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1. 发明授权

US08679800B2 Method for producing lactic acid from plant-derived raw material, and lactic-acid-producing bacterium 有权
标题翻译：从植物来源的原料生产乳酸的方法和乳酸生产菌
公开(公告)号：US08679800B2
公开(公告)日：2014-03-25
申请号：US13063929
申请日：2009-09-11
申请人： Takashi Morishige , Katsuyuki Takahashi , Hitoshi Takahashi , Mitsufumi Wada , Daisuke Mochizuki , Daisuke Miyazawa , Tadashi Araki
发明人： Takashi Morishige , Katsuyuki Takahashi , Hitoshi Takahashi , Mitsufumi Wada , Daisuke Mochizuki , Daisuke Miyazawa , Tadashi Araki
IPC分类号： C12P7/56 , C12N9/00 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12P7/56 , C12N1/20 , C12N9/1205 , C12N9/2451
摘要： The present invention provides: a lactic acid-producing Escherichia coli comprising at least one gene of a sucrose non-PTS gene group, including at least a sucrose hydrolase gene, provided that a combination of a repressor protein (cscR), a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) and a combination of a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) are excluded, wherein the lactic acid-producing Escherichia coli comprises a lactic acid production enhancing system provided by genetic recombination; and a lactic acid production method including producing lactic acid from a plant-derived sucrose-containing raw material by using the lactic acid-producing Escherichia coli.
摘要翻译：本发明提供：产生乳酸的大肠杆菌，其包含至少一个蔗糖非PTS基因组的至少一个基因，至少包含蔗糖水解酶基因，前提是阻遏蛋白（cscR），蔗糖水解酶（ cscA），果糖激酶（cscK）和蔗糖通透酶（cscB）以及蔗糖水解酶（cscA），果糖激酶（cscK）和蔗糖通透酶（cscB）的组合，其中产生乳酸的大肠杆菌包含通过遗传重组提供的乳酸生产增强系统; 以及乳酸生产方法，其包括通过使用产生乳酸的大肠杆菌从植物来源的含蔗糖的原料生产乳酸。

2. 发明授权

US08614076B2 Bacterium capable of producing lactic acid, and method for producing lactic acid 有权
标题翻译：能够生产乳酸的细菌，以及乳酸的制造方法
公开(公告)号：US08614076B2
公开(公告)日：2013-12-24
申请号：US13063923
申请日：2009-09-11
申请人： Mitsufumi Wada , Katsuyuki Takahashi , Takashi Morishige , Daisuke Miyazawa , Hitoshi Takahashi , Daisuke Mochizuki , Tadashi Araki
发明人： Mitsufumi Wada , Katsuyuki Takahashi , Takashi Morishige , Daisuke Miyazawa , Hitoshi Takahashi , Daisuke Mochizuki , Tadashi Araki
IPC分类号： C12P7/56
CPC分类号： C12P7/56 , C12N9/0006 , C12N9/0069 , C12P41/002
摘要： The present invention provides: a lactic acid-producing Escherichia coli including an enzymatic activity of at least one NAD-dependent lactate dehydrogenase and an enzymatic activity of at least one NAD-independent lactate oxidoreductase, both of which are enhanced so as to decompose one of D-lactic acid or L-lactic acid and to produce the other one of D-lactic acid or L-lactic acid; and a lactic acid production method using the lactic acid-producing Escherichia coli.
摘要翻译：本发明提供：具有至少一种NAD依赖性乳酸脱氢酶的酶活性和至少一种不依赖于NAD的乳酸氧化还原酶的酶活性的产生乳酸的大肠杆菌，两者都被增强以分解其中之一 D-乳酸或L-乳酸，并生成D-乳酸或L-乳酸中的另一种; 以及使用产乳酸的大肠杆菌的乳酸的制造方法。

3. 发明授权

US08728780B2 Process for producing hydroxycarboxylic acid 有权
标题翻译：羟基羧酸的制备方法
公开(公告)号：US08728780B2
公开(公告)日：2014-05-20
申请号：US11587806
申请日：2005-04-19
申请人： Mitsufumi Wada , Daisuke Mochizuki , Hitoshi Takahashi , Takashi Morishige , Katsuyuki Takahashi
发明人： Mitsufumi Wada , Daisuke Mochizuki , Hitoshi Takahashi , Takashi Morishige , Katsuyuki Takahashi
IPC分类号： C12P7/42
CPC分类号： C12P7/42
摘要： An object of the invention is to produce a microorganism which yields high amounts in a short time of a hydroxycarboxylic acid reduced in impurity content. This invention further provides a process for producing a hydroxycarboxylic acid, including glycolic acid, using the microorganism. This process enables a hydroxycarboxylic acid having high purity to be supplied at low cost.
摘要翻译：本发明的目的是产生微生物，其在短时间内在杂质含量降低的羟基羧酸中产生大量的量。本发明还提供使用该微生物生产羟基羧酸（包括乙醇酸）的方法。该方法能够以低成本提供具有高纯度的羟基羧酸。

