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1. 发明授权

US06333322B1 Nitrogen-containing tricyclic compounds and drugs containing the same 失效
标题翻译：含氮三环化合物和含有这些化合物的药物
公开(公告)号：US06333322B1
公开(公告)日：2001-12-25
申请号：US09125451
申请日：1998-09-21
申请人： Mitsuaki Miyamoto , Tatsuya Yoshiuchi , Keizo Sato , Makoto Kaino , Masayuki Tanaka , Motohiro Soejima , Katsuhiro Moriya , Yoshinori Sakuma , Koji Yamada , Kokichi Harada , Yukio Nishizawa , Seiichi Kobayashi , Makoto Okita , Koichi Katayama
发明人： Mitsuaki Miyamoto , Tatsuya Yoshiuchi , Keizo Sato , Makoto Kaino , Masayuki Tanaka , Motohiro Soejima , Katsuhiro Moriya , Yoshinori Sakuma , Koji Yamada , Kokichi Harada , Yukio Nishizawa , Seiichi Kobayashi , Makoto Okita , Koichi Katayama
IPC分类号： A61K315415
CPC分类号： C07D417/06 , C07D279/22 , C07D279/24 , C07D417/12 , C09B21/00 , C09B57/08
摘要： A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) effective against diseases in which histamine, leukotrienes, etc. participate and effective in preventing or treating diseases in which chemical mediators such as histamine and leukotrienes participate, for example, asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy and food allergy.
摘要翻译：苯并噻嗪，吖啶酮肟，吖啶酮肟，腙酮腙和二苯并二氮杂衍生物，其对组胺，白细胞三烯等参与并有效预防或治疗化学介质如组胺和白三烯参与的疾病有效，例如哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，花粉症，胃肠道过敏和食物过敏。

2. 发明授权

US06489336B2 Nitrogen-containing tricyclic compounds and drugs containing the same 失效
标题翻译：含氮三环化合物和含有这些化合物的药物
公开(公告)号：US06489336B2
公开(公告)日：2002-12-03
申请号：US09985416
申请日：2001-11-02
申请人： Mitsuaki Miyamoto , Tatsuya Yoshiuchi , Keizo Sato , Makoto Kaino , Masayuki Tanaka , Motohiro Soejima , Katsuhiro Moriya , Yoshinori Sakuma , Koji Yamada , Kokichi Harada , Yukio Nishizawa , Seiichi Kobayashi , Makoto Okita , Koichi Katayama
发明人： Mitsuaki Miyamoto , Tatsuya Yoshiuchi , Keizo Sato , Makoto Kaino , Masayuki Tanaka , Motohiro Soejima , Katsuhiro Moriya , Yoshinori Sakuma , Koji Yamada , Kokichi Harada , Yukio Nishizawa , Seiichi Kobayashi , Makoto Okita , Koichi Katayama
IPC分类号： A61K31473
CPC分类号： C07D417/06 , C07D279/22 , C07D279/24 , C07D417/12 , C09B21/00 , C09B57/08
摘要： A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) effective against diseases in which histamine, leukotrienes, etc. participate and effective in preventing or treating diseases in which chemical mediators such as histamine and leukotrienes participate, for example, asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy and food allergy.
摘要翻译：苯并噻嗪，吖啶酮肟，吖啶酮肟，腙酮腙和二苯并二氮杂衍生物，其对组胺，白细胞三烯等参与并有效预防或治疗化学介质如组胺和白三烯参与的疾病有效，例如哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，花粉症，胃肠道过敏和食物过敏。

