单元对从物体表面上的目标图案进行成像获得的图像信息和由用户创建的访问指示图案进行图像识别。使用图像拾取单元创建输入图案。目标模式与存储在存储单元中的相应信息相关联。通过对访问指示模式执行图像识别来生成指定信息的子集的访问指示输入。响应于由控制单元输入的访问指示来执行对应于访问指示输入的控制操作。

2. 发明授权

US5492658A Gate-cut and ejection control apparatus and control method for an injection molding machine 失效
标题翻译：注射成型机的切断喷射控制装置及控制方法
公开(公告)号：US5492658A
公开(公告)日：1996-02-20
申请号：US356207
申请日：1994-12-19
申请人： Masakazu Ohno , Yukio Yoshizawa , Shoji Miyajima , Sumio Sato , Toshio Inage , Motohiro Kobayashi
发明人： Masakazu Ohno , Yukio Yoshizawa , Shoji Miyajima , Sumio Sato , Toshio Inage , Motohiro Kobayashi
IPC分类号： B29C45/38 , B29C45/40 , B29C45/76
CPC分类号： B29C45/40 , B29C45/38 , B29C45/7626 , B29C2045/764 , Y10S425/051
摘要： The present intention intends to operate an ejector which carries out gate cut and product ejection in an injection molding machine, at optimal speeds, respectively. According to the present invention, a control unit for controlling hydraulic or electric drive means for operating one or more than one ejector pin comprises operation speed setting means for gate cut and another operation speed setting means for product ejection. Such a structure enables to carry out gate cut by operating an ejector unit controlled by an ejector unit operation speed setting means for a gate cut and, subsequently, to carry out a product ejection from metallic molds by operating the ejector unit controlled by another ejector unit operation speed setting means for product ejection. The ejector unit is set at a comparatively high operation speed for gate cut so that no gate trace will remain, and at a comparatively low operation speed for product ejection so that no cracks will be generated in the product.
摘要翻译：目的在于以最佳速度分别在注射成型机中进行浇口切割和产品喷射的喷射器。根据本发明，用于控制用于操作一个或多个顶针的液压或电驱动装置的控制单元包括用于闸板切割的操作速度设定装置和用于产品喷射的另一操作速度设定装置。这种结构能够通过操作由喷射器单元操作的喷射器单元进行闸板切割，喷射器单元操作速度设定装置用于浇口切割，并且随后通过操作由另一个喷射器单元控制的喷射器单元从金属模具执行产品喷射用于产品喷射的操作速度设定装置。喷射器单元被设置为相对较高的操作速度以进行栅极切割，使得不会留下栅极迹线，并且以相对低的操作速度进行产品喷射，使得产品中不会产生裂纹。

3. 发明授权

US07087624B2 Substituted pyrazole compounds 有权
标题翻译：取代的吡唑化合物
公开(公告)号：US07087624B2
公开(公告)日：2006-08-08
申请号：US10693461
申请日：2003-10-27
申请人： Nobuyoshi Minami , Michitaka Sato , Koichi Hasumi , Norio Yamamoto , Katsuyuki Keino , Teruaki Matsui , Arihiro Kanada , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Akira Asagarasu , Satoshi Doi , Motohiro Kobayashi , Jun Sato , Hajime Asano
发明人： Nobuyoshi Minami , Michitaka Sato , Koichi Hasumi , Norio Yamamoto , Katsuyuki Keino , Teruaki Matsui , Arihiro Kanada , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Akira Asagarasu , Satoshi Doi , Motohiro Kobayashi , Jun Sato , Hajime Asano
IPC分类号： A61K31/44 , C07D40/00
CPC分类号： C07D231/12 , A61K31/4439 , A61K31/4709 , A61K31/4725 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D405/14 , Y02A50/411
摘要： Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)-(A)n-Y, —CH2—CH(R4)-(A)n-Y, —CO-B1-A-Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor α-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases
摘要翻译：公开了由式（I）表示的取代的吡唑化合物或其盐，其中R 1是-CH（OH）-CH（R 4） - （A） -CH（R 4） - （A）n -Y， - CO（CH 2） -B 1 -I 1等（其中A是低级亚烷基; Y是可以被卤素取代的芳基等）; R 4， SUP>是氢原子或低级烷基; B 1是-CH（R 4） - 或-N（R 4） - ;和n为0或1）; R 2是氢原子，可以被羟基等取代的低级烷基或芳烷基; R 3是可以被卤素等取代的苯基或吡啶基; Q为吡啶基或喹啉基。这些取代的吡唑化合物或其盐具有优异的p38MAP激酶抑制作用，因此可用于预防或治疗肿瘤坏死因子α相关疾病，白细胞介素1相关疾病，白细胞介素6相关疾病或环氧合酶II相关疾病