4. 发明申请

US20110171703A1 BACTERIUM CAPABLE OF PRODUCING LACTIC ACID, AND METHOD FOR PRODUCING LACTIC ACID 有权
标题翻译：生产酸乳酸的细菌和生产酸乳酸的方法
公开(公告)号：US20110171703A1
公开(公告)日：2011-07-14
申请号：US13063923
申请日：2009-09-11
申请人： Mitsufumi Wada , Katsuyuki Takahashi , Takashi Morishige , Daisuke Miyazawa , Hitoshi Takahashi , Daisuke Mochizuki , Tadashi Araki
发明人： Mitsufumi Wada , Katsuyuki Takahashi , Takashi Morishige , Daisuke Miyazawa , Hitoshi Takahashi , Daisuke Mochizuki , Tadashi Araki
IPC分类号： C12P7/56 , C12N1/20
CPC分类号： C12P7/56 , C12N9/0006 , C12N9/0069 , C12P41/002
摘要： The present invention provides: a lactic acid-producing Escherichia coli including an enzymatic activity of at least one NAD-dependent lactate dehydrogenase and an enzymatic activity of at least one NAD-independent lactate oxidoreductase, both of which are enhanced so as to decompose one of D-lactic acid or L-lactic acid and to produce the other one of D-lactic acid or L-lactic acid; and a lactic acid production method using the lactic acid-producing Escherichia coli.
摘要翻译：本发明提供：具有至少一种NAD依赖性乳酸脱氢酶的酶活性和至少一种不依赖于NAD的乳酸氧化还原酶的酶活性的产生乳酸的大肠杆菌，两者都被增强以分解其中之一 D-乳酸或L-乳酸，并产生D-乳酸或L-乳酸中的另一种; 以及使用产乳酸的大肠杆菌的乳酸的制造方法。

5. 发明申请

US20110171704A1 METHOD FOR PRODUCING LACTIC ACID FROM PLANT-DERIVED RAW MATERIAL, AND LACTIC-ACID-PRODUCING BACTERIUM 有权
标题翻译：从植物衍生的原料生产柠檬酸的方法和生产酸乳杆菌的方法
公开(公告)号：US20110171704A1
公开(公告)日：2011-07-14
申请号：US13063929
申请日：2009-09-11
申请人： Takashi Morishige , Katsuyuki Takahashi , Hitoshi Takahashi , Mitsufumi Wada , Daisuke Mochizuki , Daisuke Miyazawa , Tadashi Araki
发明人： Takashi Morishige , Katsuyuki Takahashi , Hitoshi Takahashi , Mitsufumi Wada , Daisuke Mochizuki , Daisuke Miyazawa , Tadashi Araki
IPC分类号： C12P7/56 , C12N1/21
CPC分类号： C12P7/56 , C12N1/20 , C12N9/1205 , C12N9/2451
摘要： The present invention provides: a lactic acid-producing Escherichia coli comprising at least one gene of a sucrose non-PTS gene group, including at least a sucrose hydrolase gene, provided that a combination of a repressor protein (cscR), a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) and a combination of a sucrose hydrolase (cscA), a fructokinase (cscK) and a sucrose permease (cscB) are excluded, wherein the lactic acid-producing Escherichia coli comprises a lactic acid production enhancing system provided by genetic recombination; and a lactic acid production method including producing lactic acid from a plant-derived sucrose-containing raw material by using the lactic acid-producing Escherichia coli.
摘要翻译：本发明提供：产生乳酸的大肠杆菌，其包含至少一个蔗糖非PTS基因基因的至少一个基因，至少包含蔗糖水解酶基因，前提是阻遏蛋白（cscR），蔗糖水解酶（ cscA），果糖激酶（cscK）和蔗糖通透酶（cscB）以及蔗糖水解酶（cscA），果糖激酶（cscK）和蔗糖通透酶（cscB）的组合，其中产生乳酸的大肠杆菌包含通过遗传重组提供的乳酸生产增强系统; 以及乳酸生产方法，其包括通过使用产生乳酸的大肠杆菌从植物来源的含蔗糖的原料生产乳酸。