3. 发明授权

US06703388B2 Nitrogen-containing tricyclic compounds and drugs containing the same 失效
标题翻译：含氮三环化合物和含有这些化合物的药物
公开(公告)号：US06703388B2
公开(公告)日：2004-03-09
申请号：US10201952
申请日：2002-07-25
申请人： Mitsuaki Miyamoto , Tatsuya Yoshiuchi , Keizo Sato , Makoto Kaino , Masayuki Tanaka , Motohiro Soejima , Katsuhiro Moriya , Yoshinori Sakuma , Koji Yamada , Kokichi Harada , Yukio Nishizawa , Seiichi Kobayashi , Makoto Okita , Koichi Katayama
发明人： Mitsuaki Miyamoto , Tatsuya Yoshiuchi , Keizo Sato , Makoto Kaino , Masayuki Tanaka , Motohiro Soejima , Katsuhiro Moriya , Yoshinori Sakuma , Koji Yamada , Kokichi Harada , Yukio Nishizawa , Seiichi Kobayashi , Makoto Okita , Koichi Katayama
IPC分类号： A61K31551
CPC分类号： C07D417/06 , C07D279/22 , C07D279/24 , C07D417/12 , C09B21/00 , C09B57/08
摘要： A phenothiazine, acridan, acridone oxime, acridone hydrazone and dibenzodiazepine derivative represented by formula (I) effective against diseases in which histamine, leukotrienes, etc. participate and effective in preventing or treating diseases in which chemical mediators such as histamine and leukotrienes participate, for example, asthma, allergic rhinitis, atopic dermatitis, urticaria, hay fever, gastrointestinal allergy and food allergy.
摘要翻译：苯并噻嗪，吖啶酮肟，吖啶酮肟，腙酮腙和二苯并二氮杂衍生物，其对组胺，白细胞三烯等参与并有效预防或治疗化学介质如组胺和白三烯参与的疾病有效，例如哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，花粉症，胃肠道过敏和食物过敏。

4. 发明授权

US06583138B1 Heterocyclic-ring condensed benzothiazine compound 失效
标题翻译：杂环稠合苯并噻嗪化合物
公开(公告)号：US06583138B1
公开(公告)日：2003-06-24
申请号：US09622458
申请日：2001-01-04
申请人： Mitsuaki Miyamoto , Tatsuya Yoshiuchi , Keizo Sato , Motohiro Soejima , Takashi Sato , Koichi Kikuchi , Hiroyuki Yoshimura , Katsuhiro Moriya , Yoshinori Sakuma , Shigeru Akasofu , Koji Yamada
发明人： Mitsuaki Miyamoto , Tatsuya Yoshiuchi , Keizo Sato , Motohiro Soejima , Takashi Sato , Koichi Kikuchi , Hiroyuki Yoshimura , Katsuhiro Moriya , Yoshinori Sakuma , Shigeru Akasofu , Koji Yamada
IPC分类号： C07D51304
CPC分类号： C07D513/04
摘要： The invention provides a novel heterocyclic ring condensed benzothiazine compound which is effective for prevention or remedy of disease, in which histamine, leukotriene and the like participate. The heterocyclic ring condensed benzothiazine compound of the present invention or a pharmacologically acceptable salt thereof is effective for prevention or remedy of disease, in which a chemical mediator, such as histamine, leukotriene and the like, participate, for example, asthma, allergic coryza, atopic dermatitis, hives, hay fever, gastrointestinal allergy, food allergy and the like. Further, the heterocyclic ring condensed benzothiazine compound of the present invention, its pharmacologically acceptable salt or hydrates thereof is represented by the following formula: In the formula, the ring Het represents an unsaturated heterocyclic ring; R1 and R2 are the same as or different from each other, and each represents halogen atom, a lower alkyl group that may be substituted with a halogen atom, a lower alkoxy group that may be substituted with a halogen atom, a lower alkyl lower alkoxy group, cyano group; D represents a lower alkylene group and the like that may have a substituent; Q represents, for example, the formula —NR20R2 (in the formula, R20 and R21 are the same as or different from each other, and each represents hydrogen atom, a lower alkyl group that may be substituted with a halogen atom, an aryl group that may have a substituent, an arylalkyl group that may have a substituent, a heteroaryl group that may have a substituent or a heteroarylalkyl group that may have a substituent, or R20 and R21 may form a 3- to 8-membered ring along with the nitrogen atom to which they are bound); and x represents an integer of from 1 to 2.
摘要翻译：本发明提供一种新颖的杂环稠合苯并噻嗪化合物，其对组胺，白细胞三烯等参与的疾病的预防或治疗有效。本发明的杂环稠合苯并噻嗪化合物或其药理学上可接受的盐对于预防或治疗其中化学介质如组胺，白三烯等参与的疾病是有效的，例如哮喘，过敏性鼻炎，特应性皮炎，荨麻疹，花粉症，胃肠道过敏，食物过敏等。此外，本发明的杂环稠合苯并噻嗪化合物，其药理学上可接受的盐或其水合物由下式表示：式中，环Het表示不饱和杂环; R1和R2彼此相同或不同，各自表示卤素原子，可以被卤素原子取代的低级烷基，可被卤素原子取代的低级烷氧基，低级烷基低级烷氧基基团，氰基; D表示可以具有取代基的低级亚烷基等; Q表示例如式-NR20R2（式中，R20和R21彼此相同或不同，各自表示氢原子，可被卤素原子取代的低级烷基，芳基可以具有取代基的芳基烷基，可以具有取代基的芳基烷基，可以具有取代基的杂芳基或可以具有取代基的杂芳基烷基，或者R20和R21可以与氮原子）; x表示1〜2的整数。