4. 发明授权

US6142760A Drive control apparatus for electric injection molding machine 有权
标题翻译：电动注塑机驱动控制装置
公开(公告)号：US6142760A
公开(公告)日：2000-11-07
申请号：US220404
申请日：1998-12-24
申请人： Nobuya Niizeki , Motohiro Kobayashi
发明人： Nobuya Niizeki , Motohiro Kobayashi
IPC分类号： B29C45/46 , B29C45/76 , B29C45/77
CPC分类号： B29C45/76 , B29C2045/1792 , B29C2945/76006 , B29C2945/76033 , B29C2945/76083 , B29C2945/7611 , B29C2945/76511 , B29C2945/76568 , B29C2945/76605 , B29C2945/76665 , B29C45/7666
摘要： A drive control apparatus is provided for an electric injection molding machine, in which a screw is used to inject melted resin into a cavity of a metal mold. Herein, the screw is driven to move in a desired direction by using first and second servo motors, which are connected together using a belt, for example. In the drive control apparatus, a motion controller produces a drive control signal to control operation of the screw. A master servo amplifier inputs the drive control signal to control the first servo motor, wherein a position of a rotor of the first servo motor is detected and is used as a feedback value. The master servo amplifier further produces a torque instruction signal representing a ratio against rated output of the first servo motor by which the first servo motor is to be driven. For example, frequency of the torque instruction represents rotation speed of the motor, while amplitude represents magnitude of torque. A slave servo amplifier controls the second servo motor based on the torque instruction signal. The motion controller is capable of producing a synchronizing signal, which is delivered to the master and slave servo amplifiers so that the first and second servo motors are driven in a synchronized manner.
摘要翻译：为电动注射成型机提供驱动控制装置，其中使用螺杆将熔融树脂注入到金属模具的空腔中。这里，通过使用例如使用带连接在一起的第一和第二伺服电动机来驱动螺杆在期望的方向上移动。在驱动控制装置中，运动控制器产生驱动控制信号以控制螺杆的操作。主伺服放大器输入驱动控制信号以控制第一伺服电动机，其中检测第一伺服电动机的转子的位置并将其用作反馈值。主伺服放大器进一步产生表示第一伺服电动机驱动的第一伺服电动机的额定输出的比率的转矩指令信号。例如，转矩指令的频率表示电动机的转速，而幅度表示转矩的大小。从伺服放大器根据转矩指令信号控制第二伺服电机。运动控制器能够产生同步信号，其被传送到主和从伺服放大器，使得第一和第二伺服电机以同步的方式被驱动。

5. 发明授权

US06667325B1 Substituted pyrazole compounds 失效
标题翻译：取代的吡唑化合物
公开(公告)号：US06667325B1
公开(公告)日：2003-12-23
申请号：US09980579
申请日：2001-12-03
申请人： Nobuyoshi Minami , Michitaka Sato , Koichi Hasumi , Norio Yamamoto , Katsuyuki Keino , Teruaki Matsui , Arihiro Kanada , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Akira Asagarasu , Satoshi Doi , Motohiro Kobayashi , Jun Sato , Hajime Asano
发明人： Nobuyoshi Minami , Michitaka Sato , Koichi Hasumi , Norio Yamamoto , Katsuyuki Keino , Teruaki Matsui , Arihiro Kanada , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Akira Asagarasu , Satoshi Doi , Motohiro Kobayashi , Jun Sato , Hajime Asano
IPC分类号： C07D40104
CPC分类号： C07D231/12 , A61K31/4439 , A61K31/4709 , A61K31/4725 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D405/14 , Y02A50/411
摘要： Substituted pyrazole compounds represented by formula (I), or salts thereof are disclosed, wherein R1 is —CH(OH)—CH(R4)—(A)n—Y, —CH2—CH(R4)—(A)n—Y, —CO—B1—A—Y or the like (wherein A is a lower alkylene; Y is an aryl group which may be substituted, for example, by halogen, or the like; R4 is a hydrogen atom or a lower alkyl group; B1 is —CH(R4)— or —N(R4)—; and n is 0 or 1); R2 is a hydrogen atom, a lower alkyl group which may be substituted by hydroxyl or the like, or an aralkyl group; R3 is a phenyl group which may be substituted by halogen or the like, or a pyridyl group; and Q is a pyridyl or quinolyl group. These substituted pyrazole compounds or their salts have an excellent p38MAP kinase inhibiting effect and are hence useful in the prevention or treatment of tumor necrosis factor &agr;-related diseases, interleukin 1-related diseases, interleukin 6-related diseases or cyclooxygenase II-related diseases.
摘要翻译：公开了由式（I）表示的取代的吡唑化合物或其盐，其中R 1是-CH（OH）-CH（R 4） - （A）n Y，-CH 2 -CH（R 4）） - （A）nY，-CO-B 1 -AY等（其中A是低级亚烷基; Y是可以被卤素取代的芳基等; R 4 >是氢原子或低级烷基; B 1是-CH（R 4） - 或-N（R 4） - ，n是0或1）; R 2是氢原子，可以被羟基等取代的低级烷基或芳烷基; R 3是可被卤素等取代的苯基或吡啶基; Q为吡啶基或喹啉基。这些取代的吡唑化合物或其盐具有优异的p38MAP激酶抑制作用，因此可用于预防或治疗肿瘤坏死因子α相关疾病，白细胞介素1相关疾病，白介素6相关疾病或环加氧酶II相关疾病。