6. 发明申请

US20080032370A1 Process for Producng Hydroxycarboxylic Acid 有权
标题翻译：生产羟基羧酸的方法
公开(公告)号：US20080032370A1
公开(公告)日：2008-02-07
申请号：US11587806
申请日：2005-04-19
申请人： Mitsufumi Wada , Daisuke Mochizuki , Hitoshi Takahashi , Takashi Morishige , Katsuyuki Takahashi
发明人： Mitsufumi Wada , Daisuke Mochizuki , Hitoshi Takahashi , Takashi Morishige , Katsuyuki Takahashi
IPC分类号： C12P7/42 , C07C59/00
CPC分类号： C12P7/42
摘要： Hydroxycarboxylic acids including glycolic acid are promising compounds for use as a raw material for polymers or an intermediate for medicines. However, the processes for the production of hydroxycarboxylic acids which are presently known have a problem that none of them can supply an inexpensive high-purity hydroxycarboxylic acid. An object of the invention is to produce a microorganism which highly yields in a short time a hydroxycarboxylic acid reduced in impurity content and to provide a process for producing a hydroxycarboxylic acid including glycolic acid using the microorganism. A microorganism is produced, which has the imparted or enhanced activity of an enzyme catalyzing a reaction from ethylene glycol to glycolaldehyde. Using this microorganism, a hydroxycarboxylic acid including glycolic acid which is reduced in impurity content is highly produced in a short time. The production process enables a hydroxycarboxylic acid having high purity to be supplied at low cost.
摘要翻译：包括乙醇酸在内的羟基羧酸是用作聚合物或药物中间体的原料的有希望的化合物。然而，目前已知的用于生产羟基羧酸的方法具有这样的问题，即它们都不能提供廉价的高纯度羟基羧酸。本发明的目的是生产一种微生物，其在短时间内高度地产生杂质含量降低的羟基羧酸，并提供使用微生物生产包括乙醇酸的羟基羧酸的方法。产生微生物，其具有赋予或增强的催化从乙二醇到乙二醇的反应的酶的活性。使用该微生物，在短时间内高度地产生包含杂质含量降低的乙醇酸的羟基羧酸。制造方法能够以低成本供给高纯度的羟基羧酸。

7. 发明申请

US20110207187A1 BACTERIUM PRODUCING 2-DEOXY-SCYLLO-INOSOSE (DOI) AND METHOD OF PRODUCING 2-DEOXY-SCYLLO-INOSOSE (DOI) BY USING SAME 有权
标题翻译：生产2-脱氧 - 磺酰胺（DOI）的细菌和使用它们生产2-脱氧肌醇六磷酸（DOI）的方法
公开(公告)号：US20110207187A1
公开(公告)日：2011-08-25
申请号：US13126154
申请日：2009-10-30
申请人： Junko Tokuda , Tomoyuki Natsuji , Hitoshi Takahashi , Tadashi Araki , Takashi Morishige , Katsuyuki Takahashi , Mitsufumi Wada
发明人： Junko Tokuda , Tomoyuki Natsuji , Hitoshi Takahashi , Tadashi Araki , Takashi Morishige , Katsuyuki Takahashi , Mitsufumi Wada
IPC分类号： C12P7/26 , C12N1/21
CPC分类号： C12N15/52 , C12P19/02
摘要： Disclosed is an Escherichia coli producing 2-deoxy-scyllo-inosose (DOI), which, from a sucrose non-PTS gene group, has at least a sucrose hydrolase (CscA)-encoding gene and which is provided with a DOI production system or has an enhanced DOI production system. The Escherichia coli preferably further includes a system to enhance sugar uptake capacity. There is also disclosed a method of producing DOI from a plant-derived raw material containing sucrose by using the Escherichia coli.
摘要翻译：公开了一种产生2-脱氧 - 青蟹肌糖（DOI）的大肠杆菌，其从蔗糖非PTS基因组至少具有蔗糖水解酶（CscA）编码基因，并且具有DOI生产系统或具有增强的DOI生产系统。大肠杆菌优选还包括增强糖吸收能力的系统。还公开了通过使用大肠杆菌从含有蔗糖的植物来源的原料生产DOI的方法。