5. 发明授权

US07772249B2 Imidazo[1,2-b]pyridazine compound 失效
标题翻译：咪唑并[1,2-b]哒嗪化合物
公开(公告)号：US07772249B2
公开(公告)日：2010-08-10
申请号：US12397132
申请日：2009-03-03
申请人： Shigeki Hibi , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
发明人： Shigeki Hibi , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
IPC分类号： A61K31/44
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.
摘要翻译：本发明提供具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新型化合物。也就是说，它提供由下式表示的化合物或其盐。其中R1表示氢原子，C1-6烷基，C1-6烷氧基等; R2表示卤素原子，氰基，硝基，C1-10烷基，C2-10烯基，C2-10炔基等; R3表示可以具有取代基的C 6-14芳族烃环状基团或5〜14元芳香族杂环基团。 X，Y和X彼此独立地表示N或CR4（其中R4表示氢原子，卤素原子，氰基，硝基，任意卤代的C 1-6烷基等）和在这种情况下，X，Y和Z中的至少两个表示CR 4。

6. 发明授权

US07625925B2 Pyrazolo[1,5-a]pyridines and medicines containing the same 失效
标题翻译：吡唑并[1,5-a]吡啶和含有它们的药物
公开(公告)号：US07625925B2
公开(公告)日：2009-12-01
申请号：US11757595
申请日：2007-06-04
申请人： Shigeki Hibi , Koichi Kikuchi , Yorihisa Hoshino , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Yoshinori Takahashi , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
发明人： Shigeki Hibi , Koichi Kikuchi , Yorihisa Hoshino , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Yoshinori Takahashi , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
IPC分类号： A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , C07F5/025 , C07F7/2208
摘要： Compounds represented by the general formula: [wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 and R6 each represent —X5—X6—X7 (wherein X5 represents a single bond or —CO—, X6 represents a single bond, —NR3a, etc. and X7 and R3a each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.
摘要翻译：由以下通式表示的化合物：[其中R1表示甲氧基，乙基，甲硫基等，R2，R3和R4各自表示氢，卤素等，R5和R6各自表示-X5-X6-X7（其中X5表示单键或-CO-，X6表示单键，-NR3a等，X7和R3a各自表示氢，C1-10烷基等），Ar表示苯基，吡啶基等]，其盐和上述的水合物。

7. 发明申请

US20060217348A1 Pyrazolo[1,5-a] pyridines and medicines containing the same 失效
标题翻译：吡唑并[1,5-a]吡啶和含有它们的药物
公开(公告)号：US20060217348A1
公开(公告)日：2006-09-28
申请号：US11446416
申请日：2006-06-05
申请人： Shigeki Hibi , Koichi Kikuchi , Yorihisa Hoshino , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Yoshinori Takahashi , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
发明人： Shigeki Hibi , Koichi Kikuchi , Yorihisa Hoshino , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Yoshinori Takahashi , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
IPC分类号： A61K31/69 , A61K31/555 , A61K31/4745 , C07F5/02 , C07F7/22 , C07D471/02
CPC分类号： C07D471/04 , A61K31/437 , C07F5/025 , C07F7/2208
摘要： Compounds represented by the general formula: [wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 and R6 each represent —X5—X6—X7 (wherein X5 represents a single bond or —CO—, X6 represents a single bond, —NR3a, etc. and X7 and R3a each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.
摘要翻译：由以下通式表示的化合物：其中R 1表示甲氧基，乙基，甲硫基等，R 2，R 3和R 3， SUP> 4 各自表示氢，卤素等，R 5和R 6各自表示-X 5〜其中X 5表示单键或-CO-，X 6表示单键键，-NR 3a等，X 7和R 9各自表示氢，C 1-10烷基，烷基等），Ar表示苯基，吡啶基等]，其盐和上述的水合物。