6. 发明授权

US06511997B1 Aminopyrazole derivatives 有权
标题翻译：氨基吡唑衍生物
公开(公告)号：US06511997B1
公开(公告)日：2003-01-28
申请号：US09869051
申请日：2001-06-22
申请人： Nobuyoshi Minami , Michitaka Sato , Koichi Hasumi , Norio Yamamoto , Katsuyuki Keino , Teruaki Matsui , Arihiro Kanada , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Akira Asagarasu , Satoshi Doi , Motohiro Kobayashi , Jun Sato , Hajime Asano
发明人： Nobuyoshi Minami , Michitaka Sato , Koichi Hasumi , Norio Yamamoto , Katsuyuki Keino , Teruaki Matsui , Arihiro Kanada , Shuji Ohta , Takahisa Saito , Shuichiro Sato , Akira Asagarasu , Satoshi Doi , Motohiro Kobayashi , Jun Sato , Hajime Asano
IPC分类号： A61K314409
CPC分类号： C07D401/04 , C07D405/14
摘要： Aminopyrazole derivatives represented by formula (I), or salts thereof, wherein X1 and X2 are each a hydrogen atom or a halogen atom, or X1 and X2 may be united together to form a lower alkylenedioxy group, Q is a pyridyl group or a quinolyl group, R1 is a hydrogen atom, a substituted or unsubstituted lower alkyl or aryl group, R2 is a hydrogen atom, a lower alkyl group, or an aralkyl group, and R3 represents a hydrogen atom, an organic sulfonyl group, or —C(═Y)—R4 in which R4 is a hydrogen atom or an organic residue and Y is an oxygen or sulfur atom, provided that, when R3 is a hydrogen atom, R1 is a group other than a hydrogen atom and R2 is a hydrogen atom. These amimopyrazole derivatives or their salts have excellent p38MAP kinase inhibiting activities and are hence useful in the prevention or treatment of diseases associated with tumor necrosis sis factor &agr;, interleukin 1, interleukin 6 or cyclooxygenase II.
摘要翻译：式（I）表示的氨基吡唑衍生物或其盐，其中X 1和X 2各自为氢原子或卤素原子，或者X 1和X 2可以一起结合形成低级亚烷基二氧基，Q是吡啶基或喹啉基基团，R 1是氢原子，取代或未取代的低级烷基或芳基，R 2是氢原子，低级烷基或芳烷基，R 3表示氢原子，有机磺酰基或-C（ = Y）-R4，其中R4为氢原子或有机残基，Y为氧或硫原子，条件是当R3为氢原子时，R1为氢原子以外的基团，R2为氢原子。这些酰胺吡唑衍生物或其盐具有优异的p38MAP激酶抑制活性，因此可用于预防或治疗与肿瘤坏死因子α，白细胞介素1，白介素6或环加氧酶II相关的疾病。

7. 发明授权

US6124431A Peptide derivatives 失效
标题翻译：肽衍生物
公开(公告)号：US6124431A
公开(公告)日：2000-09-26
申请号：US39426
申请日：1998-03-16
申请人： Kyoichi Sakakibara , Masaaki Gondo , Koichi Miyazaki , Takeshi Ito , Akihiro Sugimura , Motohiro Kobayashi
发明人： Kyoichi Sakakibara , Masaaki Gondo , Koichi Miyazaki , Takeshi Ito , Akihiro Sugimura , Motohiro Kobayashi
IPC分类号： A61K38/00 , C07K5/02 , C07K5/027 , C07K7/02 , C07K5/08 , A61K38/06 , A61K38/07 , C07K5/10
CPC分类号： C07K5/0205 , C07K7/02 , A61K38/00 , Y10S530/83
摘要： A peptide derivative represented by the following formula or a salt thereof ##STR1## wherein A represents a hydrogen atom, and B represents a phenyl group substituted with a hydroxyl group;said derivative has an antitumor activity stronger than that of dolastatin 10, and is useful as an anticancer or antitumor agent.
摘要翻译：由下式表示的肽衍生物或其盐，其中A表示氢原子，B表示被羟基取代的苯基; 所述衍生物具有比多拉司他汀10更强的抗肿瘤活性，并且可用作抗癌剂或抗肿瘤剂。