8. 发明授权

US09150868B2 Bacterium producing 2-deoxy-scyllo-inosose (DOI) and method of producing 2-deoxy-scyllo-inosose (DOI) by using same 有权
标题翻译：产生2-脱氧十字鸟苷（DOI）的细菌和通过使用相同的方法生产2-脱氧 - 青蟹肌糖（DOI）
公开(公告)号：US09150868B2
公开(公告)日：2015-10-06
申请号：US13126154
申请日：2009-10-30
申请人： Junko Tokuda , Tomoyuki Natsuji , Hitoshi Takahashi , Tadashi Araki , Takashi Morishige , Katsuyuki Takahashi , Mitsufumi Wada
发明人： Junko Tokuda , Tomoyuki Natsuji , Hitoshi Takahashi , Tadashi Araki , Takashi Morishige , Katsuyuki Takahashi , Mitsufumi Wada
IPC分类号： C12P19/02 , C12N15/52
CPC分类号： C12N15/52 , C12P19/02
摘要： Disclosed is an Escherichia coli producing 2-deoxy-scyllo-inosose (DOI), which, from a sucrose non-PTS gene group, has at least a sucrose hydrolase (CscA)-encoding gene and which is provided with a DOI production system or has an enhanced DOI production system. The Escherichia coli preferably further includes a system to enhance sugar uptake capacity. There is also disclosed a method of producing DOI from a plant-derived raw material containing sucrose by using the Escherichia coli.
摘要翻译：公开了一种产生2-脱氧 - 青蟹肌糖（DOI）的大肠杆菌，其从蔗糖非PTS基因组至少具有蔗糖水解酶（CscA）编码基因，并且具有DOI生产系统或具有增强的DOI生产系统。大肠杆菌优选还包括增强糖吸收能力的系统。还公开了通过使用大肠杆菌从含有蔗糖的植物来源的原料生产DOI的方法。

9. 发明申请

US20110159554A1 YEAST FOR PRODUCTION OF GLUCOSE, AND METHOD FOR PRODUCTION OF GLUCOSE USING THE SAME 审中-公开
标题翻译：用于生产葡萄糖的YEAST，以及使用该葡萄糖生产葡萄糖的方法
公开(公告)号：US20110159554A1
公开(公告)日：2011-06-30
申请号：US12937675
申请日：2009-03-10
申请人： Katsuyuki Takahashi , Mitsufumi Wada , Sakurako Kimura , Ryota Fujii
发明人： Katsuyuki Takahashi , Mitsufumi Wada , Sakurako Kimura , Ryota Fujii
IPC分类号： C12P19/02 , C12N1/16
CPC分类号： C12P19/14 , C12R1/85
摘要： The invention provides: yeast having cellulose degradation ability that degrades cellulose outside the cell and glucose accumulation ability that accumulates, in a reaction liquid, glucose produced from cellulose as a result of the cellulose degradation ability, when the yeast was brought into contact with cellulose in the reaction liquid; and a method for producing glucose, wherein the glucose is produced from cellulose, the method comprising the step of bringing the yeast into contact with cellulose in a reaction liquid and the step of separating and collecting, from the reaction liquid, glucose accumulated in the reaction liquid as a result of the contact of the yeast with the cellulose.
摘要翻译：本发明提供：当酵母与纤维素接触时，具有降解细胞外纤维素的纤维素降解能力的酵母和葡萄糖积聚能力，其在反应液体中积聚由纤维素降解能力引起的纤维素由纤维素产生的葡萄糖反应液; 以及葡萄糖的制造方法，其中，所述葡萄糖由纤维素制造，所述方法包括使所述酵母与反应液中的纤维素接触的步骤，从所述反应液中分离并收集反应中积累的葡萄糖的步骤作为酵母与纤维素接触的结果的液体。

10. 发明授权

US09159513B2 Electromagnetic relay 有权
标题翻译：电磁继电器
公开(公告)号：US09159513B2
公开(公告)日：2015-10-13
申请号：US13611383
申请日：2012-09-12
申请人： Satoshi Moriyama , Ryuji Sasaki , Katsuyuki Takahashi
发明人： Satoshi Moriyama , Ryuji Sasaki , Katsuyuki Takahashi
IPC分类号： H01H51/22 , H01H50/02 , H01H50/64
CPC分类号： H01H50/56 , H01H50/02 , H01H50/026 , H01H50/642
摘要： An electromagnetic relay includes a contact including a movable spring having a base end fixed to a bottom of a housing and a tip end provided with a movable contact, and a fixed spring having a base end fixed to the bottom of the housing and a tip end provided with a fixed contact. The movable contact is provided opposite to the fixed contact so as to come in contact with the fixed contact or move away therefrom. The housing has a protrusion protruding toward a side of the fixed contact opposite to a side facing the movable contact.
摘要翻译：一种电磁继电器包括一个触点，该触点包括一个活动弹簧，该活动弹簧具有一个固定在壳体底部的基端和一个设有可动触点的末端，以及一个固定弹簧，该固定弹簧的底端固定在外壳的底部，提供固定联系人。活动触点设置成与固定触点相对，以便与固定触点接触或远离固定触点。壳体具有朝向固定触点的与面对动触头的一侧相对的一侧突出的突起。

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