8. 发明授权

US06995163B2 Tricyclic fused heterocyclic compound, process for preparing it and medicament comprising it 失效
标题翻译：三环稠合杂环化合物，其制备方法和包含它的药物
公开(公告)号：US06995163B2
公开(公告)日：2006-02-07
申请号：US10903059
申请日：2004-08-02
申请人： Shigeki Hibi , Yorihisa Hoshino , Tatsuya Yoshiuchi , Kogyoku Shin , Kouichi Kikuchi , Motohiro Soejima , Mutsuko Tabata , Yoshinori Takahashi , Hisashi Shibata , Takayuki Hida , Tetsuya Hirakawa , Mitsuhiro Ino
发明人： Shigeki Hibi , Yorihisa Hoshino , Tatsuya Yoshiuchi , Kogyoku Shin , Kouichi Kikuchi , Motohiro Soejima , Mutsuko Tabata , Yoshinori Takahashi , Hisashi Shibata , Takayuki Hida , Tetsuya Hirakawa , Mitsuhiro Ino
IPC分类号： C07D471/14 , A61K31/519 , A61P25/24
CPC分类号： C07D471/14 , C07D487/14 , C07D491/14
摘要： The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof, wherein R2 is a hydrogen atom, etc.; R3 is a hydrogen atom, etc.; M′ represents a hydrogen atom, a halogen atom or a C1-6 alkyl group; R7′ represents a hydrogen atom or a C1-6 alkyl group; and W′ represents a phenyl group, pyridyl group, thienyl group, or furyl group, each being optionally substituted; and a pharmacologically acceptable salt thereof or hydrates thereof.
摘要翻译：本发明提供具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新型化合物。也就是说，它提供由下式表示的化合物，其药理学上可接受的盐或水合物

9. 发明申请

US20090181985A1 IMIDAZO[1,2-b]PYRIDAZINE COMPOUND 失效
标题翻译：咪唑并[1,2-b]吡啶化合物
公开(公告)号：US20090181985A1
公开(公告)日：2009-07-16
申请号：US12397132
申请日：2009-03-03
申请人： Shigeki Hibi , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Matsuko Ono , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
发明人： Shigeki Hibi , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Matsuko Ono , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
IPC分类号： A61K31/519 , C07D487/02 , A61P25/18 , A61P25/22
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.
摘要翻译：本发明提供具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新型化合物。也就是说，它提供由下式表示的化合物或其盐。其中R1表示氢原子，C1-6烷基，C1-6烷氧基等; R2表示卤素原子，氰基，硝基，C1-10烷基，C2-10烯基，C2-10炔基等; R3表示可以具有取代基的C 6-14芳族烃环状基团或5〜14元芳香族杂环基团。 X，Y和X彼此独立地表示N或CR4（其中R4表示氢原子，卤素原子，氰基，硝基，任意卤代的C 1-6烷基等）和在这种情况下，X，Y和Z中的至少两个表示CR 4。

10. 发明授权

US07091215B2 Pyrazolo[1,5-a]pyridines and medicines containing the same 失效
标题翻译：吡唑并[1,5-a]吡啶和含有它们的药物
公开(公告)号：US07091215B2
公开(公告)日：2006-08-15
申请号：US10250693
申请日：2002-04-25
申请人： Shigeki Hibi , Koichi Kikuchi , Yorihisa Hoshino , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Yoshinori Takahashi , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
发明人： Shigeki Hibi , Koichi Kikuchi , Yorihisa Hoshino , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Yoshinori Takahashi , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
IPC分类号： C07D471/02 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , C07F5/025 , C07F7/2208
摘要： Compounds represented by the general formula: [wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 and R6 each represent —X5—X6—X7 (wherein X5 represents a single bond or —CO—, X6 represents a single bond, —NR3a, etc. and X7 and R3a each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.
摘要翻译：由以下通式表示的化合物：其中R 1表示甲氧基，乙基，甲硫基等，R 2，R 3和R 3， SUP> 4 各自表示氢，卤素等，R 5和R 6各自表示-X 5〜其中X 5表示单键或-CO-，X 6表示单键键，-NR 3a等，X 7和R 9各自表示氢，C 1-10烷基，烷基等），Ar表示苯基，吡啶基等]，其盐和上述的水合物。

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