8. 发明授权

US5840699A Peptide derivatives 失效
标题翻译：肽衍生物
公开(公告)号：US5840699A
公开(公告)日：1998-11-24
申请号：US945211
申请日：1997-10-21
申请人： Kyoichi Sakakibara , Masaaki Gondo , Koichi Miyazaki , Takeshi Ito , Akihiro Sugimura , Motohiro Kobayashi
发明人： Kyoichi Sakakibara , Masaaki Gondo , Koichi Miyazaki , Takeshi Ito , Akihiro Sugimura , Motohiro Kobayashi
IPC分类号： A61K38/00 , C07K5/02 , C07K5/027 , C07K5/00 , C07K7/00
CPC分类号： C07K5/0205 , A61K38/00
摘要： This invention relates to peptide derivatives of the formula ##STR1## or salts thereof, wherein: (a) Q.sub.1 represents a 1-dimethylamino-2-methylpropyl group and Q.sub.2 represents an (R)- or (S)-2-hydroxy-2-phenylethylamino group, a 2-phenylcyclopropylamino group or a 1,2,3,4-tetrahydroisoquinolin-2-yl group, or (b) Q.sub.1 represents a 1-methyl-2-pyrrolidinyl group and Q.sub.2 represents ##STR2##
摘要翻译： PCT No.PCT / JP96 / 00949 Sec。 371日期1997年10月21日 102（e）1997年10月21日PCT PCT 1996年4月8日PCT公布。公开号WO96 / 33212 PCT 日期：1996年10月24日本发明涉及下式的肽衍生物或其盐，其中：（a）Q1表示1-二甲基氨基-2-甲基丙基，Q 2表示（R） - 或（S） - 2-羟基-2-苯乙基氨基，2-苯基环丙基氨基或1,2,3,4-四氢异喹啉-2-基，或（b）Q1表示1-甲基-2-吡咯烷基，图像>

9. 发明授权

US5767237A Peptide derivatives 失效
标题翻译：肽衍生物
公开(公告)号：US5767237A
公开(公告)日：1998-06-16
申请号：US619606
申请日：1996-04-01
申请人： Kyoichi Sakakibara , Masaaki Gondo , Koichi Miyazaki , Takeshi Ito , Akihiro Sugimura , Motohiro Kobayashi
发明人： Kyoichi Sakakibara , Masaaki Gondo , Koichi Miyazaki , Takeshi Ito , Akihiro Sugimura , Motohiro Kobayashi
IPC分类号： A61K38/00 , C07K5/02 , C07K5/027 , C07K7/02 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： C07K5/0205 , C07K7/02 , A61K38/00 , Y10S530/83
摘要： A peptide derivative represented by the following formula or a salt thereof ##STR1## wherein A and B each represent either of the following (a) and (b), (a) A represents a hydrogen atom, and B represents a phenyl group substituted with a halogen atom, hydroxyl group, lower alkyl group or lower alkoxy group, or a heteroaryl group, (b) A represents --CONH--R.sup.1, --CSNH--R.sup.1, a hydroxymethyl group, a lower alkoxycarbonyl group or a carboxyl group, wherein, R.sup.1 represents a lower alkyl group or a heteroaryl group, and B represents a phenyl group optionally substituted with a halogen atom, hydroxyl group, lower alkyl group or lower alkoxy group, has an antitumor activity stronger than that of dolastatin 10, and is useful as an anticancer or antitumor agent.
摘要翻译： PCT No.PCT / JP94 / 01560 Sec。 371日期：1996年4月1日 102（e）日期1996年4月1日PCT 1994年9月22日PCT公布。出版物WO95 / 09864 日期：1995年04月13日由下式表示的肽衍生物或其盐，其中A和B各自表示以下（a）和（b）中任一项，（a）A表示氢原子，B表示被卤素原子，羟基，低级烷基或低级烷氧基或杂芳基取代的苯基，（b）A表示-CONH-R1，-CSNH-R1，羟甲基，低级烷氧基羰基或羧基，其中R1表示低级烷基或杂芳基，B表示任选被卤素原子，羟基，低级烷基或低级烷氧基取代的苯基，其抗肿瘤活性较强比多拉司他汀10多，可用作抗癌剂或抗肿瘤剂。

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